KEGG   PATHWAY: csab05417
Entry
csab05417                   Pathway                                
Name
Lipid and atherosclerosis - Chlorocebus sabaeus (green monkey)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
csab05417  Lipid and atherosclerosis
csab05417

Disease
H02505  Atherosclerosis
Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103215459  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
103215469  TNFRSF10B; TNF receptor superfamily member 10b [KO:K04722]
103215472  TNFRSF10A; TNF receptor superfamily member 10a [KO:K04722]
103215555  [KO:K07836]
103215686  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103215844  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103215984  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
103215997  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
103216224  FAS; Fas cell surface death receptor [KO:K04390]
103216299  CYP2C19; cytochrome P450 family 2 subfamily C member 19 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
103216301  CYP2C9; cytochrome P450 family 2 subfamily C member 9 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
103216303  CYP2C8; cytochrome P450 family 2 subfamily C member 8 [KO:K17718] [EC:1.14.14.1]
103216308  [KO:K17718] [EC:1.14.14.1]
103216382  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103216537  CASP7; caspase 7 [KO:K04397] [EC:3.4.22.60]
103217178  TANK; TRAF family member associated NFKB activator [KO:K12650]
103217393  NFE2L2; nuclear factor, erythroid 2 like 2 [KO:K05638]
103217584  HSPD1; heat shock protein family D (Hsp60) member 1 [KO:K04077] [EC:5.6.1.7]
103217637  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
103218446  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
103218575  OLR1; oxidized low density lipoprotein receptor 1 [KO:K08763]
103218763  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103218937  TLR4; toll like receptor 4 [KO:K10160]
103219077  ABCA1; ATP binding cassette subfamily A member 1 [KO:K05641]
103219106  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
103219309  ABCG1; ATP binding cassette subfamily G member 1 [KO:K05679]
103219366  [KO:K05414]
103219367  IFNA8; interferon alpha 8 [KO:K05414]
103219368  IFNA2; interferon alpha 2 [KO:K05414]
103219370  [KO:K05414]
103219372  [KO:K05414]
103219377  [KO:K05414]
103219378  [KO:K05414]
103219379  [KO:K05414]
103219381  [KO:K05414]
103219383  IFNB1; interferon beta 1 [KO:K05415]
103219496  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
103219524  VLDLR; very low density lipoprotein receptor [KO:K20053]
103219556  [KO:K08738]
103220127  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
103220326  CALM2; calmodulin 2 [KO:K02183]
103220705  APOB; apolipoprotein B [KO:K14462]
103220805  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
103221064  MYD88; myeloid differentiation primary response 88 [KO:K04729]
103221212  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103221246  TNFSF10; tumor necrosis factor superfamily member 10 [KO:K04721]
103221436  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
103221595  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103221596  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103221675  RXRB; retinoid X receptor beta [KO:K08525]
103221709  AGER; advanced glycosylation end-product specific receptor [KO:K19722]
103221743  HSPA1B; heat shock protein family A (Hsp70) member 1B [KO:K03283]
103221744  HSPA1L; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
103221745  HSPA1A; heat shock protein family A (Hsp70) member 1A [KO:K03283]
103222594  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103222661  MIB1; mindbomb E3 ubiquitin protein ligase 1 [KO:K10645] [EC:2.3.2.27]
103222876  BID; BH3 interacting domain death agonist [KO:K04726]
103222941  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103223125  XBP1; X-box binding protein 1 [KO:K09027]
103223257  NCF4; neutrophil cytosolic factor 4 [KO:K08012]
103223342  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
103223345  ATF4; activating transcription factor 4 [KO:K04374]
103223551  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103223553  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103223664  ATF6; activating transcription factor 6 [KO:K09054]
103223677  HSPA6; heat shock protein family A (Hsp70) member 6 [KO:K03283]
103224167  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103224221  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
103224335  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
103224362  VCAM1; vascular cell adhesion molecule 1 [KO:K06527]
103224719  CYP2J2; cytochrome P450 family 2 subfamily J member 2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
103224726  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
103224843  [KO:K08738]
103224900  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103225423  CDC42; cell division cycle 42 [KO:K04393]
103225550  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
103225637  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103225665  [KO:K08738]
103225784  MIB2; mindbomb E3 ubiquitin protein ligase 2 [KO:K10645] [EC:2.3.2.27]
103226003  IRF7; interferon regulatory factor 7 [KO:K09447]
103226136  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
103226390  IL6; interleukin 6 [KO:K05405]
103226648  CD36; CD36 molecule [KO:K06259]
103227233  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
103227364  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103227629  RHOA; ras homolog family member A [KO:K04513]
103227941  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103228018  [KO:K08738]
103228027  PPARG; peroxisome proliferator activated receptor gamma [KO:K08530]
103228213  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
103228823  NFKBIA; NFKB inhibitor alpha [KO:K04734]
103228991  ERO1A; endoplasmic reticulum oxidoreductase 1 alpha [KO:K10950] [EC:1.8.4.-]
103229169  HSPA2; heat shock protein family A (Hsp70) member 2 [KO:K26598]
103229205  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
103229352  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
103229541  CALM1; calmodulin 1 [KO:K02183]
103229726  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
103229744  TRAF3; TNF receptor associated factor 3 [KO:K03174]
103229784  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103230198  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
103230452  NCF2; neutrophil cytosolic factor 2 [KO:K08010]
103230532  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103230577  FASLG; Fas ligand [KO:K04389]
103230616  SELE; selectin E [KO:K06494]
103230618  SELP; selectin P [KO:K06496]
103230658  POU2F1; POU class 2 homeobox 1 [KO:K09364]
103230690  RXRG; retinoid X receptor gamma [KO:K08526]
103230869  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103230925  [KO:K03283]
103230928  NLRP3; NLR family pyrin domain containing 3 [KO:K12800]
103231357  [KO:K12799]
103232344  NOX1; NADPH oxidase 1 [KO:K08008]
103232640  CD40LG; CD40 ligand [KO:K03161]
103232815  IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103232832  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
103233238  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
103233293  BAD; BCL2 associated agonist of cell death [KO:K02158]
103233299  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
103233451  [KO:K08009]
103233731  TICAM1; toll like receptor adaptor molecule 1 [KO:K05842]
103233784  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
103233823  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103233893  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103234364  LDLR; low density lipoprotein receptor [KO:K12473]
103234391  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103234702  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103234720  [KO:K17709] [EC:1.14.14.-]
103234745  ARHGEF1; Rho guanine nucleotide exchange factor 1 [KO:K12330]
103234757  POU2F2; POU class 2 homeobox 2 [KO:K09364]
103234915  CALM3; calmodulin 3 [KO:K02183]
103235004  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
103235050  IRF3; interferon regulatory factor 3 [KO:K05411]
103235786  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
103235789  CXCL1; C-X-C motif chemokine ligand 1 [KO:K05505]
103235792  [KO:K05505]
103235798  CXCL3; C-X-C motif chemokine ligand 3 [KO:K05505]
103235918  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103236040  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103236047  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103236104  CASP6; caspase 6 [KO:K04396] [EC:3.4.22.59]
103236144  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
103236415  [KO:K10159]
103236614  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103236665  [KO:K04079]
103236682  [KO:K05505]
103236819  LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
103236981  LY96; lymphocyte antigen 96 [KO:K05400]
103237554  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
103237724  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
103237820  CALML5; calmodulin like 5 [KO:K02183]
103237822  CALML3; calmodulin like 3 [KO:K02183]
103238180  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103238566  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
103238638  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
103238680  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
103238923  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
103238976  HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
103239600  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
103239669  RXRA; retinoid X receptor alpha [KO:K08524]
103239674  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
103239827  [KO:K08738]
103239874  HSPA5; heat shock protein family A (Hsp70) member 5 [KO:K09490] [EC:3.6.4.10]
103240115  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
103240159  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
103240310  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103240818  SOD2; superoxide dismutase 2 [KO:K04564] [EC:1.15.1.1]
103240990  [KO:K08738]
103241278  IL1B; interleukin 1 beta [KO:K04519]
103241350  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
103241402  IL12A; interleukin 12A [KO:K05406]
103241599  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103242323  TP53; tumor protein p53 [KO:K04451]
103242403  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
103242535  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103242710  [KO:K14624]
103242750  CCL5; C-C motif chemokine ligand 5 [KO:K12499]
103242767  CCL3; C-C motif chemokine ligand 3 [KO:K05408]
103243132  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103243171  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
103243204  ERN1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
103243410  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
103244028  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
103244166  BCL2; BCL2, apoptosis regulator [KO:K02161]
103244190  [KO:K08738]
103244215  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
103244367  TICAM2; toll like receptor adaptor molecule 2 [KO:K05409]
103244532  HSPA4; heat shock protein family A (Hsp70) member 4 [KO:K09489]
103244663  CD14; CD14 molecule [KO:K04391]
103244792  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
103244892  IL12B; interleukin 12B [KO:K05425]
103245053  CD40; CD40 molecule [KO:K03160]
103245064  MMP9; matrix metallopeptidase 9 [KO:K01403] [EC:3.4.24.35]
103245120  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103245331  CYP1A1; cytochrome P450 family 1 subfamily A member 1 [KO:K07408] [EC:1.14.14.1]
103245424  CALML4; calmodulin like 4 [KO:K02183]
103245842  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
103245987  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
103246211  TLR6; toll like receptor 6 [KO:K10169]
103246271  LBP; lipopolysaccharide binding protein [KO:K05399]
103246363  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103246384  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
103246591  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
103246614  NCF1; neutrophil cytosolic factor 1 [KO:K08011]
103246657  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
103246815  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103247465  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
103247598  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103247784  [KO:K05408]
103248011  BCL2L1; BCL2 like 1 [KO:K04570]
103248335  MMP1; matrix metallopeptidase 1 [KO:K01388] [EC:3.4.24.7]
103248344  MMP3; matrix metallopeptidase 3 [KO:K01394] [EC:3.4.24.17]
103248363  [KO:K01370] [EC:3.4.22.36]
103248365  CASP1; caspase 1 [KO:K01370] [EC:3.4.22.36]
103248464  IL18; interleukin 18 [KO:K05482]
103248545  APOA4; apolipoprotein A4 [KO:K08760]
103248547  APOA1; apolipoprotein A1 [KO:K08757]
103248652  POU2F3; POU class 2 homeobox 3 [KO:K09364]
103248693  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
103248791  TIRAP; TIR domain containing adaptor protein [KO:K05403]
103248933  [KO:K01370] [EC:3.4.22.36]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
Antioxid Redox Signal 15:2301-33 (2011)
DOI:10.1089/ars.2010.3792
Reference
PMID:20203069
  Authors
Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, Tsai KL, Chen KL, Wu YJ, Tsai CS, Chang LY, Kuo WW, Lee SD
  Title
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling.
  Journal
J Appl Physiol (1985) 108:1745-56 (2010)
DOI:10.1152/japplphysiol.00879.2009
Reference
PMID:17614937
  Authors
Chen XP, Zhang TT, Du GH
  Title
Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis?
  Journal
Cardiovasc Drug Rev 25:146-61 (2007)
DOI:10.1111/j.1527-3466.2007.00009.x
Reference
PMID:20181930
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Related
pathway
csab04020  Calcium signaling pathway
csab04115  p53 signaling pathway
csab04141  Protein processing in endoplasmic reticulum
csab04151  PI3K-Akt signaling pathway
csab04210  Apoptosis
csab04620  Toll-like receptor signaling pathway
csab04621  NOD-like receptor signaling pathway
csab04668  TNF signaling pathway
csab04670  Leukocyte transendothelial migration
csab04975  Fat digestion and absorption
csab04979  Cholesterol metabolism
csab05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   

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