KEGG   PATHWAY: umr05010
Entry
umr05010                    Pathway                                
Name
Alzheimer disease - Ursus maritimus (polar bear)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
umr05010  Alzheimer disease
umr05010

Disease
H00056  Alzheimer disease
Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103656199  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
103656234  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
103656310  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
103656462  [KO:K02271]
103656470  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
103656532  KIF5B; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
103656598  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
103656636  KIF5A; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
103656658  [KO:K00413]
103656691  SLC39A4; zinc transporter ZIP4 [KO:K14710]
103656900  [KO:K00134] [EC:1.2.1.12]
103656929  SLC39A5; zinc transporter ZIP5 [KO:K14711]
103656936  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
103656991  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
103657024  [KO:K03945]
103657176  APOE; apolipoprotein E [KO:K04524]
103657183  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
103657204  CALM3; calmodulin-3 [KO:K02183]
103657232  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
103657312  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
103657400  [KO:K10881]
103657485  [KO:K02270]
103657723  [KO:K07374]
103657769  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
103657815  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X3 [KO:K05853] [EC:7.2.2.10]
103657827  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
103657893  [KO:K02266]
103657962  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
103658066  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
103658087  [KO:K03947]
103658290  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
103658551  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
103658639  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
103658750  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
103658791  FZD1; frizzled-1 [KO:K02432]
103658816  [KO:K02272]
103658820  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
103658871  IL6; interleukin-6 [KO:K05405]
103658902  [KO:K08738]
103658916  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103658927  WNT8B; protein Wnt-8b [KO:K00714]
103659239  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
103659249  [KO:K00419]
103659502  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
103659515  [KO:K03939]
103659693  SLC39A10; zinc transporter ZIP10 [KO:K14716]
103659737  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
103659742  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
103659788  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
103659841  KIF5C; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
103659901  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
103659948  FZD7; LOW QUALITY PROTEIN: frizzled-7 [KO:K02432]
103659958  FZD5; frizzled-5 [KO:K02375]
103659968  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
103660109  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
103660136  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
103660313  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
103660341  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
103660462  [KO:K02353]
103660584  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
103660617  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
103660779  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
103660955  CDK5; cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
103661007  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
103661036  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
103661038  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103661161  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
103661190  [KO:K03948]
103661230  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
103661238  FZD10; frizzled-10 [KO:K02842]
103661275  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
103661304  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
103661483  [KO:K00417]
103661502  [KO:K02268]
103661527  FZD6; frizzled-6 [KO:K02376]
103661621  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
103661721  DKK2; dickkopf-related protein 2 [KO:K02165]
103661909  DKK1; dickkopf-related protein 1 [KO:K02165]
103661934  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103662000  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
103662209  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
103662352  BACE1; beta-secretase 1 isoform X1 [KO:K04521] [EC:3.4.23.46]
103662415  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
103662441  [KO:K04741] [EC:3.4.22.-]
103662680  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
103662712  IRS1; insulin receptor substrate 1 [KO:K16172]
103662744  [KO:K07374]
103662822  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
103662888  WNT10A; protein Wnt-10a [KO:K01357]
103662923  [KO:K08738]
103663281  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
103663496  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
103663576  SLC39A6; zinc transporter ZIP6 [KO:K14712]
103663617  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
103663663  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
103663752  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
103663786  [KO:K00416]
103663788  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
103663793  WNT8A; protein Wnt-8a [KO:K00714]
103663818  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
103663827  [KO:K00418]
103664073  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
103664214  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
103664348  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
103664607  CSNK1A1; casein kinase I isoform X3 [KO:K08957] [EC:2.7.11.1]
103664628  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
103664901  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
103664961  TUBB2A; tubulin beta-2A chain isoform X1 [KO:K07375]
103665004  TUBB; tubulin beta chain [KO:K07375]
103665244  KRAS; GTPase KRas isoform X1 [KO:K07827]
103665275  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103665503  SLC39A7; zinc transporter SLC39A7 isoform X1 [KO:K14713]
103665553  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103665634  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
103665659  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
103665675  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
103665692  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
103665721  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
103665868  FZD2; frizzled-2 [KO:K02235]
103665889  WNT3; proto-oncogene Wnt-3 [KO:K00312]
103665903  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
103665908  AXIN2; axin-2 isoform X1 [KO:K04385]
103665926  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
103666073  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
103666331  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
103666354  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
103666399  PSMB2; proteasome subunit beta type-2 isoform X2 [KO:K02734] [EC:3.4.25.1]
103666614  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
103666628  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
103666660  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103666688  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103666795  WNT4; protein Wnt-4 isoform X2 [KO:K00408]
103666874  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103667024  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
103667043  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
103667123  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
103667262  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
103667420  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
103667431  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
103667513  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
103667517  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
103667559  APH1A; gamma-secretase subunit APH-1A isoform X1 [KO:K06172]
103667625  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
103667825  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103667846  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
103667893  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103667958  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
103667996  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
103668021  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
103668033  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
103668219  [KO:K11352]
103668224  [KO:K03945]
103668228  [KO:K21421] [EC:1.-.-.-]
103668412  SLC39A1; zinc transporter ZIP1 [KO:K14709]
103668450  AXIN1; axin-1 isoform X2 [KO:K02157]
103668590  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
103668648  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
103668772  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
103668880  [KO:K00415]
103668899  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
103668940  [KO:K03037]
103668942  BECN2; beclin-2 [KO:K08334]
103669030  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
103669103  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103669131  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
103669173  [KO:K02833]
103669231  [KO:K07374]
103669237  [KO:K07374]
103669286  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103669422  NRAS; GTPase NRas [KO:K07828]
103669540  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103669597  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103669629  [KO:K00572]
103669950  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial isoform X2 [KO:K11351]
103670034  [KO:K17445]
103670082  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
103670220  FZD9; frizzled-9 [KO:K02842]
103670304  CALM1; calmodulin-1 isoform X1 [KO:K02183]
103670329  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
103670332  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
103670360  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
103670755  [KO:K00416]
103670766  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103670961  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
103670962  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
103671026  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
103671035  HRAS; GTPase HRas isoform X3 [KO:K02833]
103671072  FADD; FAS-associated death domain protein [KO:K02373]
103671191  [KO:K02265]
103671240  CALM2; calmodulin-2 [KO:K02183]
103671340  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
103671416  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
103671495  IL1B; interleukin-1 beta isoform X2 [KO:K04519]
103671508  [KO:K03945]
103671542  [KO:K02270]
103671577  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
103671621  SLC39A9; zinc transporter ZIP9 [KO:K14715]
103671779  RTN4; reticulon-4 isoform X1 [KO:K20720]
103671855  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
103671864  IL1A; interleukin-1 alpha [KO:K04383]
103671936  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
103672010  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
103672016  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
103672041  NCSTN; nicastrin [KO:K06171]
103672146  [KO:K02272]
103672304  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
103672308  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
103672309  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
103672325  ATG13; autophagy-related protein 13 [KO:K08331]
103672328  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
103672587  BECN1; beclin-1 isoform X2 [KO:K08334]
103672701  [KO:K02271]
103672884  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
103672921  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
103672992  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
103673070  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
103673071  [KO:K04520]
103673122  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
103673149  [KO:K02266]
103673318  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103673319  SLC39A14; metal cation symporter ZIP14 [KO:K14720]
103673361  TUBB6; tubulin beta-6 chain [KO:K07375]
103673363  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
103673502  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
103673552  [KO:K05858] [EC:3.1.4.11]
103673560  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
103673638  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
103673681  NAE1; NEDD8-activating enzyme E1 regulatory subunit isoform X1 [KO:K04532]
103673708  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
103673753  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
103673805  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
103673823  [KO:K00411] [EC:7.1.1.8]
103673835  [KO:K02263]
103673863  [KO:K07375]
103674068  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
103674134  [KO:K00572]
103674226  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
103674244  [KO:K00417]
103674346  [KO:K02263]
103674361  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
103674425  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
103674426  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
103674585  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
103674591  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
103674739  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
103674845  [KO:K00414]
103674915  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
103674995  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
103675040  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
103675048  WNT2B; protein Wnt-2b [KO:K00182]
103675062  WNT5A; protein Wnt-5a [KO:K00444]
103675162  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103675205  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
103675231  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
103675245  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
103675253  TUBB4B; tubulin beta-4B chain [KO:K07375]
103675310  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
103675375  FZD4; frizzled-4 [KO:K02354]
103675379  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
103675380  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
103675456  TUBA1B; tubulin alpha-1B chain [KO:K07374]
103675457  [KO:K07374]
103675459  [KO:K07374]
103675484  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
103675502  ATG101; autophagy-related protein 101 isoform X1 [KO:K19730]
103675541  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
103675619  WNT10B; protein Wnt-10b [KO:K01357]
103675620  WNT1; proto-oncogene Wnt-1 [KO:K03209]
103675693  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
103675694  BID; BH3-interacting domain death agonist [KO:K04726]
103675706  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
103675753  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
103675761  WNT5B; protein Wnt-5b [KO:K00444]
103675797  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
103675819  [KO:K02271]
103675859  [KO:K02267]
103675912  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
103675953  FZD3; frizzled-3 [KO:K02329]
103676082  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
103676116  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X2 [KO:K03961]
103676125  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103676131  [KO:K03948]
103676184  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
103676238  [KO:K02183]
103676239  CALML3; calmodulin-like protein 3 [KO:K02183]
103676258  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X2 [KO:K02136]
103676280  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
103676308  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
103676372  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103676389  [KO:K08960] [EC:2.7.11.1]
103676588  WNT2; protein Wnt-2 [KO:K00182]
103676602  WNT16; protein Wnt-16 [KO:K01558]
103676612  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
103676703  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
103676794  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
103676878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103676885  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
103676947  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103677056  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
103677057  DKK4; dickkopf-related protein 4 [KO:K02165]
103677059  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103677420  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
103677527  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
103677644  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
103677737  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
103677743  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
103677754  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
103677769  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
103677897  SNCA; alpha-synuclein [KO:K04528]
103677943  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103677947  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103677987  SLC39A8; metal cation symporter ZIP8 [KO:K14714]
103678127  WNT11; LOW QUALITY PROTEIN: protein Wnt-11 [KO:K01384]
103678138  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
103678244  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
103678327  [KO:K02266]
103678534  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
103678592  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103678783  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
103678785  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
103678870  WNT3A; protein Wnt-3a [KO:K00312]
103678871  WNT9A; protein Wnt-9a [KO:K01064]
103678902  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
103679049  CALML4; calmodulin-like protein 4 isoform X3 [KO:K02183]
103679064  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103679107  APH1B; gamma-secretase subunit APH-1B isoform X1 [KO:K06172]
103679121  [KO:K02264]
103679235  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
103679246  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
103679251  [KO:K03947]
103679280  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
103679414  RTN3; reticulon-3 [KO:K20723]
103679417  [KO:K02273]
103679423  BAD; bcl2-associated agonist of cell death [KO:K02158]
103679450  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
103679486  KLC2; kinesin light chain 2 [KO:K10407]
103679522  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
103679549  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
103679563  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
103679584  RELA; transcription factor p65 [KO:K04735]
103679622  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
103679626  LRP5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
103679680  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103679714  [KO:K02265]
103679757  [KO:K02732] [EC:3.4.25.1]
103679768  [KO:K00134] [EC:1.2.1.12]
103679770  IRS4; insulin receptor substrate 4 [KO:K17446]
103679990  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103680303  [KO:K02267]
103680384  CTNNB1; catenin beta-1 [KO:K02105]
103680708  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
103680727  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
103680991  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
103681007  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
103681035  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
103681412  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
103681522  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
103681631  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
103681635  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
103681641  [KO:K00420]
103681655  SLC39A3; zinc transporter ZIP3 [KO:K14709]
103681700  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
103681710  TUBB4A; tubulin beta-4A chain [KO:K07375]
103681725  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
103681784  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
103681834  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103681888  MAP2K7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103682041  CALML6; calmodulin-like protein 6 [KO:K02183]
103682075  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
103682114  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
103682274  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
103682308  CSNK2B; casein kinase II subunit beta [KO:K03115]
103682322  TNF; tumor necrosis factor [KO:K03156]
103682383  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
103682512  [KO:K02267]
103682517  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
103682538  [KO:K02270]
121099746  [KO:K05858] [EC:3.1.4.11]
121099769  INS; insulin [KO:K04526]
121099783  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
121101236  FRAT1; proto-oncogene FRAT1 [KO:K03069]
121101237  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
121101279  IRS2; insulin receptor substrate 2 [KO:K07187]
121101896  [KO:K00134] [EC:1.2.1.12]
121102487  [KO:K03945]
121104237  [KO:K08738]
121104977  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
121106099  [KO:K03037]
121106331  FZD8; frizzled-8 [KO:K02375]
804861  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
804862  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
804863  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
804864  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
804865  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
804866  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
804867  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
804868  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
804869  COX3; cytochrome c oxidase subunit III [KO:K02262]
804870  COX2; cytochrome c oxidase subunit II [KO:K02261]
804871  CYTB; cytochrome b [KO:K00412]
804872  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
804873  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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  Journal
Mt Sinai J Med 77:59-68 (2010)
DOI:10.1002/msj.20161
Related
pathway
umr00190  Oxidative phosphorylation
umr03050  Proteasome
umr04020  Calcium signaling pathway
umr04140  Autophagy - animal
umr04141  Protein processing in endoplasmic reticulum
umr04210  Apoptosis
umr04310  Wnt signaling pathway
umr04910  Insulin signaling pathway
umr04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

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