KEGG   PATHWAY: puc05022
Entry
puc05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Panthera uncia (snow leopard)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
puc05022  Pathways of neurodegeneration - multiple diseases
puc05022

Organism
Panthera uncia (snow leopard) [GN:puc]
Gene
125921721  amyloid-beta precursor protein isoform X1 [KO:K04520]
125927337  microtubule-associated protein tau isoform X1 [KO:K04380]
125923680  alpha-synuclein isoform X1 [KO:K04528]
125913128  TAR DNA-binding protein 43 isoform X1 [KO:K23600]
125928118  RNA-binding protein FUS isoform X1 [KO:K13098]
125920777  superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
125914550  ataxin-2 isoform X1 [KO:K23625]
125928012  ataxin-2-like protein isoform X1 [KO:K23625]
125922575  huntingtin [KO:K04533]
125939426  ataxin-1 [KO:K23616]
125916368  LOW QUALITY PROTEIN: ataxin-1-like [KO:K23616]
125909239  ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
125936780  major prion protein [KO:K05634]
125931960  muscarinic acetylcholine receptor M1 [KO:K04129]
125933204  muscarinic acetylcholine receptor M3 [KO:K04131]
125909806  muscarinic acetylcholine receptor M5 [KO:K04133]
125911637  spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
125938983  metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
125938187  metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
125925154  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
125938088  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
125931611  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
125909840  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
125935985  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
125936809  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125936595  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
125927372  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125927972  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125915497  protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
125922416  short transient receptor potential channel 3 [KO:K04966]
125919046  sigma non-opioid intracellular receptor 1 [KO:K20719]
125929585  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
125920161  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
125938355  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
125916168  LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
125933228  ryanodine receptor 2 isoform X1 [KO:K04962]
125908838  ryanodine receptor 3 [KO:K04963]
125936302  proenkephalin-B [KO:K15840]
125927065  disks large homolog 4 isoform X1 [KO:K11828]
125923684  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
125926396  glutamate receptor ionotropic, NMDA 2C [KO:K05211]
125934518  glutamate receptor 1 isoform X1 [KO:K05197]
125923148  glutamate receptor 2 isoform X1 [KO:K05198]
125931944  glutamate receptor 3 [KO:K05199]
125910453  glutamate receptor 4 isoform X1 [KO:K05200]
125920056  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
125931680  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
125925380  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
125928186  syntaxin-1A [KO:K04560]
125910412  CHRNA7-FAM7A fusion protein [KO:K04809]
125914188  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
125926925  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
125928010  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
125909363  presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
125925871  presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
125924429  derlin-1 isoform X1 [KO:K11519]
125919193  transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
125911014  LOW QUALITY PROTEIN: ubiquitin-60S ribosomal protein L40-like [KO:K02927]
125929258  ubiquitin-60S ribosomal protein L40 [KO:K02927]
125937003  ubiquitin-40S ribosomal protein S27a [KO:K02977]
125922994  ubiquitin-40S ribosomal protein S27a [KO:K02977]
125911290  LOW QUALITY PROTEIN: ubiquitin-like [KO:K04551]
125909568  proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
125935683  proteasome subunit alpha type-6-like [KO:K02730] [EC:3.4.25.1]
125929800  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
125910860  proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
125914759  proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
125936433  proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
125912298  proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
125935672  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
125909463  proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
125927092  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
125927381  proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
125927310  proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
125913561  proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
125909700  proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
125939078  proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
125912096  proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
125929844  26S proteasome regulatory subunit 7 [KO:K03061]
125909259  26S proteasome regulatory subunit 4 [KO:K03062]
125915899  26S proteasome regulatory subunit 6B [KO:K03063]
125908768  26S proteasome regulatory subunit 10B [KO:K03064]
125934056  26S proteasome regulatory subunit 6A [KO:K03065]
125926676  26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
125921121  26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
125931749  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 1-like [KO:K03032]
125911095  26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
125926490  26S proteasome non-ATPase regulatory subunit 3 isoform X1 [KO:K03033]
125914211  26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
125926687  26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
125927487  26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
125929542  26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
125916298  26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
125937741  26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
125912102  26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
125911593  26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
125915784  26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
125936430  proteasomal ubiquitin receptor ADRM1 [KO:K06691]
125939091  26S proteasome complex subunit SEM1-like [KO:K10881]
125931636  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
125929361  ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
125933524  ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
125913241  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
125937952  ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
125920675  ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
125918123  uncharacterized protein LOC125918123 [KO:K04555] [EC:2.3.2.23]
125932589  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
125930113  prosaposin receptor GPR37 [KO:K04243]
125914906  septin-5 isoform X1 [KO:K04557]
125935420  synphilin-1 isoform X1 [KO:K04558]
125921311  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
125936455  vesicle-associated membrane protein-associated protein B/C [KO:K10707]
125925955  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
125919248  DNA damage-inducible transcript 3 protein [KO:K04452]
125914494  LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
125927357  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
125923516  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
125938936  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
125928966  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
125916877  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
125917114  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
125933328  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125935352  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125910552  caspase-12-like [KO:K04741] [EC:3.4.22.-]
125915804  mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
125937418  eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
125909430  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
125919632  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125934743  sodium-dependent dopamine transporter [KO:K05036]
125913014  serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
6262408  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
6262405  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
6262404  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
6262403  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
6262406  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
6262411  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
125921742  LOW QUALITY PROTEIN: NADH-ubiquinone oxidoreductase chain 6-like [KO:K03884] [EC:7.1.1.2]
6262412  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
125930443  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
125914817  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
125920691  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
125932271  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
125935595  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
125915573  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
125909361  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
125929945  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
125909832  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
125919235  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
125930105  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
125935199  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
125920384  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
125928955  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
125920952  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
125918751  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
125911004  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
125927964  acyl carrier protein, mitochondrial [KO:K03955]
125928903  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
125933363  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12-like [KO:K11352]
125920326  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
125930638  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
125909241  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
125917067  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
125917871  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
125930928  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
125911778  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959]
125921781  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
125923979  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
125921863  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
125918669  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
125929104  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
125933435  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
125924744  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
125927170  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
125931635  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
125911273  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
125925575  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
125912613  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
125934593  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
125912737  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
125934737  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
125928801  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
125937793  LOW QUALITY PROTEIN: NADH-quinone oxidoreductase subunit I-like [KO:K03941] [EC:7.1.1.2]
125930376  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
125923709  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
125932349  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
125914554  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
125930990  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 subunit C2-like [KO:K03968]
125934758  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
125913055  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
125925571  succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
125909889  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
125915800  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
6262409  CYTB; cytochrome b [KO:K00412]
125924314  cytochrome c1, heme protein, mitochondrial [KO:K00413]
125929310  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
125928461  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
125912658  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
125913473  cytochrome b-c1 complex subunit 7-like [KO:K00417]
125924521  cytochrome b-c1 complex subunit 7 [KO:K00417]
125935480  cytochrome b-c1 complex subunit 8 [KO:K00418]
125914518  cytochrome b-c1 complex subunit 9 [KO:K00419]
125924689  cytochrome b-c1 complex subunit 10-like [KO:K00420]
125928805  cytochrome b-c1 complex subunit 10 [KO:K00420]
6262414  COX3; cytochrome c oxidase subunit III [KO:K02262]
6262413  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
6262410  COX2; cytochrome c oxidase subunit II [KO:K02261]
125916388  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
125936705  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
125910170  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
125936947  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
125914098  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
125935297  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
125928132  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
125915574  cytochrome c oxidase subunit 6B2 [KO:K02267]
125915916  cytochrome c oxidase subunit 6B1 [KO:K02267]
125927223  cytochrome c oxidase subunit 6B1-like [KO:K02267]
125924801  cytochrome c oxidase subunit 6C [KO:K02268]
125937501  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
125937934  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
125915667  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
125922726  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
125931786  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
125915651  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
125935814  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
125931789  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
125914644  ATP synthase subunit alpha, mitochondrial [KO:K02132]
125920252  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
125919966  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
125918081  ATP synthase subunit delta, mitochondrial-like [KO:K02134]
125918087  ATP synthase subunit delta, mitochondrial [KO:K02134]
125936448  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
6262402  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
125912258  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
125938313  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
125924277  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
125926453  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
125911414  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
125919131  ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
125911826  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
125919974  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
125912786  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
125928983  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
125926384  ATP synthase subunit d, mitochondrial [KO:K02138]
125920764  ATP synthase subunit O, mitochondrial [KO:K02137]
125921728  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
6262407  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
125914709  apoptosis regulator Bcl-2 [KO:K02161]
125933210  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
125935487  voltage-dependent anion-selective channel protein 1 [KO:K05862]
125915177  mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
125925576  mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518]
125933286  calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
125915330  calmodulin-3 isoform X1 [KO:K02183]
125923752  calmodulin-like [KO:K02183]
125931555  calmodulin-alpha-like [KO:K02183]
125908913  calmodulin-like protein 4 isoform X1 [KO:K02183]
125909257  calmodulin-1 [KO:K02183]
125918569  calmodulin-like [KO:K02183]
125918572  calmodulin-like protein 3 [KO:K02183]
125936234  calmodulin-2 isoform X1 [KO:K02183]
125913213  calmodulin-like protein 6 [KO:K02183]
125922973  protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
125923333  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125932723  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125937053  calcineurin subunit B type 1 isoform X1 [KO:K06268]
125926203  calcineurin subunit B type 2 [KO:K06268]
125931741  bcl2-associated agonist of cell death [KO:K02158]
125925158  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125933220  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
125929964  FAS-associated death domain protein [KO:K02373]
125911772  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
125918699  BH3-interacting domain death agonist [KO:K04726]
125915138  apoptosis regulator BAX isoform X1 [KO:K02159]
125938359  bcl-2 homologous antagonist/killer [KO:K14021]
125918962  leucine-rich repeat serine/threonine-protein kinase 2 isoform X1 [KO:K08844] [EC:2.7.11.1]
125937141  LOW QUALITY PROTEIN: serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
125927245  heat shock protein 75 kDa, mitochondrial isoform X1 [KO:K09488]
125932735  voltage-dependent anion-selective channel protein 2 [KO:K15040]
125938035  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 3-like [KO:K15041]
125923311  voltage-dependent anion-selective channel protein 3 [KO:K15041]
125923105  ADP/ATP translocase 4 [KO:K05863]
125923902  ADP/ATP translocase 1 [KO:K05863]
125931938  ADP/ATP translocase 2 [KO:K05863]
125932327  ADP/ATP translocase 3 [KO:K05863]
125928445  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
125932743  peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
125929995  cytochrome c [KO:K08738]
125933126  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
125920151  cytochrome c-like [KO:K08738]
125920269  cytochrome c-like [KO:K08738]
125921158  cytochrome c-like [KO:K08738]
125919454  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
125913078  caspase-9 [KO:K04399] [EC:3.4.22.62]
125923904  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
125928525  huntingtin-interacting protein 1 [KO:K04559]
125920923  intraflagellar transport protein 57 homolog [KO:K04638]
125931707  3-hydroxyacyl-CoA dehydrogenase type-2 isoform X1 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
125913611  peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
125937060  peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
125923157  peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
125913152  Parkinson disease protein 7 [KO:K05687] [EC:3.5.1.124]
125936704  bcl-2-like protein 1 isoform X1 [KO:K04570]
125921854  mitofusin-1 [KO:K21356] [EC:3.6.5.-]
125913101  mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
125918593  optineurin isoform X1 [KO:K19946]
125935355  sequestosome-1 isoform X1 [KO:K14381]
125916442  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
125925097  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
125925099  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
125917385  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
125917395  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
125936095  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
125919296  serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
125911592  TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
125935770  WD repeat-containing protein 41 isoform X1 [KO:K23610]
125926947  guanine nucleotide exchange protein SMCR8 [KO:K23611]
125918353  guanine nucleotide exchange factor C9orf72 homolog [KO:K23609]
125929168  ras-related protein Rab-8A isoform X1 [KO:K07901]
125932119  ras-related protein Rab-39B [KO:K07925]
125936276  ras-related protein Rab-1A isoform X1 [KO:K07874]
125913121  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
125915056  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
125927563  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
125919070  autophagy-related protein 101 [KO:K19730]
125919892  autophagy-related protein 101-like [KO:K19730]
125912704  autophagy-related protein 13 isoform X1 [KO:K08331]
125924690  RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
125912665  activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
125925096  beclin-2 [KO:K08334]
125926584  beclin-1 isoform X1 [KO:K08334]
125921993  phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
125909479  beclin 1-associated autophagy-related key regulator [KO:K17889]
125933257  nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
125914658  phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
125931284  autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
125909191  autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
125917068  WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
125917872  WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
125926696  WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
125909368  zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
125911309  alsin isoform X1 [KO:K04575]
125921347  ras-related protein Rab-5A [KO:K07887]
125928294  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
125920835  charged multivesicular body protein 2b [KO:K12192]
125938790  polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
125909950  spatacsin [KO:K19026]
125938466  tumor necrosis factor [KO:K03156]
125918761  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
125913105  tumor necrosis factor receptor superfamily member 1B [KO:K05141]
125938363  death domain-associated protein 6 [KO:K02308]
125926929  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
125926707  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
125937867  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
125937868  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
125919741  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
125919935  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
125914124  nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
125911812  copper chaperone for superoxide dismutase isoform X1 [KO:K04569]
125929347  glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
125939354  glutathione peroxidase 6 isoform X1 [KO:K00432] [EC:1.11.1.9]
125939364  epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
125908720  glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
125917005  glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
125917618  glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
125934541  glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
125935626  probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
125934840  catalase [KO:K03781] [EC:1.11.1.6]
125919024  peripherin [KO:K07607]
125923358  neurofilament light polypeptide [KO:K04572]
125923357  neurofilament medium polypeptide isoform X1 [KO:K04573]
125913944  neurofilament heavy polypeptide [KO:K04574]
125918677  kinesin-1 heavy chain [KO:K10396]
125919250  kinesin heavy chain [KO:K10396]
125911885  kinesin heavy chain [KO:K10396]
125915363  kinesin light chain 3 isoform X1 [KO:K10407]
125930781  kinesin light chain 2 isoform X1 [KO:K10407]
125909119  kinesin light chain 1 isoform X1 [KO:K10407]
125917431  kinesin light chain 4-like [KO:K10407]
125918378  kinesin light chain 4 [KO:K10407]
125916747  tubulin alpha-8 chain [KO:K07374]
125916748  tubulin alpha-8 chain [KO:K07374]
125916847  tubulin alpha-3 chain [KO:K07374]
125918573  tubulin alpha chain-like 3 [KO:K07374]
125918691  tubulin alpha-8 chain [KO:K07374]
125919019  tubulin alpha-1B chain [KO:K07374]
125919020  tubulin alpha-1A chain [KO:K07374]
125919021  tubulin alpha-1C chain [KO:K07374]
125911152  tubulin alpha-4A chain isoform X1 [KO:K07374]
125914846  tubulin beta-6 chain isoform X1 [KO:K07375]
125938490  tubulin beta chain [KO:K07375]
125923767  tubulin beta-4B chain [KO:K07375]
125939600  tubulin beta-2A chain isoform X1 [KO:K07375]
125916268  tubulin beta-3 chain [KO:K07375]
125936447  tubulin beta-1 chain isoform X1 [KO:K07375]
125928929  tubulin beta-4A chain [KO:K07375]
125921776  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125916946  casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
125916975  casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
125936726  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
125938448  casein kinase II subunit beta isoform X1 [KO:K03115]
125935341  brain-derived neurotrophic factor [KO:K04355]
125937125  dynactin subunit 1 isoform X1 [KO:K04648]
125919247  dynactin subunit 2 [KO:K10424]
125919052  dynactin subunit 3 isoform X1 [KO:K10425]
125934548  dynactin subunit 4 [KO:K10426]
125927967  dynactin subunit 5 isoform X1 [KO:K10427]
125923872  dynactin subunit 6 isoform X1 [KO:K10428]
125936946  beta-centractin isoform X1 [KO:K16575]
125932913  alpha-centractin [KO:K16575]
125909462  actin-related protein 10 isoform X1 [KO:K16576]
125927680  LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
125929446  dynein axonemal heavy chain 1 [KO:K10408]
125929496  dynein axonemal heavy chain 12 isoform X1 [KO:K10408]
125937391  dynein axonemal heavy chain 6 [KO:K10408]
125914258  dynein axonemal heavy chain 10 [KO:K10408]
125929993  dynein axonemal heavy chain 11 [KO:K10408]
125937858  dynein axonemal heavy chain 8 [KO:K10408]
125925855  dynein axonemal heavy chain 14 isoform X1 [KO:K10408]
125926172  dynein axonemal heavy chain 2 [KO:K10408]
125926295  dynein axonemal heavy chain 17 isoform X1 [KO:K10408]
125911340  dynein axonemal heavy chain 7 isoform X1 [KO:K10408]
125934705  dynein axonemal heavy chain 5 [KO:K10408]
125928451  dynein axonemal heavy chain 3 [KO:K10408]
125912761  axonemal dynein light intermediate polypeptide 1 [KO:K10410]
125918965  dynein axonemal intermediate chain 1 [KO:K10409]
125927394  dynein axonemal intermediate chain 2 isoform X1 [KO:K11143]
125908697  dynein axonemal light chain 1 [KO:K10411]
125919619  dynein axonemal light chain 4 [KO:K10412]
125929736  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
125923042  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
125933297  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
125934558  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
125930886  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
125925062  calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
125926821  cyclin-dependent kinase 5 activator 1 isoform X1 [KO:K11716]
125930306  cyclin-dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
125932988  caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
125922998  dickkopf-related protein 2 [KO:K02165]
125923310  dickkopf-related protein 4 [KO:K02165]
125933548  dickkopf-related protein 1 [KO:K02165]
125920405  proto-oncogene Wnt-1 [KO:K03209]
125930076  protein Wnt-2 [KO:K00182]
125912240  protein Wnt-2b [KO:K00182]
125934822  protein Wnt-3a [KO:K00312]
125927692  proto-oncogene Wnt-3 [KO:K00312]
125913720  protein Wnt-4 [KO:K00408]
125929490  protein Wnt-5a [KO:K00444]
125920070  protein Wnt-5b [KO:K00444]
125911162  LOW QUALITY PROTEIN: protein Wnt-6 [KO:K00445]
125929663  protein Wnt-7a isoform X1 [KO:K00572]
125919709  protein Wnt-7b [KO:K00572]
125933437  protein Wnt-8b [KO:K00714]
125935540  protein Wnt-8a [KO:K00714]
125911171  protein Wnt-10a [KO:K01357]
125920404  protein Wnt-10b [KO:K01357]
125914412  protein Wnt-11 [KO:K01384]
125931011  protein Wnt-16 [KO:K01558]
125929896  frizzled-1 [KO:K02432]
125911307  frizzled-7 [KO:K02432]
125926635  frizzled-2 [KO:K02235]
125923798  frizzled-3 isoform X1 [KO:K02329]
125938072  frizzled-4 [KO:K02354]
125911259  frizzled-5 [KO:K02375]
125919776  frizzled-8 [KO:K02375]
125924487  frizzled-6 [KO:K02376]
125915041  frizzled-10 [KO:K02842]
125928505  frizzled-9 [KO:K02842]
125911115  low-density lipoprotein receptor-related protein 5 [KO:K03068]
125920089  low-density lipoprotein receptor-related protein 6 [KO:K03068]
125919606  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
125927067  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
125913233  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
125921126  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
125932834  proto-oncogene FRAT1 [KO:K03069]
125932835  GSK-3-binding protein FRAT2 [KO:K03096]
125928387  axin-1 isoform X1 [KO:K02157]
125917039  adenomatous polyposis coli protein 2-like isoform X1 [KO:K02085]
125917782  adenomatous polyposis coli protein 2-like isoform X1 [KO:K02085]
125934374  adenomatous polyposis coli protein isoform X1 [KO:K02085]
125921400  catenin beta-1 [KO:K02105]
125934572  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
125938409  advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
125937753  GTPase HRas isoform X1 [KO:K02833]
125918906  GTPase KRas isoform X1 [KO:K07827]
125912218  GTPase NRas [KO:K07828]
125931647  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
125930477  serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
125930728  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125910082  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125918032  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125918034  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125914884  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
125928028  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
125931820  NADPH oxidase 1 isoform X1 [KO:K08008]
125931598  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
125938232  NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
125912163  transcription factor p65 [KO:K04735]
125923687  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125927474  nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
125925212  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
125930836  interleukin-6 [KO:K05405]
125937435  interleukin-1 alpha isoform X1 [KO:K04383]
125937410  interleukin-1 beta isoform X1 [KO:K04519]
125912284  macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
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Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
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Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
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Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
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Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
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J Neural Transm (Vienna) 116:1111-62 (2009)
DOI:10.1007/s00702-009-0240-y
Reference
PMID:30743990
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Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
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Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
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Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
  Journal
Nat Neurosci 21:1332-1340 (2018)
DOI:10.1038/s41593-018-0235-9
Reference
PMID:25132814
  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
  Journal
Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
PMID:25413678
  Authors
Zheng C, Geetha T, Babu JR
  Title
Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
  Journal
Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
PMID:32397599
  Authors
Park H, Kang JH, Lee S
  Title
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
  Journal
Int J Mol Sci 21:E3369 (2020)
DOI:10.3390/ijms21093369
Reference
PMID:31783880
  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
  Title
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
DOI:10.1186/s13041-019-0504-x
Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
  Journal
Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
  Journal
Trends Pharmacol Sci 35:583-91 (2014)
DOI:10.1016/j.tips.2014.09.002
Reference
PMID:28279350
  Authors
Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Fullgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC
  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
  Journal
Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
  Authors
Kim I, Xu W, Reed JC
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Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
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Related
pathway
puc00190  Oxidative phosphorylation
puc03050  Proteasome
puc04020  Calcium signaling pathway
puc04120  Ubiquitin mediated proteolysis
puc04137  Mitophagy - animal
puc04140  Autophagy - animal
puc04141  Protein processing in endoplasmic reticulum
puc04142  Lysosome
puc04210  Apoptosis
puc04310  Wnt signaling pathway
puc04724  Glutamatergic synapse
puc04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
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