KEGG   PATHWAY: aamp04151
Entry
aamp04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Arvicola amphibius (Eurasian water vole)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
aamp04151  PI3K-Akt signaling pathway
aamp04151

Other DBs
GO: 0043491
Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119800992  Egf; pro-epidermal growth factor [KO:K04357]
119807169  Tgfa; protransforming growth factor alpha [KO:K08774]
119814097  Areg; amphiregulin [KO:K09782]
119814061  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
119826229  Fgf2; fibroblast growth factor 2 [KO:K18497]
119800369  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
119800397  Fgf9; fibroblast growth factor 9 [KO:K04358]
119814352  Fgf7; fibroblast growth factor 7 [KO:K04358]
119808412  Fgf6; fibroblast growth factor 6 [KO:K04358]
119808698  Fgf10; fibroblast growth factor 10 [KO:K04358]
119802892  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
119812198  Fgf3; fibroblast growth factor 3 [KO:K04358]
119805412  Fgf16; fibroblast growth factor 16 [KO:K04358]
119825456  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
119805928  Fgf5; fibroblast growth factor 5 [KO:K04358]
119805944  Fgf4; fibroblast growth factor 4 [KO:K04358]
119813362  Fgf20; fibroblast growth factor 20 [KO:K04358]
119806542  Fgf19; fibroblast growth factor 19 [KO:K22603]
119802871  Fgf21; fibroblast growth factor 21 [KO:K22429]
119807114  Fgf23; fibroblast growth factor 23 [KO:K22428]
119801207  Ngf; beta-nerve growth factor [KO:K02582]
119815449  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
119807825  Ntf3; neurotrophin-3 isoform X1 [KO:K04356]
119802440  Ntf4; neurotrophin-4 [KO:K12457]
119805421  Ins; insulin [KO:K04526]
119803277  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
119802040  Igf2; insulin-like growth factor II [KO:K13769]
119825753  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
119823283  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
119810057  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
119826417  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
119801389  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
119803565  Kitlg; kit ligand isoform X1 [KO:K05461]
119803021  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
119822340  vascular endothelial growth factor A-like [KO:K05448]
119822341  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
119801722  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
119819672  Pgf; placenta growth factor isoform X1 [KO:K16859]
119812191  Vegfc; vascular endothelial growth factor C [KO:K05449]
119805399  Vegfd; LOW QUALITY PROTEIN: vascular endothelial growth factor D [KO:K05449]
119803884  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
119823684  Angpt1; angiopoietin-1 [KO:K05465]
119813161  Angpt2; angiopoietin-2 [KO:K05466]
119815725  Angpt4; angiopoietin-4 [KO:K05467]
119801198  Efna4; ephrin-A4 [KO:K05462]
119801284  Efna1; ephrin-A1 isoform X1 [KO:K05462]
119801318  Efna3; ephrin-A3 [KO:K05462]
119817904  Efna2; ephrin-A2 [KO:K05462]
119820458  Efna5; ephrin-A5 isoform X1 [KO:K05462]
119810480  Gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
119825112  Nrtn; neurturin [KO:K25414]
119817983  Artn; artemin isoform X1 [KO:K25415]
119811184  Pspn; persephin [KO:K25416]
119812357  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119811725  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
119803504  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
119821978  Erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
119811944  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
119827742  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
119805838  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119805848  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119811014  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
119811259  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119812129  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
119805744  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
119805841  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119805908  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119816377  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
119812353  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
119800869  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
119816678  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
119825604  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
119802616  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
119807129  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
119815474  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
119814133  Csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
119799770  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
119824393  Flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
119824995  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
119813056  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
119813736  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
119806540  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
119817629  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
119816636  Epha2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
119807136  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
119813014  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
119818434  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
119806329  Sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
119800249  Hras; GTPase HRas isoform X1 [KO:K02833]
119804230  GTPase KRas-like [KO:K07827]
119806318  Kras; GTPase KRas isoform X1 [KO:K07827]
119801497  Nras; GTPase NRas [KO:K07828]
119808272  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
119805902  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
119809903  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119827491  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
119824680  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119813356  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119820738  Irs1; insulin receptor substrate 1 [KO:K16172]
119826466  Tlr2; toll-like receptor 2 [KO:K10159]
119818005  Tlr4; toll-like receptor 4 [KO:K10160]
119814535  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
119824999  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
119817382  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
119825237  Cd19; B-lymphocyte antigen CD19 [KO:K06465]
119809104  Pik3ap1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
119811381  somatotropin [KO:K05438]
119817109  prolactin-6A1-like [KO:K05439]
119817110  prolactin-6A1-like [KO:K05439]
119817986  prolactin [KO:K05439]
119810132  Osm; oncostatin-M [KO:K05418]
119825919  Il2; interleukin-2 [KO:K05429]
119808459  Il6; interleukin-6 [KO:K05405]
119811116  Il4; interleukin-4 [KO:K05430]
119826635  Il7; interleukin-7 isoform X1 [KO:K05431]
121677052  interferon alpha-12-like [KO:K05414]
121677053  interferon alpha-12-like [KO:K05414]
121677054  interferon alpha-9-like [KO:K05414]
119817047  interferon alpha-12-like [KO:K05414]
119817048  LOW QUALITY PROTEIN: interferon alpha-12-like [KO:K05414]
119817051  interferon alpha-12-like [KO:K05414]
119817054  interferon alpha-12-like [KO:K05414]
119817055  interferon alpha-12-like [KO:K05414]
119817056  interferon alpha-12-like [KO:K05414]
119817057  interferon alpha-12-like [KO:K05414]
119817059  interferon alpha-12-like [KO:K05414]
119817275  interferon alpha-12-like [KO:K05414]
119805874  interferon alpha-12-like [KO:K05414]
119805875  interferon alpha-12-like [KO:K05414]
119805877  interferon alpha-12-like [KO:K05414]
119805879  interferon alpha-12-like [KO:K05414]
119805881  interferon alpha-12-like [KO:K05414]
119805882  interferon alpha-12-like [KO:K05414]
119805887  interferon alpha-12-like [KO:K05414]
119805888  interferon alpha-12-like [KO:K05414]
119805889  interferon alpha-12-like [KO:K05414]
119805892  interferon alpha-9-like [KO:K05414]
119816165  Ifnb1; LOW QUALITY PROTEIN: interferon beta [KO:K05415]
119817276  interferon beta-like [KO:K05415]
119824181  Epo; erythropoietin isoform X1 [KO:K05437]
119811411  Csf3; granulocyte colony-stimulating factor [KO:K05423]
119808721  Ghr; growth hormone receptor isoform X1 [KO:K05080]
119809891  Prlr; prolactin receptor isoform X1 [KO:K05081]
119809568  Osmr; oncostatin-M-specific receptor subunit beta [KO:K05057]
119817084  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
119823009  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
119804964  Il2rg; cytokine receptor common subunit gamma [KO:K05070]
119814257  interleukin-3 receptor subunit alpha-like isoform X1 [KO:K04737]
119800734  Il6r; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
119814441  Il4r; interleukin-4 receptor subunit alpha [KO:K05071]
119810072  Il7r; interleukin-7 receptor subunit alpha [KO:K05072]
119825470  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
119824686  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
119810451  Epor; erythropoietin receptor [KO:K05079]
119816863  Csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
119816123  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119822265  Jak2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
119811901  Jak3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
119807796  Col1a2; collagen alpha-2(I) chain [KO:K06236]
119811687  Col1a1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
119822685  Col2a1; LOW QUALITY PROTEIN: collagen alpha-1(II) chain [KO:K19719]
119804378  Col4a6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
119804832  Col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
119812350  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
119812512  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
119820835  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
119820836  Col4a3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
119808825  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
119809467  collagen alpha-4(VI) chain-like [KO:K06238]
119822631  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
119809703  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
119823034  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
119820261  Col6a3; collagen alpha-3(VI) chain [KO:K06238]
119814582  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
119823741  Col9a1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
119817443  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
119803917  Lama1; laminin subunit alpha-1 [KO:K05637]
119820891  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
119814499  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
119814925  Lama5; laminin subunit alpha-5 [KO:K06240]
119821243  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
119818873  Lamb1; laminin subunit beta-1 [KO:K05636]
119809168  Lamb2; laminin subunit beta-2 [KO:K06243]
119827216  Lamb3; laminin subunit beta-3 [KO:K06244]
119827740  Lamc1; laminin subunit gamma-1 [KO:K05635]
119827480  Lamc2; laminin subunit gamma-2 [KO:K06246]
119819149  Lamc3; laminin subunit gamma-3 [KO:K06247]
119811323  Chad; chondroadherin [KO:K06248]
119803793  Reln; reelin [KO:K06249] [EC:3.4.21.-]
119815510  Thbs1; thrombospondin-1 [KO:K16857]
119800800  Thbs3; thrombospondin-3 [KO:K04659]
119821374  Thbs2; thrombospondin-2 [KO:K04659]
119809736  Thbs4; thrombospondin-4 [KO:K04659]
119812455  cartilage oligomeric matrix protein [KO:K04659]
119820335  Fn1; fibronectin isoform X1 [KO:K05717]
119823299  Spp1; osteopontin [KO:K06250]
119813249  Vtn; vitronectin [KO:K06251]
119827810  Tnr; tenascin-R [KO:K06252]
119827975  Tnn; tenascin-N isoform X1 [KO:K06252]
119822456  Tnxb; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
119816998  Tnc; tenascin isoform X1 [KO:K06252]
119808130  Vwf; von Willebrand factor [KO:K03900]
119806454  bone sialoprotein 2 [KO:K06253]
119808745  Itga1; integrin alpha-1 [KO:K06480]
119809195  Itga2; integrin alpha-2 [KO:K06481]
119812773  Itga2b; integrin alpha-IIb [KO:K06476]
119812125  Itga3; integrin alpha-3 [KO:K06482]
119819439  Itga4; integrin alpha-4 [KO:K06483]
119822836  Itga5; integrin alpha-5 isoform X1 [KO:K06484]
119819436  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
119803481  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
119816642  Itga8; integrin alpha-8 [KO:K06584]
119810059  Itga9; LOW QUALITY PROTEIN: integrin alpha-9 [KO:K06585]
119800727  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
119809398  Itga11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
119818595  Itgav; integrin alpha-V isoform X1 [KO:K06487]
119802025  Itgb1; integrin beta-1 [KO:K05719]
119813347  Itgb3; integrin beta-3 [KO:K06493]
119811868  Itgb4; integrin beta-4 isoform X1 [KO:K06525]
119824871  Itgb5; integrin beta-5 isoform X1 [KO:K06588]
119819234  Itgb6; integrin beta-6 isoform X1 [KO:K06589]
119823057  Itgb7; integrin beta-7 [KO:K06590]
119819639  Itgb8; integrin beta-8 [KO:K06591]
119823930  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
119816315  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119810503  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119826317  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119808979  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119817743  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119812102  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119809677  F2r; proteinase-activated receptor 1 [KO:K03914]
119799823  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
119808071  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
119826703  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
119811565  Lpar2; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 2 [KO:K04291]
119800698  Lpar3; lysophosphatidic acid receptor 3 [KO:K04294]
119805467  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
119805945  LOW QUALITY PROTEIN: lysophosphatidic acid receptor 4-like [KO:K04275]
119808436  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
119800095  Lpar6; lysophosphatidic acid receptor 6 [KO:K04273]
119816464  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
119824505  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
119806987  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
119826318  Gnb4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
119809908  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
119800221  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
119802568  Gng3; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
119817037  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
119827664  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
119800840  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
119816264  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
119811057  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
119819148  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
119821677  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
119825980  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
119826883  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
119807595  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
119801689  Gng14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
119807698  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
119812877  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
119808263  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
119812508  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
119819055  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
119812089  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
119812321  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
119813044  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
119813272  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
119816370  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
119810200  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
119823279  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
119818627  Tsc1; hamartin isoform X1 [KO:K07206]
119811857  Tsc2; tuberin isoform X1 [KO:K07207]
119807890  Rheb; GTP-binding protein Rheb [KO:K07208]
119812888  Mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
119816408  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
119813137  Rptor; LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
119813700  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
119801210  Eif4e; eukaryotic translation initiation factor 4E [KO:K03259]
119817130  Eif4e1b; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
119805270  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-like [KO:K03259]
119805282  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-like [KO:K03259]
119826625  eukaryotic translation initiation factor 4E-like [KO:K03259]
119820579  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
119814876  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
119813254  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
119809415  eukaryotic translation initiation factor 4B-like [KO:K03258]
119822551  Eif4b; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
119821193  40S ribosomal protein S6-like [KO:K02991]
119818034  Rps6; 40S ribosomal protein S6 [KO:K02991]
119807118  40S ribosomal protein S6-like [KO:K02991]
119800250  40S ribosomal protein S6-like [KO:K02991]
119812144  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119801836  Pkn1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
119800764  Pkn2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
119818697  Pkn3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
119821263  Sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
119814095  Sgk2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
119826673  serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
119818643  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119820487  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119827246  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119806257  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
119803887  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
119806133  Pten; LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119801433  Them4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
119811275  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
119812170  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
119810133  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
119820863  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
119814870  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
119823069  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
119803585  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
119799986  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
119809096  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
119818532  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
119827484  Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
119822257  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
119824016  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
119818479  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
119818916  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
119827044  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
119823256  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
119804726  heat shock protein HSP 90-alpha-like [KO:K04079]
119819465  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
119826175  heat shock protein HSP 90-beta-like [KO:K04079]
119803322  Hsp90b1; LOW QUALITY PROTEIN: endoplasmin [KO:K09487]
119810757  Cdc37; hsp90 co-chaperone Cdc37 isoform X1 [KO:K09554]
119801276  Crtc2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
119827974  Phlpp1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
119802161  Phlpp2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
119819884  Tcl1a; LOW QUALITY PROTEIN: T-cell leukemia/lymphoma protein 1A [KO:K10167]
119805209  Mtcp1; protein p13 MTCP-1 [KO:K16837]
119807052  Nos3; LOW QUALITY PROTEIN: nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
119813231  Brca1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
119824224  Gsk3b; LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
119808488  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
119802804  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
119814634  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
119800022  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
119819699  G6pc2; LOW QUALITY PROTEIN: glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
119812167  G6pc1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
119812873  G6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
119822940  Myc; myc proto-oncogene protein [KO:K04377]
119827335  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
119823049  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
119807071  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
119803337  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
119803317  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119807882  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119808297  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
119823258  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
119820977  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
119804174  G1/S-specific cyclin-E2-like [KO:K06626]
119826163  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
119820620  Foxo3; forkhead box protein O3 [KO:K09408]
119802072  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
119827881  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119814996  Bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
119808319  Ywhaq; 14-3-3 protein theta [KO:K16197]
119815003  Ywhab; LOW QUALITY PROTEIN: 14-3-3 protein beta/alpha [KO:K16197]
119823278  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
119804234  14-3-3 protein theta-like [KO:K16197]
119826292  14-3-3 protein zeta/delta [KO:K16197]
119812405  Ywhae; 14-3-3 protein epsilon [KO:K06630]
119804628  Ywhah; 14-3-3 protein eta [KO:K16198]
119825607  Ywhag; 14-3-3 protein gamma [KO:K16198]
119820525  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
119815691  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
119827718  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
119817619  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
119820446  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
119819075  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
119822546  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
119814789  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
119821362  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
119801303  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
119826298  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
119806715  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
119807891  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
119822471  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
119800874  Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
119818907  Rxra; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
119823130  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
119804668  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119816335  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
119812324  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
119803437  Rela; transcription factor p65 isoform X1 [KO:K04735]
119801102  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119820985  Myb; transcriptional activator Myb isoform X1 [KO:K09420]
119803501  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
119818608  cellular tumor antigen p53-like [KO:K04451]
119813419  Tp53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
aamp00010  Glycolysis / Gluconeogenesis
aamp04010  MAPK signaling pathway
aamp04012  ErbB signaling pathway
aamp04062  Chemokine signaling pathway
aamp04064  NF-kappa B signaling pathway
aamp04068  FoxO signaling pathway
aamp04110  Cell cycle
aamp04115  p53 signaling pathway
aamp04150  mTOR signaling pathway
aamp04210  Apoptosis
aamp04370  VEGF signaling pathway
aamp04510  Focal adhesion
aamp04620  Toll-like receptor signaling pathway
aamp04630  JAK-STAT signaling pathway
aamp04662  B cell receptor signaling pathway
aamp04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

DBGET integrated database retrieval system