KEGG   PATHWAY: rno05205
Entry
rno05205                    Pathway                                
Name
Proteoglycans in cancer - Rattus norvegicus (rat)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
rno05205  Proteoglycans in cancer
rno05205

Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100313996  Mir10a; rno-miR-10a-5p [KO:K16864]
100314000  Mir21; rno-miR-21-5p [KO:K16863]
100314226  Mir10b; rno-miR-10b-5p [KO:K16864]
100360552  Fzd7; frizzled-7 precursor [KO:K02432]
100361457  Actg1l1; actin, gamma 1 propeptide-like [KO:K05692]
114486  Braf; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
114487  Wnt2; protein Wnt-2 precursor [KO:K00182]
114633  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
114850  Wnt7a; protein Wnt-7a precursor [KO:K00572]
114851  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
116466  Wnt2b; protein Wnt-2b [KO:K00182]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116670  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
116689  Ptpn6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
117273  Rhoa; transforming protein RhoA [KO:K04513]
120098222  [KO:K05692]
134484121  [KO:K00922] [EC:2.7.1.153]
140584  Wnt11; protein Wnt-11 [KO:K01384]
161476  Hspb2; heat shock protein beta-2 isoform 1 [KO:K09543]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
170921  Itga2; integrin alpha-2 precursor [KO:K06481]
171140  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
24245  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2 [KO:K04515] [EC:2.7.11.17]
24246  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
24329  Egfr; epidermal growth factor receptor isoform 2 precursor [KO:K04361] [EC:2.7.10.1]
24337  Erbb2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
24446  Hgf; hepatocyte growth factor preproprotein [KO:K05460]
24482  Igf1; insulin-like growth factor I isoform d preproprotein [KO:K05459]
24483  Igf2; insulin-like growth factor II isoform 2 preproprotein [KO:K13769]
24511  Itgb1; integrin beta-1 precursor [KO:K05719]
24525  Kras; GTPase KRas [KO:K07827]
24553  Met; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
24577  Myc; myc proto-oncogene protein [KO:K04377]
24605  Nras; GTPase NRas [KO:K07828]
246097  Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
24668  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
24669  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1 [KO:K06269] [EC:3.1.3.16]
24680  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
24681  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
24771  Sdc4; syndecan-4 precursor [KO:K16338]
24782  Slc9a1; sodium/hydrogen exchanger 1 [KO:K05742]
24835  Tnf; tumor necrosis factor [KO:K03156]
24842  Tp53; cellular tumor antigen p53 [KO:K04451]
24881  Wnt1; proto-oncogene Wnt-1 precursor [KO:K03209]
24882  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
24890  Esr1; estrogen receptor [KO:K08550]
25023  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
25125  Stat3; signal transducer and activator of transcription 3 [KO:K04692]
25156  Vav1; proto-oncogene vav [KO:K05730]
25216  Sdc1; syndecan-1 precursor [KO:K06257]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25236  Gpc3; glypican-3 precursor [KO:K08109]
25262  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform 3 [KO:K04958]
25273  Smo; protein smoothened precursor [KO:K06226]
25358  Timp3; metalloproteinase inhibitor 3 precursor [KO:K16866]
25385  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
25400  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
25402  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
25404  Cav1; caveolin-1 isoform alpha [KO:K06278]
25406  Cd44; CD44 antigen precursor [KO:K06256]
25433  Hbegf; proheparin-binding EGF-like growth factor precursor [KO:K08523]
25482  Mras; ras-related protein M-Ras [KO:K07831]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
25537  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
25589  Kdr; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
25594  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
25614  Ptk2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
25615  Sdc2; syndecan-2 precursor [KO:K16336]
25619  Plau; urokinase-type plasminogen activator precursor [KO:K01348] [EC:3.4.21.73]
25622  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform 2 [KO:K07293] [EC:3.1.3.48]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
25661  Fn1; fibronectin precursor [KO:K05717]
25679  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
25697  Ctsl; procathepsin L preproprotein [KO:K01365] [EC:3.4.22.15]
25718  Igf1r; insulin-like growth factor 1 receptor isoform 2 precursor [KO:K05087] [EC:2.7.10.1]
25738  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
257645  Itgb5; integrin beta-5 precursor [KO:K06588]
266608  Fzd9; frizzled-9 precursor [KO:K02842]
266715  Fzd3; frizzled-3 precursor [KO:K02329]
282581  Fzd6; frizzled-6 precursor [KO:K02376]
282582  Wnt5b; protein Wnt-5b precursor [KO:K00444]
287357  Wnt9a; protein Wnt-9a precursor [KO:K01064]
287765  Ddx5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
287876  Actg1; actin, cytoplasmic 2 [KO:K05692]
288077  Hcls1; hematopoietic lineage cell-specific protein [KO:K06106]
29139  Dcn; decorin precursor [KO:K04660]
29161  Cav3; caveolin-3 [KO:K12959]
291678  Wnt8a; protein Wnt-8a precursor [KO:K00714]
29169  Vtn; vitronectin precursor [KO:K06251]
29186  Cd63; CD63 antigen [KO:K06497]
29260  Tlr4; toll-like receptor 4 precursor [KO:K10160]
29302  Itgb3; integrin beta-3 precursor [KO:K06493]
29304  Rps6; small ribosomal subunit protein eS6 [KO:K02991]
29337  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
29357  Smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
293621  Hras; GTPase HRas [KO:K02833]
293860  Flna; filamin-A [KO:K04437]
29393  Col1a1; collagen alpha-1(I) chain precursor [KO:K06236]
293990  Wnt8b; protein Wnt-8b precursor [KO:K00714]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
29431  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
29496  Erbb3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
29499  Shh; sonic hedgehog protein precursor [KO:K11988]
29513  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
295378  Vav3; guanine nucleotide exchange factor VAV3 [KO:K05730]
29560  Hif1a; hypoxia-inducible factor 1-alpha [KO:K08268]
296456  Itgav; integrin alpha-V isoform 1 precursor [KO:K06487]
296603  Vav2; guanine nucleotide exchange factor VAV2 [KO:K05730]
297173  RSA-14-44; ras homolog gene family, member A [KO:K04513]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
300253  Eif4b; eukaryotic translation initiation factor 4B [KO:K03258]
303181  Wnt3a; protein Wnt-3a precursor [KO:K00312]
303586  Wnt9b; protein Wnt-9b precursor [KO:K01064]
303991  Hoxd10; homeobox protein Hox-D10 [KO:K09295]
304109  Tiam1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
304813  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
306570  Ank1; ankyrin-1 isoform 1 [KO:K10380]
310159  Drosha; ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
310553  Tlr2; toll-like receptor 2 precursor [KO:K10159]
313641  Hspg2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
313845  Sos1; son of sevenless homolog 1 [KO:K03099]
314436  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
314850  Frs2; fibroblast growth factor receptor substrate 2 [KO:K12461]
314856  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
315196  Wnt7b; protein Wnt-7b isoform 1 [KO:K00572]
315294  Wnt10b; protein Wnt-10b precursor [KO:K01357]
315346  Itga5; integrin alpha-5 [KO:K06484]
315655  Rdx; radixin [KO:K05762]
316526  Wnt6; protein Wnt-6 precursor [KO:K00445]
316527  Wnt10a; protein Wnt-10a precursor [KO:K01357]
317674  Fzd5; frizzled-5 precursor [KO:K02375]
360482  Tfap4; transcription factor AP-4 [KO:K09108]
360820  Pxn; paxillin isoform 1 [KO:K05760]
361388  Gab1; GRB2-associated-binding protein 1 [KO:K09593]
361568  Rras; ras-related protein R-Ras [KO:K07829]
361598  Iqgap1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
361696  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
361833  Ank3; ankyrin-3 isoform 2 [KO:K09259]
362036  Ank2; ankyrin-2 [KO:K09255]
363425  Cav2; caveolin-2 [KO:K12958]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
363913  Fzd10; frizzled-10 precursor [KO:K02842]
364754  Fzd8; frizzled-8 precursor [KO:K02375]
365355  Rras2; ras-related protein R-Ras2 [KO:K07830]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
367072  Arhgef12; rho guanine nucleotide exchange factor 12 [KO:K07532]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
368128  Hpse2; inactive heparanase-2 precursor [KO:K07965] [EC:3.2.1.-]
414065  Nanog; homeobox protein NANOG [KO:K10164]
445442  Thbs1; thrombospondin-1 isoform 1 precursor [KO:K16857]
497867  Nudt16l1; tudor-interacting repair regulator protein [KO:K16867]
499076  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
500047  Wnt16; protein Wnt-16 precursor [KO:K01558]
500985  Cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
50692  Plaur; urokinase plasminogen activator surface receptor precursor [KO:K03985]
54250  Fgf2; fibroblast growth factor 2 [KO:K18497]
54319  Ezr; ezrin [KO:K08007]
56718  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
58868  Fzd1; frizzled-1 precursor [KO:K02432]
58919  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
58920  Gpc1; glypican-1 precursor [KO:K08107]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
59086  Tgfb1; transforming growth factor beta-1 proprotein precursor [KO:K13375]
59323  Erbb4; receptor tyrosine-protein kinase erbB-4 precursor [KO:K05085] [EC:2.7.10.1]
59327  Twist2; twist-related protein 2 [KO:K09069]
60323  Arhgef1; rho guanine nucleotide exchange factor 1 [KO:K12330]
60352  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
60465  Cttn; src substrate cortactin isoform 2 [KO:K06106]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
64031  Pdcd4; programmed cell death protein 4 [KO:K16865]
64363  Araf; serine/threonine-protein kinase A-Raf isoform 1 [KO:K08845] [EC:2.7.11.1]
64465  Cdc42; cell division control protein 42 homolog [KO:K04393]
64512  Fzd2; frizzled-2 precursor [KO:K02235]
64537  Hpse; heparanase precursor [KO:K07964] [EC:3.2.1.166]
64546  Il12b; interleukin-12 subunit beta precursor [KO:K05425]
64558  Fzd4; frizzled-4 precursor [KO:K02354]
64566  Wnt5a; protein Wnt-5a precursor [KO:K00444]
689314  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
79114  Fgfr1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
81504  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
81521  Msn; moesin [KO:K05763]
81649  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
81678  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
81682  Lum; lumican precursor [KO:K08122]
81686  Mmp2; 72 kDa type IV collagenase precursor [KO:K01398] [EC:3.4.24.24]
81687  Mmp9; matrix metalloproteinase-9 precursor [KO:K01403] [EC:3.4.24.35]
81745  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
81762  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
81809  Tgfb2; transforming growth factor beta-2 proprotein precursor [KO:K13376]
81822  Actb; actin, cytoplasmic 1 [KO:K05692]
83785  Vegfa; vascular endothelial growth factor A isoform 6 precursor [KO:K05448]
83805  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
83840  Rps6kb1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
84352  Col1a2; collagen alpha-2(I) chain precursor [KO:K06236]
84353  Ctnnb1; catenin beta-1 [KO:K02105]
84399  Ihh; indian hedgehog protein precursor [KO:K11989]
84426  Wnt4; protein Wnt-4 precursor [KO:K00408]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
85384  Sos2; son of sevenless homolog 2 [KO:K03099]
85489  Twist1; twist-related protein 1 [KO:K09069]
89830  Ptch1; protein patched homolog 1 isoform 2 [KO:K06225]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
rno04010  MAPK signaling pathway
rno04020  Calcium signaling pathway
rno04066  HIF-1 signaling pathway
rno04150  mTOR signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04210  Apoptosis
rno04310  Wnt signaling pathway
rno04340  Hedgehog signaling pathway
rno04350  TGF-beta signaling pathway
rno04370  VEGF signaling pathway
rno04510  Focal adhesion
rno04520  Adherens junction
rno04810  Regulation of actin cytoskeleton
KO pathway
ko05205   

DBGET integrated database retrieval system