KEGG   PATHWAY: pbg04010
Entry
pbg04010                    Pathway                                
Name
MAPK signaling pathway - Prionailurus bengalensis (leopard cat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pbg04010  MAPK signaling pathway
pbg04010

Other DBs
GO: 0000165
Organism
Prionailurus bengalensis (leopard cat) [GN:pbg]
Gene
122486958  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
122475057  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
122473119  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
122487331  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
122476158  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
122477612  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
122485369  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
122471886  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
122472785  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
122476562  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
122487824  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
122487259  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
122487338  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
122473885  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
122485467  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
122473743  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
122472339  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
122481337  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
122485798  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
122473309  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
122471544  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
122485799  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
122485800  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
122494747  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
122494749  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
122494746  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
122480698  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122486980  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
122485801  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122471545  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122494748  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
122471226  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
122480621  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
122486926  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
122472418  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122478050  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122493457  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122475009  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
122496932  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
122468170  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
122490417  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
122468800  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
122483972  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
122466911  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
122494101  RASGRP4; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 4 [KO:K12363]
122474939  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
122485189  NF1; neurofibromin isoform X1 [KO:K08052]
122490769  RASA1; LOW QUALITY PROTEIN: ras GTPase-activating protein 1 [KO:K04352]
122491919  RASA2; LOW QUALITY PROTEIN: ras GTPase-activating protein 2 [KO:K08053]
122480933  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
122474003  RAP1B; ras-related protein Rap-1b [KO:K07836]
122477450  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
122496971  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
122478793  EREG; proepiregulin [KO:K09784]
122478792  AREG; amphiregulin [KO:K09782]
122488446  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
122469044  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
122480538  FGF9; fibroblast growth factor 9 [KO:K04358]
122484103  FGF4; fibroblast growth factor 4 [KO:K04358]
122484388  FGF3; fibroblast growth factor 3 [KO:K04358]
122492387  FGF18; fibroblast growth factor 18 [KO:K04358]
122494030  FGF10; fibroblast growth factor 10 [KO:K04358]
122467573  FGF20; fibroblast growth factor 20 [KO:K04358]
122472591  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122486611  FGF22; fibroblast growth factor 22 [KO:K04358]
122478739  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
122468669  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
122477434  FGF16; fibroblast growth factor 16 [KO:K04358]
122492630  FGF8; fibroblast growth factor 8 [KO:K04358]
122472551  FGF6; fibroblast growth factor 6 [KO:K04358]
122484387  FGF19; fibroblast growth factor 19 [KO:K22603]
122494859  FGF21; fibroblast growth factor 21 [KO:K22429]
122472692  FGF23; fibroblast growth factor 23 [KO:K22428]
122480987  NGF; beta-nerve growth factor [KO:K02582]
122483648  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
122472160  NTF3; neurotrophin-3 [KO:K04356]
122494840  NTF4; neurotrophin-4 [KO:K12457]
122484127  INS; insulin [KO:K04526]
122472604  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
122484126  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
122471191  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
122472773  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
122482899  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
122475093  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
122480903  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
122472441  KITLG; kit ligand isoform X1 [KO:K05461]
122494815  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
122489562  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
122483956  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
122469337  PGF; placenta growth factor isoform X1 [KO:K16859]
122470391  VEGFC; vascular endothelial growth factor C [KO:K05449]
122477565  VEGFD; vascular endothelial growth factor D [KO:K05449]
122487823  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
122495712  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
122470174  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
122496446  ANGPT4; angiopoietin-4 [KO:K05467]
122491824  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
122488595  EFNA2; ephrin-A2 [KO:K05462]
122476371  EFNA1; ephrin-A1 [KO:K05462]
122475951  EFNA3; ephrin-A3 [KO:K05462]
122476409  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
122494477  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
122486767  NRTN; neurturin [KO:K25414]
122479389  ARTN; artemin [KO:K25415]
122486534  PSPN; persephin [KO:K25416]
122487677  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122485481  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
122473747  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
122481727  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
122473425  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
122493321  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122479132  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122491274  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122485394  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
122475682  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
122474678  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
122488640  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
122468290  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
122478872  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
122493456  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
122493494  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
122478870  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
122480968  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
122481013  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
122485844  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
122478869  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
122488133  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
122475108  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
122479981  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
122493003  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
122485897  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
122469065  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122497238  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122484176  HRAS; GTPase HRas isoform X1 [KO:K02833]
122473961  KRAS; GTPase KRas [KO:K07827]
122480981  NRAS; GTPase NRas [KO:K07828]
122493859  RRAS; ras-related protein R-Ras [KO:K07829]
122483585  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
122491939  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
122477714  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
122488405  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122487521  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
122468485  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122486708  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
122467306  LOW QUALITY PROTEIN: ragulator complex protein LAMTOR3-like [KO:K04370]
122478209  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
122473842  LOW QUALITY PROTEIN: ragulator complex protein LAMTOR3-like [KO:K04370]
122470517  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122471493  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
122480454  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
122486633  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
122480127  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
122490178  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
122477554  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
122476758  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
122472782  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122477978  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
122476504  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
122495809  MYC; myc proto-oncogene protein [KO:K04377]
122489541  SRF; serum response factor [KO:K04378]
122469346  FOS; proto-oncogene c-Fos [KO:K04379]
122485735  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
122480105  STMN1; stathmin [KO:K04381]
122467661  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
122468029  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
122467662  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
122468734  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
122476393  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
122478253  TNF; tumor necrosis factor [KO:K03156]
122497170  IL1A; interleukin-1 alpha [KO:K04383]
122497169  IL1B; interleukin-1 beta [KO:K04519]
122494005  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
122476025  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
122469354  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
122473857  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
122496688  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
122491608  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
122475250  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
122492079  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
122476073  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122492668  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
122488155  CD14; monocyte differentiation antigen CD14 [KO:K04391]
122471262  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122474541  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
122472709  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
122485969  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
122480065  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
122480120  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
122494374  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
122470647  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
122474992  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
122489403  DAXX; death domain-associated protein 6 [KO:K02308]
122492160  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
122477987  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
122473209  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
122483712  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
122480620  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
122486654  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
122474523  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
122472775  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
122490077  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
122486904  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
122497236  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
122496692  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
122494097  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
122483301  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
122491570  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
122496222  STK4; serine/threonine-protein kinase 4 [KO:K04411]
122495651  STK3; serine/threonine-protein kinase 3 [KO:K04412]
122483976  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
122473980  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
122489134  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
122484467  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
122481226  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
122485762  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
122469274  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
122494287  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
122492733  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
122473479  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
122491644  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
122481465  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
122480150  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
122490389  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
122489770  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122490157  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
122486085  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
122470283  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
122471481  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
122484971  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
122488616  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122485071  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
122485830  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
122483747  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
122473008  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
122471844  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
122476821  FLNA; filamin-A isoform X1 [KO:K04437]
122485124  CRK; adapter molecule crk isoform X1 [KO:K04438]
122470502  CRKL; crk-like protein [KO:K04438]
122483332  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
122484836  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
122485896  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122478691  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122492960  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122490348  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
122490350  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
122472987  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
122472989  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
122470229  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
122476270  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
122487271  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
122469441  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
122483966  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
122496519  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
122470886  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
122495133  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
122480569  JUN; transcription factor AP-1 [KO:K04448]
122487095  JUND; transcription factor jun-D [KO:K04449]
122481480  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
122484900  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
122473818  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
122469223  MAX; LOW QUALITY PROTEIN: protein max [KO:K04453]
122490917  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
122471344  HSPB1; heat shock protein beta-1 [KO:K04455]
122469592  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122494042  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122476061  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122469173  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
122474051  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
122483606  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
122476615  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
122492214  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
122484144  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122471707  DUSP4; LOW QUALITY PROTEIN: dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122487294  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122493237  DUSP5; LOW QUALITY PROTEIN: dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122473114  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122497213  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122472452  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
122477242  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
122476484  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
122485656  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
122494920  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
122496784  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
122483090  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
122478300  heat shock 70 kDa protein 1-like [KO:K03283]
122478299  heat shock 70 kDa protein 1 [KO:K03283]
122476339  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
122491755  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
122468470  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
122485025  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
122473418  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
122485712  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
122493134  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122472994  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122477442  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122485181  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
122478010  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122493183  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
122484468  RELA; transcription factor p65 [KO:K04735]
122493902  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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PMID:12191611
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Tanoue T, Nishida E.
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Pharmacol Ther 93:193-202 (2002)
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PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Gene 320:3-21 (2003)
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
pbg04070  Phosphatidylinositol signaling system
pbg04110  Cell cycle
pbg04115  p53 signaling pathway
pbg04210  Apoptosis
pbg04310  Wnt signaling pathway
pbg04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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