KEGG   PATHWAY: ccan05169
Entry
ccan05169                   Pathway                                
Name
Epstein-Barr virus infection - Castor canadensis (American beaver)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
ccan05169  Epstein-Barr virus infection
ccan05169

Organism
Castor canadensis (American beaver) [GN:ccan]
Gene
109686661  Cr2; complement receptor type 2 [KO:K04012]
109682663  Cd19; B-lymphocyte antigen CD19 [KO:K06465]
109674702  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-15 beta chain-like [KO:K06752]
109674703  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
109674664  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
109674665  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
109685982  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
109686704  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
109686705  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
109686673  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
109686675  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
109686676  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
109695178  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
109695186  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109695196  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
109701180  Tlr2; toll-like receptor 2 [KO:K10159]
109684529  Myd88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729]
109684435  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
109690874  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
109693564  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
109692995  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
109692528  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
109698497  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109681514  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109696400  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109691919  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
109697260  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
109682963  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109687142  Rela; transcription factor p65 isoform X1 [KO:K04735]
109690391  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
109679557  Il6; interleukin-6 [KO:K05405]
109683803  Ddx58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
109691285  Mavs; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
109688807  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
109698137  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
109697216  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
109698071  Irf7; interferon regulatory factor 7 [KO:K09447]
109683903  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
109690928  interferon alpha-21-like [KO:K05414]
109702568  interferon alpha-2-like [KO:K05414]
109688729  interferon alpha-21-like [KO:K05414]
109688957  interferon alpha-21-like [KO:K05414]
109689103  interferon alpha-4-like [KO:K05414]
109689580  interferon alpha-1/13-like [KO:K05414]
109689888  interferon alpha-17-like [KO:K05414]
109689666  interferon alpha-1/13-like [KO:K05414]
109690286  interferon alpha-10-like [KO:K05414]
109689981  interferon alpha-4-like [KO:K05414]
109690431  interferon alpha-10-like [KO:K05414]
109686809  interferon alpha/beta receptor 1-like [KO:K05130]
109699947  Ifnar2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
109699504  Jak1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
109693177  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
109679865  LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
109682738  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
109686120  Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
109685847  Irf9; interferon regulatory factor 9 [KO:K04693]
109688641  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
109675879  LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3-like [KO:K14216] [EC:2.7.7.84]
109675880  LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
109681969  2'-5'-oligoadenylate synthase 3-like isoform X1 [KO:K14216] [EC:2.7.7.84]
109681970  2'-5'-oligoadenylate synthase 2-like [KO:K14216] [EC:2.7.7.84]
109702386  Cxcl10; C-X-C motif chemokine 10 [KO:K12671]
109685577  Isg15; ubiquitin-like protein ISG15 [KO:K12159]
109691142  Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
109700274  Fadd; FAS-associated death domain protein [KO:K02373]
109689613  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
109678183  Bid; BH3-interacting domain death agonist isoform X1 [KO:K04726]
109699272  Bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
109693757  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
109682703  Bax; apoptosis regulator BAX [KO:K02159]
109686692  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
109679656  cytochrome c-like [KO:K08738]
109697493  cytochrome c, somatic [KO:K08738]
109690717  cytochrome c-like [KO:K08738]
109690039  Apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
109692548  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
109678444  caspase-3 [KO:K02187] [EC:3.4.22.56]
109678454  caspase-3-like [KO:K02187] [EC:3.4.22.56]
109684407  Cd3e; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
109699105  Cd3g; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
109699106  Cd3d; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
109686860  26S protease regulatory subunit 7 [KO:K03061]
109699136  Psmc1; 26S protease regulatory subunit 4 isoform X1 [KO:K03062]
109697926  Psmc4; 26S protease regulatory subunit 6B [KO:K03063]
109683953  Psmc6; 26S protease regulatory subunit 10B [KO:K03064]
109696180  Psmc3; 26S protease regulatory subunit 6A [KO:K03065]
109700522  Psmc5; 26S protease regulatory subunit 8 [KO:K03066]
109694093  Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
109681474  Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
109681478  26S proteasome non-ATPase regulatory subunit 1-like [KO:K03032]
109694416  Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
109696998  Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
109684901  Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
109692680  Psmd6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
109697205  Psmd7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
109699533  Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
109681222  Psmd4; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
109692595  Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
109695827  Psmd8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
109689085  Adrm1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
109683819  Sem1; 26S proteasome complex subunit DSS1 [KO:K10881]
109686707  Tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
109686711  Tap2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
109686696  Tapbp; tapasin [KO:K08058]
109681442  Pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
109681282  Calr; calreticulin [KO:K08057]
109684269  calreticulin-like [KO:K08057]
109687279  HLA class I histocompatibility antigen, Cw-1 alpha chain-like isoform X1 [KO:K06751]
109687282  patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
109687284  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
109687287  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
109690375  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
109690377  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
109700906  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
109692718  B2m; beta-2-microglobulin [KO:K08055]
109685383  Snw1; LOW QUALITY PROTEIN: SNW domain-containing protein 1 [KO:K06063]
109694116  Sin3a; LOW QUALITY PROTEIN: paired amphipathic helix protein Sin3a [KO:K11644]
109692991  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
109682730  Hdac2; LOW QUALITY PROTEIN: histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
109675849  LOW QUALITY PROTEIN: nuclear receptor corepressor 2-like [KO:K06065]
109684873  LOW QUALITY PROTEIN: nuclear receptor corepressor 2-like [KO:K06065]
109690279  Sap30l; histone deacetylase complex subunit SAP30L [KO:K19202]
109701388  Sap30; histone deacetylase complex subunit SAP30 [KO:K19202]
109689843  corepressor interacting with RBPJ 1 [KO:K06066]
109689846  Cir1; corepressor interacting with RBPJ 1 [KO:K06066]
109703390  Rbpj; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
109689293  Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
109697826  Hes1; transcription factor HES-1 [KO:K06054]
109679130  Runx3; runt-related transcription factor 3 [KO:K09279]
109699943  Myc; myc proto-oncogene protein [KO:K04377]
109695879  Usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
109693333  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
109674834  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
109696503  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
109691045  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109696612  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
109698312  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
109696190  Ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
109699936  LOW QUALITY PROTEIN: DNA polymerase kappa-like [KO:K03511] [EC:2.7.7.7]
109692314  Traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
109681900  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109689664  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109682432  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109694666  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109682554  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109688536  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109691810  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109686235  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109691665  Map3k14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
109692401  Relb; transcription factor RelB isoform X1 [KO:K09253]
109691303  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
109694060  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
109695843  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
109682072  Nfkbie; NF-kappa-B inhibitor epsilon [KO:K05872]
109693003  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
109698434  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
109686728  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109686738  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109703004  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
109699331  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
109695449  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
109692052  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
109698990  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
109697389  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
109689865  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
109689849  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109697648  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
109700777  Jun; transcription factor AP-1 [KO:K04448]
109687369  Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
109695130  Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
109693654  Entpd1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
109689299  Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
109699663  Cd44; CD44 antigen isoform X1 [KO:K06256]
109683028  Itgal; integrin alpha-L isoform X1 [KO:K05718]
109693172  Icam1; intercellular adhesion molecule 1 [KO:K06490]
109700441  Vim; vimentin [KO:K07606]
109697032  Tnfaip3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
109698332  Jak3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
109687324  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
109696666  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
109688078  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
109700662  E3 ubiquitin-protein ligase NEDD4-like [KO:K10591] [EC:2.3.2.26]
109692922  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109677916  uncharacterized protein LOC109677916 [KO:K06856]
109692203  Btk; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
109693650  Blnk; B-cell linker protein [KO:K07371]
109696649  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
109702695  Skp2; S-phase kinase-associated protein 2 [KO:K03875]
109701269  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
109696351  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
109688460  G1/S-specific cyclin-D2-like [KO:K10151]
109688461  G1/S-specific cyclin-D2 [KO:K10151]
109682157  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
109686224  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
109684671  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
109684667  CTD kinase subunit alpha-like [KO:K02091] [EC:2.7.11.22]
109677666  Ccna1; cyclin-A1 [KO:K06627]
109681820  Ccna2; cyclin-A2 [KO:K06627]
109693086  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
109695602  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
109698572  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
109691094  Rb1; retinoblastoma-associated protein isoform X1 [KO:K06618]
109690765  E2f1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
109693815  transcription factor E2F2-like [KO:K09389]
109693824  E2f2; transcription factor E2F2 [KO:K09389]
109697329  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
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  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
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Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
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Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
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Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
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PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
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Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
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J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
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Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
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Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
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MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
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Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
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Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
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Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
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Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
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J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
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PMID:25403939
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Kang H, Kiess A, Chung CH
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Emerging biomarkers in head and neck cancer in the era of genomics.
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Nat Rev Clin Oncol 12:11-26 (2015)
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Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
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Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
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Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
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Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
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PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
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Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
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Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
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J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
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Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
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Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
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Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
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Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
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Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
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Future Virol 4:79-91 (2009)
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Reference
PMID:10818681
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Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
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Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
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El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
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Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
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Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
ccan03050  Proteasome
ccan04010  MAPK signaling pathway
ccan04020  Calcium signaling pathway
ccan04064  NF-kappa B signaling pathway
ccan04110  Cell cycle
ccan04115  p53 signaling pathway
ccan04210  Apoptosis
ccan04612  Antigen processing and presentation
ccan04620  Toll-like receptor signaling pathway
ccan04622  RIG-I-like receptor signaling pathway
ccan04630  JAK-STAT signaling pathway
ccan04662  B cell receptor signaling pathway
KO pathway
ko05169   
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