KEGG   PATHWAY: sasa04010
Entry
sasa04010                   Pathway                                
Name
MAPK signaling pathway - Salmo salar (Atlantic salmon)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
sasa04010  MAPK signaling pathway
sasa04010

Other DBs
GO: 0000165
Organism
Salmo salar (Atlantic salmon) [GN:sasa]
Gene
106606768  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
106606804  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
106567450  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
106563134  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
106585428  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
106579993  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
106566685  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
106571974  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
106583449  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
106565299  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
106599779  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
106569134  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
106584318  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
106613910  probable voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
106572493  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
106578905  voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854]
106589457  cacna1g; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
106606743  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
106567031  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
106583479  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
106565294  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
106573448  voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858]
106576572  voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858]
106561208  voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858]
106565177  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
106566000  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
106582605  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
106565153  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
106583452  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
106565298  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
106565323  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
106584529  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
106561009  cacna2d4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
106600985  voltage-dependent L-type calcium channel subunit beta-1-like [KO:K04862]
106607253  voltage-dependent L-type calcium channel subunit beta-1-like [KO:K04862]
106578706  voltage-dependent L-type calcium channel subunit beta-2-like [KO:K04863]
100380803  cacb2; Voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
106571945  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864]
106575807  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04865]
106586393  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04865]
106582346  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04865]
106585672  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
106601772  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
106564879  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
106601533  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
106601469  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
106606871  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
106594488  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
106602081  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
106595341  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
106586345  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
106601773  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
106606650  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
106564880  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
106585659  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
106606715  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
106606721  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
106564881  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
106595108  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
106576934  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
106606119  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
106570000  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
106588442  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
106575226  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
106605807  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
106605811  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
106570002  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
106588444  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
106576929  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
106605817  voltage-dependent calcium channel gamma-8 subunit-like [KO:K04873]
106570001  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
106588443  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
106592286  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
106564260  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
106569146  KAPCB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106613442  prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106599750  KAPCB; cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
106606839  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
106564882  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
106594520  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
106563990  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
106563994  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
106593748  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
106593532  guanine nucleotide-binding protein subunit alpha-12-like [KO:K04346]
106598933  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
106606473  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
106606536  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
106560325  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
100195016  gbg12; Guanine nucleotide-binding protein GI/GS/GO subunit gamma-12 [KO:K04347]
106584173  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
106604405  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
106603034  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
106608629  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
106612112  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
106580517  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like [KO:K04348] [EC:3.1.3.16]
106563625  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
106568136  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like [KO:K04348] [EC:3.1.3.16]
106585124  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like [KO:K04348] [EC:3.1.3.16]
100196828  ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100195067  pp2bc; Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
106586010  calcineurin subunit B type 1 [KO:K06268]
106578839  calcineurin subunit B type 1-like [KO:K06268]
100380679  canb1; calcineurin subunit B type 1 [KO:K06268]
106589933  calcineurin subunit B type 1-like [KO:K06268]
106573487  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
106561174  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
106561157  ras-specific guanine nucleotide-releasing factor 2-like [KO:K12326]
106568132  ras-specific guanine nucleotide-releasing factor 2-like [KO:K12326]
106589171  RAS guanyl-releasing protein 1-like [KO:K04350]
106611065  RAS guanyl-releasing protein 1-like [KO:K04350]
106591819  RAS guanyl-releasing protein 1-like [KO:K04350]
106608563  RAS guanyl-releasing protein 2-like [KO:K12361]
100194852  grp2; RAS guanyl-releasing protein 2 [KO:K12361]
106577535  rasgrp2; RAS guanyl releasing protein 2 [KO:K12361]
106606711  ras guanyl-releasing protein 3-like [KO:K12362]
106576952  ras guanyl-releasing protein 3-like [KO:K12362]
106604533  rapgef2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
106611555  rap guanine nucleotide exchange factor 2-like [KO:K08018]
106567758  neurofibromin [KO:K08052]
106581254  neurofibromin-like [KO:K08052]
106603288  neurofibromin-like [KO:K08052]
106613084  neurofibromin-like [KO:K08052]
106580138  ras GTPase-activating protein 1-like [KO:K04352]
106585767  ras GTPase-activating protein 1-like [KO:K04352]
106580875  rasa2; RAS p21 protein activator 2 [KO:K08053]
106567206  RAP1B; ras-related protein O-Krev [KO:K04353]
106572472  RAP1B; ras-related protein Rap-1A-like [KO:K04353]
106566052  RAP1A; ras-related protein Rap-1A-like [KO:K04353]
106582744  RAP1B; ras-related protein Rap-1A-like [KO:K04353]
106576640  ras-related protein Rap-1b [KO:K07836]
106593497  RAP1B; ras-related protein Rap-1b [KO:K07836]
106611584  egf; epidermal growth factor [KO:K04357]
106565349  protransforming growth factor alpha-like [KO:K08774]
106583550  protransforming growth factor alpha-like [KO:K08774]
100286458  ereg; Proepiregulin [KO:K09784]
106603858  FGF1; putative fibroblast growth factor 1 [KO:K18496]
100196882  fgf1; fibroblast growth factor 1 [KO:K18496]
106604591  fibroblast growth factor 2-like [KO:K18497]
106611625  fgf2; fibroblast growth factor 2 [KO:K18497]
106606274  fibroblast growth factor 8-like [KO:K04358]
106563568  fibroblast growth factor 10-like [KO:K04358]
106588752  fibroblast growth factor 8b-like [KO:K04358]
106603257  fibroblast growth factor 18-like [KO:K04358]
106604097  fgf16; fibroblast growth factor 16 [KO:K04358]
106602193  fibroblast growth factor 20-like [KO:K04358]
106602194  fibroblast growth factor 20-like [KO:K04358]
106604790  fibroblast growth factor 18-like [KO:K04358]
106604596  fibroblast growth factor 18-like [KO:K04358]
106611619  fibroblast growth factor 18-like [KO:K04358]
106611819  fibroblast growth factor 18-like [KO:K04358]
106609473  fibroblast growth factor 4B-like [KO:K04358]
106562463  fibroblast growth factor 7-like [KO:K04358]
106562498  fibroblast growth factor 7-like [KO:K04358]
106561973  fibroblast growth factor 3-like [KO:K04358]
106561974  fibroblast growth factor 4B-like [KO:K04358]
106570895  fibroblast growth factor 5-like [KO:K04358]
106573153  fibroblast growth factor 4B-like [KO:K04358]
106573196  FGF6; fibroblast growth factor 6-like [KO:K04358]
106561637  fibroblast growth factor 3-like [KO:K04358]
106561638  fibroblast growth factor 4B-like [KO:K04358]
106568123  fibroblast growth factor 18-like [KO:K04358]
106580010  fibroblast growth factor 17-like [KO:K04358]
106564590  fibroblast growth factor 8b-like [KO:K04358]
106612037  fibroblast growth factor 20-like [KO:K04358]
106613753  fibroblast growth factor 10-like [KO:K04358]
106568156  fibroblast growth factor 10-like [KO:K04358]
106576263  fibroblast growth factor 4B-like [KO:K04358]
106576696  fibroblast growth factor 8-like [KO:K04358]
106580601  fgf10; fibroblast growth factor 10 [KO:K04358]
106587666  fibroblast growth factor 7-like [KO:K04358]
100195676  fgf3; fibroblast growth factor 3 [KO:K04358]
106585924  fibroblast growth factor 5-like [KO:K04358]
106585328  fibroblast growth factor 17 [KO:K04358]
106584266  fibroblast growth factor 10-like [KO:K04358]
106584957  fibroblast growth factor 10-like [KO:K04358]
106587135  fibroblast growth factor 3-like [KO:K04358]
106587136  fibroblast growth factor 4B-like [KO:K04358]
106586997  fibroblast growth factor 19-like [KO:K22603]
106579352  fibroblast growth factor 21-like [KO:K22429]
106576344  fibroblast growth factor 23-like [KO:K22428]
106609464  fibroblast growth factor 23-like [KO:K22428]
106609463  fibroblast growth factor 23-like [KO:K22428]
106561358  fibroblast growth factor 23-like [KO:K22428]
106573277  fibroblast growth factor 23-like [KO:K22428]
106566077  nerve growth factor-like [KO:K02582]
106566305  nerve growth factor-like [KO:K02582]
106592688  nerve growth factor-like [KO:K02582]
106582728  nerve growth factor-like [KO:K02582]
106563519  brain-derived neurotrophic factor [KO:K04355]
106587487  brain-derived neurotrophic factor-like [KO:K04355]
106593821  ntf3; neurotrophin 3 [KO:K04356]
106603941  INS; insulin-like [KO:K04526]
106567474  INS; insulin [KO:K04526]
106612054  insulin-like [KO:K04526]
106609475  insulin-like growth factor I [KO:K05459]
100136517  insulin-like growth factor I [KO:K05459]
100136550  IGF-II; insulin-like growth factor II [KO:K13769]
106590378  platelet-derived growth factor subunit A-like [KO:K04359]
106601849  platelet-derived growth factor subunit A-like [KO:K04359]
106606462  platelet-derived growth factor subunit A-like [KO:K04359]
106564521  platelet-derived growth factor subunit A-like [KO:K04359]
106564525  platelet-derived growth factor subunit A-like [KO:K04359]
106591430  ell-associated factor Eaf-like [KO:K17386]
106592643  alpha-protein kinase 1-like [KO:K17386]
106604525  pdgfc; platelet derived growth factor C [KO:K05450]
106611576  platelet-derived growth factor C-like [KO:K05450]
106613208  pdgfd; platelet derived growth factor D [KO:K05450]
106581363  platelet-derived growth factor D-like [KO:K05450]
106565101  uncharacterized LOC106565101 [KO:K05453]
106583500  csf1; colony stimulating factor 1 [KO:K05453]
106561562  kit ligand-like [KO:K05461]
106573113  kitlg; KIT ligand [KO:K05461]
106576341  uncharacterized LOC106576341 [KO:K05461]
106584182  vascular endothelial growth factor A-A [KO:K05448]
106605015  vascular endothelial growth factor A-A-like [KO:K05448]
106607898  vascular endothelial growth factor A-A-like [KO:K05448]
106571482  vascular endothelial growth factor A-A-like [KO:K05448]
106612094  vegfb; vascular endothelial growth factor B [KO:K05448]
106593515  placenta growth factor-like [KO:K16859]
106611025  placenta growth factor-like [KO:K16859]
106571724  vascular endothelial growth factor A-like [KO:K16859]
106602932  vascular endothelial growth factor C-like [KO:K05449]
106609067  vascular endothelial growth factor D-like [KO:K05449]
106610161  vascular endothelial growth factor C-like [KO:K05449]
106563734  vascular endothelial growth factor C-like [KO:K05449]
100380462  vegfc; vascular endothelial growth factor c [KO:K05449]
100195607  vegfd; Vascular endothelial growth factor D [KO:K05449]
106609646  hepatocyte growth factor-like [KO:K05460]
106573447  hepatocyte growth factor-like [KO:K05460]
106576483  hepatocyte growth factor-like [KO:K05460]
106561209  hepatocyte growth factor-like [KO:K05460]
106563779  angiopoietin-1-like [KO:K05465]
106570047  angiopoietin-1-like [KO:K05465]
106591204  angiopoietin-1-like [KO:K05465]
106595324  angiopoietin-1-like [KO:K05465]
106588502  angiopoietin-1-like [KO:K05465]
106597178  angiopoietin-1-like [KO:K05465]
106596162  angiopoietin-1-like [KO:K05465]
106612545  angiopoietin-2-like [KO:K05466]
106570762  angiopoietin-2-like [KO:K05466]
106589817  angiopoietin-2-like [KO:K05466]
106589155  angiopoietin-2-like [KO:K05466]
106589146  trithorax group protein osa-like [KO:K05466]
106570832  ephrin-A2-like [KO:K05462]
106566624  ephrin-A5b-like [KO:K05462]
106574320  ephrin-A1-like [KO:K05462]
106605933  ephrin-A4-like [KO:K05462]
106575452  ephrin-A2-like [KO:K05462]
106575486  ephrin-A2-like [KO:K05462]
106574641  ephrin-A4-like [KO:K05462]
106563326  ephrin-A5-like [KO:K05462]
106613575  ephrin-A2-like [KO:K05462]
106570105  ephrin-A1-like [KO:K05462]
106570106  ephrin-A3-like [KO:K05462]
106574064  ephrin-A2-like [KO:K05462]
106580594  ephrin-A5-like [KO:K05462]
106585191  ephrin-A5b-like [KO:K05462]
106598406  ephrin-A1-like [KO:K05462]
106588171  ephrin-A3-like [KO:K05462]
106588172  ephrin-A1-like [KO:K05462]
106595655  ephrin-A3-like [KO:K05462]
106564161  gdnf; glial cell derived neurotrophic factor [KO:K05452]
106568186  glial cell line-derived neurotrophic factor-like [KO:K05452]
106585911  glial cell line-derived neurotrophic factor-like [KO:K05452]
106569826  neurturin-like [KO:K25414]
106573557  neurturin-like [KO:K25414]
106613707  neurturin-like [KO:K25414]
106568971  artemin-like [KO:K25415]
106560342  artn; artemin [KO:K25415]
106598943  artemin-like [KO:K25415]
106584185  neurturin-like [KO:K25415]
106590535  artemin-like [KO:K25416]
106564446  persephin-like [KO:K25416]
106600426  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
106569312  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
106579586  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
106590362  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
106579080  erbb2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
106567054  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
106572678  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
106565537  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
106583220  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
106575810  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
106592198  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
106586446  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
106582203  erbb4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
106567959  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
106563063  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
106579865  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
106585563  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
106568122  fibroblast growth factor receptor homolog 1-like [KO:K05093] [EC:2.7.10.1]
106576891  fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
106579428  fibroblast growth factor receptor 2-like [KO:K05093] [EC:2.7.10.1]
106603480  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
106568015  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
106601618  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
106601645  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
106579090  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
106597526  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
106606109  death domain-containing membrane protein NRADD-like [KO:K02583]
106581868  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
106605284  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
106562076  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
106568346  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
106585685  ntrk2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
106580092  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
106583950  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
106560567  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
106600510  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
106573762  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
106588078  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100194499  igf1r; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
106560269  platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
106584117  pdgfra; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100380851  pgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
106604848  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
106611876  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
106602933  macrophage colony-stimulating factor 1 receptor 1-like [KO:K05090] [EC:2.7.10.1]
106604846  macrophage colony-stimulating factor 1 receptor 1-like [KO:K05090] [EC:2.7.10.1]
106611874  macrophage colony-stimulating factor 1 receptor 1-like [KO:K05090] [EC:2.7.10.1]
100329180  macrophage colony stimulating factor receptor-like protein [KO:K05090] [EC:2.7.10.1]
106560270  mast/stem cell growth factor receptor Kit-like [KO:K05091] [EC:2.7.10.1]
106584118  kit; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
106591942  mast/stem cell growth factor receptor kita-like [KO:K05091] [EC:2.7.10.1]
106579503  receptor-type tyrosine-protein kinase FLT3-like [KO:K05092] [EC:2.7.10.1]
106590453  receptor-type tyrosine-protein kinase FLT3-like [KO:K05092] [EC:2.7.10.1]
106604726  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
106611743  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
106579544  vascular endothelial growth factor receptor 1-like [KO:K05096] [EC:2.7.10.1]
106591469  vascular endothelial growth factor receptor 1-like [KO:K05096] [EC:2.7.10.1]
106612321  vascular endothelial growth factor receptor 3-like [KO:K05097] [EC:2.7.10.1]
106584120  kdr; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
106573120  hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
106561553  hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
106568558  tek; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
106566859  ephrin type-A receptor 2-like [KO:K05103] [EC:2.7.10.1]
106572015  ephrin type-A receptor 2-like [KO:K05103] [EC:2.7.10.1]
106565994  ephrin type-A receptor 2-like [KO:K05103] [EC:2.7.10.1]
106582764  epha2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
106604566  proto-oncogene tyrosine-protein kinase receptor Ret-like [KO:K05126] [EC:2.7.10.1]
106576823  proto-oncogene tyrosine-protein kinase receptor Ret-like [KO:K05126] [EC:2.7.10.1]
106587111  growth factor receptor-bound protein 2-like [KO:K04364]
106607067  growth factor receptor-bound protein 2 [KO:K04364]
106564671  growth factor receptor-bound protein 2-like [KO:K04364]
100306767  grb2; growth factor receptor-bound protein 2 [KO:K04364]
106601599  sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
106584773  son of sevenless homolog 1-like [KO:K03099]
106611443  son of sevenless homolog 2-like [KO:K03099]
106564790  son of sevenless homolog 1-like [KO:K03099]
106573361  GTPase HRas-like [KO:K02833]
100196603  rash; GTPase HRas [KO:K02833]
106601908  GTPase HRas-like [KO:K07827]
106606379  GTPase HRas-like [KO:K07827]
106561428  GTPase KRas [KO:K07827]
100380437  rask; GTPase KRas [KO:K07827]
106600695  rras; related RAS viral (r-ras) oncogene homolog [KO:K07830]
106562341  ras-related protein R-Ras2-like [KO:K07830]
106587534  ras-related protein R-Ras2 [KO:K07830]
106583918  ras-related protein R-Ras-like [KO:K07830]
106574266  ras-related protein M-Ras [KO:K07831]
106575193  ras-related protein M-Ras-like [KO:K07831]
106582394  ras-related protein M-Ras-like [KO:K07831]
106586304  ras-related protein M-Ras-like [KO:K07831]
106580530  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
106585138  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
106571905  RAF1b; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
106566757  RAF1a; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
100136351  raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
106584829  map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106600441  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
106613775  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106569535  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
100194780  mp2k2; Dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100196020  lamtor3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
106570952  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106600714  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
106592057  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
100380511  mk03; Mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
106569835  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
106613848  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
106574026  MAP kinase-interacting serine/threonine-protein kinase 1-like [KO:K04372] [EC:2.7.11.1]
106584368  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
106612640  ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
106612512  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
106603065  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
106604080  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
106610660  ribosomal protein S6 kinase 2 alpha-like [KO:K04373] [EC:2.7.11.1]
106563584  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
106579471  ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
106589820  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
106590479  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
106591110  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
106607446  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
106564394  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
100195072  atf4; Cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
106566498  ETS domain-containing protein Elk-1-like [KO:K04375]
106565630  ETS domain-containing protein Elk-4-like [KO:K04376]
106583110  ETS domain-containing protein Elk-4-like [KO:K04376]
106568625  myc; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
106578682  transcriptional regulator Myc-like [KO:K04377]
100380346  myc2; Transcriptional regulator Myc-2 [KO:K04377]
106590162  c-myc; transcriptional regulator Myc [KO:K04377]
100380531  myc; Viral myc transforming protein [KO:K04377]
106604182  serum response factor-like [KO:K04378]
106584839  serum response factor-like [KO:K04378]
106564784  serum response factor-like [KO:K04378]
106576882  serum response factor-like [KO:K04378]
106591288  proto-oncogene c-Fos-like [KO:K04379]
106608293  proto-oncogene c-Fos-like [KO:K04379]
106608294  proto-oncogene c-Fos-like [KO:K04379]
106611096  proto-oncogene c-Fos-like [KO:K04379]
106571028  proto-oncogene c-Fos-like [KO:K04379]
106571032  proto-oncogene c-Fos-like [KO:K04379]
106600872  microtubule-associated protein tau-like [KO:K04380]
106607459  microtubule-associated protein tau-like [KO:K04380]
100306810  tau; Microtubule-associated protein tau [KO:K04380]
106584327  stathmin; stathmin-like [KO:K04381]
106605008  stathmin; stathmin-like [KO:K04381]
106570260  STMN1; stathmin-like [KO:K04381]
106588646  STMN1; stathmin-like [KO:K04381]
106599096  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
106560559  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
106576937  pla2g4f; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
106577847  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
106577820  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
106577823  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
106583972  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
100136457  tnf-alpha-1; tumor necrosis factor alpha-1 precursor [KO:K03156]
100136458  tnf-alpha-2; tumor necrosis factor alpha-2 precursor [KO:K03156]
100136509  tumor necrosis factor alpha [KO:K03156]
106589058  tumor necrosis factor-like [KO:K03156]
106562915  IL-1b3; interleukin-1 beta-like [KO:K04519]
106570815  interleukin-1 beta-like [KO:K04519]
100136449  interleukin-1 beta [KO:K04519]
100136559  TGFB1; transforming growth factor beta-1 [KO:K13375]
106563563  TGF-beta; transforming growth factor beta-1 [KO:K13375]
106613337  transforming growth factor beta-1-like [KO:K13375]
106584161  transforming growth factor beta-2-like [KO:K13376]
106604392  transforming growth factor beta-2-like [KO:K13376]
106605021  transforming growth factor beta-2-like [KO:K13376]
106612106  transforming growth factor beta-2-like [KO:K13376]
106590795  transforming growth factor beta-3-like [KO:K13377]
106608297  transforming growth factor beta-3-like [KO:K13377]
106611047  tgfb3; transforming growth factor beta 3 [KO:K13377]
106571074  transforming growth factor beta-3-like [KO:K13377]
106575188  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
100196751  tnr1a; Tumor necrosis factor receptor superfamily member 1A [KO:K03158]
106567387  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
106582258  interleukin-1 receptor type 1-like [KO:K04386]
106586476  interleukin-1 receptor type 1-like [KO:K04386]
100136530  il-1rl; interleukin-1 receptor-like protein [KO:K04386]
100136401  il-1racp; interleukin 1 receptor accessory protein [KO:K04723]
106599285  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
106579675  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
106569209  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
106590284  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
106606173  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
106586454  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
100195227  tgfr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
106588201  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
106613961  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
106579980  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
100196289  tnfl6; Tumor necrosis factor ligand superfamily member 6 [KO:K04389]
106577010  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
100380364  tnr6; Tumor necrosis factor receptor superfamily member 6 [KO:K04390]
106609976  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
106601744  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
106606203  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
106606735  RAC1; ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
106589605  rac1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
106590297  RAC2; ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
106601466  RAC2; ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
106601467  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
106564435  RAC2; ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
106610298  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
106606208  ras-related C3 botulinum toxin substrate 1-like [KO:K07861]
106595201  ras-related C3 botulinum toxin substrate 1-like [KO:K07861]
106589606  rac3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
106576553  CDC42; cell division control protein 42 homolog [KO:K04393]
106605852  cell division control protein 42 homolog [KO:K04393]
106569986  CDC42; cell division control protein 42 homolog [KO:K04393]
106565619  CDC42; cell division control protein 42 homolog [KO:K04393]
106567263  cdc42; cell division control protein 42 homolog [KO:K04393]
106572399  CDC42; cell division control protein 42 homolog [KO:K04393]
106588426  cell division control protein 42 homolog [KO:K04393]
106583122  CDC42; cell division control protein 42 homolog [KO:K04393]
106562229  tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171]
106587422  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
106602722  CASP3; caspase-3-like [KO:K02187] [EC:3.4.22.56]
106612018  caspase-3-like [KO:K02187] [EC:3.4.22.56]
100194892  casp3; Caspase-3 [KO:K02187] [EC:3.4.22.56]
106566762  traf2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
106567744  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
106563303  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
106563020  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
106585142  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
106588403  DAXX; death domain-associated protein 6-like [KO:K02308]
106569963  death domain-associated protein 6-like [KO:K02308]
100169859  myd88; myeloid differentiation primary response 88 [KO:K04729]
106566344  interleukin-1 receptor-associated kinase 1-like [KO:K04730] [EC:2.7.11.1]
100196744  irak4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
106562692  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
106592035  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
106567216  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
106566617  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
106598934  GA45A; growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
106560326  GA45A; growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
106613608  GA45B; growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
106568974  GA45A; growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
106573930  GA45B; growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
106563369  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
106563370  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
100196442  ga45g; Growth arrest and DNA-damage-inducible protein GADD45 gamma [KO:K04402]
106585195  GA45G; growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
106584172  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
106590780  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403]
106594427  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403]
106607744  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like [KO:K04404]
106571309  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like [KO:K04404]
106577524  ecsit; ECSIT signalling integrator [KO:K04405]
106564791  mitogen-activated protein kinase kinase kinase kinase 3-like [KO:K04406] [EC:2.7.11.1]
106577155  mitogen-activated protein kinase kinase kinase kinase 3-like [KO:K04406] [EC:2.7.11.1]
106608247  mitogen-activated protein kinase kinase kinase kinase 3-like [KO:K04406] [EC:2.7.11.1]
106585154  mitogen-activated protein kinase kinase kinase kinase 3-like [KO:K04406] [EC:2.7.11.1]
106582256  mitogen-activated protein kinase kinase kinase kinase 4-like [KO:K04407] [EC:2.7.11.1]
106586477  mitogen-activated protein kinase kinase kinase kinase 4-like [KO:K04407] [EC:2.7.11.1]
100196367  tnik; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
106611981  mitogen-activated protein kinase kinase kinase kinase 4-like [KO:K04407] [EC:2.7.11.1]
100380347  pak3; Serine/threonine-protein kinase PAK 3 [KO:K04409] [EC:2.7.11.1]
106612881  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
106595470  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
106594148  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
106595887  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
106584354  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
106613860  pak2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
100380329  stk4; Serine/threonine-protein kinase 4 [KO:K04411]
106570786  serine/threonine-protein kinase 3-like [KO:K04412]
106570788  serine/threonine-protein kinase 3 [KO:K04412]
106602940  M4K2; mitogen-activated protein kinase kinase kinase kinase 2-like [KO:K04414] [EC:2.7.11.1]
106608590  mitogen-activated protein kinase kinase kinase kinase 2-like [KO:K04414] [EC:2.7.11.1]
106563748  M4K2; mitogen-activated protein kinase kinase kinase kinase 2-like [KO:K04414] [EC:2.7.11.1]
106577529  mitogen-activated protein kinase kinase kinase kinase 2-like [KO:K04414] [EC:2.7.11.1]
106578553  mitogen-activated protein kinase kinase kinase 8-like [KO:K04415] [EC:2.7.11.25]
100380500  m3k8; Mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
106571505  map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
106562896  mitogen-activated protein kinase kinase kinase 1-like [KO:K04416] [EC:2.7.11.25]
106608687  mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
106577540  mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
106574243  mitogen-activated protein kinase kinase kinase 2-like [KO:K04420] [EC:2.7.11.25]
106575171  mitogen-activated protein kinase kinase kinase 2-like [KO:K04420] [EC:2.7.11.25]
106606859  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
106590696  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
106595351  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
106600704  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
106612493  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
106610814  mitogen-activated protein kinase kinase kinase MLK4-like [KO:K17534] [EC:2.7.11.25]
106589668  mitogen-activated protein kinase kinase kinase MLK4-like [KO:K17534] [EC:2.7.11.25]
106566706  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
106571953  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
106566170  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
106582660  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
106582565  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
106582576  mitogen-activated protein kinase kinase kinase 13-like [KO:K04422] [EC:2.7.11.25]
106600095  mitogen-activated protein kinase kinase kinase MLT-like [KO:K04424] [EC:2.7.11.25]
106581757  mitogen-activated protein kinase kinase kinase MLT-like [KO:K04424] [EC:2.7.11.25]
106569504  map3k20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
106586235  mitogen-activated protein kinase kinase kinase MLT-like [KO:K04424] [EC:2.7.11.25]
106605130  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
106583027  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
106607751  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
106571336  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
106572417  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
100196829  map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
106610755  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
106571331  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
106611248  mitogen-activated protein kinase kinase kinase 4-like [KO:K04428] [EC:2.7.11.25]
106589750  mitogen-activated protein kinase kinase kinase 4-like [KO:K04428] [EC:2.7.11.25]
100380319  taok3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
106579406  serine/threonine-protein kinase TAO2-like [KO:K04429] [EC:2.7.11.1]
106579820  serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
106581166  serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
106583946  serine/threonine-protein kinase TAO2-like [KO:K04429] [EC:2.7.11.1]
106600755  serine/threonine-protein kinase TAO2-like [KO:K04429] [EC:2.7.11.1]
106613037  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
106563797  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
106568210  serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
106603990  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
106564451  serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
106601504  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
106578855  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
106589490  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
100196891  map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
106587435  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
106564723  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
106601934  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
106606355  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
106606359  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100136944  mkk6a; mitogen-activated protein kinase kinase 6a [KO:K04433] [EC:2.7.12.2]
100192337  mkk6b; MAPK kinase 6b [KO:K04433] [EC:2.7.12.2]
100192338  mkk6c; MAPK kinase 6c [KO:K04433] [EC:2.7.12.2]
106561607  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
106561900  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
106573101  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
106587053  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
106561234  C-Jun-amino-terminal kinase-interacting protein 2-like [KO:K04435]
106573413  C-Jun-amino-terminal kinase-interacting protein 2-like [KO:K04435]
106600681  mapk8ip3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
106583929  C-Jun-amino-terminal kinase-interacting protein 3-like [KO:K04436]
100380643  flna; filamin-A [KO:K04437]
106566436  crk-like protein [KO:K04438]
106603721  adapter molecule crk-like [KO:K04438]
106563168  crk-like protein [KO:K04438]
106580783  adapter molecule crk-like [KO:K04438]
106567578  adapter molecule crk-like [KO:K04438]
100306842  crk; v-crk sarcoma virus CT10 oncogene homolog (avian) [KO:K04438]
106603582  arrestin red cell isoform 2 [KO:K04439]
106608931  arrestin red cell isoform 1-like [KO:K04439]
106567894  arrestin red cell isoform 3 [KO:K04439]
106577890  arrestin red cell isoform 1-like [KO:K04439]
106613326  beta-arrestin-1 [KO:K04439]
106604288  mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
106560362  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
106604910  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
106568502  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
106576863  mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
106579004  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
106563760  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
106589346  mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
106609456  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
106609457  MK12; mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106561402  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106566975  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106566983  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
106573286  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106572737  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106572761  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106566105  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106566106  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106576243  MK12; mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106576244  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
100137046  p38b; mitogen activated protein kinase p38b [KO:K04441] [EC:2.7.11.24]
100196619  mk13; Mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100136932  p38a; mitogen activated protein kinase p38a [KO:K04441] [EC:2.7.11.24]
106580195  mapkapk5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
106585864  MAP kinase-activated protein kinase 5-like [KO:K04442] [EC:2.7.11.1]
106566648  MAPK2; MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
106571864  MAPK2; MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
106583822  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
106565813  MAPK3; MAP kinase-activated protein kinase 3-like [KO:K04444] [EC:2.7.11.1]
106565558  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
100194763  mapk3; mitogen-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
106603776  ribosomal protein S6 kinase alpha-5-like [KO:K04445] [EC:2.7.11.1]
106611337  ribosomal protein S6 kinase alpha-5-like [KO:K04445] [EC:2.7.11.1]
106563461  ribosomal protein S6 kinase alpha-4-like [KO:K16510] [EC:2.7.11.1]
106561325  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
106611433  cdc25b; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
106593289  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
106583607  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
106605067  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
106569777  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
106588230  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
106573250  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
106561519  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
106562446  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
106587624  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
106600411  jun; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
106613963  JUN; transcription factor AP-1-like [KO:K04448]
106569413  transcription factor AP-1-like [KO:K04448]
106568560  transcription factor AP-1-like [KO:K04448]
106584280  JUN; transcription factor AP-1-like [KO:K04448]
106572830  transcription factor AP-1-like [KO:K04448]
106568945  JUND; transcription factor jun-D-like [KO:K04449]
106573907  JUND; transcription factor jun-D-like [KO:K04449]
106582491  cyclic AMP-dependent transcription factor ATF-2-like [KO:K04450]
106586246  atf2; activating transcription factor 2 [KO:K04450]
106602901  tp53; tumor protein p53 [KO:K04451]
106608673  P53; cellular tumor antigen p53-like [KO:K04451]
106577554  cellular tumor antigen p53-like [KO:K04451]
106582666  DNA damage-inducible transcript 3 protein-like [KO:K04452]
106588122  MAX; protein max-like [KO:K04453]
106608157  MAX; protein max [KO:K04453]
106611077  protein max-like [KO:K04453]
106571089  protein max-like [KO:K04453]
106568324  myocyte-specific enhancer factor 2C-like [KO:K04454]
106563077  myocyte-specific enhancer factor 2C-like [KO:K04454]
100500787  myocyte-specific enhancer factor 2C [KO:K04454]
106580134  myocyte-specific enhancer factor 2C-like [KO:K04454]
106603948  heat shock protein beta-1-like [KO:K04455]
106567403  heat shock protein beta-1-like [KO:K04455]
106568216  heat shock protein beta-1-like [KO:K04455]
100196153  hspb1; heat shock protein, alpha-crystallin-related, 1 [KO:K04455]
106582637  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106585772  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106602915  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106607890  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106610858  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106564869  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106613111  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106581334  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106571474  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100194605  akt2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
106589689  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106603341  ppm1n; protein phosphatase, Mg2+/Mn2+ dependent 1N (putative) [KO:K04457] [EC:3.1.3.16]
106610975  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
106612376  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
106598722  protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
106571506  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
100380523  ppm1a; protein phosphatase 1A, magnesium dependent, alpha isoform [KO:K04457] [EC:3.1.3.16]
106609810  ptprr; protein tyrosine phosphatase, receptor type R [KO:K04458] [EC:3.1.3.48]
106561045  ptpn5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
106584593  tyrosine-protein phosphatase non-receptor type 5-like [KO:K18018] [EC:3.1.3.48]
106572094  tyrosine-protein phosphatase non-receptor type 7-like [KO:K18019] [EC:3.1.3.48]
100380564  ptn7; Tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
106604105  dual specificity protein phosphatase 1-like [KO:K21278] [EC:3.1.3.16 3.1.3.48]
106611914  dual specificity protein phosphatase 1-like [KO:K21278] [EC:3.1.3.16 3.1.3.48]
106568147  dual specificity protein phosphatase 4-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106600694  tyrosine-protein phosphatase vhp-1-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106564480  DUS5; dual specificity protein phosphatase 5-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106580476  dual specificity protein phosphatase 2-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106566750  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106563492  dual specificity protein phosphatase 4-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106583919  tyrosine-protein phosphatase vhp-1-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106590170  DUS5; dual specificity protein phosphatase 5-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106561046  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106584592  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106566241  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106571910  DUS7; dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106596522  dual specificity protein phosphatase 16-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106573116  dual specificity protein phosphatase 6-like [KO:K21946] [EC:3.1.3.16 3.1.3.48]
100306828  dus6; Dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
106607590  dual specificity protein phosphatase 10-like [KO:K20216] [EC:3.1.3.16 3.1.3.48]
106571212  dual specificity protein phosphatase 10-like [KO:K20216] [EC:3.1.3.16 3.1.3.48]
106583869  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
106579333  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
106572628  serine/threonine-protein phosphatase 5-like [KO:K04460] [EC:3.1.3.16]
106613338  serine/threonine-protein phosphatase 5-like [KO:K04460] [EC:3.1.3.16]
106610913  ppm1b; protein phosphatase, Mg2+/Mn2+ dependent 1B [KO:K04461] [EC:3.1.3.16]
106578933  protein phosphatase 1B-like [KO:K04461] [EC:3.1.3.16]
106589410  protein phosphatase 1B-like [KO:K04461] [EC:3.1.3.16]
106601018  heat shock 70 kDa protein-like [KO:K03283]
106603659  HSP70; heat shock cognate 70 kDa protein [KO:K03283]
106607232  heat shock 70 kDa protein-like [KO:K03283]
106607282  heat shock 70 kDa protein-like [KO:K03283]
106566386  heat shock 70 kDa protein-like [KO:K03283]
106567641  heat shock cognate 70 kDa protein-like [KO:K03283]
106572869  heat shock 70 kDa protein-like [KO:K03283]
106596195  hsp70; heat shock 70 kDa protein [KO:K03283]
100196655  hsp70-3; heat shock protein 70 [KO:K03283]
106599929  HSP70; heat shock 70 kDa protein-like [KO:K03283]
100194521  hspa8; heat shock protein 8 [KO:K03283]
106613013  heat shock cognate 70 kDa protein-like [KO:K03283]
106612562  MDS1 and EVI1 complex locus protein EVI1-like [KO:K04462] [EC:2.1.1.367]
106580920  MDS1 and EVI1 complex locus protein EVI1-like [KO:K04462] [EC:2.1.1.367]
106586755  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
106572532  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
106567334  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
106565406  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
106583344  probable nuclear hormone receptor HR38 [KO:K04465]
100380862  m3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
106607326  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
106579033  uncharacterized LOC106579033 [KO:K04466] [EC:2.7.11.25]
106579286  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
106579422  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
106589264  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
106580426  ikbkb; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
106572992  NF-kappa-B essential modulator-like [KO:K07210]
106590733  ikbkg; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
106592447  NF-kappa-B essential modulator-like [KO:K07210]
106600752  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
106613077  nlk; nemo like kinase [KO:K04468] [EC:2.7.11.24]
106581270  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
106583944  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
106604768  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
106611703  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
106606070  nuclear factor NF-kappa-B p100 subunit-like [KO:K04469]
100380298  nfkb2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 [KO:K04469]
106608684  putative transcription factor p65 homolog [KO:K04735]
106577543  transcription factor p65-like [KO:K04735]
100380715  relb; RELB proto-oncogene, NF-kB subunit [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Nat Rev Drug Discov 8:480-99 (2009)
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