KEGG   PATHWAY: fca04014
Entry
fca04014                    Pathway                                
Name
Ras signaling pathway - Felis catus (domestic cat)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
fca04014  Ras signaling pathway
fca04014

Other DBs
GO: 0032318
Organism
Felis catus (domestic cat) [GN:fca]
Gene
100127108  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100135772  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
100135774  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
100136904  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
100141386  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100142682  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100142683  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100144611  NGF; beta-nerve growth factor [KO:K02582]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
100500937  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100510799  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101080471  RALB; ras-related protein Ral-B [KO:K07835]
101080496  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101080565  ETS2; protein C-ets-2 [KO:K21932]
101080595  FGF21; fibroblast growth factor 21 [KO:K22429]
101080675  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
101080757  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
101081105  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101081386  AFDN; afadin isoform X1 [KO:K05702]
101081387  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X3 [KO:K04368] [EC:2.7.12.2]
101081534  CALM2; calmodulin-2 [KO:K02183]
101081603  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101081809  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
101081928  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
101082014  BRAP; BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
101082017  RALBP1; ralA-binding protein 1 [KO:K08773]
101082021  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101082033  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
101082196  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101082206  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101082222  [KO:K07293] [EC:3.1.3.48]
101082454  [KO:K04393]
101082574  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
101082828  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
101082829  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101082845  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101083342  [KO:K16342] [EC:3.1.1.4]
101083489  SHC2; SHC-transforming protein 2 isoform X2 [KO:K17447]
101083671  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X6 [KO:K25768]
101083745  FGF22; fibroblast growth factor 22 [KO:K04358]
101083766  FGF20; fibroblast growth factor 20 [KO:K04358]
101083969  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
101084011  RHOA; transforming protein RhoA [KO:K04513]
101084052  PLD1; phospholipase D1 isoform X2 [KO:K01115] [EC:3.1.4.4]
101084059  RIN1; ras and Rab interactor 1 [KO:K17638]
101084335  FGF9; fibroblast growth factor 9 [KO:K04358]
101084346  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101084600  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101084652  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101084778  FGF16; fibroblast growth factor 16 [KO:K04358]
101084799  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101084885  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
101084984  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101085368  VEGFC; vascular endothelial growth factor C [KO:K05449]
101085456  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
101085481  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101085500  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
101085951  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
101086055  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101086110  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101086433  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101086526  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101086544  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101086580  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101086824  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
101087099  FGF19; fibroblast growth factor 19 [KO:K22603]
101087130  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101087171  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101087287  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087622  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101088219  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101088292  FLT1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
101088326  GAB1; GRB2-associated-binding protein 1 isoform X4 [KO:K09593]
101088476  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101088478  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
101088621  RASAL1; rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
101088695  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
101088742  PDGFC; platelet-derived growth factor C [KO:K05450]
101088748  RGL2; ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
101088847  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101088915  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101088970  PRKCB; protein kinase C beta type isoform X3 [KO:K19662] [EC:2.7.11.13]
101089188  EXOC2; exocyst complex component 2 [KO:K17637]
101089378  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101089486  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
101089987  FOXO4; forkhead box protein O4 [KO:K12358]
101090074  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
101090260  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101090461  ETS1; LOW QUALITY PROTEIN: protein C-ets-1 [KO:K02678]
101090489  FGF10; fibroblast growth factor 10 [KO:K04358]
101090494  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101090495  RASAL3; RAS protein activator like-3 [KO:K17634]
101090558  RALGDS; ral guanine nucleotide dissociation stimulator isoform X2 [KO:K08732]
101090606  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101090719  PLAAT3; phospholipase A and acyltransferase 3 isoform X3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101090765  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101090817  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X2 [KO:K04544]
101091003  RALA; ras-related protein Ral-A [KO:K07834]
101091011  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101091063  CALM3; calmodulin-3 [KO:K02183]
101091172  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
101091185  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
101091201  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101091274  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101091384  [KO:K01047] [EC:3.1.1.4]
101091420  RASA4B; ras GTPase-activating protein 4B isoform X1 [KO:K17630]
101091459  FGF6; fibroblast growth factor 6 [KO:K04358]
101091467  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101091560  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101091639  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101091796  PLA2G5; phospholipase A2 group V isoform X2 [KO:K01047] [EC:3.1.1.4]
101091855  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101091884  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101091892  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101091904  KSR2; kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
101091955  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
101091977  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101092035  PLA2G2C; LOW QUALITY PROTEIN: putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101092156  KSR1; kinase suppressor of Ras 1 isoform X11 [KO:K14958]
101092214  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
101092248  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101092407  NF1; neurofibromin isoform X1 [KO:K08052]
101092465  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101092578  RASA3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
101092784  MRAS; ras-related protein M-Ras isoform X2 [KO:K07831]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101092911  SHC1; SHC-transforming protein 1 isoform X3 [KO:K06279]
101092925  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101092938  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X5 [KO:K17631]
101092941  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
101093110  RASGRP1; RAS guanyl-releasing protein 1 isoform X4 [KO:K04350]
101093286  [KO:K02649]
101093317  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101093319  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101093644  IGF2; insulin-like growth factor II isoform X3 [KO:K13769]
101093695  ARF6; ADP-ribosylation factor 6 [KO:K07941]
101093783  RAB5B; ras-related protein Rab-5B [KO:K07888]
101094210  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
101094274  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101094356  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101094450  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
101094467  RASGRP4; RAS guanyl-releasing protein 4 isoform X4 [KO:K12363]
101094530  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
101094570  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
101094623  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
101094657  RASSF1; ras association domain-containing protein 1 isoform X3 [KO:K09850]
101094679  CALM1; calmodulin-1 [KO:K02183]
101094727  FLT4; vascular endothelial growth factor receptor 3 isoform X3 [KO:K05097] [EC:2.7.10.1]
101094772  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101094822  EFNA3; ephrin-A3 [KO:K05462]
101094921  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
101094942  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
101094966  RAB5C; ras-related protein Rab-5C [KO:K07889]
101095077  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
101095151  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
101095156  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
101095198  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101095350  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
101095353  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101095522  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101095617  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101095865  SHC3; SHC-transforming protein 3 [KO:K17448]
101095904  PGF; placenta growth factor isoform X8 [KO:K16859]
101095993  RAP1B; ras-related protein Rap-1b [KO:K07836]
101096047  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101096184  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101096187  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
101096267  PLA2G3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
101096604  RELA; transcription factor p65 [KO:K04735]
101096744  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101097059  ZAP70; tyrosine-protein kinase ZAP-70 isoform X2 [KO:K07360] [EC:2.7.10.2]
101097385  RALGAPB; ral GTPase-activating protein subunit beta isoform X6 [KO:K25769]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101097491  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101097703  [KO:K02183]
101097982  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101098329  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
101098348  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
101098518  FGF18; fibroblast growth factor 18 [KO:K04358]
101098862  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101099050  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
101099264  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101099307  [KO:K02183]
101099543  REL; proto-oncogene c-Rel [KO:K09254]
101099916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101099995  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
101100063  FGF23; fibroblast growth factor 23 [KO:K22428]
101100214  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101100281  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101100428  NTF4; neurotrophin-4 [KO:K12457]
101100534  RASAL2; ras GTPase-activating protein nGAP isoform X10 [KO:K17633]
101100864  FGFR4; fibroblast growth factor receptor 4 isoform X5 [KO:K05095] [EC:2.7.10.1]
101101237  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101101347  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101101410  GAB2; GRB2-associated-binding protein 2 isoform X2 [KO:K08091]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101101519  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101101581  [KO:K13618] [EC:3.1.1.111]
102899245  [KO:K08732]
102901787  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
102902667  [KO:K02183]
109492578  HTR7; 5-hydroxytryptamine receptor 7 isoform X3 [KO:K04163]
111556546  FGF4; fibroblast growth factor 4 [KO:K04358]
111556666  FGF3; fibroblast growth factor 3 [KO:K04358]
111557526  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
111557556  EFNA2; ephrin-A2 isoform X2 [KO:K05462]
111559549  [KO:K10785]
111561761  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
123380358  [KO:K04540]
493669  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
493690  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
493701  BCL2L1; bcl-2-like protein 1 [KO:K04570]
493703  VEGFD; vascular endothelial growth factor D [KO:K05449]
493705  HGF; hepatocyte growth factor precursor [KO:K05460]
493706  CSF1R; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
493766  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
493796  FLT3LG; fms related tyrosine kinase 3 ligand precursor [KO:K05454]
493804  INS; insulin precursor [KO:K04526]
493845  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
493937  KITLG; kit ligand precursor [KO:K05461]
493945  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
493963  NTF3; neurotrophin-3 precursor [KO:K04356]
493978  EGF; pro-epidermal growth factor precursor [KO:K04357]
751103  HRAS; GTPase HRas isoform X1 [KO:K02833]
751104  KRAS; GTPase KRas isoform X2 [KO:K07827]
751105  NRAS; GTPase NRas [KO:K07828]
768269  BAD; bcl2-associated agonist of cell death [KO:K02158]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
fca04010  MAPK signaling pathway
fca04015  Rap1 signaling pathway
fca04020  Calcium signaling pathway
fca04144  Endocytosis
fca04151  PI3K-Akt signaling pathway
fca04660  T cell receptor signaling pathway
fca04720  Long-term potentiation
fca04810  Regulation of actin cytoskeleton
KO pathway
ko04014   

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