KEGG   PATHWAY: mcoc04010
Entry
mcoc04010                   Pathway                                
Name
MAPK signaling pathway - Mastomys coucha (southern multimammate mouse)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcoc04010  MAPK signaling pathway
mcoc04010

Other DBs
GO: 0000165
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116067850  voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
116089786  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
116099482  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
116084337  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
116101525  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
116102419  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
116079029  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
116076770  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
116076137  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
116069682  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116097487  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
116072134  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
116084426  Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
116099984  Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
116077033  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
116089728  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
116079136  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
116090169  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
116077583  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
116075312  Cacng2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
116102918  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
116076862  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
116078422  Cacng5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
116101514  Cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
116101513  Cacng7; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
116104112  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
116093928  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116069698  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116076783  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116102917  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116101512  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
116068678  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
116099017  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
116069754  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
116093830  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116084124  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116084832  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116096012  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
116071362  Ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
116072459  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
116083194  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
116090682  Rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
116103453  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
116079748  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
116101938  Rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
116093009  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
116079194  Nf1; neurofibromin isoform X1 [KO:K08052]
116083408  Rasa1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
116073884  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
116092927  ras-related protein Rap-1A-like [KO:K04353]
116093571  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
116075736  Rap1b; ras-related protein Rap-1b [KO:K07836]
116093773  Egf; pro-epidermal growth factor [KO:K04357]
116099176  Tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
116104470  Ereg; proepiregulin [KO:K09784]
116070647  Areg; amphiregulin [KO:K09782]
116087087  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116095116  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
116098343  Fgf6; fibroblast growth factor 6 [KO:K04358]
116100989  Fgf3; fibroblast growth factor 3 [KO:K04358]
116100990  Fgf4; fibroblast growth factor 4 [KO:K04358]
116101280  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116083356  Fgf10; fibroblast growth factor 10 [KO:K04358]
116093940  Fgf16; fibroblast growth factor 16 [KO:K04358]
116084437  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116084719  Fgf9; fibroblast growth factor 9 [KO:K04358]
116076064  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
116078435  Fgf18; fibroblast growth factor 18 [KO:K04358]
116071359  Fgf20; fibroblast growth factor 20 [KO:K04358]
116090856  Fgf7; fibroblast growth factor 7 [KO:K04358]
116100991  Fgf19; fibroblast growth factor 19 [KO:K22603]
116100498  Fgf21; fibroblast growth factor 21 [KO:K22429]
116098344  Fgf23; fibroblast growth factor 23 [KO:K22428]
116093520  Ngf; beta-nerve growth factor isoform X1 [KO:K02582]
116090620  Bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
116099618  Ntf3; neurotrophin-3 isoform X1 [KO:K04356]
116102198  Ntf4; neurotrophin-4 [KO:K12457]
116101481  insulin-1 [KO:K04526]
116076407  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
116103249  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
116068639  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116076069  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
116093026  Pdgfc; platelet-derived growth factor C [KO:K05450]
116072446  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
116093601  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
116076467  Kitlg; kit ligand isoform X1 [KO:K05461]
116102173  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
116074720  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
116103472  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
116079820  Pgf; placenta growth factor [KO:K16859]
116069284  Vegfc; vascular endothelial growth factor C [KO:K05449]
116090438  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
116097489  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
116082804  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
116068986  Angpt2; angiopoietin-2 isoform X1 [KO:K05466]
116091151  Angpt4; angiopoietin-4 [KO:K05467]
116093165  Efna1; ephrin-A1 isoform X1 [KO:K05462]
116093166  Efna3; ephrin-A3 isoform X1 [KO:K05462]
116093175  Efna4; ephrin-A4 [KO:K05462]
116076345  Efna2; ephrin-A2 [KO:K05462]
116088835  Efna5; ephrin-A5 isoform X1 [KO:K05462]
116083531  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
116074689  Nrtn; neurturin [KO:K25414]
116095512  Artn; artemin isoform X1 [KO:K25415]
116075510  Pspn; persephin [KO:K25416]
116071392  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116077605  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116076169  Erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
116088530  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
116069056  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116103077  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116069961  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116082061  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
116078356  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
116094433  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
116093096  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
116082168  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
116068825  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
116102373  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116071260  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
116087226  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
116087228  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
116071281  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
116068778  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
116068780  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116078943  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116071284  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
116098601  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
116096241  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
116096958  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
116099474  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
116076719  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
116080813  Sos1; son of sevenless homolog 1 [KO:K03099]
116080934  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116099791  Kras; GTPase KRas isoform X1 [KO:K07827]
116093530  Nras; GTPase NRas [KO:K07828]
116102164  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
116102825  Rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
116072312  Mras; ras-related protein M-Ras [KO:K07831]
116073820  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
116098774  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116099433  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116073764  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116076013  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
116093838  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
116102969  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116073648  Mapk6; mitogen-activated protein kinase 6 [KO:K04371] [EC:2.7.11.24]
116085641  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116096445  Mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
116076077  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
116095781  Rps6ka1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
116088229  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
116079208  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
116090108  Rps6ka3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
116076129  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
116073994  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
116098993  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
116082253  Myc; myc proto-oncogene protein [KO:K04377]
116074963  Srf; serum response factor isoform X1 [KO:K04378]
116080518  Fos; proto-oncogene c-Fos [KO:K04379]
116076902  Mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
116096811  Stmn1; stathmin [KO:K04381]
116100272  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
116100719  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
116090743  Pla2g4b; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
116090754  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
116090758  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
116090760  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
116074547  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
116090915  Il1a; interleukin-1 alpha [KO:K04383]
116090916  Il1b; interleukin-1 beta [KO:K04519]
116101857  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
116068447  Tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
116080097  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
116099614  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
116088348  Il1r1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
116085769  Il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
116095983  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
116073579  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
116070785  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
116103761  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
116087597  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
116068714  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116075508  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
116077969  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
116096877  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116070032  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
116069240  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
116089826  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
116075120  Daxx; death domain-associated protein 6 [KO:K02308]
116073051  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
116086115  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
116078433  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
116090551  Traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
116099018  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
116075868  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
116081743  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
116076094  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
116097745  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
116072359  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
116079936  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
116088345  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
116101937  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
116102599  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
116085808  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116091355  Stk4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
116082317  Stk3; serine/threonine-protein kinase 3 [KO:K04412]
116103446  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
116086796  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
116083778  Map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
116103407  Map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
116086949  Map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
116076740  Map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
116079640  Map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
116101890  Map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
116070422  Map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
116080495  Map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
116085741  Map3k13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
116090306  Map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
116096782  Map3k6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
116097922  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
116088003  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
116079226  Map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
116102979  Taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
116068277  Taok3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
116078702  Taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
116079018  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
116068848  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116077938  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
116079135  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
116090498  Mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
116078020  Mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
116078619  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
116086142  Flna; filamin-A isoform X1 [KO:K04437]
116085656  Crkl; crk-like protein [KO:K04438]
116078814  Crk; adapter molecule crk isoform X1 [KO:K04438]
116102626  Arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
116077020  Arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
116085336  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116067982  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116076765  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116075101  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
116075516  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
116077765  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
116077791  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
116068345  Mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
116098772  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
116073034  Mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
116080005  Rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
116103460  Rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
116090957  Cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
116087416  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
116070090  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
116096245  Jun; transcription factor AP-1 [KO:K04448]
116069482  Jund; transcription factor jun-D [KO:K04449]
116091666  Atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
116077116  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
116076417  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
116079888  Max; protein max isoform X1 [KO:K04453]
116083115  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
116070952  Hspb1; heat shock protein beta-1 [KO:K04455]
116101889  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116104026  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116079779  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116081055  Ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
116091383  LOW QUALITY PROTEIN: protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
116076004  Ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
116102258  Ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
116099696  Ptpn7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
116078286  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
116103239  Dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116104000  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116099697  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116092345  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116069144  Dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116073078  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116076131  Dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
116093133  Dusp9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
116068315  Dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
116078006  Dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
116101699  Ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
116080896  Ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
116103294  Hspa6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
116074790  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
116075039  heat shock 70 kDa protein 1A [KO:K03283]
116073211  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
116095046  Mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
116072039  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
116077931  Mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
116080043  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
116079161  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
116103881  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116069014  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
116086280  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
116077179  Nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
116093825  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116103943  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
116103403  Rela; transcription factor p65 isoform X1 [KO:K04735]
116101766  Relb; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mcoc04070  Phosphatidylinositol signaling system
mcoc04110  Cell cycle
mcoc04115  p53 signaling pathway
mcoc04210  Apoptosis
mcoc04310  Wnt signaling pathway
mcoc04668  TNF signaling pathway
KO pathway
ko04010   
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