KEGG   PATHWAY: umr05417
Entry
umr05417                    Pathway                                
Name
Lipid and atherosclerosis - Ursus maritimus (polar bear)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
umr05417  Lipid and atherosclerosis
umr05417

Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103671941  APOB; apolipoprotein B-100 [KO:K14462]
103662517  APOA4; apolipoprotein A-IV [KO:K08760]
103662516  APOA1; apolipoprotein A-I [KO:K08757]
103678713  LDLR; low-density lipoprotein receptor [KO:K12473]
103669134  OLR1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
103680187  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
103662453  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
103662455  LOW QUALITY PROTEIN: interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
103674825  RHOA; transforming protein RhoA [KO:K04513]
103660117  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
103660958  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
103678592  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103666874  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103676125  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103675162  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103663617  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
103670766  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103666688  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103661038  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103676878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103657107  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103679423  BAD; bcl2-associated agonist of cell death [KO:K02158]
103674345  BCL2L1; bcl-2-like protein 1 isoform X2 [KO:K04570]
103676164  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
103676947  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103679990  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103667893  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103660837  SOD2; superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
103665907  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103667436  POU2F1; POU domain, class 2, transcription factor 1 isoform X2 [KO:K09364]
103662302  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
103680181  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
103669702  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
103672841  CD40LG; CD40 ligand [KO:K03161]
103678992  cytochrome P450 1A1 isoform X1 [KO:K07408] [EC:1.14.14.1]
103663082  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
103682274  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
103672992  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
103668228  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
103670166  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
103673846  cytochrome b-245 light chain [KO:K08009]
103672508  NCF2; neutrophil cytosol factor 2 [KO:K08010]
103676418  NCF4; neutrophil cytosol factor 4 [KO:K08012]
103670095  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103669776  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103663212  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
103672573  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
103666578  CDC42; cell division control protein 42 homolog [KO:K04393]
103660510  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
103681888  MAP2K7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103671011  FOS; proto-oncogene c-Fos [KO:K04379]
103670861  JUN; transcription factor AP-1 [KO:K04448]
103667270  C-C motif chemokine 2 [KO:K14624]
103678731  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103665307  CXCL8; interleukin-8 [KO:K10030]
103658475  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103665687  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103674115  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103665451  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103665538  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103674004  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103669173  LOW QUALITY PROTEIN: GTPase HRas-like [KO:K02833]
103671035  HRAS; GTPase HRas isoform X3 [KO:K02833]
103665244  KRAS; GTPase KRas isoform X1 [KO:K07827]
103669422  NRAS; GTPase NRas [KO:K07828]
103669286  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103657827  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
103679584  RELA; transcription factor p65 [KO:K04735]
103677947  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103667721  SELE; E-selectin [KO:K06494]
103667691  P-selectin isoform X3 [KO:K06496]
103669326  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
103662452  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
103662454  stromelysin-1-like [KO:K01394] [EC:3.4.24.17]
103669705  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
103661934  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103671495  IL1B; interleukin-1 beta isoform X2 [KO:K04519]
103658871  IL6; interleukin-6 [KO:K05405]
103682322  TNF; tumor necrosis factor [KO:K03156]
103659711  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
103662283  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
103658293  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
103682293  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1 [KO:K03283]
103682294  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
103682295  heat shock 70 kDa protein 1-like [KO:K03283]
121106055  heat shock 70 kDa protein 1 isoform X1 [KO:K03283]
103672248  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
103663821  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
103664050  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
103656761  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
103676491  HSP90B1; endoplasmin [KO:K09487]
103658031  toll-like receptor 2 [KO:K10159]
103669764  lipopolysaccharide-binding protein-like isoform X1 [KO:K05399]
103669766  lipopolysaccharide-binding protein [KO:K05399]
103663749  CD14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391]
103681265  LY96; lymphocyte antigen 96 [KO:K05400]
103670382  TLR4; toll-like receptor 4 [KO:K10160]
103660655  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
103680724  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103675405  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
103679690  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103659308  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103676518  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103666926  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103660092  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103658916  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103677059  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103679680  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103666055  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103679954  TIR domain-containing adapter molecule 2-like [KO:K05409]
103681847  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
103656774  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103682068  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
103664756  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
103659501  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
103671004  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
103656833  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
103671092  IRF7; LOW QUALITY PROTEIN: interferon regulatory factor 7 [KO:K09447]
103657131  IRF3; interferon regulatory factor 3 [KO:K05411]
103662147  interferon alpha-1/2-like [KO:K05414]
103662148  interferon alpha-1/2-like [KO:K05414]
103662149  interferon alpha-2-like [KO:K05414]
103680385  interferon alpha-1/2-like [KO:K05414]
103680386  interferon alpha-1/2-like [KO:K05414]
103666985  interferon alpha-1/2-like [KO:K05414]
121103043  interferon alpha-1/2-like [KO:K05414]
103662150  IFNB1; interferon beta [KO:K05415]
103658666  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
103669544  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
103679944  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
103665560  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
103658229  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
103677438  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
103670589  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103681714  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
103675192  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
103679942  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
103672667  TLR6; toll-like receptor 6 [KO:K10169]
103675043  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
103659828  ras-related protein Rap-1b-like [KO:K07836]
103656863  RAP1B; ras-related protein Rap-1b [KO:K07836]
103667294  CCL5; C-C motif chemokine 5 [KO:K12499]
103667298  C-C motif chemokine 3-like [KO:K05408]
103667297  C-C motif chemokine 3 [KO:K05408]
103667299  regakine-1-like [KO:K05408]
103665390  growth-regulated protein homolog beta-like [KO:K05505]
103665312  growth-regulated alpha protein-like [KO:K05505]
103681335  IL12A; interleukin-12 subunit alpha [KO:K05406]
103664531  IL12B; interleukin-12 subunit beta isoform X1 [KO:K05425]
103682420  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
103662382  IL18; interleukin-18 [KO:K05482]
103670323  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
103658290  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
103656598  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
103672910  ERO1A; ERO1-like protein alpha isoform X2 [KO:K10950] [EC:1.8.4.-]
103669597  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103661761  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
103664598  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
103668027  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
103674683  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
103671855  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
103671936  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
103676372  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103665903  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
103675245  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
103663496  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
103659239  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
103678544  ABCA1; phospholipid-transporting ATPase ABCA1 [KO:K05641]
103680718  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
103659605  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X2 [KO:K05638]
103657888  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
103663329  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
103668498  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
103678785  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
103658473  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
103669832  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103673717  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103673552  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103674425  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
103674426  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
103679549  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
121099746  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
103669754  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
103670304  CALM1; calmodulin-1 isoform X1 [KO:K02183]
103682041  CALML6; calmodulin-like protein 6 [KO:K02183]
103676238  calmodulin [KO:K02183]
103676239  CALML3; calmodulin-like protein 3 [KO:K02183]
103671240  CALM2; calmodulin-2 [KO:K02183]
103679049  CALML4; calmodulin-like protein 4 isoform X3 [KO:K02183]
103657204  CALM3; calmodulin-3 [KO:K02183]
103673318  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103677943  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103667825  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103678534  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
103671340  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
103676141  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
103671065  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K04722]
103656234  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
103668115  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103659742  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
103675694  BID; BH3-interacting domain death agonist [KO:K04726]
103658902  cytochrome c [KO:K08738]
103662923  cytochrome c-like [KO:K08738]
121104237  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
103660136  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
103666628  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
103661832  CASP6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
103680991  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
103657312  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
103660368  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
Antioxid Redox Signal 15:2301-33 (2011)
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Related
pathway
umr04020  Calcium signaling pathway
umr04115  p53 signaling pathway
umr04141  Protein processing in endoplasmic reticulum
umr04151  PI3K-Akt signaling pathway
umr04210  Apoptosis
umr04620  Toll-like receptor signaling pathway
umr04621  NOD-like receptor signaling pathway
umr04668  TNF signaling pathway
umr04670  Leukocyte transendothelial migration
umr04975  Fat digestion and absorption
umr04979  Cholesterol metabolism
umr05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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