KEGG   PATHWAY: ecra04010
Entry
ecra04010                   Pathway                                
Name
MAPK signaling pathway - Etheostoma cragini (Arkansas darter)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ecra04010  MAPK signaling pathway
ecra04010

Other DBs
GO: 0000165
Organism
Etheostoma cragini (Arkansas darter) [GN:ecra]
Gene
117961643  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
117958666  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
117944726  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
117958822  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
117938808  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
117942646  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
117947687  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117950134  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
117954222  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
117947003  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
117937375  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
117950367  voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04855]
117958546  voltage-dependent T-type calcium channel subunit alpha-1H-like isoform X1 [KO:K04855]
117957686  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
117952270  voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04856]
117942791  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
117947748  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
117948720  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
117938675  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X1 [KO:K04858]
117942962  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
117943519  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
117943844  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
117948210  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
117938615  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
117958423  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
117937674  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
117947783  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04864]
117947945  voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04864]
117952805  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
117939616  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
117958674  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
117960532  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
117957593  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
117952531  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
117957403  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
117954217  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
117958598  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
117960522  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
117937316  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
117958345  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
117957127  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
117946280  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
117957050  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
117946266  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
117957065  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
117946250  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
117950657  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
117958732  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
117959235  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117954412  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
117957906  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117937306  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
117957402  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
117954179  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117946209  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
117957719  gna12a; guanine nucleotide-binding protein subunit alpha-12a isoform X1 [KO:K04346]
117957409  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
117954094  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
117955523  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
117962077  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117944773  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
117952058  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117960087  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
117940971  calcineurin subunit B type 1-like [KO:K06268]
117934534  ras-specific guanine nucleotide-releasing factor 1-like isoform X1 [KO:K04349]
117948555  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
117944754  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117959126  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117935395  RAS guanyl-releasing protein 1-like isoform X1 [KO:K04350]
117941957  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
117935227  RAS guanyl-releasing protein 2-like [KO:K12361]
117960582  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
117951280  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
117941828  nf1a; neurofibromin isoform X1 [KO:K08052]
117945189  ras GTPase-activating protein 1-like isoform X1 [KO:K04352]
117942365  rasa2; ras GTPase-activating protein 2 [KO:K08053]
117943332  ras-related protein Rap-1A-like [KO:K04353]
117947038  ras-related protein Rap-1b [KO:K04353]
117951707  egf; pro-epidermal growth factor [KO:K04357]
117943608  tgfa; protransforming growth factor alpha [KO:K08774]
117945333  proepiregulin-like isoform X1 [KO:K09784]
117955760  putative fibroblast growth factor 1 isoform X1 [KO:K18496]
117951719  fibroblast growth factor 1-like [KO:K18496]
117951309  fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
117950965  fgf22; fibroblast growth factor 22 [KO:K04358]
117944737  fgf17; fibroblast growth factor 17 [KO:K04358]
117944920  fgf10b; fibroblast growth factor 10b [KO:K04358]
117951205  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
117951718  fgf16; fibroblast growth factor 16 [KO:K04358]
117951787  fibroblast growth factor 9-like [KO:K04358]
117937676  fgf8b; fibroblast growth factor 8b [KO:K04358]
117945439  fgf5; fibroblast growth factor 5 [KO:K04358]
117945553  fgf3; fibroblast growth factor 3 [KO:K04358]
117952068  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
117952169  fibroblast growth factor 4-like [KO:K04358]
117952193  fgf20b; fibroblast growth factor 20b [KO:K04358]
117952708  fgf9; fibroblast growth factor 4A [KO:K04358]
117938987  fibroblast growth factor 6-like [KO:K04358]
117959590  fgf10a; fibroblast growth factor 10a [KO:K04358]
117947975  fgf4; fibroblast growth factor 4 [KO:K04358]
117948068  fgf7; fibroblast growth factor 7 [KO:K04358]
117960792  fgf8a; fibroblast growth factor 8 isoform X1 [KO:K04358]
117948458  fibroblast growth factor 6-like [KO:K04358]
117948667  fgf19; fibroblast growth factor 19 [KO:K22603]
117937000  fgf21; fibroblast growth factor 21 [KO:K22429]
117938770  fgf23; fibroblast growth factor 23 [KO:K22428]
117948453  fibroblast growth factor 23-like [KO:K22428]
117943932  ngfb; nerve growth factor [KO:K02582]
117947652  ngfa; neurotrophin-7 [KO:K02582]
117947818  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
117938646  ntf3; neurotrophin-3 [KO:K04356]
117951814  insb; preproinsulin b [KO:K04526]
117938750  igf1; insulin-like growth factor I [KO:K05459]
117948913  igf2b; insulin-like growth factor 2b [KO:K13769]
117957643  pdgfab; platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359]
117961247  platelet-derived growth factor subunit A-like [KO:K04359]
117952403  si:ch211-79m20.1; bromodomain-containing protein 4 isoform X1 [KO:K17386]
117952126  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
117942180  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
117949116  kitlga; kit ligand a [KO:K05461]
117938398  uncharacterized protein LOC117938398 [KO:K05461]
117951670  vegfba; vascular endothelial growth factor A [KO:K05448]
117946336  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
117961167  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
117935621  pgfb; placenta growth factor [KO:K16859]
117961361  pgfa; vascular endothelial growth factor A isoform X1 [KO:K16859]
117946828  vegfd; vascular endothelial growth factor D [KO:K05449]
117939671  vascular endothelial growth factor C-like [KO:K05449]
117960845  vegfc; vascular endothelial growth factor C [KO:K05449]
117948721  hepatocyte growth factor isoform X1 [KO:K05460]
117938959  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
117943765  angpt4; angiopoietin-4 [KO:K05465]
117956808  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
117956786  angpt2b; angiopoietin-2b [KO:K05466]
117960225  angpt2a; angiopoietin-2a [KO:K05466]
117935549  efna2a; ephrin-A2 [KO:K05462]
117956932  efna1a; ephrin-A1a isoform X1 [KO:K05462]
117957019  efna3a; ephrin-A3 isoform X1 [KO:K05462]
117945168  efna5b; ephrin-A5b isoform X1 [KO:K05462]
117959283  ephrin-A5b-like [KO:K05462]
117946738  efna1b; ephrin-A1b [KO:K05462]
117946739  efna3b; ephrin-A3b [KO:K05462]
117946744  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
117944381  glial cell line-derived neurotrophic factor-like [KO:K05452]
117959596  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
117954732  neurturin-like [KO:K25414]
117934600  persephin [KO:K25416]
117954310  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
117937271  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117944075  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
117947750  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
117952536  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
117939396  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
117944490  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
117942512  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca [KO:K05093] [EC:2.7.10.1]
117960195  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117935936  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117955330  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
117957931  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
117937308  ngfrb; nerve growth factor receptor b [KO:K02583]
117946570  nradd; death domain-containing membrane protein NRADD [KO:K02583]
117945668  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
117944365  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
117959577  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
117953563  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
117950623  insrb; insulin receptor b isoform X1 [KO:K04527] [EC:2.7.10.1]
117948865  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
117945857  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
117950139  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
117951210  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
117956051  csf1rb; macrophage colony-stimulating factor 1 receptor 2 [KO:K05090] [EC:2.7.10.1]
117951211  csf1ra; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
117950146  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
117936515  kitb; KIT proto-oncogene, receptor tyrosine kinase b [KO:K05091] [EC:2.7.10.1]
117938211  flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
117951764  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
117938210  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
117951482  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
117950140  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
117949070  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
117942965  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
117947532  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
117960079  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
117957842  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
117935404  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
117939769  son of sevenless homolog 1-like [KO:K03099]
117949110  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
117948705  kras; GTPase KRas isoform X1 [KO:K07827]
117958506  zgc:55558; GTPase HRas [KO:K07827]
117951836  rras2; ras-related protein R-Ras2 [KO:K07830]
117958478  rras; ras-related protein R-Ras [KO:K07830]
117952937  si:ch73-116o1.2; ras-related protein M-Ras [KO:K07831]
117944848  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
117938524  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117947286  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117949315  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117950204  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
117954500  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
117935506  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
117944578  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117957522  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117950609  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
117950979  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
117936384  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
117951776  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
117937627  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
117946217  ribosomal protein S6 kinase alpha-2-like isoform X1 [KO:K04373] [EC:2.7.11.1]
117952445  atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
117942820  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
117938040  myca; transcriptional regulator Myc-A isoform X1 [KO:K04377]
117953951  transcriptional regulator Myc-B-like [KO:K04377]
117960286  srfb; serum response factor b isoform X1 [KO:K04378]
117936115  fosaa; proto-oncogene c-Fos isoform X1 [KO:K04379]
117961110  proto-oncogene c-Fos-like [KO:K04379]
117961111  proto-oncogene c-Fos-like [KO:K04379]
117936513  mapta; microtubule-associated protein tau isoform X1 [KO:K04380]
117956257  stathmin-like isoform X1 [KO:K04381]
117946941  stmn1b; stathmin 1b [KO:K04381]
117951142  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
117957742  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
117960725  cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
117957260  tumor necrosis factor-like [KO:K03156]
117944585  interleukin-1 beta-like [KO:K04519]
117941999  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
117951661  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
117946043  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
117935617  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
117961404  transforming growth factor beta-3 proprotein-like [KO:K13377]
117946254  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
117947296  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117952382  interleukin-1 receptor type 1-like [KO:K04386]
117943491  butyrophilin subfamily 2 member A1-like [KO:K04674] [EC:2.7.11.30]
117937762  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
117956907  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
117946465  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
117939789  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
117949987  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117951831  cd40lg; CD40 ligand [KO:K04389]
117960374  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
117937041  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117958741  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117952575  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117936772  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
117943341  cdc42; cell division control protein 42 homolog [KO:K04393]
117957009  cell division control protein 42 homolog [KO:K04393]
117946299  cdc42l; cell division cycle 42, like [KO:K04393]
117947828  cell division control protein 42 homolog isoform X1 [KO:K04393]
117951222  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
117951380  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
117960699  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
117945290  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
117958915  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117959390  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117956851  daxx; death domain-associated protein 6 [KO:K02308]
117937605  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
117949437  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
117948342  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
117936160  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
117950933  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
117945120  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
117954090  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402]
117952378  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
117961933  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
117934794  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
117960528  mitogen-activated protein kinase kinase kinase kinase 3-like [KO:K04406] [EC:2.7.11.1]
117951421  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
117952359  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
117939200  mitogen-activated protein kinase kinase kinase kinase 4-like isoform X1 [KO:K04407] [EC:2.7.11.1]
117935857  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
117950156  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
117944109  serine/threonine-protein kinase 4-like [KO:K04411]
117956560  stk3; serine/threonine-protein kinase 3 [KO:K04412]
117934757  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
117937733  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
117934752  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
117939603  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
117958168  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
117937594  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
117935405  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
117941825  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
117960044  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
117943579  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
117948021  map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
117953234  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
117952606  zak; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
117953717  mitogen-activated protein kinase kinase kinase 20-like [KO:K04424] [EC:2.7.11.25]
117961775  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
117946066  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117935477  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
117961374  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117960393  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
117955700  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
117944606  taok3a; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
117937274  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
117958075  serine/threonine-protein kinase TAO2-like [KO:K04429] [EC:2.7.11.1]
117959331  taok3b; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
117941648  taok1a; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
117936603  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
117958775  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
117957114  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117936952  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
117958358  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
117948612  mapk8ip1a; C-Jun-amino-terminal kinase-interacting protein 1a isoform X1 [KO:K04434]
117945896  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
117949545  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
117957957  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
117947170  flna; filamin-A isoform X1 [KO:K04437]
117955511  adapter molecule crk-like [KO:K04438]
117959323  crkl; crk-like protein isoform X1 [KO:K04438]
117941715  crk; adapter molecule crk [KO:K04438]
117934796  arrb2b; arrestin, beta 2b [KO:K04439]
117936667  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117952085  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117959822  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117960867  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117948650  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
117943738  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
117938704  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
117938858  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
117947167  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
117947245  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
117947999  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117944296  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
117943571  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
117947996  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04443] [EC:2.7.11.1]
117942755  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
117944034  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
117935846  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
117955063  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
117936248  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
117956558  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
117946387  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
117949714  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
117948259  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
117949980  jun; transcription factor AP-1 [KO:K04448]
117959572  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117953876  transcription factor AP-1-like [KO:K04448]
117950314  transcription factor jun-D-like [KO:K04449]
117953659  transcription factor jun-D-like [KO:K04449]
117952621  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117962210  tp53; cellular tumor antigen p53 [KO:K04451]
117943942  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
117935588  protein max-like isoform X1 [KO:K04453]
117961465  max; protein max isoform X1 [KO:K04453]
117945210  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
117955447  hspb1; heat shock protein beta-1 [KO:K04455]
117959332  heat shock protein beta-1-like [KO:K04455]
117934639  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117955971  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117936379  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117959968  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117941951  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117955696  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
117936058  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
117942189  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
117949248  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
117951932  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
117948849  dusp8a; dual specificity protein phosphatase 8a isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117943039  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117945157  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117958476  si:ch211-195b15.8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117959085  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117960101  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117940383  dual specificity protein phosphatase 16-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117948014  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117949164  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
117961908  dusp10; dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
117936902  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
117957718  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
117942123  ppp5c; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
117936443  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
117960809  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
117955208  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
117958074  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
117958251  heat shock 70 kDa protein 1 [KO:K03283]
117946926  LOW QUALITY PROTEIN: heat shock cognate 70 kDa protein-like [KO:K03283]
117947674  hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
117940932  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X1 [KO:K04462] [EC:2.1.1.367]
117948151  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
117937273  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
117943407  probable nuclear hormone receptor HR38 [KO:K04465]
117947683  nr4a1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
117937009  uncharacterized protein LOC117937009 [KO:K04466] [EC:2.7.11.25]
117958471  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
117936511  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
117960217  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
117945478  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117947160  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117941829  nlk2; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
117934772  rela; transcription factor p65 isoform X1 [KO:K04735]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
ecra04070  Phosphatidylinositol signaling system
ecra04110  Cell cycle
ecra04115  p53 signaling pathway
ecra04210  Apoptosis
ecra04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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