KEGG   PATHWAY: pvp05022
Entry
pvp05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Pteropus vampyrus (large flying fox)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
pvp05022  Pathways of neurodegeneration - multiple diseases
pvp05022

Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288264  DNAL4; dynein light chain 4, axonemal [KO:K10412]
105288270  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
105288320  [KO:K08960] [EC:2.7.11.1]
105288463  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
105288552  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
105288600  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
105288707  SPG11; spatacsin isoform X4 [KO:K19026]
105288773  RYR3; ryanodine receptor 3 [KO:K04963]
105288781  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105288836  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
105288852  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105288866  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
105288878  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
105288933  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105288974  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
105289192  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
105289209  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
105289224  ATXN2; ataxin-2 isoform X2 [KO:K23625]
105289274  [KO:K02266]
105289298  RAB5A; ras-related protein Rab-5A [KO:K07887]
105289318  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105289401  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
105289441  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
105289473  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105289553  SNCA; alpha-synuclein [KO:K04528]
105289628  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
105289649  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
105289933  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
105290018  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
105290020  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
105290037  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
105290042  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
105290059  CAT; catalase [KO:K03781] [EC:1.11.1.6]
105290124  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
105290127  CALM1; calmodulin-1 [KO:K02183]
105290156  WNT16; protein Wnt-16 [KO:K01558]
105290165  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X2 [KO:K03949]
105290170  GPR37; prosaposin receptor GPR37 [KO:K04243]
105290188  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105290328  CTNNB1; catenin beta-1 [KO:K02105]
105290422  PINK1; serine/threonine-protein kinase PINK1, mitochondrial isoform X1 [KO:K05688] [EC:2.7.11.1]
105290434  WNT4; protein Wnt-4 [KO:K00408]
105290624  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
105290643  DNALI1; LOW QUALITY PROTEIN: axonemal dynein light intermediate polypeptide 1 [KO:K10410]
105290726  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
105290744  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
105290808  APP; amyloid-beta A4 protein isoform X1 [KO:K04520]
105290810  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
105290870  SNCAIP; synphilin-1 isoform X1 [KO:K04558]
105290959  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
105290990  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
105291036  [KO:K07374]
105291037  [KO:K07374]
105291051  WNT10A; protein Wnt-10a [KO:K01357]
105291052  WNT6; protein Wnt-6 isoform X2 [KO:K00445]
105291055  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
105291071  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
105291229  [KO:K02927]
105291230  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
105291298  UBB; polyubiquitin-B [KO:K08770]
105291321  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
105291367  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
105291380  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
105291422  RB1CC1; RB1-inducible coiled-coil protein 1 [KO:K17589]
105291475  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
105291512  FZD3; frizzled-3 isoform X1 [KO:K02329]
105291606  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
105291659  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105291670  KIF5C; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
105291699  OPTN; optineurin isoform X1 [KO:K19946]
105291714  ATP5F1C; ATP synthase subunit gamma, mitochondrial [KO:K02136]
105291733  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
105291735  DLG4; disks large homolog 4 isoform X3 [KO:K11828]
105291754  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
105291934  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
105291960  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
105291961  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
105291987  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
105291989  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
105292171  NEFM; neurofilament medium polypeptide [KO:K04573]
105292172  NEFL; neurofilament light polypeptide [KO:K04572]
105292202  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
105292262  PSMA8; proteasome subunit alpha type-7-like isoform X2 [KO:K02731] [EC:3.4.25.1]
105292457  [KO:K04565] [EC:1.15.1.1]
105292532  DERL1; derlin-1 isoform X1 [KO:K11519]
105292546  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
105292607  PSEN2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
105292615  DNAH14; dynein heavy chain 14, axonemal [KO:K10408]
105292618  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
105292672  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
105292717  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
105292810  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
105292883  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
105292913  CALM2; calmodulin-2 isoform X1 [KO:K02183]
105292938  [KO:K02270]
105293010  DKK2; dickkopf-related protein 2 [KO:K02165]
105293029  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105293031  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105293104  FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390]
105293123  DKK1; dickkopf-related protein 1 [KO:K02165]
105293152  IL6; interleukin-6 isoform X2 [KO:K05405]
105293163  [KO:K08738]
105293278  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
105293340  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
105293413  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
105293418  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
105293448  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
105293469  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105293607  WNT8A; protein Wnt-8a [KO:K00714]
105293648  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105293721  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105293880  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 isoform X1 [KO:K05611] [EC:3.4.19.12]
105293916  [KO:K02271]
105293940  ATXN1; ataxin-1 [KO:K23616]
105294059  KRAS; GTPase KRas isoform X2 [KO:K07827]
105294061  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105294106  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
105294112  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105294187  FZD4; frizzled-4 [KO:K02354]
105294193  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
105294208  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
105294211  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
105294330  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105294358  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
105294377  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
105294412  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105294424  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
105294429  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105294477  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
105294552  FZD1; frizzled-1 [KO:K02432]
105294564  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
105294623  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105294656  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
105294703  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105294710  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105294780  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
105294857  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:5.6.1.10]
105294870  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
105294928  [KO:K02271]
105294978  WNT7A; protein Wnt-7a [KO:K00572]
105295029  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105295165  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
105295171  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105295240  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
105295478  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
105295499  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
105295516  [KO:K05863]
105295633  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
105295781  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105295843  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
105295979  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105295986  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
105296085  TUBB1; tubulin beta-1 chain [KO:K07375]
105296089  VAPB; vesicle-associated membrane protein-associated protein B/C [KO:K10707]
105296096  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105296192  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
105296266  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105296521  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
105296533  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105296550  NRAS; GTPase NRas isoform X1 [KO:K07828]
105296558  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X2 [KO:K11353]
105296589  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
105296654  RAB8A; ras-related protein Rab-8A [KO:K07901]
105296776  [KO:K07375]
105296814  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
105296849  SEPT5; septin-5 isoform X1 [KO:K04557]
105296904  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
105296936  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105296977  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
105297143  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105297147  [KO:K00416]
105297234  TUBA8; tubulin alpha-8 chain [KO:K07374]
105297238  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
105297256  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
105297267  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
105297298  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
105297322  CALM3; calmodulin-3 [KO:K02183]
105297346  KLC3; kinesin light chain 3 [KO:K10407]
105297353  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
105297445  GRIA4; glutamate receptor 4 isoform X2 [KO:K05200]
105297472  [KO:K04741] [EC:3.4.22.-]
105297527  WNT10B; protein Wnt-10b [KO:K01357]
105297529  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105297536  TUBA1B; tubulin alpha-1B chain isoform X1 [KO:K07374]
105297537  [KO:K07374]
105297538  PRPH; peripherin [KO:K07607]
105297584  [KO:K07374]
105297603  [KO:K03968]
105297627  WNT11; protein Wnt-11 [KO:K01384]
105297663  PARK7; protein/nucleic acid deglycase DJ-1 [KO:K05687] [EC:3.5.1.124]
105297702  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105297704  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
105297724  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
105297749  AXIN2; axin-2 [KO:K04385]
105297760  ERN1; LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
105297824  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105297836  [KO:K02273]
105297846  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105297848  BAD; bcl2-associated agonist of cell death [KO:K02158]
105297863  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
105297886  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
105297932  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
105297953  CCS; copper chaperone for superoxide dismutase [KO:K04569]
105297957  SPTBN2; spectrin beta chain, non-erythrocytic 2 [KO:K23932]
105297999  RELA; transcription factor p65 [KO:K04735]
105298025  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105298070  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105298116  FZD7; frizzled-7 [KO:K02432]
105298127  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105298131  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959]
105298163  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
105298209  PDYN; proenkephalin-B [KO:K15840]
105298309  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
105298400  FZD5; frizzled-5 [KO:K02375]
105298415  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
105298543  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
105298557  TUBB4B; tubulin beta-4B chain [KO:K07375]
105298564  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105298580  PRNP; major prion protein [KO:K05634]
105298593  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
105298613  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105298737  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105298800  ATG2B; autophagy-related protein 2 homolog B [KO:K17906]
105298814  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
105298832  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
105298839  [KO:K02263]
105298936  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105298980  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
105299021  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105299180  [KO:K02183]
105299248  DNAL1; dynein light chain 1, axonemal isoform X1 [KO:K10411]
105299254  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
105299258  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
105299427  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
105299441  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
105299444  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105299454  DCTN4; dynactin subunit 4 [KO:K10426]
105299460  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
105299561  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
105299568  FZD10; frizzled-10 [KO:K02842]
105299678  STX1A; syntaxin-1A isoform X1 [KO:K04560]
105299684  FZD9; frizzled-9 [KO:K02842]
105299689  HIP1; huntingtin-interacting protein 1 [KO:K04559]
105299797  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105299863  WNT5A; protein Wnt-5a isoform X5 [KO:K00444]
105299873  DNAH12; dynein heavy chain 12, axonemal [KO:K10408]
105299885  DCTN6; dynactin subunit 6 [KO:K10428]
105299958  WNT3A; protein Wnt-3a [KO:K00312]
105299974  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
105299978  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105300002  WNT9A; protein Wnt-9a [KO:K01064]
105300193  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 isoform X2 [KO:K03031]
105300213  MAP3K10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
105300217  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
105300232  RYR1; ryanodine receptor 1 [KO:K04961]
105300378  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
105300529  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
105300530  DKK4; dickkopf-related protein 4 [KO:K02165]
105300538  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105300597  [KO:K00417]
105300788  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
105300789  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X2 [KO:K03957]
105300868  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105300873  FZD6; frizzled-6 isoform X1 [KO:K02376]
105300922  [KO:K00419]
105300929  NEFH; neurofilament heavy polypeptide [KO:K04574]
105300938  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
105300991  DAXX; death domain-associated protein 6 [KO:K02308]
105301000  [KO:K14021]
105301035  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105301036  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105301042  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105301070  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105301083  TUBB4A; tubulin beta-4A chain [KO:K07375]
105301118  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105301194  [KO:K00411] [EC:7.1.1.8]
105301214  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
105301227  HTT; huntingtin [KO:K04533]
105301261  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
105301304  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105301307  SLC6A3; LOW QUALITY PROTEIN: sodium-dependent dopamine transporter [KO:K05036]
105301308  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105301309  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
105301374  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
105301411  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
105301482  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
105301667  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105301679  DCTN5; dynactin subunit 5 [KO:K10427]
105301762  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105301970  [KO:K00413]
105302044  WNT7B; protein Wnt-7b [KO:K00572]
105302165  WDR41; WD repeat-containing protein 41 [KO:K23610]
105302210  TRPC3; LOW QUALITY PROTEIN: short transient receptor potential channel 3 [KO:K04966]
105302219  [KO:K00420]
105302238  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2 [KO:K03940] [EC:7.1.1.2]
105302259  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
105302307  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
105302384  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
105302414  [KO:K00414]
105302452  [KO:K04634]
105302513  [KO:K07925]
105302543  [KO:K07925]
105302549  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X2 [KO:K03948]
105302566  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
105302646  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
105302767  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
105302783  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105302799  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
105302898  [KO:K02268]
105303030  UBE2G2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
105303101  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
105303190  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
105303219  PSMA2; proteasome subunit alpha type-2 isoform X1 [KO:K02726] [EC:3.4.25.1]
105303252  AXIN1; axin-1 isoform X1 [KO:K02157]
105303324  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 isoform X1 [KO:K03966]
105303396  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
105303399  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
105303403  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
105303424  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
105303449  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
105303453  WNT3; proto-oncogene Wnt-3 [KO:K00312]
105303454  WNT9B; protein Wnt-9b [KO:K01064]
105303480  FZD2; frizzled-2 [KO:K02235]
105303569  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X2 [KO:K04554] [EC:2.3.2.23]
105303599  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
105303606  CALML6; calmodulin-like protein 6 [KO:K02183]
105303717  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
105303753  CDK5; cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
105303837  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
105303843  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
105303918  [KO:K02272]
105303981  IL1A; interleukin-1 alpha [KO:K04383]
105303982  IL1B; interleukin-1 beta [KO:K04519]
105304165  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
105304199  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
105304244  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
105304293  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
105304363  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
105304445  KLC1; kinesin light chain 1 [KO:K10407]
105304450  [KO:K04961]
105304499  [KO:K02266]
105304505  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105304578  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
105304583  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
105304627  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
105304667  WNT8B; protein Wnt-8b [KO:K00714]
105304748  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X2 [KO:K04553] [EC:2.3.2.23]
105304852  TUBB3; tubulin beta-3 chain [KO:K07375]
105304910  [KO:K02267]
105305094  [KO:K04565] [EC:1.15.1.1]
105305214  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
105305278  AGER; advanced glycosylation end product-specific receptor isoform X9 [KO:K19722]
105305325  TNF; tumor necrosis factor [KO:K03156]
105305337  [KO:K02927]
105305340  CSNK2B; casein kinase II subunit beta [KO:K03115]
105305378  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
105305394  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
105305404  BECN2; beclin-2 [KO:K08334]
105305449  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
105305451  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
105305459  ARAF; serine/threonine-protein kinase A-Raf isoform X8 [KO:K08845] [EC:2.7.11.1]
105305487  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
105305502  [KO:K02263]
105305503  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105305546  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
105305558  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
105305799  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X2 [KO:K03937]
105305805  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
105305847  ATXN1L; ataxin-1-like [KO:K23616]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105306053  [KO:K00415]
105306057  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
105306136  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
105306187  [KO:K10408]
105306274  BECN1; beclin-1 isoform X1 [KO:K08334]
105306339  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
105306353  TUBB6; tubulin beta-6 chain [KO:K07375]
105306380  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
105306407  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
105306431  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
105306436  DCTN3; dynactin subunit 3 isoform X4 [KO:K10425]
105306438  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
105306445  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
105306559  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
105306564  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
105306578  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
105306643  [KO:K02267]
105306689  RAB1A; ras-related protein Rab-1A [KO:K07874]
105306744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105306771  GPX5; epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
105306782  ACTR1B; beta-centractin isoform X1 [KO:K16575]
105306783  [KO:K02265]
105306845  [KO:K02264]
105306976  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
105307005  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
105307010  ATG101; autophagy-related protein 101 [KO:K19730]
105307126  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
105307149  FZD8; frizzled-8 [KO:K02375]
105307210  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
105307242  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
105307287  [KO:K04809]
105307329  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
105307377  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
105307381  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
105307466  [KO:K02731] [EC:3.4.25.1]
105307475  FADD; FAS-associated death domain protein [KO:K02373]
105307507  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
105307510  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
105307529  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
105307700  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
105307710  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
105307806  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 isoform X1 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
105307875  [KO:K02270]
105307890  [KO:K02270]
105307906  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
105308002  [KO:K05863]
105308064  NOX1; NADPH oxidase 1 isoform X2 [KO:K08008]
105308138  TUBB; tubulin beta chain [KO:K07375]
105308244  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105308283  [KO:K04441] [EC:2.7.11.24]
105308386  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
105308414  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
105308466  WNT2; protein Wnt-2 [KO:K00182]
105308512  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105308561  [KO:K21421] [EC:1.-.-.-]
105308580  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
105308727  CUNH9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
105308762  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
105308818  [KO:K19662] [EC:2.7.11.13]
105308883  [KO:K02271]
105308921  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
105308931  ACTR10; actin-related protein 10 [KO:K16576]
105309056  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105309288  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
105309462  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105309466  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105309658  ACTR1A; alpha-centractin [KO:K16575]
105309689  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
105309810  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
105309827  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105310140  [KO:K04555] [EC:2.3.2.23]
105310149  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
105310590  [KO:K07375]
105311019  [KO:K00418]
105311066  [KO:K03954]
105311212  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
111728746  [KO:K14021]
111734519  [KO:K03939]
111742157  [KO:K03944]
111745811  [KO:K04565] [EC:1.15.1.1]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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CNS Neurosci Ther 23:5-22 (2017)
DOI:10.1111/cns.12655
Reference
PMID:19828789
  Authors
Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH Jr, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, Pigino G, Brady ST
  Title
Axonal transport defects in neurodegenerative diseases.
  Journal
J Neurosci 29:12776-86 (2009)
DOI:10.1523/JNEUROSCI.3463-09.2009
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:23361386
  Authors
Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Reference
PMID:31558780
  Authors
Sleigh JN, Rossor AM, Fellows AD, Tosolini AP, Schiavo G
  Title
Axonal transport and neurological disease.
  Journal
Nat Rev Neurol 15:691-703 (2019)
DOI:10.1038/s41582-019-0257-2
Reference
PMID:20434225
  Authors
Perlson E, Maday S, Fu MM, Moughamian AJ, Holzbaur EL
  Title
Retrograde axonal transport: pathways to cell death?
  Journal
Trends Neurosci 33:335-44 (2010)
DOI:10.1016/j.tins.2010.03.006
Related
pathway
pvp00190  Oxidative phosphorylation
pvp03050  Proteasome
pvp04020  Calcium signaling pathway
pvp04120  Ubiquitin mediated proteolysis
pvp04137  Mitophagy - animal
pvp04140  Autophagy - animal
pvp04141  Protein processing in endoplasmic reticulum
pvp04142  Lysosome biogenesis
pvp04210  Apoptosis
pvp04310  Wnt signaling pathway
pvp04724  Glutamatergic synapse
pvp04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   

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