KEGG   PATHWAY: pviv04151
Entry
pviv04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Prionailurus viverrinus (fishing cat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
pviv04151  PI3K-Akt signaling pathway
pviv04151

Other DBs
GO: 0043491
Organism
Prionailurus viverrinus (fishing cat) [GN:pviv]
Gene
125164093  EGF; pro-epidermal growth factor [KO:K04357]
125162665  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
125164858  EREG; proepiregulin [KO:K09784]
125163964  AREG; amphiregulin isoform X1 [KO:K09782]
125176643  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
125164816  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
125174830  FGF9; fibroblast growth factor 9 [KO:K04358]
125159740  FGF22; fibroblast growth factor 22 [KO:K04358]
125168004  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
125146613  FGF3; fibroblast growth factor 3 [KO:K04358]
125147026  FGF4; fibroblast growth factor 4 [KO:K04358]
125162051  FGF10; fibroblast growth factor 10 [KO:K04358]
125148058  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
125163288  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
125171159  FGF6; fibroblast growth factor 6 [KO:K04358]
125156453  FGF18; fibroblast growth factor 18 [KO:K04358]
125164454  FGF20; fibroblast growth factor 20 [KO:K04358]
125164481  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
125157705  FGF16; fibroblast growth factor 16 [KO:K04358]
125146612  FGF19; fibroblast growth factor 19 [KO:K22603]
125153070  FGF21; fibroblast growth factor 21 [KO:K22429]
125169501  FGF23; fibroblast growth factor 23 [KO:K22428]
125174035  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
125146904  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
125171325  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
125153003  NTF4; neurotrophin-4 isoform X1 [KO:K12457]
125146894  INS; insulin [KO:K04526]
125171123  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
125146892  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
125154510  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
125170976  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
125146630  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
125164369  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
125172928  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
125170205  KITLG; kit ligand [KO:K05461]
125152992  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
125165878  VEGFA; vascular endothelial growth factor A [KO:K05448]
125146750  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
125168901  PGF; placenta growth factor isoform X1 [KO:K16859]
125164102  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
125157092  VEGFD; vascular endothelial growth factor D [KO:K05449]
125160804  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
125156604  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
125163559  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
125162169  ANGPT4; angiopoietin-4 [KO:K05467]
125159753  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
125155391  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
125155441  EFNA3; ephrin-A3 [KO:K05462]
125163246  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
125155630  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
125165321  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
125148687  NRTN; neurturin [KO:K25414]
125173339  ARTN; artemin [KO:K25415]
125160259  PSPN; persephin [KO:K25416]
125160878  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
125158497  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
125169914  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
125171576  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
125163506  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
125147994  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
125159206  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
125171815  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
125158718  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
125155826  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
125150787  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
125149652  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
125167768  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
125163328  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
125166177  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
125174524  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
125164043  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
125175495  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
125175490  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
125175108  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
125164023  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
125160764  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
125150336  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
125173072  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
125148237  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
125151442  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
125167677  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
125161831  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
125146782  HRAS; GTPase HRas isoform X1 [KO:K02833]
125170295  KRAS; GTPase KRas [KO:K07827]
125171937  NRAS; GTPase NRas [KO:K07828]
125152491  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125167652  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125149335  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125154521  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
125149069  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125172805  IRS1; insulin receptor substrate 1 [KO:K16172]
125163954  TLR2; toll-like receptor 2 [KO:K10159]
125150458  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
125154068  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
125168154  uncharacterized protein LOC125168154 [KO:K06856]
125168156  LOW QUALITY PROTEIN: uncharacterized protein LOC125168156 [KO:K06856]
125149842  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
125154769  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
125147820  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
125151566  GH1; somatotropin [KO:K05438]
125165886  PRL; prolactin [KO:K05439]
125149195  OSM; oncostatin-M isoform X1 [KO:K05418]
125164688  IL2; interleukin-2 [KO:K05429]
125152182  IL6; interleukin-6 isoform X1 [KO:K05405]
125171069  IL4; interleukin-4 [KO:K05430]
125156710  IL7; interleukin-7 isoform X1 [KO:K05431]
125150359  interferon alpha-like [KO:K05414]
125150391  interferon alpha-like [KO:K05414]
125150421  interferon alpha [KO:K05414]
125150431  interferon alpha [KO:K05414]
125150435  interferon alpha-like [KO:K05414]
125150749  interferon alpha-2-like [KO:K05414]
125150820  interferon alpha-2-like [KO:K05414]
125150775  interferon beta [KO:K05415]
125153971  EPO; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
125158446  CSF3; granulocyte colony-stimulating factor [KO:K05423]
125170240  GHR; growth hormone receptor isoform X1 [KO:K05080]
125176303  PRLR; prolactin receptor [KO:K05081]
125168630  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
125170257  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
125170904  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
125157955  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
125159255  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
125155265  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
125154127  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
125172581  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
125174560  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
125175082  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
125160158  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
125173804  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
125173198  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
125150241  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
125160535  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
125158627  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
125161150  COL1A2; collagen alpha-2(I) chain [KO:K06236]
125170867  COL2A1; collagen alpha-1(II) chain [KO:K19719]
125162119  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
125162130  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
125157295  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
125157548  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
125173315  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
125173316  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
125158880  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
125159082  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
125159088  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
125174422  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
125175170  collagen alpha-4(VI) chain-like [KO:K06238]
125175500  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
125166320  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
125171769  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
125162329  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
125165961  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
125148766  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
125161630  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
125148702  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
125166189  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
125151448  LAMB1; laminin subunit beta-1 [KO:K05636]
125148915  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
125155428  LAMB3; laminin subunit beta-3 [KO:K06244]
125151455  LAMB4; laminin subunit beta-4 [KO:K06245]
125155356  LAMC1; laminin subunit gamma-1 [KO:K05635]
125155688  LAMC2; laminin subunit gamma-2 [KO:K06246]
125150287  LAMC3; laminin subunit gamma-3 [KO:K06247]
125151926  CHAD; chondroadherin [KO:K06248]
125161025  RELN; reelin [KO:K06249] [EC:3.4.21.-]
125168227  THBS1; thrombospondin-1 [KO:K16857]
125166172  THBS2; thrombospondin-2 [KO:K04659]
125173513  THBS4; thrombospondin-4 [KO:K04659]
125155647  THBS3; thrombospondin-3 [KO:K04659]
125156766  COMP; cartilage oligomeric matrix protein [KO:K04659]
125172662  FN1; fibronectin isoform X1 [KO:K05717]
125163269  SPP1; osteopontin isoform X1 [KO:K06250]
125152079  VTN; vitronectin [KO:K06251]
125166098  TNXB; tenascin-X isoform X1 [KO:K06252]
125155175  TNN; tenascin-N isoform X1 [KO:K06252]
125155460  TNR; tenascin-R [KO:K06252]
125150097  TNC; tenascin isoform X1 [KO:K06252]
125170119  VWF; von Willebrand factor [KO:K03900]
125164694  IBSP; bone sialoprotein 2 [KO:K06253]
125148667  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
125172671  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
125158705  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
125158524  ITGA3; integrin alpha-3 [KO:K06482]
125172067  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
125170000  ITGA5; integrin alpha-5 [KO:K06484]
125171916  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
125170187  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
125171108  ITGA8; integrin alpha-8 [KO:K06584]
125174963  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
125173824  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
125167533  ITGA11; integrin alpha-11 [KO:K06587]
125172290  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
125170118  ITGB1; integrin beta-1 [KO:K05719]
125152049  ITGB3; integrin beta-3 [KO:K06493]
125151589  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
125174964  ITGB5; integrin beta-5 [KO:K06588]
125173514  ITGB6; integrin beta-6 [KO:K06589]
125169707  ITGB7; integrin beta-7 [KO:K06590]
125160558  ITGB8; integrin beta-8 [KO:K06591]
125156382  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
125174838  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
125175184  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125172980  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125161995  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125172124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
125150373  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125158892  F2R; proteinase-activated receptor 1 [KO:K03914]
125175985  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
125160698  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
125150834  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
125161224  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
125171623  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
125157601  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
125170113  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
125163387  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
125174023  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
125153968  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
125169798  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
125174748  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
125168849  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
125167801  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
125177104  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
125176527  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3-like [KO:K04540]
125148085  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
125173739  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
125159625  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
125153016  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
125150994  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
125160271  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
125152138  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
125173040  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
125160270  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
125158487  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
125160243  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
125151482  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
125151856  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
125153912  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
125159722  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
125146632  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
125172525  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
125147656  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
125150812  TSC1; hamartin isoform X1 [KO:K07206]
125154230  TSC2; tuberin isoform X1 [KO:K07207]
125157619  RHEB; GTP-binding protein Rheb [KO:K07208]
125154788  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
125172574  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
125152176  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
125164115  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
125163681  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
125171739  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
125172154  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
125164588  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
125157328  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
125151143  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
125147134  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
125169539  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
125151839  40S ribosomal protein S6-like [KO:K02991]
125152371  40S ribosomal protein S6-like [KO:K02991]
125150290  RPS6; 40S ribosomal protein S6 [KO:K02991]
125151135  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125156291  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
125172471  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
125150303  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
125166306  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
125162003  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
125156512  SGK3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
125167750  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125152911  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125155304  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125160203  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
125160166  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
125147837  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125159504  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
125164370  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
125172646  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
125153770  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
125176421  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
125148417  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
125171565  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
125163831  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
125164262  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
125159266  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
125175047  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
125168935  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
125167344  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
125168560  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
125146761  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
125155472  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
125165614  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
125166184  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
125168713  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
125170771  HSP90B1; endoplasmin [KO:K09487]
125150199  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
125175598  LOW QUALITY PROTEIN: hsp90 co-chaperone Cdc37-like [KO:K09554]
125155793  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
125152962  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
125149151  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
125168892  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
125167193  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
125159372  MTCP1; protein p13 MTCP-1 [KO:K16837]
125154173  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
125158583  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
125174815  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125153000  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
125170279  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
125167656  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
125162375  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
125158417  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
125158544  G6PC1; glucose-6-phosphatase catalytic subunit 1 isoform X1 [KO:K01084] [EC:3.1.3.9]
125173828  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
125156689  MYC; myc proto-oncogene protein [KO:K04377]
125176918  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
125166021  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
125170074  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
125170849  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
125170174  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
125161240  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
125169721  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
125165233  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125153464  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
125156155  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
125165393  FOXO3; forkhead box protein O3 [KO:K09408]
125152701  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
125154937  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125162403  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
125158856  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
125162226  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
125156355  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
125158326  YWHAQ; 14-3-3 protein theta [KO:K16197]
125149194  14-3-3 protein zeta/delta-like [KO:K16197]
125152160  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
125150660  14-3-3 protein epsilon-like [KO:K06630]
125154335  YWHAG; 14-3-3 protein gamma [KO:K16198]
125149321  YWHAH; 14-3-3 protein eta isoform X1 [KO:K16198]
125176067  BAD; bcl2-associated agonist of cell death [KO:K02158]
125162001  BCL2L1; bcl-2-like protein 1 [KO:K04570]
125149087  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
125172087  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
125173452  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
125172214  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
125169892  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125160384  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
125146741  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
125148303  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
125155795  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
125150367  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
125161255  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
125166104  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
125159502  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
125149938  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
125170795  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
125159286  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
125147812  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
125163712  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
125176511  RELA; transcription factor p65 [KO:K04735]
125163593  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125166235  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
125170075  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
125151405  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
pviv00010  Glycolysis / Gluconeogenesis
pviv04010  MAPK signaling pathway
pviv04012  ErbB signaling pathway
pviv04062  Chemokine signaling pathway
pviv04064  NF-kappa B signaling pathway
pviv04068  FoxO signaling pathway
pviv04110  Cell cycle
pviv04115  p53 signaling pathway
pviv04150  mTOR signaling pathway
pviv04210  Apoptosis
pviv04370  VEGF signaling pathway
pviv04510  Focal adhesion
pviv04620  Toll-like receptor signaling pathway
pviv04630  JAK-STAT signaling pathway
pviv04662  B cell receptor signaling pathway
pviv04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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