KEGG   PATHWAY: btax05163
Entry
btax05163                   Pathway                                
Name
Human cytomegalovirus infection - Budorcas taxicolor (takin)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
btax05163  Human cytomegalovirus infection
btax05163

Disease
H00368  Cytomegalovirus infection
Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128043403  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128043471  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
128043506  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
128043555  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
128043619  E2F2; transcription factor E2F2 [KO:K09389]
128043889  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
128043920  TSC2; tuberin isoform X1 [KO:K07207]
128043958  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
128044413  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
128044465  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
128044474  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
128044537  NRAS; GTPase NRas [KO:K07828]
128044567  RHOA; transforming protein RhoA [KO:K04513]
128044674  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
128044759  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
128044816  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
128045517  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
128045803  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
128045815  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
128046227  [KO:K08738]
128046429  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
128046449  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
128046520  RHEB; GTP-binding protein Rheb [KO:K07208]
128046532  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
128046584  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
128046639  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
128046764  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
128046927  [KO:K04548]
128046952  IL6; interleukin-6 [KO:K05405]
128047312  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
128047314  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
128047322  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
128047362  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
128047373  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
128047386  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
128047426  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
128047644  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
128047668  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
128047841  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
128047885  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
128047923  BID; BH3-interacting domain death agonist [KO:K04726]
128047937  KRAS; GTPase KRas [KO:K07827]
128047979  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
128048350  [KO:K04374]
128048391  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
128048527  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
128048580  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
128049417  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
128049447  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
128049579  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
128049678  CCR3; C-C chemokine receptor type 3 [KO:K04178]
128049778  [KO:K04180]
128049822  [KO:K04451]
128049958  CXCL8; interleukin-8 [KO:K10030]
128050274  STING1; stimulator of interferon genes protein [KO:K12654]
128050339  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
128050433  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
128050540  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
128050561  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
128050664  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
128050674  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
128050932  CALR; calreticulin [KO:K08057]
128050979  [KO:K06751]
128051420  [KO:K04176]
128051508  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
128051614  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
128052144  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
128052214  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
128052307  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
128052409  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
128052429  [KO:K05414]
128052430  [KO:K05414]
128052431  [KO:K05414]
128052432  [KO:K05414]
128052433  [KO:K05414]
128052459  [KO:K05414]
128052476  [KO:K05414]
128052529  [KO:K06621]
128052606  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
128052625  [KO:K05415]
128052626  [KO:K05415]
128052627  [KO:K05415]
128052628  [KO:K05415]
128052635  [KO:K05415]
128052636  [KO:K05415]
128052637  [KO:K05415]
128052638  [KO:K05415]
128052639  [KO:K05415]
128052640  [KO:K05415]
128052652  [KO:K05415]
128052682  [KO:K05414]
128052694  [KO:K05414]
128052696  [KO:K05414]
128052697  [KO:K05414]
128052706  [KO:K05414]
128053541  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
128053757  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
128053799  [KO:K08055]
128053800  [KO:K08055]
128053843  [KO:K08738]
128053854  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
128053892  SOS2; son of sevenless homolog 2 [KO:K03099]
128053924  [KO:K08738]
128054019  [KO:K08738]
128054045  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
128054050  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
128054080  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
128054091  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
128054267  CALM1; calmodulin-1 [KO:K02183]
128054611  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
128054958  [KO:K04176]
128055236  [KO:K06751]
128055280  [KO:K06751]
128055281  [KO:K06751]
128055294  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
128055305  [KO:K06751]
128055318  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
128055373  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
128055374  SOS1; son of sevenless homolog 1 [KO:K03099]
128055475  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
128055536  TAPBP; tapasin [KO:K08058]
128055613  VEGFA; vascular endothelial growth factor A [KO:K05448]
128055801  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
128055992  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
128056049  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
128056062  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
128056082  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
128056161  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
128056281  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
128056429  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
128056569  IL1B; interleukin-1 beta [KO:K04519]
128056580  E2F3; transcription factor E2F3 [KO:K06620]
128056632  TSC1; hamartin isoform X1 [KO:K07206]
128056684  CALM2; calmodulin-2 [KO:K02183]
128056772  TNF; tumor necrosis factor [KO:K03156]
128056879  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
128056953  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
128057155  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
128057539  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
128058011  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
128058174  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
128058230  [KO:K02183]
128058237  CTNNB1; catenin beta-1 [KO:K02105]
128058250  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
128058303  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
128058335  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
128058399  E2F1; transcription factor E2F1 [KO:K17454]
128058829  [KO:K04632]
128059120  MYC; myc proto-oncogene protein [KO:K04377]
128059235  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
128059256  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
128059988  [KO:K07205]
128060102  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
128060385  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
128060929  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
128061241  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
128061269  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
128061341  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
128061467  ITGAV; integrin alpha-V [KO:K06487]
128061475  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
128061491  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128061601  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
128061687  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
128061711  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
128061812  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
128061813  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128062160  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128062501  CRKL; crk-like protein [KO:K04438]
128062630  PXN; paxillin isoform X1 [KO:K05760]
128062922  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
128062941  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
128062963  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
128063092  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
128063096  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
128063153  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
128063240  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
128063251  CX3CL1; fractalkine isoform X1 [KO:K05508]
128063810  CALM3; calmodulin-3 [KO:K02183]
128063870  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128064207  BAX; apoptosis regulator BAX [KO:K02159]
128064208  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
128064366  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
128064562  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
128064578  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
128064617  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
128064672  TP53; cellular tumor antigen p53 [KO:K04451]
128064775  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
128064804  [KO:K05408]
128064805  [KO:K12499]
128064806  [KO:K05408]
128064807  [KO:K05408]
128064808  [KO:K12964]
128064809  [KO:K05408]
128064843  CRK; adapter molecule crk isoform X1 [KO:K04438]
128064875  ITGB3; integrin beta-3 [KO:K06493]
128065049  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
128065178  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
128065365  [KO:K14624]
128065393  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128065610  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
128065663  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
128066059  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
128066123  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
128066235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
128066420  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
128066552  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
128066643  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
128066952  AKAP13; A-kinase anchor protein 13 [KO:K16529]
128067048  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128067290  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
128067328  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
128067499  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
128067677  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
128067871  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
128068195  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
128068203  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 isoform X1 [KO:K07205]
128068238  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
128068336  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
128068526  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
128068545  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
128068546  RELA; transcription factor p65 [KO:K04735]
128068641  FADD; FAS-associated death domain protein [KO:K02373]
128068668  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
128068689  HRAS; GTPase HRas isoform X1 [KO:K02833]
128068699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
128069030  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
128069489  [KO:K08738]
128069947  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
128070470  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
128070914  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
128071103  [KO:K05870]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
PMID:14720582
  Authors
Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
PMID:15380778
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
DOI:10.1016/j.micinf.2004.05.026
Reference
PMID:29547547
  Authors
Murray MJ, Peters NE, Reeves MB
  Title
Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.
  Journal
Pathogens 7:E30 (2018)
DOI:10.3390/pathogens7010030
Reference
PMID:27501260
  Authors
Campadelli-Fiume G, Collins-McMillen D, Gianni T, Yurochko AD
  Title
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome.
  Journal
Annu Rev Virol 3:215-236 (2016)
DOI:10.1146/annurev-virology-110615-035618
Reference
PMID:28132838
  Authors
Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB
  Title
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
  Journal
Cell Host Microbe 21:231-243 (2017)
DOI:10.1016/j.chom.2017.01.001
Reference
PMID:29082387
  Authors
Hancock MH, Nelson JA
  Title
Modulation of the NFkappab Signalling Pathway by Human Cytomegalovirus.
  Journal
Virology (Hyderabad) 1:104 (2017)
Reference
PMID:21383764
  Authors
Rahman MM, McFadden G
  Title
Modulation of NF-kappaB signalling by microbial pathogens.
  Journal
Nat Rev Microbiol 9:291-306 (2011)
DOI:10.1038/nrmicro2539
Reference
PMID:27060663
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
  Journal
Biochem Pharmacol 114:69-81 (2016)
DOI:10.1016/j.bcp.2016.03.021
Reference
PMID:28035083
  Authors
Lee S, Chung YH, Lee C
  Title
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.
  Journal
Biomol Ther (Seoul) 25:69-79 (2017)
DOI:10.4062/biomolther.2016.208
Reference
PMID:23145028
  Authors
Langemeijer EV, Slinger E, de Munnik S, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ
  Title
Constitutive beta-catenin signaling by the viral chemokine receptor US28.
  Journal
PLoS One 7:e48935 (2012)
DOI:10.1371/journal.pone.0048935
Reference
PMID:15990176
  Authors
Couty JP, Gershengorn MC
  Title
G-protein-coupled receptors encoded by human herpesviruses.
  Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:10.1016/j.tips.2005.06.004
Reference
PMID:25549333
  Authors
Fiallos E, Judkins J, Matlaf L, Prichard M, Dittmer D, Cobbs C, Soroceanu L
  Title
Human cytomegalovirus gene expression in long-term infected glioma stem cells.
  Journal
PLoS One 9:e116178 (2014)
DOI:10.1371/journal.pone.0116178
Reference
PMID:24445563
  Authors
Vischer HF, Siderius M, Leurs R, Smit MJ
  Title
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
  Journal
Nat Rev Drug Discov 13:123-39 (2014)
DOI:10.1038/nrd4189
Reference
PMID:20398729
  Authors
Slinger E, Langemeijer E, Siderius M, Vischer HF, Smit MJ
  Title
Herpesvirus-encoded GPCRs rewire cellular signaling.
  Journal
Mol Cell Endocrinol 331:179-84 (2011)
DOI:10.1016/j.mce.2010.04.007
Reference
PMID:11175803
  Authors
Murphy PM
  Title
Viral exploitation and subversion of the immune system through chemokine mimicry.
  Journal
Nat Immunol 2:116-22 (2001)
DOI:10.1038/84214
Reference
PMID:16352349
  Authors
Vischer HF, Leurs R, Smit MJ
  Title
HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks.
  Journal
Trends Pharmacol Sci 27:56-63 (2006)
DOI:10.1016/j.tips.2005.11.006
Reference
PMID:25805993
  Authors
de Munnik SM, Smit MJ, Leurs R, Vischer HF
  Title
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
  Journal
Front Pharmacol 6:40 (2015)
DOI:10.3389/fphar.2015.00040
Reference
PMID:15172446
  Authors
Michelson S
  Title
Consequences of human cytomegalovirus mimicry.
  Journal
Hum Immunol 65:465-75 (2004)
DOI:10.1016/j.humimm.2004.02.002
Reference
PMID:29237840
  Authors
Tu CC, Arnolds KL, O'Connor CM, Spencer JV
  Title
Human Cytomegalovirus UL111A and US27 Gene Products Enhance the CXCL12/CXCR4 Signaling Axis via Distinct Mechanisms.
  Journal
J Virol 92:e01981-17 (2018)
DOI:10.1128/JVI.01981-17
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:22454101
  Authors
Noriega V, Redmann V, Gardner T, Tortorella D
  Title
Diverse immune evasion strategies by human cytomegalovirus.
  Journal
Immunol Res 54:140-51 (2012)
DOI:10.1007/s12026-012-8304-8
Reference
PMID:17145306
  Authors
Loureiro J, Ploegh HL
  Title
Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions.
  Journal
Adv Immunol 92:225-305 (2006)
DOI:10.1016/S0065-2776(06)92006-9
Reference
PMID:10707064
  Authors
Fortunato EA, McElroy AK, Sanchez I, Spector DH
  Title
Exploitation of cellular signaling and regulatory pathways by human cytomegalovirus.
  Journal
Trends Microbiol 8:111-9 (2000)
DOI:10.1016/S0966-842X(00)01699-1
Reference
PMID:15389728
  Authors
Cinatl J Jr, Scholz M, Doerr HW
  Title
Role of tumor cell immune escape mechanisms in cytomegalovirus-mediated oncomodulation.
  Journal
Med Res Rev 25:167-85 (2005)
DOI:10.1002/med.20018
Reference
PMID:14975530
  Authors
Cinatl J Jr, Vogel JU, Kotchetkov R, Wilhelm Doerr H
  Title
Oncomodulatory signals by regulatory proteins encoded by human cytomegalovirus: a novel role for viral infection in tumor progression.
  Journal
FEMS Microbiol Rev 28:59-77 (2004)
DOI:10.1016/j.femsre.2003.07.005
Reference
PMID:12062798
  Authors
Castillo JP, Kowalik TF
  Title
Human cytomegalovirus immediate early proteins and cell growth control.
  Journal
Gene 290:19-34 (2002)
DOI:10.1016/S0378-1119(02)00566-8
Reference
PMID:15352160
  Authors
Kalejta RF
  Title
Human cytomegalovirus pp71: a new viral tool to probe the mechanisms of cell cycle progression and oncogenesis controlled by the retinoblastoma family of tumor suppressors.
  Journal
J Cell Biochem 93:37-45 (2004)
DOI:10.1002/jcb.20177
Reference
PMID:20969904
  Authors
Brune W
  Title
Inhibition of programmed cell death by cytomegaloviruses.
  Journal
Virus Res 157:144-50 (2011)
DOI:10.1016/j.virusres.2010.10.012
Reference
PMID:28869497
  Authors
Brune W, Andoniou CE
  Title
Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus.
  Journal
Viruses 9:E249 (2017)
DOI:10.3390/v9090249
Reference
PMID:27160907
  Authors
Yamin R, Lecker LSM, Weisblum Y, Vitenshtein A, Le-Trilling VTK, Wolf DG, Mandelboim O
  Title
HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2.
  Journal
Cell Rep 15:1542-1553 (2016)
DOI:10.1016/j.celrep.2016.04.042
Reference
PMID:28488292
  Authors
Wang X, Sanchez J, Stone MJ, Payne RJ
  Title
Sulfation of the Human Cytomegalovirus Protein UL22A Enhances Binding to the Chemokine RANTES.
  Journal
Angew Chem Int Ed Engl 56:8490-8494 (2017)
DOI:10.1002/anie.201703059
Related
pathway
btax00590  Arachidonic acid metabolism
btax03050  Proteasome
btax04010  MAPK signaling pathway
btax04064  NF-kappa B signaling pathway
btax04110  Cell cycle
btax04150  mTOR signaling pathway
btax04151  PI3K-Akt signaling pathway
btax04210  Apoptosis
btax04612  Antigen processing and presentation
btax04623  Cytosolic DNA-sensing pathway
btax04630  JAK-STAT signaling pathway
btax04668  TNF signaling pathway
btax04810  Regulation of actin cytoskeleton
KO pathway
ko05163   

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