KEGG   PATHWAY: vlg05022
Entry
vlg05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Vulpes lagopus (Arctic fox)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
vlg05022  Pathways of neurodegeneration - multiple diseases
vlg05022

Organism
Vulpes lagopus (Arctic fox) [GN:vlg]
Gene
121479288  amyloid-beta precursor protein isoform X1 [KO:K04520]
121472963  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
121492762  SNCA; alpha-synuclein [KO:K04528]
121496718  TAR DNA-binding protein 43 [KO:K23600]
121487657  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
121489323  LOW QUALITY PROTEIN: RNA-binding protein FUS-like [KO:K13098]
121479538  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
121475524  ATXN2; ataxin-2 isoform X1 [KO:K23625]
121487313  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
121489071  HTT; huntingtin isoform X1 [KO:K04533]
121499690  ATXN1L; ataxin-1-like [KO:K23616]
121500412  ATXN1; ataxin-1 [KO:K23616]
121493359  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
121478271  major prion protein [KO:K05634]
121472174  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
121486583  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
121478258  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
121472014  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
121479810  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
121475906  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
121484745  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
121485024  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
121476506  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
121477755  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
121478236  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
121472045  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
121477887  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
121473288  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121487652  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121480810  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
121493461  TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
121496273  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
121495032  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121479635  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
121479576  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
121483797  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
121486536  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
121484398  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
121478016  PDYN; proenkephalin-B [KO:K15840]
121499760  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
121473250  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
121488229  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
121479649  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
121472747  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
121481281  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
121488075  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
121480895  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
121482829  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
121499629  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
121473438  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
121479835  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
121494863  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
121483414  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
121493117  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
121488121  STX1A; syntaxin-1A isoform X1 [KO:K04560]
121490130  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
121473526  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
121475557  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
121486620  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
121493104  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
121499842  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
121498861  DERL1; derlin-1 [KO:K11519]
121494933  transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
121484819  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
121495766  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
121483090  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
121477878  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
121491317  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
121487133  polyubiquitin-like [KO:K04551]
121500166  UBB; polyubiquitin-B [KO:K04551]
121475451  UBC; LOW QUALITY PROTEIN: polyubiquitin-C [KO:K08770]
121473903  proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
121500084  proteasome subunit alpha type-6-like [KO:K02730] [EC:3.4.25.1]
121493786  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
121472279  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
121495064  proteasome subunit alpha type-2-like [KO:K02726] [EC:3.4.25.1]
121483899  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
121478069  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
121494777  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
121487730  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
121481339  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
121482361  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
121482978  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
121476475  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
121477132  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
121484953  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
121478949  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
121472355  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
121487435  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
121487458  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
121494287  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
121495609  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
121489391  proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
121492831  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
121493353  proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
121474450  proteasome subunit beta type-6-like [KO:K02738] [EC:3.4.25.1]
121492681  proteasome subunit beta type-6-like [KO:K02738] [EC:3.4.25.1]
121500426  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
121472829  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
121472953  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
121494851  proteasome subunit beta type-3-like [KO:K02735] [EC:3.4.25.1]
121481629  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
121490146  proteasome subunit beta type-2-like [KO:K02734] [EC:3.4.25.1]
121493885  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
121494801  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
121492141  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
121501798  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
121488865  26S proteasome regulatory subunit 4-like [KO:K03062]
121496205  uncharacterized protein LOC121496205 isoform X1 [KO:K03062]
121497986  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
121493181  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
121484698  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
121478103  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 10B-like [KO:K03064]
121493675  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
121471808  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
121474166  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
121477457  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
121497292  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
121473831  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
121475710  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
121473773  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
121473527  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
121496152  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
121500700  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
121501455  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
121490830  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
121471852  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
121482678  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 8-like [KO:K03031]
121485757  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
121477985  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
121474893  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
121498566  26S proteasome complex subunit SEM1-like [KO:K10881]
121488669  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
121471571  ubiquitin carboxyl-terminal hydrolase isozyme L1-like [KO:K05611] [EC:3.4.19.12]
121487267  ubiquitin carboxyl-terminal hydrolase isozyme L1-like [KO:K05611] [EC:3.4.19.12]
121483156  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
121496072  UBA7; ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
121472898  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
121475599  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
121475748  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
121471358  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
121500528  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
121497975  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
121479400  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
121499574  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
121475141  GPR37; prosaposin receptor GPR37 [KO:K04243]
121475801  SEPTIN5; septin-5 isoform X1 [KO:K04557]
121496136  synphilin-1 isoform X1 [KO:K04558]
121473875  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
121477915  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
121501527  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
121491175  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
121475808  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
121473044  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
121473786  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
121481859  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
121495379  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
121482830  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121493739  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121494640  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121499341  LOW QUALITY PROTEIN: caspase-12-like [KO:K04741] [EC:3.4.22.-]
121484923  MAP3K10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
121491533  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
121493546  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
121492052  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
121477472  SLC6A3; sodium-dependent dopamine transporter isoform X1 [KO:K05036]
121497182  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
23629759  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
23629747  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
23629753  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
23629755  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
23629754  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
23629756  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
23629757  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
121471864  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
121500930  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
121479502  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
121483574  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
121493526  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
121488990  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
121479013  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
121497618  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
121495658  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
121489210  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
121484318  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
121488680  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
121490077  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
121474904  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
121477165  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
121484898  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
121490982  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
121491446  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
121493054  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
121494305  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
121495247  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
121474681  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
121490800  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
121494964  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
121474096  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
121480080  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
121497517  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
121486485  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
121480128  acyl carrier protein, mitochondrial [KO:K03955]
121494608  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
121481642  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
121496004  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
121486758  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
121493192  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
121501157  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
121494694  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
121489530  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
121482582  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958]
121480538  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
121474623  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
121477548  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
121495392  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
121494405  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
121485817  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
121498780  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
121487695  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
121483164  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
121480600  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
121471392  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
121471242  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
121486326  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial-like [KO:K03937]
121487827  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
121481609  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
121477553  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
121495617  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
121472262  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
121498612  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
121493923  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
121476412  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
121477422  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
121496660  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
121471960  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
121487600  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
121499656  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
121485588  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
23629758  CYTB; cytochrome b [KO:K00412]
121498717  cytochrome c1, heme protein, mitochondrial [KO:K00413]
121496068  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
121487529  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
121481241  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
121498800  cytochrome b-c1 complex subunit 7 [KO:K00417]
121483881  cytochrome b-c1 complex subunit 8 [KO:K00418]
121478804  cytochrome b-c1 complex subunit 8 [KO:K00418]
121495960  cytochrome b-c1 complex subunit 8 [KO:K00418]
121496096  cytochrome b-c1 complex subunit 8 [KO:K00418]
121475680  cytochrome b-c1 complex subunit 9 [KO:K00419]
121495624  cytochrome b-c1 complex subunit 10 [KO:K00420]
23629752  COX3; cytochrome c oxidase subunit III [KO:K02262]
23629748  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
23629749  COX2; cytochrome c oxidase subunit II [KO:K02261]
121472989  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
121477740  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
121497097  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
121500236  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
121485330  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
121480374  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
121471705  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
121491245  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
121488341  cytochrome c oxidase subunit 6A2, mitochondrial isoform X1 [KO:K02266]
121475436  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
121485052  cytochrome c oxidase subunit 6B2 isoform X1 [KO:K02267]
121485797  cytochrome c oxidase subunit 6B1 [KO:K02267]
121496730  cytochrome c oxidase subunit 6B1-like [KO:K02267]
121491039  cytochrome c oxidase subunit 6B1-like [KO:K02267]
121498660  cytochrome c oxidase subunit 6C [KO:K02268]
121483806  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
121485169  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
121491937  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
121492120  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
121492953  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
121482288  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
121474273  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
121477994  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
121478414  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
121497750  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
121489922  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
121478606  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
121492391  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
121497079  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
121489690  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
121482801  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
121475302  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
121501410  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
121479375  LOW QUALITY PROTEIN: uncharacterized protein LOC121479375 [KO:K02132]
121497526  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
121492007  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
121497456  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
121494345  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
121478029  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
23629751  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
121487278  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
121480369  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
121476362  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
121472595  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
121480226  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
121496296  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
121497567  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
121501566  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
121494943  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
121489008  ATP synthase subunit d, mitochondrial-like [KO:K02138]
121481999  ATP synthase subunit d, mitochondrial-like [KO:K02138]
121482347  ATP synthase subunit d, mitochondrial-like [KO:K02138]
121478265  ATP synthase subunit d, mitochondrial-like [KO:K02138]
121478568  ATP synthase subunit d, mitochondrial-like [KO:K02138]
121486442  ATP synthase subunit d, mitochondrial-like [KO:K02138]
121500417  ATP synthase subunit d, mitochondrial [KO:K02138]
121479590  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
121490919  ATP synthase subunit O, mitochondrial-like [KO:K02137]
121473935  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
121477083  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
121479306  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
23629750  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
121481811  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
121495756  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
121484747  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
121471956  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
121486349  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
121485632  CALML4; calmodulin-like protein 4 [KO:K02183]
121485676  CALM3; calmodulin-3 [KO:K02183]
121485677  calmodulin-1 [KO:K02183]
121478795  calmodulin-1 [KO:K02183]
121496486  calmodulin-like protein 3 [KO:K02183]
121497964  CALML5; calmodulin-like protein 5 [KO:K02183]
121490986  CALM2; calmodulin-2 [KO:K02183]
121493011  CALM1; calmodulin-1 [KO:K02183]
121500599  CALML6; calmodulin-like protein 6 [KO:K02183]
121493375  calmodulin-alpha-like [KO:K02183]
121488319  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121497400  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121493459  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121490871  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
121495449  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
121501608  BAD; bcl2-associated agonist of cell death [KO:K02158]
121498932  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
121475736  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
121471748  FADD; FAS-associated death domain protein [KO:K02373]
121480703  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
121480314  BH3-interacting domain death agonist-like [KO:K04726]
121480402  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
121484229  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
121497413  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
121480288  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
121490681  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
121486666  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
121486531  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
121489937  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
121482482  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 3-like [KO:K15041]
121489244  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
121482903  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
121483578  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
121484768  ADP/ATP translocase 2-like [KO:K05863]
121493538  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
121486851  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
121480404  cytochrome c-like [KO:K08738]
121488803  cytochrome c-like [KO:K08738]
121482342  cytochrome c-like [KO:K08738]
121474881  cytochrome c [KO:K08738]
121481178  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
121498045  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
121489913  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
121486409  HIP1; huntingtin-interacting protein 1 isoform X1 [KO:K04559]
121474074  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
121482238  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
121481095  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
121500473  PARK7; Parkinson disease protein 7 [KO:K05687] [EC:3.5.1.124]
121478042  BCL2L1; bcl-2-like protein 1 [KO:K04570]
121477335  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
121497172  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
121497430  OPTN; optineurin isoform X1 [KO:K19946]
121494449  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
121478113  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
121487644  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
121499267  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
121491543  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
121501631  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
121489911  WDR41; WD repeat-containing protein 41 [KO:K23610]
121499622  SMCR8; LOW QUALITY PROTEIN: guanine nucleotide exchange protein SMCR8 [KO:K23611]
121495433  C9orf72; guanine nucleotide exchange C9orf72 homolog isoform X1 [KO:K23609]
121495907  RAB8A; ras-related protein Rab-8A [KO:K07901]
121482290  RAB39B; ras-related protein Rab-39B [KO:K07925]
121492084  RAB1A; ras-related protein Rab-1A [KO:K07874]
121496713  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
121475361  ULK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
121499608  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
121480328  ATG101; autophagy-related protein 101 isoform X1 [KO:K19730]
121501622  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
121498508  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
121501658  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
121473902  BECN1; beclin-1 isoform X1 [KO:K08334]
121487649  BECN2; beclin-2 [KO:K08334]
121478786  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
121493539  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
121488149  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
121491613  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
121471906  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
121493696  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
121487586  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
121472810  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
121499726  WD repeat domain phosphoinositide-interacting protein 2-like isoform X1 [KO:K17908]
121493396  ZFYVE1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
121480629  ALS2; alsin isoform X1 [KO:K04575]
121478865  RAB5A; ras-related protein Rab-5A [KO:K07887]
121486443  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
121479474  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
121479309  CHMP2B; charged multivesicular body protein 2b isoform X1 [KO:K12192]
121499412  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
121485180  SPG11; spatacsin isoform X1 [KO:K19026]
121500453  TNF; tumor necrosis factor [KO:K03156]
121480007  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
121497550  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
121497399  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
121499935  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
121473314  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
121482054  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
121485950  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
121491672  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
121491673  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
121475796  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
121472063  CCS; copper chaperone for superoxide dismutase isoform X1 [KO:K04569]
121481645  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
121486663  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
121496493  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
121499318  epididymal secretory glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
121499383  GPX6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
121492887  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
121500851  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
121494184  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
121501679  CAT; catalase [KO:K03781] [EC:1.11.1.6]
121479695  PRPH; peripherin isoform X1 [KO:K07607]
121498190  NEFL; neurofilament light polypeptide [KO:K04572]
121497659  NEFM; neurofilament medium polypeptide [KO:K04573]
121475227  NEFH; neurofilament heavy polypeptide isoform X1 [KO:K04574]
121482077  KIF5C; kinesin heavy chain [KO:K10396]
121497220  KIF5B; kinesin-1 heavy chain [KO:K10396]
121492068  KIF5A; kinesin heavy chain [KO:K10396]
121490103  KLC4; kinesin light chain 4 [KO:K10407]
121485655  KLC3; kinesin light chain 3 [KO:K10407]
121472341  KLC2; kinesin light chain 2 [KO:K10407]
121492855  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
121480316  TUBA8; tubulin alpha-8 chain [KO:K07374]
121480622  tubulin alpha-1B chain-like [KO:K07374]
121480623  TUBA4A; tubulin alpha-4A chain [KO:K07374]
121475457  tubulin alpha-3 chain-like [KO:K07374]
121475654  tubulin alpha-3 chain [KO:K07374]
121472874  tubulin alpha-8 chain [KO:K07374]
121480223  TUBA1B; tubulin alpha-1B chain isoform X1 [KO:K07374]
121480224  TUBA1A; tubulin alpha-1A chain [KO:K07374]
121480225  tubulin alpha-1C chain [KO:K07374]
121497374  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
121497356  tubulin alpha-1C chain-like [KO:K07374]
121493286  LOW QUALITY PROTEIN: tubulin alpha chain-like [KO:K07374]
121473856  TUBB8B; LOW QUALITY PROTEIN: tubulin beta 8B [KO:K07375]
121473893  TUBB4B; tubulin beta-4B chain isoform X1 [KO:K07375]
121489905  TUBB; tubulin beta chain [KO:K07375]
121478026  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
121490298  TUBB6; tubulin beta-6 chain [KO:K07375]
121500201  tubulin beta chain-like [KO:K07375]
121500259  TUBB2B; tubulin beta-2B chain [KO:K07375]
121500448  tubulin beta-2A chain [KO:K07375]
121500849  nascent polypeptide-associated complex subunit alpha, muscle-specific form-like [KO:K07375]
121495705  TUBB4A; tubulin beta-4A chain [KO:K07375]
121489623  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121478001  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
121497107  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
121484179  CSNK2B; casein kinase II subunit beta [KO:K03115]
121476611  BDNF; brain-derived neurotrophic factor [KO:K04355]
121490571  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
121491131  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
121496239  DCTN3; dynactin subunit 3 [KO:K10425]
121486705  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
121486146  DCTN5; dynactin subunit 5 [KO:K10427]
121488960  DCTN6; dynactin subunit 6 [KO:K10428]
121484291  ACTR1A; alpha-centractin [KO:K16575]
121491046  ACTR1B; beta-centractin [KO:K16575]
121493637  ACTR10; actin-related protein 10 [KO:K16576]
121472692  HAP1; huntingtin-associated protein 1 isoform X1 [KO:K04647]
121472981  DNAH17; dynein heavy chain 17, axonemal isoform X1 [KO:K10408]
121480818  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
121474865  DNAH11; LOW QUALITY PROTEIN: dynein heavy chain 11, axonemal [KO:K10408]
121475839  DNAH10; dynein heavy chain 10, axonemal isoform X1 [KO:K10408]
121477407  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
121486817  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
121487565  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
121487588  DNAH14; LOW QUALITY PROTEIN: dynein heavy chain 14, axonemal [KO:K10408]
121491342  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
121499580  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
121500057  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
121495474  DNAH12; dynein heavy chain 12, axonemal [KO:K10408]
121495552  DNAH1; LOW QUALITY PROTEIN: dynein heavy chain 1, axonemal [KO:K10408]
121481556  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
121496196  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
121473785  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
121492177  DNAL4; dynein light chain 4, axonemal [KO:K10412]
121489104  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
121486819  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
121487187  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
121493044  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
121471842  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
121485762  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
121472580  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
121490120  CDK5; cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
121485514  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
121493902  DKK2; dickkopf-related protein 2 [KO:K02165]
121475827  DKK1; dickkopf-related protein 1 [KO:K02165]
121490083  DKK4; dickkopf-related protein 4 [KO:K02165]
121480178  WNT1; proto-oncogene Wnt-1 isoform X1 [KO:K03209]
121474438  WNT2; protein Wnt-2 isoform X1 [KO:K00182]
121490731  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
121474007  WNT3; proto-oncogene Wnt-3 [KO:K00312]
121474467  WNT3A; protein Wnt-3a [KO:K00312]
121498205  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
121479913  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
121495641  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
121480717  WNT6; protein Wnt-6 [KO:K00445]
121490476  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
121495152  WNT7A; protein Wnt-7a [KO:K00572]
121476849  WNT8B; protein Wnt-8b [KO:K00714]
121495235  WNT8A; protein Wnt-8a [KO:K00714]
121474006  WNT9B; protein Wnt-9b [KO:K01064]
121475053  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
121480841  WNT10A; protein Wnt-10a [KO:K01357]
121480042  WNT10B; protein Wnt-10b [KO:K01357]
121475935  WNT11; protein Wnt-11 [KO:K01384]
121474824  WNT16; protein Wnt-16 [KO:K01558]
121480659  FZD7; frizzled-7 isoform X1 [KO:K02432]
121474752  FZD1; frizzled-1 [KO:K02432]
121472594  FZD2; frizzled-2 [KO:K02235]
121498183  FZD3; frizzled-3 isoform X1 [KO:K02329]
121476036  FZD4; frizzled-4 isoform X1 [KO:K02354]
121480532  FZD5; frizzled-5 [KO:K02375]
121498057  FZD8; frizzled-8 [KO:K02375]
121498902  FZD6; frizzled-6 isoform X1 [KO:K02376]
121475662  FZD10; frizzled-10 [KO:K02842]
121486703  FZD9; frizzled-9 [KO:K02842]
121479920  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
121501656  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
121491223  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
121477470  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
121499761  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
121499953  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
121476462  proto-oncogene FRAT1-like [KO:K03069]
121476396  LOW QUALITY PROTEIN: GSK-3-binding protein FRAT2-like [KO:K03096]
121486746  AXIN1; axin-1 isoform X1 [KO:K02157]
121473774  AXIN2; axin-2 isoform X1 [KO:K04385]
121489860  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
121495587  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
121478755  CTNNB1; catenin beta-1 [KO:K02105]
121486399  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
121475913  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
121472124  HRAS; GTPase HRas isoform X1 [KO:K02833]
121479900  KRAS; GTPase KRas isoform X1 [KO:K07827]
121491321  NRAS; GTPase NRas [KO:K07828]
121483180  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
121489076  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121494281  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121484067  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121495470  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121475510  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121486545  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121483370  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
121483550  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
121476453  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
121471268  RELA; transcription factor p65 isoform X1 [KO:K04735]
121492781  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121472657  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
121497643  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
121474963  IL6; interleukin-6 [KO:K05405]
121491336  IL1A; interleukin-1 alpha [KO:K04383]
121490494  IL1B; interleukin-1 beta [KO:K04519]
121487528  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
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Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
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Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
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J Cell Mol Med 14:457-87 (2010)
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Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
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J Neural Transm (Vienna) 116:1111-62 (2009)
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Reference
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Int J Mol Sci 20:E719 (2019)
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PMID:15272267
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Ross CA, Poirier MA
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Protein aggregation and neurodegenerative disease.
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Nat Med 10 Suppl:S10-7 (2004)
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  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
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Nat Neurosci 21:1332-1340 (2018)
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PMID:25132814
  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
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Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
PMID:25413678
  Authors
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  Title
Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
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Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
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  Authors
Park H, Kang JH, Lee S
  Title
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Int J Mol Sci 21:E3369 (2020)
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Reference
PMID:31783880
  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
  Title
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
DOI:10.1186/s13041-019-0504-x
Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
  Journal
Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
  Journal
Trends Pharmacol Sci 35:583-91 (2014)
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Reference
PMID:28279350
  Authors
Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Fullgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC
  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
  Journal
Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
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Nat Rev Drug Discov 7:1013-30 (2008)
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Reference
PMID:21722302
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Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
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J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
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Halliday M, Hughes D, Mallucci GR
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Fine-tuning PERK signaling for neuroprotection.
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J Neurochem 142:812-826 (2017)
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Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
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Axonal transport deficits and neurodegenerative diseases.
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Axonal transport and neurological disease.
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Retrograde axonal transport: pathways to cell death?
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Related
pathway
vlg00190  Oxidative phosphorylation
vlg03050  Proteasome
vlg04020  Calcium signaling pathway
vlg04120  Ubiquitin mediated proteolysis
vlg04137  Mitophagy - animal
vlg04140  Autophagy - animal
vlg04141  Protein processing in endoplasmic reticulum
vlg04142  Lysosome
vlg04210  Apoptosis
vlg04310  Wnt signaling pathway
vlg04724  Glutamatergic synapse
vlg04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
LinkDB

DBGET integrated database retrieval system