KEGG   PATHWAY: nasi04151
Entry
nasi04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
nasi04151  PI3K-Akt signaling pathway
nasi04151

Other DBs
GO: 0043491
Organism
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) [GN:nasi]
Gene
112397683  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112407200  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
112405661  EREG; proepiregulin [KO:K09784]
112405655  AREG; amphiregulin isoform X1 [KO:K09782]
112404439  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
112399728  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
112402142  FGF7; fibroblast growth factor 7 [KO:K04358]
112402396  FGF4; fibroblast growth factor 4 [KO:K04358]
112409712  FGF20; fibroblast growth factor 20 [KO:K04358]
112396316  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
112396572  FGF10; fibroblast growth factor 10 [KO:K04358]
112405089  FGF18; fibroblast growth factor 18 [KO:K04358]
112405643  FGF5; fibroblast growth factor 5 [KO:K04358]
112405664  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
112401472  FGF17; fibroblast growth factor 17 [KO:K04358]
112391905  FGF6; fibroblast growth factor 6 [KO:K04358]
112393035  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
112402399  FGF19; fibroblast growth factor 19 [KO:K22603]
112415337  FGF21; fibroblast growth factor 21 [KO:K22429]
112391690  FGF23; fibroblast growth factor 23 [KO:K22428]
112413081  NGF; beta-nerve growth factor [KO:K02582]
112412908  BDNF; brain-derived neurotrophic factor [KO:K04355]
112391847  NTF3; neurotrophin-3 [KO:K04356]
112415672  NTF4; neurotrophin-4 [KO:K12457]
112402369  INS; insulin [KO:K04526]
112391070  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
112402368  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
112412068  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
112410849  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
112400383  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
112415757  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
112397834  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
112410676  KITLG; kit ligand isoform X1 [KO:K05461]
112415594  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
112413893  VEGFA; vascular endothelial growth factor A [KO:K05448]
112401987  VEGFB; vascular endothelial growth factor B [KO:K16858]
112394889  PGF; placenta growth factor isoform X1 [KO:K16859]
112399152  VEGFD; vascular endothelial growth factor D [KO:K05449]
112399668  VEGFC; vascular endothelial growth factor C [KO:K05449]
112404733  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112407155  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
112415209  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
112398537  ANGPT4; angiopoietin-4 [KO:K05467]
112398685  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
112401703  EFNA4; ephrin-A4 [KO:K05462]
112401786  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
112401823  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
112406019  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
112400325  NRTN; neurturin [KO:K25414]
112409986  ARTN; artemin [KO:K25415]
112400276  PSPN; persephin [KO:K25416]
112412693  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112398419  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112394287  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
112411861  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
112413123  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
112406930  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
112391392  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
112400078  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
112399508  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
112401754  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
112405444  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
112400209  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
112390977  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112400744  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
112391109  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112395209  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
112400776  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
112406702  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
112406568  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
112413371  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
112400779  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
112408223  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
112406011  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
112402775  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
112403824  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
112410317  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112405189  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112391586  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
112402519  HRAS; GTPase HRas isoform X1 [KO:K02833]
112391643  KRAS; GTPase KRas isoform X1 [KO:K07827]
112413065  NRAS; GTPase NRas [KO:K07828]
112407243  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112393112  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112400165  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112412232  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112399342  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112396733  IRS1; insulin receptor substrate 1 [KO:K16172]
112407985  TLR2; toll-like receptor 2 [KO:K10159]
112411200  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
112399896  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112390842  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
112399325  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
112393073  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
112410331  LOW QUALITY PROTEIN: somatotropin-like [KO:K05438]
112396620  PRL; prolactin isoform X1 [KO:K05439]
112415172  OSM; oncostatin-M [KO:K05418]
112399755  IL2; interleukin-2 [KO:K05429]
112397463  interleukin-3-like [KO:K04736]
112395338  IL6; interleukin-6 [KO:K05405]
112401382  IL4; interleukin-4 [KO:K05430]
112403878  IL7; interleukin-7 isoform X1 [KO:K05431]
112407025  interferon alpha-1-like [KO:K05414]
112395020  interferon alpha-1-like [KO:K05414]
112395023  interferon alpha-1-like [KO:K05414]
112395027  interferon alpha-1-like [KO:K05414]
112407026  IFNB1; interferon beta [KO:K05415]
112399876  EPO; erythropoietin [KO:K05437]
112398888  CSF3; granulocyte colony-stimulating factor [KO:K05423]
112396558  GHR; growth hormone receptor [KO:K05080]
112406010  PRLR; prolactin receptor isoform X1 [KO:K05081]
112406031  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
112391117  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
112410829  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
112408519  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
112415234  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
112401726  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
112399331  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
112405988  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
112408548  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
112408636  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
112400203  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
112395487  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
112412959  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112392497  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
112414751  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
112399950  COL1A1; collagen alpha-1(I) chain [KO:K06236]
112414553  COL1A2; collagen alpha-2(I) chain [KO:K06236]
112394308  COL2A1; collagen alpha-1(II) chain [KO:K19719]
112402080  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
112402095  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
112396748  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
112396749  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
112405545  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
112405565  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
112404694  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
112401495  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
112401501  collagen alpha-6(VI) chain [KO:K06238]
112408631  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
112408657  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
112395527  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
112403050  COL9A3; LOW QUALITY PROTEIN: collagen alpha-3(IX) chain [KO:K08131]
112405930  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
112409100  LAMA2; laminin subunit alpha-2 [KO:K05637]
112412147  LAMA1; laminin subunit alpha-1 [KO:K05637]
112402951  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
112408327  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
112396971  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
112397922  LAMB1; laminin subunit beta-1 [KO:K05636]
112394660  LAMB2; laminin subunit beta-2 [KO:K06243]
112403506  LAMB3; laminin subunit beta-3 [KO:K06244]
112391177  LAMC1; laminin subunit gamma-1 [KO:K05635]
112391277  LAMC2; laminin subunit gamma-2 [KO:K06246]
112411540  LAMC3; laminin subunit gamma-3 [KO:K06247]
112400522  CHAD; chondroadherin [KO:K06248]
112395038  RELN; reelin [KO:K06249] [EC:3.4.21.-]
112391175  THBS1; thrombospondin-1 [KO:K16857]
112399630  THBS2; thrombospondin-2 [KO:K04659]
112406748  THBS4; thrombospondin-4 [KO:K04659]
112414728  COMP; cartilage oligomeric matrix protein [KO:K04659]
112401735  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
112411833  FN1; fibronectin isoform X1 [KO:K05717]
112393839  SPP1; osteopontin [KO:K06250]
112394473  VTN; vitronectin [KO:K06251]
112395435  TNXB; tenascin-X isoform X1 [KO:K06252]
112411497  TNC; tenascin isoform X1 [KO:K06252]
112408944  TNR; tenascin-R [KO:K06252]
112408954  TNN; tenascin-N [KO:K06252]
112391767  VWF; von Willebrand factor [KO:K03900]
112393811  IBSP; bone sialoprotein 2 [KO:K06253]
112396545  ITGA1; integrin alpha-1 [KO:K06480]
112396551  ITGA2; integrin alpha-2 [KO:K06481]
112410314  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
112398462  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
112414149  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
112393994  ITGA5; integrin alpha-5 [KO:K06484]
112391504  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
112394129  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
112402880  ITGA8; integrin alpha-8 [KO:K06584]
112407165  ITGA9; integrin alpha-9 [KO:K06585]
112391349  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
112401332  ITGA11; integrin alpha-11 [KO:K06587]
112403267  ITGAV; integrin alpha-V [KO:K06487]
112413437  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
112410352  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
112410370  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
112407275  ITGB5; integrin beta-5 [KO:K06588]
112393605  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
112394105  ITGB7; integrin beta-7 [KO:K06590]
112395332  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
112397030  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
112402798  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112403325  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112406349  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112404930  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112400438  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112414874  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112391428  F2R; proteinase-activated receptor 1 [KO:K03914]
112402293  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
112397450  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
112407853  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
112414774  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
112415092  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
112408422  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
112391757  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
112406558  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
112409899  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
112399926  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
112391810  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
112406364  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
112405787  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
112392854  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
112402139  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
112410724  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
112415074  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 isoform X1 [KO:K04542]
112396396  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
112415625  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
112391353  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
112414544  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 isoform X1 [KO:K04546]
112392790  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112409571  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
112414575  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
112398559  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
112410487  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
112401896  PIK3R5; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
112401930  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
112409350  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
112396326  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
112405979  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
112407082  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
112396166  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
112411342  TSC1; hamartin isoform X1 [KO:K07206]
112409519  TSC2; tuberin isoform X1 [KO:K07207]
112405904  RHEB; GTP-binding protein Rheb [KO:K07208]
112409401  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
112402675  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112410361  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
112413144  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
112396716  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
112397866  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
112406614  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-like [KO:K03259]
112393719  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
112402503  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
112408022  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112411041  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4B-like [KO:K03258]
112394126  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
112401091  RPS6; 40S ribosomal protein S6 [KO:K02991]
112410312  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112414710  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
112398821  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
112411417  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
112409111  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
112398354  LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
112400904  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
112398198  serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
112405757  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112408453  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112415459  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112401407  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
112395044  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
112399575  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112411659  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
112413111  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112399680  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
112405714  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
112415426  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
112410281  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
112411217  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
112393770  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
112414997  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
112390441  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
112411138  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
112400485  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
112415231  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
112402324  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
112409649  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112403384  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
112403461  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
112413816  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
112409314  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
112413951  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
112391039  HSP90B1; endoplasmin [KO:K09487]
112400258  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
112401723  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
112406160  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
112393415  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
112408349  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
112408337  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
112406062  MTCP1; protein p13 MTCP-1 [KO:K16837]
112405905  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
112397998  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
112415982  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112415516  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
112391784  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
112403085  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
112405031  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
112410110  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
112400500  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
112407380  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
112397143  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
112402178  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112414074  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112391736  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
112394072  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
112394295  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
112414528  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112391672  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
112413996  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
112407307  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
112392336  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
112406578  FOXO3; forkhead box protein O3 [KO:K09408]
112401248  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
112391613  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112398987  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
112407323  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
112400835  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
112394793  YWHAQ; 14-3-3 protein theta [KO:K16197]
112407567  14-3-3 protein theta [KO:K16197]
112392764  YWHAE; 14-3-3 protein epsilon [KO:K06630]
112403328  LOW QUALITY PROTEIN: 14-3-3 protein gamma-like [KO:K16198]
112399970  YWHAG; 14-3-3 protein gamma [KO:K16198]
112415138  YWHAH; 14-3-3 protein eta [KO:K16198]
112402326  BAD; bcl2-associated agonist of cell death [KO:K02158]
112398447  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
112406137  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
112402819  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
112395221  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
112391502  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
112394733  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
112402296  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
112397455  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
112411704  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
112400124  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
112401787  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
112406282  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
112395436  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
112413739  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
112411563  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
112394274  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
112400454  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112392983  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112413114  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112402272  RELA; transcription factor p65 [KO:K04735]
112393728  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112409162  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
112394100  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
112401891  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
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Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
nasi00010  Glycolysis / Gluconeogenesis
nasi04010  MAPK signaling pathway
nasi04012  ErbB signaling pathway
nasi04062  Chemokine signaling pathway
nasi04064  NF-kappa B signaling pathway
nasi04068  FoxO signaling pathway
nasi04110  Cell cycle
nasi04115  p53 signaling pathway
nasi04150  mTOR signaling pathway
nasi04210  Apoptosis
nasi04370  VEGF signaling pathway
nasi04510  Focal adhesion
nasi04620  Toll-like receptor signaling pathway
nasi04630  JAK-STAT signaling pathway
nasi04662  B cell receptor signaling pathway
nasi04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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