KEGG   PATHWAY: setr04010
Entry
setr04010                   Pathway                                
Name
MAPK signaling pathway - Suncus etruscus (white-toothed pygmy shrew)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
setr04010  MAPK signaling pathway
setr04010

Other DBs
GO: 0000165
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
126030243  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
126020490  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
126022196  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
126013230  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
126013529  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
125999147  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
126008536  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
126000814  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
126006357  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
126004344  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
126013608  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
126014017  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
126014432  CACNA2D3; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
126022195  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
126017373  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
126014465  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
126022513  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
126008765  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
126019212  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
126006287  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
126030924  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
126018659  CACNG4; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
126018836  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
126028041  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
126028026  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
126028033  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
126030328  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
126005939  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
126017297  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
126030861  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126027978  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126030440  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
126030830  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
126010822  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
126003300  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
126030882  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
126027877  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
126028224  protein phosphatase 3 catalytic subunit alpha-like [KO:K04348] [EC:3.1.3.16]
126012641  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
126024674  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
126022691  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
125997691  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
126032385  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
126019028  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
126023857  RASGRP3; LOW QUALITY PROTEIN: ras guanyl-releasing protein 3 [KO:K12362]
126028506  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
126003878  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
126007754  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
126001889  RASA1; ras GTPase-activating protein 1 [KO:K04352]
126025533  RASA2; ras GTPase-activating protein 2 [KO:K08053]
125997373  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
126021897  RAP1B; ras-related protein Rap-1b [KO:K07836]
126006387  ras-related protein Rap-1b [KO:K07836]
126027570  EGF; pro-epidermal growth factor [KO:K04357]
126024677  TGFA; protransforming growth factor alpha [KO:K08774]
126032182  EREG; proepiregulin [KO:K09784]
126032638  AREG; amphiregulin [KO:K09782]
126027928  FGF1; fibroblast growth factor 1 [KO:K18496]
126003833  FGF2; fibroblast growth factor 2 [KO:K18497]
126011901  FGF18; fibroblast growth factor 18 [KO:K04358]
126003322  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
125994821  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
126030532  FGF22; fibroblast growth factor 22 [KO:K04358]
126015702  FGF9; fibroblast growth factor 9 [KO:K04358]
126006634  FGF6; LOW QUALITY PROTEIN: fibroblast growth factor 6 [KO:K04358]
126006877  FGF20; fibroblast growth factor 20 [KO:K04358]
126032628  FGF5; fibroblast growth factor 5 [KO:K04358]
126001075  FGF10; fibroblast growth factor 10 [KO:K04358]
126018801  FGF3; fibroblast growth factor 3 [KO:K04358]
126019083  FGF4; fibroblast growth factor 4 [KO:K04358]
126020032  FGF7; fibroblast growth factor 7 [KO:K04358]
126018800  FGF19; fibroblast growth factor 19 [KO:K22603]
126028612  FGF21; fibroblast growth factor 21 [KO:K22429]
126006944  FGF23; fibroblast growth factor 23 [KO:K22428]
125997353  NGF; beta-nerve growth factor [KO:K02582]
126019007  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
126006607  NTF3; neurotrophin-3 [KO:K04356]
126027220  NTF4; neurotrophin-4 [KO:K12457]
126019098  INS; insulin [KO:K04526]
126022310  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
126019086  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
126030482  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
126006376  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
126003432  PDGFC; platelet-derived growth factor C [KO:K05450]
126016055  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
125997278  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
126022954  KITLG; kit ligand [KO:K05461]
126028621  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
125996266  VEGFA; vascular endothelial growth factor A [KO:K05448]
126017939  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
126004091  PGF; placenta growth factor [KO:K16859]
126007180  VEGFC; vascular endothelial growth factor C [KO:K05449]
125998737  VEGFD; vascular endothelial growth factor D [KO:K05449]
126008496  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
126009505  ANGPT1; angiopoietin-1 [KO:K05465]
126033630  ANGPT2; angiopoietin-2 [KO:K05466]
126017359  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
126001958  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
126029639  EFNA2; ephrin-A2 [KO:K05462]
126020759  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
126020762  EFNA1; ephrin-A1 [KO:K05462]
126020137  EFNA4; ephrin-A4 [KO:K05462]
126000344  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
126029749  NRTN; neurturin [KO:K25414]
126011288  ARTN; artemin [KO:K25415]
126030115  PSPN; persephin [KO:K25416]
126013961  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
126016368  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
126022960  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
126023244  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
126006406  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
125994891  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
126032236  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
126012016  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
126018196  NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583]
126020472  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
126004189  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
126031127  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
126021814  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
126032431  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
126006402  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
126006483  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
126032299  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
126015636  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
126015921  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
126015747  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
126032296  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
126004843  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
126004527  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
126006516  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
125995054  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
126003551  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
126023864  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
125999018  SOS2; son of sevenless homolog 2 [KO:K03099]
126019084  HRAS; GTPase HRas [KO:K02833]
126022823  KRAS; GTPase KRas isoform X1 [KO:K07827]
125997372  NRAS; GTPase NRas [KO:K07828]
126027209  RRAS; ras-related protein R-Ras [KO:K07829]
126018972  RRAS2; ras-related protein R-Ras2 [KO:K07830]
126012178  MRAS; ras-related protein M-Ras [KO:K07831]
125999333  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
126010754  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125998044  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126021920  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
126029670  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
126026260  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
126029893  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
126033704  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126029626  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
126011150  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
126024784  RPS6KA2; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
125998721  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
126011044  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
126006324  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125999215  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
126004544  ELK4; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-4 [KO:K04376]
125997181  MYC; myc proto-oncogene protein [KO:K04377]
125996561  SRF; serum response factor [KO:K04378]
126004042  FOS; protein c-Fos [KO:K04379]
126020348  MAPT; LOW QUALITY PROTEIN: microtubule-associated protein tau [KO:K04380]
126009635  stathmin-like [KO:K04381]
126010065  stathmin-like [KO:K04381]
126011335  STMN1; stathmin isoform X1 [KO:K04381]
126014260  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
126020067  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
126020108  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
126020233  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
126020234  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
125996221  TNF; tumor necrosis factor [KO:K03156]
126023995  IL1A; interleukin-1 alpha [KO:K04383]
126024019  IL1B; interleukin-1 beta [KO:K04519]
126028183  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
126003348  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
126004037  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
126006951  TNFRSF1A; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
126024218  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
126012158  interleukin-1 receptor accessory protein-like [KO:K04723]
126003919  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
125997897  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
126028335  CD14; monocyte differentiation antigen CD14 [KO:K04391]
126030488  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126006381  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
126013731  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
125994825  cell division control protein 42 homolog [KO:K04393]
126024665  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
125998704  cell division control protein 42 homolog [KO:K04393]
126018299  cell division control protein 42 homolog [KO:K04393]
126011308  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
126028736  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
126027480  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
126006887  caspase-3-like [KO:K02187] [EC:3.4.22.56]
126007206  caspase-3-like [KO:K02187] [EC:3.4.22.56]
126007207  caspase-3-like [KO:K02187] [EC:3.4.22.56]
126009254  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
125995679  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
125998189  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
125999355  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
126022862  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
126017923  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
126003398  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
126031185  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
126010817  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
126006234  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
126031061  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
126031207  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
126023904  MAP4K3; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
126024546  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
126027596  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
126013242  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
126017532  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
126012201  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
126022427  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
126017350  STK4; serine/threonine-protein kinase 4 [KO:K04411]
126009450  STK3; serine/threonine-protein kinase 3 [KO:K04412]
126019013  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
126014144  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
126001850  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
126018025  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
126008841  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
126017334  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
126004128  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
126028105  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
126029828  MAP3K21; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
126022462  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
126012038  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
126009163  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
126011391  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
126029694  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
126006708  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
125996544  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
126029510  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
126030686  TAOK3; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
126006062  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
126013713  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
126031156  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
126013729  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
126008206  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
126017610  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
126006133  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
126000898  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
125999073  FLNA; filamin-A isoform X1 [KO:K04437]
126021156  CRK; LOW QUALITY PROTEIN: adapter molecule crk [KO:K04438]
126033713  CRKL; crk-like protein [KO:K04438]
126018158  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
126011248  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
126015663  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126032054  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126033690  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125996324  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
125996366  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
126006273  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
126006370  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
126029498  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
126004547  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
126014065  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
126003538  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
126017914  RPS6KA4; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
126017365  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
126020311  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
126027342  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
126010979  JUN; transcription factor Jun [KO:K04448]
126029440  JUND; transcription factor JunD [KO:K04449]
126006901  LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2-like [KO:K04450]
126009077  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
125998025  TP53; LOW QUALITY PROTEIN: cellular tumor antigen p53 [KO:K04451]
126022241  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
126004094  MAX; protein max [KO:K04453]
126001940  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
126029588  HSPB1; heat shock protein beta-1 [KO:K04455]
126013417  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126033346  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126028133  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126004041  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
126021914  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
126018917  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
126004355  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
126012235  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
126022425  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126014424  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126006840  DUSP4; LOW QUALITY PROTEIN: dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126024652  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126033601  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126019017  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126022733  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
125999446  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
126003344  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
126019460  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
126028227  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
126023873  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
126013732  heat shock cognate 71 kDa protein-like [KO:K03283]
125996185  heat shock 70 kDa protein 1-like [KO:K03283]
125996186  heat shock 70 kDa protein 1 [KO:K03283]
125996188  heat shock 70 kDa protein 1-like [KO:K03283]
126015401  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
126017986  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
126011772  histone-lysine N-methyltransferase MECOM-like [KO:K04462] [EC:2.1.1.367]
126010834  histone-lysine N-methyltransferase MECOM-like [KO:K04462] [EC:2.1.1.367]
126021899  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
126013663  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
126022480  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
126016597  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
126033816  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
126006407  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
125999080  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
126006367  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
126027544  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
126033811  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
126019025  RELA; transcription factor p65 [KO:K04735]
126028569  RELB; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
setr04070  Phosphatidylinositol signaling system
setr04110  Cell cycle
setr04115  p53 signaling pathway
setr04210  Apoptosis
setr04310  Wnt signaling pathway
setr04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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