KEGG   PATHWAY: pyu05010
Entry
pyu05010                    Pathway                                
Name
Alzheimer disease - Puma yagouaroundi (jaguarundi)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
pyu05010  Alzheimer disease
pyu05010

Disease
H00056  Alzheimer disease
Organism
Puma yagouaroundi (jaguarundi) [GN:pyu]
Gene
121009729  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
121009893  [KO:K02263]
121009986  [KO:K07375]
121010229  [KO:K02266]
121010269  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
121010360  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
121010452  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
121010516  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121010691  [KO:K00418]
121010701  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
121010824  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
121010888  WNT8A; protein Wnt-8a [KO:K00714]
121011002  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121011065  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
121011166  [KO:K00414]
121011444  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121011450  PSMC4; 26S proteasome regulatory subunit 6B isoform X1 [KO:K03063]
121011508  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
121011523  [KO:K02270]
121011554  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
121011557  [KO:K02267]
121011859  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
121011897  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
121012342  [KO:K02263]
121012365  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
121012476  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
121012479  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
121012552  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
121012712  DKK4; dickkopf-related protein 4 [KO:K02165]
121012848  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
121013159  PSMB1; proteasome subunit beta type-1 isoform X1 [KO:K02732] [EC:3.4.25.1]
121013412  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
121013560  [KO:K02128]
121013570  [KO:K02272]
121013601  [KO:K04634]
121013658  [KO:K03945]
121013826  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
121013887  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
121013900  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
121013911  [KO:K02128]
121014343  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
121014448  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
121014485  IRS1; insulin receptor substrate 1 [KO:K16172]
121014548  FZD8; frizzled-8 [KO:K02375]
121014641  KIF5B; kinesin-1 heavy chain [KO:K10396]
121014751  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
121014841  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
121014870  [KO:K02183]
121014873  [KO:K02183]
121014875  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
121014969  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121014984  BECN2; beclin-2 [KO:K08334]
121015111  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121015188  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
121015264  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
121015275  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
121015294  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
121015318  AXIN2; axin-2 [KO:K04385]
121015327  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
121015367  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
121015470  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
121015474  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
121015504  NCSTN; nicastrin [KO:K06171]
121015838  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
121016029  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
121016051  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
121016285  RTN4; reticulon-4 isoform X1 [KO:K20720]
121016298  [KO:K02265]
121016318  CALM2; calmodulin-2 [KO:K02183]
121016389  [KO:K02265]
121016555  DKK1; dickkopf-related protein 1 [KO:K02165]
121016588  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
121016685  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
121016686  WNT3A; protein Wnt-3a [KO:K00312]
121016766  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
121016831  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
121016834  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
121017138  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
121017140  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
121017178  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
121017370  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
121017530  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
121017634  [KO:K17445]
121017718  FZD9; frizzled-9 [KO:K02842]
121017835  [KO:K03957]
121017884  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
121017895  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
121018175  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
121018585  APOE; apolipoprotein E [KO:K04524]
121018608  KLC3; kinesin light chain 3 [KO:K10407]
121018659  CALM3; calmodulin-3 isoform X1 [KO:K02183]
121018850  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
121018883  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
121019071  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
121019078  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
121019338  CALML6; calmodulin-like protein 6 [KO:K02183]
121019380  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
121019403  [KO:K00415]
121019463  [KO:K05863]
121019534  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
121019699  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
121019790  AXIN1; axin-1 isoform X1 [KO:K02157]
121019824  [KO:K02267]
121019953  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
121019955  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
121020003  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
121020006  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
121020143  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
121020155  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
121020160  WNT9B; protein Wnt-9b [KO:K01064]
121020230  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
121020261  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
121020288  TUBB4B; tubulin beta-4B chain [KO:K07375]
121020299  TUBB2B; tubulin beta-2B chain [KO:K07375]
121020564  [KO:K07375]
121020585  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121020796  [KO:K04741] [EC:3.4.22.-]
121020843  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
121020998  [KO:K00134] [EC:1.2.1.12]
121021007  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
121021042  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
121021062  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
121021093  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
121021203  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
121021303  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
121021313  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
121021383  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
121021430  [KO:K00420]
121021465  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
121021496  SLC39A3; zinc transporter ZIP3 isoform X1 [KO:K14709]
121021539  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
121021542  TUBB4A; tubulin beta-4A chain [KO:K07375]
121021590  [KO:K07374]
121021720  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
121021783  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
121021883  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
121021909  BID; BH3-interacting domain death agonist [KO:K04726]
121021956  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
121021982  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
121022026  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
121022084  TUBA8; tubulin alpha-8 chain [KO:K07374]
121022112  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
121022123  WNT5B; protein Wnt-5b [KO:K00444]
121022226  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121022312  TNF; tumor necrosis factor [KO:K03156]
121022315  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
121022378  CSNK2B; casein kinase II subunit beta [KO:K03115]
121022470  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
121022649  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
121022686  [KO:K00419]
121022734  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
121022775  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
121022826  HRAS; GTPase HRas isoform X1 [KO:K02833]
121022836  WNT4; protein Wnt-4 [KO:K00408]
121022910  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
121022994  [KO:K02266]
121023018  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121023080  TUBB; tubulin beta chain [KO:K07375]
121023215  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
121023356  [KO:K02267]
121023676  RTN3; reticulon-3 isoform X1 [KO:K20723]
121023724  [KO:K02273]
121023725  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
121023741  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
121023814  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
121023858  KLC2; kinesin light chain 2 [KO:K10407]
121023867  FADD; FAS-associated death domain protein [KO:K02373]
121023907  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
121023931  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
121023937  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
121023947  BAD; bcl2-associated agonist of cell death [KO:K02158]
121023959  RELA; transcription factor p65 [KO:K04735]
121023965  INS; insulin [KO:K04526]
121023971  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
121024217  IRS2; insulin receptor substrate 2 [KO:K07187]
121024259  FZD10; frizzled-10 [KO:K02842]
121024361  SLC39A1; zinc transporter ZIP1 [KO:K14709]
121024502  [KO:K05863]
121024508  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
121024689  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
121024701  [KO:K04522] [EC:3.4.23.-]
121024703  [KO:K00411] [EC:7.1.1.8]
121024748  FZD3; frizzled-3 isoform X1 [KO:K02329]
121024801  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
121024956  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
121025049  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
121025331  [KO:K02271]
121025390  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
121025397  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
121025521  [KO:K02267]
121025718  IRS4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446]
121026003  [KO:K21421] [EC:1.-.-.-]
121026060  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
121026083  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
121026094  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
121026160  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
121026225  [KO:K02128]
121026766  [KO:K03948]
121026789  [KO:K03948]
121026899  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
121027050  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121027060  [KO:K00416]
121027103  [KO:K00417]
121027626  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
121027641  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
121027672  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
121027695  WNT2B; protein Wnt-2b [KO:K00182]
121027738  NRAS; GTPase NRas [KO:K07828]
121027961  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
121027988  FZD1; frizzled-1 [KO:K02432]
121028241  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121028242  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
121028407  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
121028423  WNT16; protein Wnt-16 [KO:K01558]
121028442  WNT2; protein Wnt-2 [KO:K00182]
121028606  [KO:K08738]
121028638  IL6; interleukin-6 isoform X1 [KO:K05405]
121028710  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
121028842  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
121028847  [KO:K02265]
121028938  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
121029272  SLC39A7; zinc transporter SLC39A7 isoform X1 [KO:K14713]
121029298  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
121029473  KLC4; kinesin light chain 4 [KO:K10407]
121029544  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
121029678  [KO:K02270]
121029907  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
121030343  [KO:K08738]
121030544  KIF5C; kinesin heavy chain [KO:K10396]
121030609  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
121030730  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
121030854  SLC39A10; zinc transporter ZIP10 [KO:K14716]
121030905  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959]
121030909  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
121030921  FZD7; frizzled-7 isoform X1 [KO:K02432]
121030961  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
121030981  FZD5; frizzled-5 [KO:K02375]
121031082  WNT10A; protein Wnt-10a [KO:K01357]
121031083  WNT6; protein Wnt-6 [KO:K00445]
121031099  TUBA4A; tubulin alpha-4A chain [KO:K07374]
121031307  [KO:K03947]
121031422  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
121031504  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
121031542  DKK2; dickkopf-related protein 2 [KO:K02165]
121031655  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
121031768  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
121031803  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
121031828  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
121031875  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121031906  SLC39A8; metal cation symporter ZIP8 [KO:K14714]
121031929  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121031936  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
121031972  SLC39A9; zinc transporter ZIP9 [KO:K14715]
121032012  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
121032180  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
121032181  CALM1; calmodulin-1 [KO:K02183]
121032262  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
121032335  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
121032358  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121032405  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
121032498  SNCA; alpha-synuclein [KO:K04528]
121032976  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
121032993  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
121033006  SLC39A6; zinc transporter ZIP6 [KO:K14712]
121033019  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121033067  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
121033178  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
121033206  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
121033506  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
121033545  [KO:K03957]
121033661  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
121033733  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121033850  [KO:K02137]
121033874  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
121034013  [KO:K08738]
121034018  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121034026  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
121034071  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
121034081  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
121034562  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
121034769  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
121034919  [KO:K08738]
121034940  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
121034971  PSMB7; proteasome subunit beta type-7 isoform X1 [KO:K02739] [EC:3.4.25.1]
121035386  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
121035445  BACE1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
121035897  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
121035978  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
121036049  [KO:K04520]
121036053  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
121036249  [KO:K02271]
121036286  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121036296  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform X1 [KO:K03960]
121036442  [KO:K00134] [EC:1.2.1.12]
121036454  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
121036680  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
121036774  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
121036791  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121036822  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
121036853  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
121036923  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121036995  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
121037105  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
121037114  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
121037247  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
121037465  FRAT1; proto-oncogene FRAT1 [KO:K03069]
121037466  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
121037468  WNT8B; protein Wnt-8b [KO:K00714]
121037531  [KO:K11352]
121037957  [KO:K02128]
121038261  [KO:K00420]
121038271  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
121038479  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
121038547  ATG101; autophagy-related protein 101 [KO:K19730]
121038575  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
121038622  [KO:K07374]
121038623  [KO:K07374]
121038624  [KO:K07374]
121038637  WNT1; proto-oncogene Wnt-1 [KO:K03209]
121038640  WNT10B; protein Wnt-10b [KO:K01357]
121038795  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
121038809  KRAS; GTPase KRas isoform X1 [KO:K07827]
121038896  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
121038918  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
121039007  [KO:K02730] [EC:3.4.25.1]
121039179  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
121039303  WNT11; protein Wnt-11 [KO:K01384]
121039342  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
121039382  FZD4; frizzled-4 isoform X1 [KO:K02354]
121039398  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
121039672  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
121039687  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
121039877  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121039879  SLC39A14; metal cation symporter ZIP14 isoform X1 [KO:K14720]
121039907  LPL; lipoprotein lipase isoform X1 [KO:K01059] [EC:3.1.1.34]
121040083  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
121040175  WNT7B; protein Wnt-7b [KO:K00572]
121040247  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
121040318  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
121040352  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
121040562  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
121040597  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
121040872  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
121040880  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
121040888  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
121040909  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
121040931  SLC39A5; zinc transporter ZIP5 isoform X1 [KO:K14711]
121041205  WNT7A; protein Wnt-7a [KO:K00572]
121041241  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121041326  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121041441  RYR3; ryanodine receptor 3 [KO:K04963]
121041442  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
121041495  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
121041772  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
121041809  APH1B; gamma-secretase subunit APH-1B isoform X1 [KO:K06172]
121041863  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121041895  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
121042004  [KO:K02264]
121042025  [KO:K00237]
121042216  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
121042244  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
121042523  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
121042730  [KO:K00417]
121042768  [KO:K02268]
121042823  FZD6; frizzled-6 [KO:K02376]
121042890  [KO:K00134] [EC:1.2.1.12]
121042958  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
121043133  [KO:K00413]
121043142  SLC39A4; zinc transporter ZIP4 [KO:K14710]
121043437  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
121043441  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
121043443  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
121043466  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
121043470  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
121044072  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
121044344  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
121044392  [KO:K02270]
121044460  IL1B; interleukin-1 beta [KO:K04519]
121044461  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
121044477  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
121044517  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
121044712  [KO:K03955]
121044831  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
121044888  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
121044889  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
121044921  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 isoform X1 [KO:K03033]
121045044  BECN1; beclin-1 isoform X1 [KO:K08334]
121045102  FZD2; frizzled-2 [KO:K02235]
121045379  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
121045417  NAE1; NEDD8-activating enzyme E1 regulatory subunit isoform X1 [KO:K04532]
26129851  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
26129852  COX3; cytochrome c oxidase subunit III [KO:K02262]
26129855  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
26129857  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
26129864  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
26129867  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
26129872  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
26129874  COX2; cytochrome c oxidase subunit II [KO:K02261]
26129875  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
26129876  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
26129877  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
26129880  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
26129881  CYTB; cytochrome b [KO:K00412]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Aberrant insulin signaling in Alzheimer's disease: current knowledge.
  Journal
Front Neurosci 9:204 (2015)
DOI:10.3389/fnins.2015.00204
Reference
PMID:20101724
  Authors
Funderburk SF, Marcellino BK, Yue Z
  Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
  Journal
Mt Sinai J Med 77:59-68 (2010)
DOI:10.1002/msj.20161
Related
pathway
pyu00190  Oxidative phosphorylation
pyu03050  Proteasome
pyu04020  Calcium signaling pathway
pyu04140  Autophagy - animal
pyu04141  Protein processing in endoplasmic reticulum
pyu04210  Apoptosis
pyu04310  Wnt signaling pathway
pyu04910  Insulin signaling pathway
pyu04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

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