KEGG   PATHWAY: fca04015
Entry
fca04015                    Pathway                                
Name
Rap1 signaling pathway - Felis catus (domestic cat)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
fca04015  Rap1 signaling pathway
fca04015

Other DBs
GO: 0007264
Organism
Felis catus (domestic cat) [GN:fca]
Gene
100127108  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100135772  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
100135774  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
100136904  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
100141386  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100144392  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100144611  NGF; beta-nerve growth factor [KO:K02582]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
100500937  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100510799  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101080259  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
101080297  EVL; ena/VASP-like protein isoform X4 [KO:K23487]
101080471  RALB; ras-related protein Ral-B [KO:K07835]
101080496  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101080543  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
101080595  FGF21; fibroblast growth factor 21 [KO:K22429]
101080742  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
101081027  F2RL3; proteinase-activated receptor 4 isoform X1 [KO:K04236]
101081032  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
101081386  AFDN; afadin isoform X1 [KO:K05702]
101081387  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X3 [KO:K04368] [EC:2.7.12.2]
101081534  CALM2; calmodulin-2 [KO:K02183]
101081654  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
101082021  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101082196  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101082206  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101082274  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101082454  [KO:K04393]
101082668  APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
101082809  DOCK4; dedicator of cytokinesis protein 4 isoform X3 [KO:K17697]
101082920  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
101083745  FGF22; fibroblast growth factor 22 [KO:K04358]
101083757  KRIT1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
101083766  FGF20; fibroblast growth factor 20 [KO:K04358]
101084011  RHOA; transforming protein RhoA [KO:K04513]
101084335  FGF9; fibroblast growth factor 9 [KO:K04358]
101084600  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101084652  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101084778  FGF16; fibroblast growth factor 16 [KO:K04358]
101084908  CRKL; crk-like protein isoform X1 [KO:K04438]
101084954  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X5 [KO:K08018]
101084984  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101085263  ENAH; protein enabled homolog isoform X1 [KO:K05746]
101085368  VEGFC; vascular endothelial growth factor C [KO:K05449]
101085387  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
101085456  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
101085481  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101085940  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
101085951  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
101086055  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101086100  CRK; adapter molecule crk isoform X1 [KO:K04438]
101086110  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101086264  VAV2; guanine nucleotide exchange factor VAV2 isoform X7 [KO:K05730]
101086433  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101086824  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
101086887  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
101087000  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
101087099  FGF19; fibroblast growth factor 19 [KO:K22603]
101087130  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101087258  ITGB2; integrin beta-2 [KO:K06464]
101087287  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
101087417  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101087555  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087851  PRKCZ; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101087957  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101087973  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101088157  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101088292  FLT1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
101088478  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
101088695  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
101088742  PDGFC; platelet-derived growth factor C [KO:K05450]
101088970  PRKCB; protein kinase C beta type isoform X3 [KO:K19662] [EC:2.7.11.13]
101089465  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
101089486  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
101089679  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101089813  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101090005  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101090260  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101090489  FGF10; fibroblast growth factor 10 [KO:K04358]
101090558  RALGDS; ral guanine nucleotide dissociation stimulator isoform X2 [KO:K08732]
101090606  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101090765  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101090795  P2RY1; P2Y purinoceptor 1 [KO:K04270]
101090942  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101091003  RALA; ras-related protein Ral-A [KO:K07834]
101091063  CALM3; calmodulin-3 [KO:K02183]
101091211  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
101091274  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
101091354  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X7 [KO:K05629]
101091459  FGF6; fibroblast growth factor 6 [KO:K04358]
101091467  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101091536  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
101091824  PFN1; profilin-1 [KO:K05759]
101091892  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101091972  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
101091977  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101092159  ITGB3; integrin beta-3 [KO:K06493]
101092262  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101092346  BRAF; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
101092367  TLN2; talin-2 isoform X2 [KO:K06271]
101092465  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101092556  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
101092689  THBS1; thrombospondin-1 [KO:K16857]
101092784  MRAS; ras-related protein M-Ras isoform X2 [KO:K07831]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101092837  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101092925  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101092955  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X3 [KO:K04351]
101092961  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101093057  TLN1; talin-1 isoform X3 [KO:K06271]
101093077  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
101093286  [KO:K02649]
101093319  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101093787  RAP1GAP; rap1 GTPase-activating protein 1 isoform X2 [KO:K17700]
101094148  ADCY7; adenylate cyclase type 7 isoform X2 [KO:K08047] [EC:4.6.1.1]
101094274  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101094327  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101094356  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101094450  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
101094530  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
101094570  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
101094679  CALM1; calmodulin-1 [KO:K02183]
101094708  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
101094727  FLT4; vascular endothelial growth factor receptor 3 isoform X3 [KO:K05097] [EC:2.7.10.1]
101094772  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101094805  VASP; vasodilator-stimulated phosphoprotein isoform X3 [KO:K06274]
101094822  EFNA3; ephrin-A3 [KO:K05462]
101094942  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
101095077  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
101095198  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101095391  CDH1; cadherin-1 [KO:K05689]
101095411  PFN4; profilin-4 [KO:K05759]
101095904  PGF; placenta growth factor isoform X8 [KO:K16859]
101095942  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101095954  FYB1; FYN-binding protein 1 isoform X1 [KO:K17698]
101095993  RAP1B; ras-related protein Rap-1b [KO:K07836]
101096047  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101096187  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
101096619  SKAP1; src kinase-associated phosphoprotein 1 isoform X3 [KO:K17699]
101096625  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X3 [KO:K05726]
101096689  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703]
101096744  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101096829  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
101096838  DRD2; D(2) dopamine receptor isoform X3 [KO:K04145]
101096877  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
101097058  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
101097212  VAV1; proto-oncogene vav isoform X3 [KO:K05730]
101097342  CTNNB1; catenin beta-1 [KO:K02105]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101097703  [KO:K02183]
101097735  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101097982  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101097996  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
101098453  [KO:K04632]
101098507  ACTB; actin, cytoplasmic 1 [KO:K05692]
101098518  FGF18; fibroblast growth factor 18 [KO:K04358]
101098924  PFN3; profilin-3 [KO:K05759]
101099149  SIPA1; signal-induced proliferation-associated protein 1 isoform X4 [KO:K08013]
101099307  [KO:K02183]
101099431  RGS14; regulator of G-protein signaling 14 [KO:K17706]
101099507  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
101099994  PFN2; profilin-2 isoform X1 [KO:K05759]
101100063  FGF23; fibroblast growth factor 23 [KO:K22428]
101100101  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
101100214  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101100223  PARD3; partitioning defective 3 homolog isoform X8 [KO:K04237]
101100281  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101100320  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
101100378  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101100749  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
101100861  F2R; LOW QUALITY PROTEIN: proteinase-activated receptor 1 [KO:K03914]
101100864  FGFR4; fibroblast growth factor receptor 4 isoform X5 [KO:K05095] [EC:2.7.10.1]
101100883  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
101100930  ITGA2B; integrin alpha-IIb [KO:K06476]
101100950  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
101101135  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101101237  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101101353  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X2 [KO:K04534]
101101375  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101101519  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101101605  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
102899245  [KO:K08732]
102899848  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102900772  [KO:K04632]
102901787  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
102902667  [KO:K02183]
105260786  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105261071  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
109494208  ADORA2B; adenosine receptor A2b [KO:K04267]
111556320  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
111556546  FGF4; fibroblast growth factor 4 [KO:K04358]
111556666  FGF3; fibroblast growth factor 3 [KO:K04358]
111557556  EFNA2; ephrin-A2 isoform X2 [KO:K05462]
111559549  [KO:K10785]
493669  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
493703  VEGFD; vascular endothelial growth factor D [KO:K05449]
493705  HGF; hepatocyte growth factor precursor [KO:K05460]
493706  CSF1R; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
493766  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
493804  INS; insulin precursor [KO:K04526]
493845  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
493926  CNR1; cannabinoid receptor 1 [KO:K04277]
493937  KITLG; kit ligand precursor [KO:K05461]
493978  EGF; pro-epidermal growth factor precursor [KO:K04357]
751103  HRAS; GTPase HRas isoform X1 [KO:K02833]
751104  KRAS; GTPase KRas isoform X2 [KO:K07827]
751105  NRAS; GTPase NRas [KO:K07828]
751821  ITGB1; integrin beta-1 precursor [KO:K05719]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
fca04010  MAPK signaling pathway
fca04014  Ras signaling pathway
fca04020  Calcium signaling pathway
fca04151  PI3K-Akt signaling pathway
fca04510  Focal adhesion
fca04520  Adherens junction
fca04660  T cell receptor signaling pathway
fca04810  Regulation of actin cytoskeleton
KO pathway
ko04015   

DBGET integrated database retrieval system