KEGG   PATHWAY: lcat04151
Entry
lcat04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Lemur catta (Ring-tailed lemur)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
lcat04151  PI3K-Akt signaling pathway
lcat04151

Other DBs
GO: 0043491
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123627755  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123637024  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
123624720  EREG; proepiregulin [KO:K09784]
123624721  AREG; amphiregulin [KO:K09782]
123637917  FGF1; fibroblast growth factor 1 [KO:K18496]
123638827  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
123637964  FGF18; fibroblast growth factor 18 [KO:K04358]
123622454  FGF7; fibroblast growth factor 7 [KO:K04358]
123632208  FGF22; fibroblast growth factor 22 [KO:K04358]
123640719  FGF6; fibroblast growth factor 6 [KO:K04358]
123648417  FGF10; fibroblast growth factor 10 [KO:K04358]
123649197  FGF9; fibroblast growth factor 9 [KO:K04358]
123641892  FGF4; fibroblast growth factor 4 [KO:K04358]
123626358  FGF20; fibroblast growth factor 20 [KO:K04358]
123626704  FGF17; fibroblast growth factor 17 [KO:K04358]
123642170  FGF3; fibroblast growth factor 3 [KO:K04358]
123650103  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123627370  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
123642172  FGF19; fibroblast growth factor 19 [KO:K22603]
123623856  FGF21; fibroblast growth factor 21 [KO:K22429]
123640148  FGF23; fibroblast growth factor 23 [KO:K22428]
123635087  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
123642542  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
123640712  NTF3; neurotrophin-3 [KO:K04356]
123623840  NTF4; neurotrophin-4 [KO:K12457]
123642915  INS; insulin [KO:K04526]
123639374  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123642914  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
123632534  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123639237  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
123638516  PDGFC; platelet-derived growth factor C [KO:K05450]
123641878  PDGFD; platelet-derived growth factor D [KO:K05450]
123635010  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
123639466  KITLG; kit ligand isoform X1 [KO:K05461]
123631928  VEGFA; vascular endothelial growth factor A [KO:K05448]
123641432  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
123646604  PGF; placenta growth factor isoform X1 [KO:K16859]
123638671  VEGFC; vascular endothelial growth factor C [KO:K05449]
123628106  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
123647201  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123644674  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
123626572  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
123622470  ANGPT4; angiopoietin-4 [KO:K05467]
123632816  EFNA2; ephrin-A2 [KO:K05462]
123648052  EFNA5; ephrin-A5 [KO:K05462]
123634049  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
123634050  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
123634052  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
123648068  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
123636477  NRTN; neurturin [KO:K25414]
123634238  ARTN; artemin isoform X1 [KO:K25415]
123636107  PSPN; persephin [KO:K25416]
123647442  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123620839  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
123639666  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
123643488  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
123626670  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123650464  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
123622909  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
123623468  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
123620742  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
123634790  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
123634791  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
123645777  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
123635850  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
123645036  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123624835  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
123638073  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
123638075  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
123624843  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
123648920  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
123648918  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
123621678  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
123624844  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
123646854  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123645784  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
123635942  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
123649762  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
123650792  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123636823  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123649468  SOS2; son of sevenless homolog 2 [KO:K03099]
123642937  HRAS; GTPase HRas isoform X1 [KO:K02833]
123639921  KRAS; GTPase KRas [KO:K07827]
123635081  NRAS; GTPase NRas [KO:K07828]
123638125  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123631625  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123633879  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123632778  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
123626228  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123643492  IRS1; insulin receptor substrate 1 [KO:K16172]
123638501  TLR2; toll-like receptor 2 [KO:K10159]
123646094  TLR4; toll-like receptor 4 [KO:K10160]
123631548  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123643379  LOW QUALITY PROTEIN: uncharacterized protein LOC123643379 [KO:K06856]
123643441  immunoglobulin gamma-1 heavy chain-like [KO:K06856]
123643449  immunoglobulin delta heavy chain-like [KO:K06856]
123643456  immunoglobulin epsilon heavy chain-like [KO:K06856]
123643464  uncharacterized protein LOC123643464 [KO:K06856]
123646461  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
123632520  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
123650186  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
123621267  somatotropin [KO:K05438]
123638329  PRL; prolactin [KO:K05439]
123625829  OSM; oncostatin-M [KO:K05418]
123637712  IL2; interleukin-2 [KO:K05429]
123646908  IL6; interleukin-6 [KO:K05405]
123637755  IL4; interleukin-4 isoform X1 [KO:K05430]
123644763  IL7; interleukin-7 isoform X1 [KO:K05431]
123645632  interferon alpha-5-like [KO:K05414]
123645638  interferon alpha-10-like [KO:K05414]
123645752  interferon alpha-5-like [KO:K05414]
123645754  interferon alpha-5-like [KO:K05414]
123645755  interferon alpha-5-like [KO:K05414]
123645758  interferon alpha-10-like [KO:K05414]
123646712  interferon alpha-5-like [KO:K05414]
123646249  IFNB1; interferon beta [KO:K05415]
123631644  EPO; erythropoietin isoform X1 [KO:K05437]
123620853  CSF3; granulocyte colony-stimulating factor [KO:K05423]
123648039  GHR; growth hormone receptor [KO:K05080]
123648111  PRLR; prolactin receptor isoform X1 [KO:K05081]
123648057  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
123623027  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
123639296  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
123628744  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
123628072  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
123634024  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
123632505  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
123647965  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
123630696  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
123630694  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
123634704  EPOR; erythropoietin receptor [KO:K05079]
123635757  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
123635562  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
123646669  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
123639564  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
123647251  COL1A2; collagen alpha-2(I) chain [KO:K06236]
123620722  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
123640465  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
123644098  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
123644099  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
123649315  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
123649345  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
123628143  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
123628302  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
123628643  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
123643847  collagen alpha-4(VI) chain-like [KO:K06238]
123643905  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
123630827  COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
123630829  COL6A1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
123643240  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
123622760  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
123632162  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
123635697  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
123621697  LAMA1; laminin subunit alpha-1 [KO:K05637]
123633252  LAMA2; laminin subunit alpha-2 [KO:K05637]
123621656  laminin subunit alpha-3-like isoform X1 [KO:K06240]
123622511  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
123633180  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
123647712  LAMB1; laminin subunit beta-1 [KO:K05636]
123623287  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
123626918  LAMB3; laminin subunit beta-3 [KO:K06244]
123647710  LAMB4; laminin subunit beta-4 [KO:K06245]
123627028  LAMC1; laminin subunit gamma-1 [KO:K05635]
123626869  LAMC2; laminin subunit gamma-2 [KO:K06246]
123646589  LAMC3; laminin subunit gamma-3 [KO:K06247]
123620468  CHAD; chondroadherin [KO:K06248]
123647073  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
123621930  THBS1; thrombospondin-1 [KO:K16857]
123638557  cartilage oligomeric matrix protein [KO:K04659]
123648362  THBS4; thrombospondin-4 [KO:K04659]
123633462  THBS2; thrombospondin-2 [KO:K04659]
123634060  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
123644039  FN1; fibronectin isoform X1 [KO:K05717]
123627314  SPP1; osteopontin [KO:K06250]
123620286  VTN; vitronectin [KO:K06251]
123631770  TNXB; tenascin-X [KO:K06252]
123646646  TNC; tenascin isoform X1 [KO:K06252]
123634827  TNN; tenascin-N [KO:K06252]
123635275  TNR; tenascin-R isoform X1 [KO:K06252]
123640137  VWF; von Willebrand factor [KO:K03900]
123627312  bone sialoprotein 2 [KO:K06253]
123648588  ITGA1; integrin alpha-1 [KO:K06480]
123648225  ITGA2; integrin alpha-2 [KO:K06481]
123621031  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
123620728  ITGA3; integrin alpha-3 [KO:K06482]
123643670  ITGA4; integrin alpha-4 [KO:K06483]
123639686  ITGA5; integrin alpha-5 [KO:K06484]
123643937  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
123639684  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
123625492  ITGA8; integrin alpha-8 [KO:K06584]
123627265  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
123633876  ITGA10; integrin alpha-10 [KO:K06586]
123631783  ITGA11; integrin alpha-11 [KO:K06587]
123643975  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
123626683  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
123620572  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
123650804  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
123630462  ITGB5; integrin beta-5 [KO:K06588]
123643427  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
123639774  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
123647178  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
123644599  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123629856  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123630278  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123634506  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
123639706  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123648578  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123634187  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
123648568  F2R; proteinase-activated receptor 1 [KO:K03914]
123641300  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
123646880  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
123646547  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
123638322  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
123635466  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
123640118  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
123649358  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
123636000  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
123631640  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
123640104  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
123630284  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
123622795  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
123641343  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
123627584  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
123648542  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
123633190  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
123623917  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
123646542  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 isoform X1 [KO:K04545]
123647376  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
123637148  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123635536  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123631427  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
123647151  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
123620748  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
123647726  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
123650941  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
123650942  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
123631504  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
123632712  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
123648605  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
123635597  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
123650376  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
123646562  TSC1; hamartin [KO:K07206]
123631484  TSC2; tuberin isoform X1 [KO:K07207]
123647499  RHEB; GTP-binding protein Rheb [KO:K07208]
123631490  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
123634479  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
123650672  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
123626684  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
123623478  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
123627336  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
123643836  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
123620401  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
123642847  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
123639783  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
123621504  40S ribosomal protein S6-like [KO:K02991]
123637699  40S ribosomal protein S6-like [KO:K02991]
123645978  RPS6; 40S ribosomal protein S6 [KO:K02991]
123621118  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123637810  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
123635434  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
123646394  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
123633293  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
123622503  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
123644474  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
123624322  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123627566  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123643797  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123623594  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
123646972  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
123650328  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
123635133  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
123637775  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
123633863  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
123626658  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
123624632  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
123641707  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
123622192  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
123637931  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
123626639  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
123650004  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
123628382  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
123629279  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
123650175  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
123622540  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
123631894  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
123648241  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
123641399  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
123627069  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
123622409  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
123631934  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
123639365  HSP90B1; endoplasmin [KO:K09487]
123634232  CDC37; hsp90 co-chaperone Cdc37 isoform X1 [KO:K09554]
123634005  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
123621549  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
123624988  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
123630479  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
123628909  MTCP1; protein p13 MTCP-1 [KO:K16837]
123647518  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
123620994  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
123630505  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
123623844  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
123639941  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
123622288  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
123650946  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
123620984  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
123621018  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
123643602  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
123644625  MYC; myc proto-oncogene protein [KO:K04377]
123642799  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
123632883  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
123639989  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
123639673  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
123639589  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
123647595  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
123640152  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
123631868  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
123644579  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
123624519  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
123633137  FOXO3; forkhead box protein O3 [KO:K09408]
123625011  RBL2; retinoblastoma-like protein 2 [KO:K16332]
123634668  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
123637184  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
123644808  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
123622634  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
123636586  YWHAQ; 14-3-3 protein theta [KO:K16197]
123620707  YWHAE; 14-3-3 protein epsilon [KO:K06630]
123632590  YWHAG; 14-3-3 protein gamma [KO:K16198]
123625877  YWHAH; 14-3-3 protein eta isoform X1 [KO:K16198]
123641429  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
123622846  BCL2L1; bcl-2-like protein 1 [KO:K04570]
123621883  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
123635958  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
123644073  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
123643408  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
123640339  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123646158  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
123647675  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
123633885  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
123634008  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
123642645  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
123647634  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
123631772  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
123633922  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
123628160  induced myeloid leukemia cell differentiation protein Mcl-1-like [KO:K02539]
123645800  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
123639819  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
123628501  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
123650134  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
123626609  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123641353  RELA; transcription factor p65 isoform X1 [KO:K04735]
123627206  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123633297  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
123639534  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
123627975  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
123650900  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
lcat00010  Glycolysis / Gluconeogenesis
lcat04010  MAPK signaling pathway
lcat04012  ErbB signaling pathway
lcat04062  Chemokine signaling pathway
lcat04064  NF-kappa B signaling pathway
lcat04068  FoxO signaling pathway
lcat04110  Cell cycle
lcat04115  p53 signaling pathway
lcat04150  mTOR signaling pathway
lcat04210  Apoptosis
lcat04370  VEGF signaling pathway
lcat04510  Focal adhesion
lcat04620  Toll-like receptor signaling pathway
lcat04630  JAK-STAT signaling pathway
lcat04662  B cell receptor signaling pathway
lcat04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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