KEGG   PATHWAY: hgl04014
Entry
hgl04014                    Pathway                                
Name
Ras signaling pathway - Heterocephalus glaber (naked mole-rat)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
hgl04014  Ras signaling pathway
hgl04014

Other DBs
GO: 0032318
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
106007527  Egf; epidermal growth factor [KO:K04357]
101723712  Tgfa; transforming growth factor alpha [KO:K08774]
101717777  Fgf1; fibroblast growth factor 1 [KO:K18496]
101720583  Fgf2; fibroblast growth factor 2 [KO:K18497]
101718946  Fgf18; fibroblast growth factor 18 [KO:K04358]
101714076  Fgf7; fibroblast growth factor 7 [KO:K04358]
101710458  Fgf3; fibroblast growth factor 3 [KO:K04358]
101707706  Fgf17; fibroblast growth factor 17 [KO:K04358]
101707578  Fgf10; fibroblast growth factor 10 [KO:K04358]
101700281  Fgf5; fibroblast growth factor 5 [KO:K04358]
101701734  Fgf20; fibroblast growth factor 20 [KO:K04358]
101711919  Fgf4; fibroblast growth factor 4 [KO:K04358]
101701530  Fgf9; fibroblast growth factor 9 [KO:K04358]
101720536  Fgf22; fibroblast growth factor 22 [KO:K04358]
101699438  Fgf8; fibroblast growth factor 8 [KO:K04358]
101716030  Fgf16; fibroblast growth factor 16 [KO:K04358]
101722884  Fgf6; fibroblast growth factor 6 [KO:K04358]
101710827  Fgf19; fibroblast growth factor 19 [KO:K22603]
101717974  Fgf21; fibroblast growth factor 21 [KO:K22429]
101713698  Fgf23; fibroblast growth factor 23 [KO:K22428]
101722226  Ngf; nerve growth factor [KO:K02582]
101704465  Bdnf; brain derived neurotrophic factor [KO:K04355]
101696620  Ntf3; neurotrophin 3 [KO:K04356]
101710673  Ntf4; neurotrophin 4 [KO:K12457]
101719971  Ins; insulin [KO:K04526]
101707684  Igf1; insulin like growth factor 1 [KO:K05459]
101720309  Igf2; insulin like growth factor 2 [KO:K13769]
101725739  Pdgfa; platelet derived growth factor subunit A [KO:K04359]
101698830  Pdgfb; platelet derived growth factor subunit B [KO:K17386]
101696768  Pdgfd; platelet derived growth factor D [KO:K05450]
101710927  Pdgfc; platelet derived growth factor C [KO:K05450]
101709756  Csf1; colony stimulating factor 1 [KO:K05453]
101697092  Kitlg; KIT ligand [KO:K05461]
101698597  Flt3lg; fms related tyrosine kinase 3 ligand [KO:K05454]
101702403  Vegfa; vascular endothelial growth factor A [KO:K05448]
101700074  Vegfb; vascular endothelial growth factor B [KO:K16858]
101725085  Pgf; placental growth factor [KO:K16859]
101719504  Vegfc; vascular endothelial growth factor C [KO:K05449]
101726005  Vegfd; vascular endothelial growth factor D [KO:K05449]
101707056  Hgf; hepatocyte growth factor [KO:K05460]
101725800  Angpt1; angiopoietin 1 [KO:K05465]
101710564  Angpt2; angiopoietin 2 [KO:K05466]
101717722  angiopoietin-4 [KO:K05467]
101718402  angiopoietin-4-like [KO:K05467]
101718756  angiopoietin-4-like [KO:K05467]
101706062  angiopoietin-4-like [KO:K05467]
101724262  Efna5; ephrin A5 [KO:K05462]
101711422  Efna4; ephrin A4 [KO:K05462]
101703816  Efna2; ephrin A2 [KO:K05462]
101710579  Efna3; ephrin A3 [KO:K05462]
101709969  Efna1; ephrin A1 [KO:K05462]
101723771  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101700324  Fgfr1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
101709077  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101711651  Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101700214  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101724251  Ngfr; nerve growth factor receptor [KO:K02583]
101724441  Ntrk1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
101720037  Ntrk2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
101722168  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
101710224  Igf1r; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101697360  Pdgfra; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101721151  Pdgfrb; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101719513  Csf1r; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101726400  Kit; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
101713724  Flt3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
101711333  Flt1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
101702013  Flt4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
101726029  Kdr; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
101725772  Met; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
101710501  Tek; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
101714513  Epha2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
101717035  Grb2; growth factor receptor bound protein 2 [KO:K04364]
101721604  Gab1; GRB2 associated binding protein 1 [KO:K09593]
101719954  Gab2; GRB2 associated binding protein 2 [KO:K08091]
101717434  Shc1; SHC adaptor protein 1 [KO:K06279]
101723930  Shc2; SHC adaptor protein 2 [KO:K17447]
101715363  Shc3; SHC adaptor protein 3 [KO:K17448]
101717788  Shc4; SHC adaptor protein 4 [KO:K17449]
101701336  Ptpn11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
101707893  Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
101701753  Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
101705192  Plcg1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
101715321  Plcg2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
101699646  Rasgrp1; RAS guanyl releasing protein 1 [KO:K04350]
101714183  Rasgrp2; RAS guanyl releasing protein 2 [KO:K12361]
101717811  Rasgrp3; RAS guanyl releasing protein 3 [KO:K12362]
101708596  Rasgrp4; RAS guanyl releasing protein 4 [KO:K12363]
101714129  T-cell receptor beta-1 chain C region [KO:K10785]
101716577  Zap70; zeta-chain (TCR) associated protein kinase 70kDa [KO:K07360] [EC:2.7.10.2]
101711455  Lat; linker for activation of T-cells [KO:K07362]
101719078  Htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
101703108  Gnb1; G protein subunit beta 1 [KO:K04536]
101711479  Gnb2; G protein subunit beta 2 [KO:K04537]
101718903  Gnb3; G protein subunit beta 3 [KO:K07825]
101714761  Gnb4; G protein subunit beta 4 [KO:K04538]
101698655  Gnb5; G protein subunit beta 5 [KO:K04539]
101719408  Gng2; G protein subunit gamma 2 [KO:K07826]
101726057  Gng3; G protein subunit gamma 3 [KO:K04540]
101696772  Gng4; G protein subunit gamma 4 [KO:K04541]
101718403  Gng5; G protein subunit gamma 5 [KO:K04542]
101711281  Gng7; G protein subunit gamma 7 [KO:K04543]
106007571  Gng8; G protein subunit gamma 8 [KO:K04544]
106007577  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101721082  Gng11; G protein subunit gamma 11 [KO:K04546]
101725110  Gng12; G protein subunit gamma 12 [KO:K04347]
101709292  Gng13; G protein subunit gamma 13 [KO:K04547]
101720513  Gngt1; G protein subunit gamma transducin 1 [KO:K04548]
101721190  Gngt2; G protein subunit gamma transducin 2 [KO:K04549]
101707235  Prkaca; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101721558  Prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101699491  Rasgrf1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
101698054  Rasgrf2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
101720185  Grin1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
101716707  Grin2a; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
101723091  Grin2b; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
101704751  Calm2; calmodulin 2 [KO:K02183]
101713746  Calm1; calmodulin 1 [KO:K02183]
101724181  Calm3; calmodulin 3 [KO:K02183]
101716865  Calml3; calmodulin like 3 [KO:K02183]
101725309  Calml5; calmodulin like 5 [KO:K02183]
101714220  calmodulin-like [KO:K02183]
101712577  Calml6; calmodulin like 6 [KO:K02183]
101707626  Calml4; calmodulin like 4 [KO:K02183]
101716053  Hras; HRas proto-oncogene, GTPase [KO:K02833]
101718997  Kras; KRAS proto-oncogene, GTPase [KO:K07827]
101719269  Nras; neuroblastoma RAS viral oncogene homolog [KO:K07828]
101709042  Mras; muscle RAS oncogene homolog [KO:K07831]
101723449  Rras; related RAS viral (r-ras) oncogene homolog [KO:K07829]
101722671  Rras2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
101719382  Nf1; neurofibromin 1 [KO:K08052]
101713771  Rasa1; RAS p21 protein activator 1 [KO:K04352]
101725433  Rasa2; RAS p21 protein activator 2 [KO:K08053]
101724956  Rasa3; RAS p21 protein activator 3 [KO:K12380]
101720607  Rasa4b; RAS p21 protein activator 4B [KO:K17630]
101710189  Syngap1; synaptic Ras GTPase activating protein 1 [KO:K17631]
101697586  Rasal1; RAS protein activator like 1 [KO:K17632]
101710345  Rasal2; RAS protein activator like 2 [KO:K17633]
101725297  Rasal3; RAS protein activator like 3 [KO:K17634]
101707605  Rassf1; Ras association domain family member 1 [KO:K09850]
101697054  Rassf5; Ras association domain family member 5 [KO:K08015]
101704401  Stk4; serine/threonine kinase 4 [KO:K04411]
101711984  Tiam1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
101706434  Rac1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
101725000  Rac2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
101723777  Rac3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
101713465  Pak1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
101710712  Pak2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
101712811  Pak3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
101720492  Pak4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
101697197  Pak5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
101706200  Pak6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
101710109  Rhoa; ras homolog family member A [KO:K04513]
101711934  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
101715249  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
101712941  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
101718815  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
101717096  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101703691  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
101700695  Akt1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
101719164  Akt2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
101701289  Akt3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
101712077  Ikbkg; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
101719306  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
101711077  Ikbkb; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101696485  Nfkb1; nuclear factor kappa B subunit 1 [KO:K02580]
101716738  Rela; RELA proto-oncogene, NF-kB subunit [KO:K04735]
101726042  Bad; BCL2 associated agonist of cell death [KO:K02158]
101713410  Bcl2l1; BCL2 like 1 [KO:K04570]
101720105  bcl-2-like protein 1 [KO:K04570]
101714065  Foxo4; forkhead box O4 [KO:K12358]
101698642  Faslg; Fas ligand [KO:K04389]
101708298  Ralgapa1; Ral GTPase activating protein catalytic alpha subunit 1 [KO:K25768]
101726219  Ralgapa2; Ral GTPase activating protein catalytic alpha subunit 2 [KO:K25768]
101701956  ral GTPase-activating protein subunit alpha-1-like [KO:K25768]
101725900  Ralgapb; Ral GTPase activating protein non-catalytic beta subunit [KO:K25769]
101700047  Ralgds; ral guanine nucleotide dissociation stimulator [KO:K08732]
101714703  Rgl1; ral guanine nucleotide dissociation stimulator like 1 [KO:K17635]
101717973  Rgl2; ral guanine nucleotide dissociation stimulator like 2 [KO:K17636]
101706563  Rala; RAS like proto-oncogene A [KO:K07834]
101699253  Ralb; RAS like proto-oncogene B [KO:K07835]
101700438  Pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
101713528  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
101705272  Exoc2; exocyst complex component 2 [KO:K17637]
101713766  Tbk1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
101699322  Rel; REL proto-oncogene, NF-kB subunit [KO:K09254]
101698286  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101715259  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
101712980  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
101711056  Ralbp1; ralA binding protein 1 [KO:K08773]
101701374  Cdc42; cell division cycle 42 [KO:K04393]
101711269  cell division control protein 42 homolog [KO:K04393]
101702949  Afdn; afadin, adherens junction formation factor [KO:K05702]
101725341  Shoc2; SHOC2, leucine rich repeat scaffold protein [KO:K19613]
101721841  Raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
101715628  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101707562  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101706099  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101702687  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101703405  Pla1a; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
101708051  Pla2g3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
101699902  Pla2g1b; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
101696546  Pla2g10; phospholipase A2 group X [KO:K01047] [EC:3.1.1.4]
101702299  Pla2g12b; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
101711308  Pla2g5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
101725417  Pla2g2e; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
101725805  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
101726523  Pla2g2f; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
101696389  Pla2g2c; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
101710939  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
101711672  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
101706727  Pla2g12a; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
101705849  Pla2g4e; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
101706202  Pla2g4f; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
101703792  Pla2g4b; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
101717491  Pla2g4d; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
101713091  Pla2g4c; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
101704061  Pla2g4a; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
101710669  Pla2g6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
101712273  Pla2g16; HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101713128  HRAS-like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101725319  Elk1; ELK1, ETS transcription factor [KO:K04375]
101717727  Ets1; ETS proto-oncogene 1, transcription factor [KO:K02678]
101715881  Ets2; ETS proto-oncogene 2, transcription factor [KO:K21932]
101708618  Brap; BRCA1 associated protein [KO:K10632] [EC:2.3.2.27]
101698408  Ksr1; kinase suppressor of ras 1 [KO:K14958]
101710530  Ksr2; kinase suppressor of ras 2 [KO:K18529] [EC:2.7.11.1]
101700232  Rapgef5; Rap guanine nucleotide exchange factor 5 [KO:K08019]
101698757  Rap1a; RAP1A, member of RAS oncogene family [KO:K04353]
101726671  Rap1b; RAP1B, member of RAS oncogene family [KO:K07836]
101714409  ras-related protein Rap-1b [KO:K07836]
101706315  Plce1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
101716044  Prkca; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
101722702  Prkcb; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
101698346  Prkcg; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
101726644  Rin1; Ras and Rab interactor 1 [KO:K17638]
101724428  Abl1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
101704827  Abl2; ABL proto-oncogene 2, non-receptor tyrosine kinase [KO:K08887] [EC:2.7.10.2]
101710661  Rab5a; RAB5A, member RAS oncogene family [KO:K07887]
101724150  Rab5b; RAB5B, member RAS oncogene family [KO:K07888]
101696324  Rab5c; RAB5C, member RAS oncogene family [KO:K07889]
101703058  Arf6; ADP ribosylation factor 6 [KO:K07941]
101701143  ADP-ribosylation factor 6-like [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
hgl04010  MAPK signaling pathway
hgl04015  Rap1 signaling pathway
hgl04020  Calcium signaling pathway
hgl04144  Endocytosis
hgl04151  PI3K-Akt signaling pathway
hgl04660  T cell receptor signaling pathway
hgl04720  Long-term potentiation
hgl04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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