KEGG   PATHWAY: fca04061
Entry
fca04061                    Pathway                                
Name
Viral protein interaction with cytokine and cytokine receptor - Felis catus (domestic cat)
Description
Viruses have evolved diverse mechanisms to evade detection and destruction by the immune system, including copying and repurposing host cytokine and cytokine receptor genes. Viral cytokines and cytokine receptors, together with a group of structurally unique, soluble, cytokine-binding or cytokine receptor-binding proteins, represent the three major molecular strategies for subversion and modulation of the host cytokine networks mainly in large DNA viruses. Viral cytokines and cytokine receptor homologs, including other binding proteins, may activate or inhibit cytokine signaling and possibly affect different aspects of immunity.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
fca04061  Viral protein interaction with cytokine and cytokine receptor
fca04061

Organism
Felis catus (domestic cat) [GN:fca]
Gene
493689  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
101081091  C-C motif chemokine 3-like [KO:K05408]
100302540  chemokine (C-C motif) ligand 3-like precursor [KO:K05408]
101097189  C-C motif chemokine 8 [KO:K16596]
101086016  CCL14; C-C motif chemokine 14 [KO:K21092]
102902542  CCL16; C-C motif chemokine 16 [KO:K21093]
101086516  C-C motif chemokine 23 [KO:K05511]
101099760  C-C motif chemokine 13 [KO:K16595]
101096931  C-C motif chemokine 7 [KO:K05509]
100127112  MCP-1; C-C motif chemokine 2 [KO:K14624]
101086511  CCL27; C-C motif chemokine 27 [KO:K16598]
109493846  uncharacterized protein LOC109493846 [KO:K16598]
101086275  CCL24; C-C motif chemokine 24 [KO:K21097]
101086525  CCL26; C-C motif chemokine 26 [KO:K21096]
101091759  CCL28; C-C motif chemokine 28 [KO:K05513]
493832  CCL17; C-C motif chemokine 17 precursor [KO:K21083]
101091326  CCL22; C-C motif chemokine 22 [KO:K21095]
100302541  chemokine (C-C motif) ligand 4-like precursor [KO:K12964]
101089032  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
101100011  CCL1; C-C motif chemokine 1 [KO:K05514]
102899861  CCL25; C-C motif chemokine 25 [KO:K13072]
101087015  CCL19; C-C motif chemokine 19 [KO:K05512]
101087275  CCL21; C-C motif chemokine 21 [KO:K16062]
111560177  growth-regulated protein homolog gamma-like [KO:K05505]
102901432  growth-regulated protein homolog gamma-like [KO:K05505]
101094593  CXCL6; C-X-C motif chemokine 6 [KO:K05506]
493836  CXCL8; interleukin-8 precursor [KO:K10030]
101094344  platelet basic protein [KO:K10029]
101094096  platelet factor 4-like [KO:K05407]
101100388  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
101100131  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101099880  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
101096888  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
493806  CXCL12; stromal cell-derived factor 1 precursor [KO:K10031]
101087962  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
101081599  cytokine SCM-1 beta [KO:K22675]
101084670  CX3CL1; fractalkine isoform X1 [KO:K05508]
493683  IL10; interleukin-10 precursor [KO:K05443]
493687  IL6; interleukin-6 precursor [KO:K05405]
751114  IL2; interleukin-2 precursor [KO:K05429]
493688  IL18; interleukin-18 precursor [KO:K05482]
101090582  IL19; interleukin-19 [KO:K05444]
101096130  IL20; interleukin-20 [KO:K22667]
101095874  IL24; interleukin-24 [KO:K22668]
493755  TNF; tumor necrosis factor precursor [KO:K03156]
101084961  LTA; lymphotoxin-alpha [KO:K05468]
101096542  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
100174789  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
101094391  IL34; interleukin-34 isoform X1 [KO:K22633]
101091467  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100191004  CCR1; C-C chemokine receptor type 1 [KO:K04176]
100049057  CCR2; C-C chemokine receptor type 2 [KO:K04177]
100191005  CCR3; C-C chemokine receptor type 3 [KO:K04178]
102900629  CCR4; C-C chemokine receptor type 4 isoform X1 [KO:K04179]
493769  CCR5; C-C chemokine receptor type 5 [KO:K04180]
101100307  CCR6; C-C chemokine receptor type 6 [KO:K04181]
101099650  CCR8; C-C chemokine receptor type 8 [KO:K04183]
101083247  CCR9; C-C chemokine receptor type 9 isoform X1 [KO:K04184]
101088872  ACKR4; atypical chemokine receptor 4 [KO:K04186]
101092409  CCR10; C-C chemokine receptor type 10 [KO:K04185]
101084327  CCR7; C-C chemokine receptor type 7 [KO:K04182]
101085650  C-X-C chemokine receptor type 2 [KO:K04175]
101085396  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
101094573  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
101092459  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
493676  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101080817  ACKR3; atypical chemokine receptor 3 isoform X3 [KO:K04304]
101083750  XCR1; chemokine XC receptor 1 [KO:K04193]
101099898  CX3CR1; CX3C chemokine receptor 1 isoform X2 [KO:K04192]
101087601  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
101090038  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
101085689  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
101089832  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
493953  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
101092622  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
101090239  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
493938  IL18R1; interleukin-18 receptor 1 precursor [KO:K05173]
101084868  IL18RAP; interleukin-18 receptor accessory protein isoform X1 [KO:K05174]
101086565  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
101081159  IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
101100741  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
493957  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
101080392  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
101081146  LTBR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 3 [KO:K03159]
101089877  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
105261012  tumor necrosis factor receptor superfamily member 1A-like [KO:K04722]
493706  CSF1R; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
Reference
  Authors
Alcami A
  Title
Viral mimicry of cytokines, chemokines and their receptors.
  Journal
Nat Rev Immunol 3:36-50 (2003)
DOI:10.1038/nri980
Reference
  Authors
Pontejo SM, Murphy PM
  Title
Chemokines encoded by herpesviruses.
  Journal
J Leukoc Biol 102:1199-1217 (2017)
DOI:10.1189/jlb.4RU0417-145RR
Reference
  Authors
de Munnik SM, Smit MJ, Leurs R, Vischer HF
  Title
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
  Journal
Front Pharmacol 6:40 (2015)
DOI:10.3389/fphar.2015.00040
Reference
  Authors
Vischer HF, Siderius M, Leurs R, Smit MJ
  Title
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
  Journal
Nat Rev Drug Discov 13:123-39 (2014)
DOI:10.1038/nrd4189
Reference
PMID:9325239
  Authors
Smith CA, Smith TD, Smolak PJ, Friend D, Hagen H, Gerhart M, Park L, Pickup DJ, Torrance D, Mohler K, Schooley K, Goodwin RG
  Title
Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors.
  Journal
Virology 236:316-27 (1997)
DOI:10.1006/viro.1997.8730
Reference
PMID:9621074
  Authors
Isegawa Y, Ping Z, Nakano K, Sugimoto N, Yamanishi K
  Title
Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor.
  Journal
J Virol 72:6104-12 (1998)
DOI:10.1128/JVI.72.7.6104-6112.1998
Reference
PMID:9600978
  Authors
Damon I, Murphy PM, Moss B
  Title
Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog.
  Journal
Proc Natl Acad Sci U S A 95:6403-7 (1998)
DOI:10.1073/pnas.95.11.6403
Reference
  Authors
Dewin DR, Catusse J, Gompels UA
  Title
Identification and characterization of U83A viral chemokine, a broad and potent beta-chemokine agonist for human CCRs with unique selectivity and inhibition by spliced isoform.
  Journal
J Immunol 176:544-56 (2006)
DOI:10.4049/jimmunol.176.1.544
Reference
  Authors
Fitzsimons CP, Gompels UA, Verzijl D, Vischer HF, Mattick C, Leurs R, Smit MJ
  Title
Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51.
  Journal
Mol Pharmacol 69:888-98 (2006)
DOI:10.1124/mol.105.015222
Reference
  Authors
Wang D, Bresnahan W, Shenk T
  Title
Human cytomegalovirus encodes a highly specific RANTES decoy receptor.
  Journal
Proc Natl Acad Sci U S A 101:16642-7 (2004)
DOI:10.1073/pnas.0407233101
Reference
  Authors
Viejo-Borbolla A, Martinez-Martin N, Nel HJ, Rueda P, Martin R, Blanco S, Arenzana-Seisdedos F, Thelen M, Fallon PG, Alcami A
  Title
Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.
  Journal
PLoS Pathog 8:e1002497 (2012)
DOI:10.1371/journal.ppat.1002497
Reference
  Authors
Alejo A, Ruiz-Arguello MB, Ho Y, Smith VP, Saraiva M, Alcami A
  Title
A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.
  Journal
Proc Natl Acad Sci U S A 103:5995-6000 (2006)
DOI:10.1073/pnas.0510462103
Reference
  Authors
Tadagaki K, Nakano K, Yamanishi K
  Title
Human herpesvirus 7 open reading frames U12 and U51 encode functional beta-chemokine receptors.
  Journal
J Virol 79:7068-76 (2005)
DOI:10.1128/JVI.79.11.7068-7076.2005
Reference
  Authors
Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG
  Title
Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.
  Journal
J Leukoc Biol 74:676-82 (2003)
DOI:10.1189/jlb.0503206
Reference
  Authors
Najarro P, Lee HJ, Fox J, Pease J, Smith GL
  Title
Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1.
  Journal
J Gen Virol 84:3325-36 (2003)
DOI:10.1099/vir.0.19591-0
Reference
  Authors
Najarro P, Gubser C, Hollinshead M, Fox J, Pease J, Smith GL
  Title
Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue.
  Journal
J Gen Virol 87:809-16 (2006)
DOI:10.1099/vir.0.81427-0
Reference
  Authors
Catusse J, Spinks J, Mattick C, Dyer A, Laing K, Fitzsimons C, Smit MJ, Gompels UA
  Title
Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes.
  Journal
Eur J Immunol 38:763-77 (2008)
DOI:10.1002/eji.200737618
Reference
PMID:8992974
  Authors
Liu Y, de Waal Malefyt R, Briere F, Parham C, Bridon JM, Banchereau J, Moore KW, Xu J
  Title
The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor.
  Journal
J Immunol 158:604-13 (1997)
Reference
  Authors
Yoon SI, Jones BC, Logsdon NJ, Walter MR
  Title
Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.
  Journal
Structure 13:551-64 (2005)
DOI:10.1016/j.str.2005.01.016
Reference
  Authors
Kotenko SV, Saccani S, Izotova LS, Mirochnitchenko OV, Pestka S
  Title
Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).
  Journal
Proc Natl Acad Sci U S A 97:1695-700 (2000)
DOI:10.1073/pnas.97.4.1695
Reference
  Authors
Chang WL, Baumgarth N, Yu D, Barry PA
  Title
Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality.
  Journal
J Virol 78:8720-31 (2004)
DOI:10.1128/JVI.78.16.8720-8731.2004
Reference
  Authors
Li H, Wang H, Nicholas J
  Title
Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling.
  Journal
J Virol 75:3325-34 (2001)
DOI:10.1128/JVI.75.7.3325-3334.2001
Reference
  Authors
Nicot C, Mulloy JC, Ferrari MG, Johnson JM, Fu K, Fukumoto R, Trovato R, Fullen J, Leonard WJ, Franchini G
  Title
HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells.
  Journal
Blood 98:823-9 (2001)
DOI:10.1182/blood.v98.3.823
Reference
  Authors
Xiang Y, Moss B
  Title
IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins.
  Journal
Proc Natl Acad Sci U S A 96:11537-42 (1999)
DOI:10.1073/pnas.96.20.11537
Reference
  Authors
Bartlett NW, Dumoutier L, Renauld JC, Kotenko SV, McVey CE, Lee HJ, Smith GL
  Title
A new member of the interleukin 10-related cytokine family encoded by a poxvirus.
  Journal
J Gen Virol 85:1401-12 (2004)
DOI:10.1099/vir.0.79980-0
Reference
PMID:9557689
  Authors
Strockbine LD, Cohen JI, Farrah T, Lyman SD, Wagener F, DuBose RF, Armitage RJ, Spriggs MK
  Title
The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor.
  Journal
J Virol 72:4015-21 (1998)
DOI:10.1128/JVI.72.5.4015-4021.1998
Reference
  Authors
Snow AL, Martinez OM
  Title
Epstein-Barr virus: evasive maneuvers in the development of PTLD.
  Journal
Am J Transplant 7:271-7 (2007)
DOI:10.1111/j.1600-6143.2006.01650.x
Reference
  Authors
Shim AH, Chang RA, Chen X, Longnecker R, He X
  Title
Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.
  Journal
Proc Natl Acad Sci U S A 109:12962-7 (2012)
DOI:10.1073/pnas.1205309109
Reference
  Authors
Filippova M, Song H, Connolly JL, Dermody TS, Duerksen-Hughes PJ
  Title
The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis.
  Journal
J Biol Chem 277:21730-9 (2002)
DOI:10.1074/jbc.M200113200
Reference
  Authors
Brunetti CR, Paulose-Murphy M, Singh R, Qin J, Barrett JW, Tardivel A, Schneider P, Essani K, McFadden G
  Title
A secreted high-affinity inhibitor of human TNF from Tanapox virus.
  Journal
Proc Natl Acad Sci U S A 100:4831-6 (2003)
DOI:10.1073/pnas.0737244100
Reference
  Authors
Sciortino MT, Medici MA, Marino-Merlo F, Zaccaria D, Giuffre-Cuculletto M, Venuti A, Grelli S, Bramanti P, Mastino A
  Title
Involvement of gD/HVEM interaction in NF-kB-dependent inhibition of apoptosis by HSV-1 gD.
  Journal
Biochem Pharmacol 76:1522-32 (2008)
DOI:10.1016/j.bcp.2008.07.030
Reference
  Authors
Smith W, Tomasec P, Aicheler R, Loewendorf A, Nemcovicova I, Wang EC, Stanton RJ, Macauley M, Norris P, Willen L, Ruckova E, Nomoto A, Schneider P, Hahn G, Zajonc DM, Ware CF, Wilkinson GW, Benedict CA
  Title
Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.
  Journal
Cell Host Microbe 13:324-35 (2013)
DOI:10.1016/j.chom.2013.02.003
KO pathway
ko04061   
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