Entry
Name
Herpes simplex virus 1 infection - Salmo salar (Atlantic salmon)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
Ortholog table
Organism
Salmo salar (Atlantic salmon) [GN:
sasa ]
Gene
106601456 tumor necrosis factor ligand superfamily member 14-like [KO:K05477 ]
106606846 tumor necrosis factor ligand superfamily member 14-like [KO:K05477 ]
106585332 tumor necrosis factor ligand superfamily member 15-like [KO:K05477 ]
100196844 tnr14; Tumor necrosis factor receptor superfamily member 14 [KO:K05152 ]
106572765 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
106572767 tumor necrosis factor receptor superfamily member 5-like [KO:K05152 ]
106572768 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
106572807 tumor necrosis factor receptor superfamily member 5-like [KO:K05152 ]
106572808 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
106572809 tumor necrosis factor receptor superfamily member 5-like [KO:K05152 ]
106572816 tumor necrosis factor receptor superfamily member 5-like [KO:K05152 ]
106572817 tumor necrosis factor receptor superfamily member 5-like [KO:K05152 ]
106572813 tumor necrosis factor receptor superfamily member 5-like [KO:K05152 ]
106590733 ikbkg; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210 ]
106575638 tigit; T-cell immunoreceptor with Ig and ITIM domains [KO:K06081 ]
106590780 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403 ]
106594427 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403 ]
106607744 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like [KO:K04404 ]
106571309 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like [KO:K04404 ]
106602525 eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237 ]
106608216 eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237 ]
100195154 if2a; Eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
106568294 EI2BA; translation initiation factor eIF-2B subunit alpha-like [KO:K03239 ]
106580370 EI2BA; translation initiation factor eIF-2B subunit alpha-like [KO:K03239 ]
106585290 EI2BA; translation initiation factor eIF-2B subunit alpha-like [KO:K03239 ]
106608291 translation initiation factor eIF-2B subunit beta-like [KO:K03754 ]
100195606 ei2bb; Translation initiation factor eIF-2B subunit beta [KO:K03754 ]
106569082 translation initiation factor eIF-2B subunit gamma-like [KO:K03241 ]
100380535 ei2bg; Translation initiation factor eIF-2B subunit gamma [KO:K03241 ]
106608321 translation initiation factor eIF-2B subunit delta-like [KO:K03680 ]
106571016 translation initiation factor eIF-2B subunit delta-like [KO:K03680 ]
100306763 eif2b5; eukaryotic translation initiation factor 2B subunit epsilon [KO:K03240 ]
100136558 STAT1; signal transducer and activator of transcription 1 alpha [KO:K11220 ]
106586142 signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220 ]
100270812 stat2; signal transducer and activator of transcription 2 [KO:K11221 ]
106609532 zinc finger and SCAN domain-containing protein 2-like [KO:K09228 ]
106576508 zinc finger protein with KRAB and SCAN domains 8-like [KO:K09228 ]
106583350 zinc finger and SCAN domain-containing protein 2-like [KO:K09228 ]
106605100 zinc finger and SCAN domain-containing protein 2-like [KO:K09228 ]
106600927 zinc finger and SCAN domain-containing protein 31-like [KO:K09228 ]
106564035 zinc finger and SCAN domain-containing protein 2-like [KO:K09228 ]
106569933 zinc finger and SCAN domain-containing protein 2-like [KO:K09228 ]
106565089 zinc finger and SCAN domain-containing protein 2-like [KO:K09228 ]
106569843 BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751 ]
106569935 major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
106569936 Sasa-ZCA; H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
106569938 Sasa-ZBA; H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
106569947 Sasa-UGA; major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
106582436 Sasa-UHA; major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
106597513 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
106597015 major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
106592784 major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
106588377 HA1L; H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
106588378 major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
106588380 Sasa-ZE; class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
106588401 Sasa-UBA; class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
106588381 Sasa-ZAA; major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
106588402 Sasa-UBA; major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
106574261 DCB; H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
106574265 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
106584517 DEA; H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
106586334 DCB; H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
106605250 rano class II histocompatibility antigen, B alpha chain-like [KO:K06752 ]
106567570 Sasa-DBB; HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752 ]
106567571 Sasa-DBA; H-2 class II histocompatibility antigen, A-K alpha chain-like [KO:K06752 ]
106564356 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
106564360 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
106565699 DAA; H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
100136577 DB1; H-2 class II histocompatibility antigen, I-E beta chain [KO:K06752 ]
106592694 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
106600246 DAB; H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752 ]
106604844 HG2A; H-2 class II histocompatibility antigen gamma chain-like [KO:K06505 ]
106611871 HG2A; HLA class II histocompatibility antigen gamma chain-like [KO:K06505 ]
106598808 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
106568747 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
106600405 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
106567700 phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
106599005 phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649 ]
106560529 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
106613635 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
106569403 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
106568949 phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649 ]
106573900 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
106563018 phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649 ]
106584012 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
106587034 phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649 ]
106580340 4EBP2; eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205 ]
106585258 4EBP2; eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205 ]
106613961 tumor necrosis factor ligand superfamily member 6-like [KO:K04389 ]
106579980 tumor necrosis factor ligand superfamily member 6-like [KO:K04389 ]
100196289 tnfl6; Tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
106577010 tumor necrosis factor receptor superfamily member 6-like [KO:K04390 ]
100380364 tnr6; Tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
106575188 tumor necrosis factor receptor superfamily member 1A-like [KO:K03158 ]
100196751 tnr1a; Tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
106567387 tumor necrosis factor receptor superfamily member 1A-like [KO:K03158 ]
106562229 tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171 ]
106587422 tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Granger SW, Rickert S
Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
Journal
Reference
Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
Journal
Reference
Authors
MacLeod IJ, Minson T
Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
Journal
Reference
Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
Journal
Reference
Authors
Gianni T, Campadelli-Fiume G
Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
Journal
Reference
Authors
Spear PG
Title
Herpes simplex virus: receptors and ligands for cell entry.
Journal
Reference
Authors
Boutell C, Everett RD
Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
Journal
Reference
Authors
Ma Y, He B
Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
Journal
Reference
Authors
Su C, Zhan G, Zheng C
Title
Evasion of host antiviral innate immunity by HSV-1, an update.
Journal
Reference
Authors
Melchjorsen J, Matikainen S, Paludan SR
Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
Journal
Reference
Authors
Morrison LA
Title
The Toll of herpes simplex virus infection.
Journal
Reference
Authors
Zheng C
Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
Journal
Reference
Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
Journal
Reference
Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
Journal
Reference
Authors
Sanchez R, Mohr I
Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
Journal
Reference
Authors
Wysocka J, Herr W
Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
Journal
Reference
Authors
Fleming SB
Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
Journal
Reference
Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
Journal
Reference
Authors
Gu H, Zheng Y, Roizman B
Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
Journal
Reference
Authors
Tavalai N, Stamminger T
Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
Journal
Reference
Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal
Reference
Authors
Neumann J, Eis-Hubinger AM, Koch N
Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
Journal
Reference
Authors
Liu X, Cohen JI
Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
Journal
Reference
Authors
Vink EI, Smiley JR, Mohr I
Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
Journal
Reference
Authors
Sandri-Goldin RM
Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
Journal
Reference
Authors
Sandri-Goldin RM
Title
Viral regulation of mRNA export.
Journal
Reference
Authors
Yu X, He S
Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
Journal
Related pathway
sasa04620 Toll-like receptor signaling pathway
sasa04622 RIG-I-like receptor signaling pathway
KO pathway
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