KEGG   PATHWAY: anu04010
Entry
anu04010                    Pathway                                
Name
MAPK signaling pathway - Arvicanthis niloticus (African grass rat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
anu04010  MAPK signaling pathway
anu04010

Other DBs
GO: 0000165
Organism
Arvicanthis niloticus (African grass rat) [GN:anu]
Gene
117722924  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
117710818  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
117715086  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
117705045  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117716078  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
117695376  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
117711804  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
117710364  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
117718733  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
117716104  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
117720397  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
117693330  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
117706223  Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
117715240  Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
117710687  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
117713497  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
117718775  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
117703087  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
117711440  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
117719323  Cacng2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
117712063  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
117711917  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
117711948  Cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
117701074  Cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
117700666  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
117701089  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
117723055  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117706647  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117709948  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
117717067  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
117701003  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
117698098  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
117715105  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
117723254  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
117705132  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117705334  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117706625  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117712605  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
117701820  calcineurin subunit B type 1-like [KO:K06268]
117709539  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
117693363  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
117700436  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117703370  Rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
117709994  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
117717216  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
117720118  Rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
117707165  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
117711363  Nf1; neurofibromin isoform X1 [KO:K08052]
117700410  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
117693413  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
117707587  Rap1a; ras-related protein Rap-1A [KO:K04353]
117696422  Rap1b; ras-related protein Rap-1b [KO:K07836]
117707556  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
117715660  Tgfa; protransforming growth factor alpha [KO:K08774]
117712449  Ereg; proepiregulin [KO:K09784]
117712996  Areg; amphiregulin [KO:K09782]
117720104  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
117706759  Fgf2; fibroblast growth factor 2 [KO:K18497]
117721842  Fgf20; fibroblast growth factor 20 [KO:K04358]
117696768  Fgf3; fibroblast growth factor 3 [KO:K04358]
117697008  Fgf4; fibroblast growth factor 4 [KO:K04358]
117705560  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
117715525  Fgf6; fibroblast growth factor 6 [KO:K04358]
117715766  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
117706309  Fgf9; fibroblast growth factor 9 [KO:K04358]
117724025  Fgf10; fibroblast growth factor 10 [KO:K04358]
117699942  Fgf5; fibroblast growth factor 5 [KO:K04358]
117694706  Fgf16; fibroblast growth factor 16 [KO:K04358]
117703422  Fgf7; fibroblast growth factor 7 [KO:K04358]
117710953  Fgf18; fibroblast growth factor 18 [KO:K04358]
117696425  Fgf22; fibroblast growth factor 22 [KO:K04358]
117695519  Fgf19; fibroblast growth factor 19 [KO:K22603]
117697847  Fgf21; fibroblast growth factor 21 [KO:K22429]
117715613  Fgf23; fibroblast growth factor 23 [KO:K22428]
117706566  Ngf; beta-nerve growth factor [KO:K02582]
117704234  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
117715189  Ntf3; neurotrophin-3 isoform X1 [KO:K04356]
117714866  Ntf4; neurotrophin-4 [KO:K12457]
117722990  insulin-2 isoform X1 [KO:K04526]
117723507  insulin-2 [KO:K04526]
117696437  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
117715108  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
117698163  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
117718445  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
117699878  Pdgfd; platelet-derived growth factor D [KO:K05450]
117707723  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
117706885  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
117696325  Kitlg; kit ligand isoform X1 [KO:K05461]
117711914  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
117722213  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
117716334  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
117697288  Pgf; placenta growth factor [KO:K16859]
117695345  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
117721236  Vegfc; vascular endothelial growth factor C [KO:K05449]
117720586  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
117719114  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
117721576  Angpt2; angiopoietin-2 [KO:K05466]
117703641  Angpt4; angiopoietin-4 [KO:K05467]
117722397  Efna5; ephrin-A5 isoform X1 [KO:K05462]
117707050  Efna1; ephrin-A1 [KO:K05462]
117707051  Efna3; ephrin-A3 isoform X1 [KO:K05462]
117707085  Efna4; ephrin-A4 [KO:K05462]
117696126  Efna2; ephrin-A2 [KO:K05462]
117723666  Gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
117705570  Nrtn; neurturin [KO:K25414]
117709501  Artn; artemin isoform X1 [KO:K25415]
117705496  Pspn; persephin [KO:K25416]
117712744  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
117710649  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
117696453  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
117705699  Erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
117722071  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
117704198  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117712554  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117713886  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
117711825  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
117707235  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
117713532  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
117697878  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
117715978  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
117712829  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
117719688  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
117720183  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
117700528  LOW QUALITY PROTEIN: mast/stem cell growth factor receptor Kit-like [KO:K05091] [EC:2.7.10.1]
117713018  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
117697747  Flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
117697779  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
117710955  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
117712867  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
117720551  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
117709160  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
117709018  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
117715252  Ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
117711195  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
117716781  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
117716983  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
117706664  Hras; GTPase HRas isoform X1 [KO:K02833]
117714902  Kras; GTPase KRas isoform X1 [KO:K07827]
117706966  Nras; GTPase NRas [KO:K07828]
117705110  Rras; ras-related protein R-Ras [KO:K07829]
117724680  Rras2; ras-related protein R-Ras2 [KO:K07830]
117693357  Mras; ras-related protein M-Ras [KO:K07831]
117694504  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
117721084  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117715476  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117699009  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117696143  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
117707647  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
117717711  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117693439  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117708566  Mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
117696340  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
117700123  Rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
117709038  Rps6ka1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
117694159  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
117695270  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
117719125  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
117694184  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
117716269  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
117719150  Myc; myc proto-oncogene protein [KO:K04377]
117695826  myc proto-oncogene protein-like [KO:K04377]
117695848  myc proto-oncogene protein-like [KO:K04377]
117696009  myc proto-oncogene protein-like [KO:K04377]
117722353  Srf; serum response factor isoform X1 [KO:K04378]
117697448  Fos; proto-oncogene c-Fos [KO:K04379]
117710422  Mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
117709589  Stmn1; stathmin [KO:K04381]
117716597  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
117700374  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
117703209  Pla2g4f; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
117703336  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
117704087  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
117704168  Pla2g4b; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
117724681  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
117704255  Il1a; interleukin-1 alpha [KO:K04383]
117704054  Il1b; interleukin-1 beta isoform X1 [KO:K04519]
117713589  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
117716112  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
117697375  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
117714946  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117722628  Il1r1; interleukin-1 receptor type 1 [KO:K04386]
117718055  Il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
117708549  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
117693333  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
117716367  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
117700780  Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
117719855  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
117697870  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117718817  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117710799  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
117708461  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
117723297  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
117721984  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
117710914  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117724473  Daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
117693388  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
117694459  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
117718426  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
117703656  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
117715599  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
117713452  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
117696104  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
117719404  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
117700141  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
117714365  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
117716796  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
117722194  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
117722768  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
117715539  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
117717699  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
117704245  Stk4; serine/threonine-protein kinase 4 [KO:K04411]
117719155  Stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
117708898  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
117714402  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
117723859  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
117718167  Map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
117719731  Map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
117710722  Map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
117696947  Map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
117707223  Map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
117723358  Map3k21; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
117718612  Map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
117717508  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
117702926  Map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
117708406  Map3k6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
117701010  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117698575  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117700162  Map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
117722033  Taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
117697895  Taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
117711258  Taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
117710639  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
117697775  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117710465  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
117710811  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
117703326  Mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
117718876  Mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
117710645  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
117694155  Flna; filamin-A isoform X1 [KO:K04437]
117717801  Crkl; crk-like protein [KO:K04438]
117710148  Crk; adapter molecule crk isoform X1 [KO:K04438]
117710144  Arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
117711031  Arrb2; beta-arrestin-2 [KO:K04439]
117705037  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117709966  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117724304  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117724423  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117718601  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
117718602  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117698177  Mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
117716254  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
117693694  Mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
117697424  Rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
117711631  Rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
117704695  Cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
117719854  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
117723386  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
117709069  Jun; transcription factor AP-1 [KO:K04448]
117721921  Jund; transcription factor jun-D [KO:K04449]
117703314  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117710574  Tp53; cellular tumor antigen p53 [KO:K04451]
117696642  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
117697364  Max; protein max isoform X1 [KO:K04453]
117700449  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
117697658  Hspb1; heat shock protein beta-1 [KO:K04455]
117697536  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117706636  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117721481  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117696996  Ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
117696596  Ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
117716152  Ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
117716278  Ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
117711593  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
117714870  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117693535  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117709728  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117713863  Dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117704371  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117721664  Dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117696551  Dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
117695355  Dusp9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
117716531  Dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
117710738  Dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
117700548  Ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
117716788  Ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
117705832  heat shock cognate 71 kDa protein-like [KO:K03283]
117698957  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
117724403  heat shock 70 kDa protein 1A [KO:K03283]
117724405  heat shock 70 kDa protein 1A [KO:K03283]
117724950  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
117724951  heat shock 70 kDa protein 1A [KO:K03283]
117712747  Hspa6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
117699356  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
117710519  Mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
117718915  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
117711275  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
117701914  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
117712831  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
117721547  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
117695513  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117710510  Nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
117707042  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
117706853  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
117722582  Rela; transcription factor p65 [KO:K04735]
117709369  Relb; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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MAP kinases.
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Pharmacol Ther 93:193-202 (2002)
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PMID:12947395
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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PMID:12676795
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Huang EJ, Reichardt LF.
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Gene 320:3-21 (2003)
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PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
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KO pathway
ko04010   
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