KEGG   PATHWAY: tup04014
Entry
tup04014                    Pathway                                
Name
Ras signaling pathway - Tupaia chinensis (Chinese tree shrew)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
tup04014  Ras signaling pathway
tup04014

Other DBs
GO: 0032318
Organism
Tupaia chinensis (Chinese tree shrew) [GN:tup]
Gene
102490423  EGF; epidermal growth factor [KO:K04357]
102497817  TGFA; transforming growth factor alpha [KO:K08774]
102472932  FGF1; fibroblast growth factor 1 [KO:K18496]
102498637  FGF2; fibroblast growth factor 2 [KO:K18497]
102489294  FGF9; fibroblast growth factor 9 [KO:K04358]
102500824  FGF16; fibroblast growth factor 16 [KO:K04358]
102496950  FGF18; fibroblast growth factor 18 [KO:K04358]
102470973  FGF20; fibroblast growth factor 20 [KO:K04358]
102477924  FGF17; fibroblast growth factor 17 [KO:K04358]
102492980  FGF5; fibroblast growth factor 5 [KO:K04358]
102478652  FGF6; fibroblast growth factor 6 [KO:K04358]
102470048  FGF3; fibroblast growth factor 3 [KO:K04358]
102470471  FGF4; fibroblast growth factor 4 [KO:K04358]
102496545  FGF8; fibroblast growth factor 8 [KO:K04358]
102500031  FGF10; fibroblast growth factor 10 [KO:K04358]
102494532  FGF22; fibroblast growth factor 22 [KO:K04358]
102476072  FGF7; fibroblast growth factor 7 [KO:K04358]
102470889  FGF19; fibroblast growth factor 19 [KO:K22603]
102480823  fibroblast growth factor 19-like [KO:K22603]
102474175  FGF21; fibroblast growth factor 21 [KO:K22429]
102479073  FGF23; fibroblast growth factor 23 [KO:K22428]
102501945  NGF; nerve growth factor [KO:K02582]
102475289  BDNF; brain derived neurotrophic factor [KO:K04355]
102484355  NTF3; neurotrophin 3 [KO:K04356]
102468545  NTF4; neurotrophin 4 [KO:K12457]
102481191  INS; insulin [KO:K04526]
102490248  IGF1; insulin like growth factor 1 [KO:K05459]
102481608  IGF2; insulin like growth factor 2 [KO:K13769]
102499235  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102482500  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102485007  PDGFD; platelet derived growth factor D [KO:K05450]
102487522  PDGFC; platelet derived growth factor C [KO:K05450]
102492960  CSF1; colony stimulating factor 1 [KO:K05453]
102501429  KITLG; KIT ligand [KO:K05461]
102494016  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
102499303  VEGFA; vascular endothelial growth factor A [KO:K05448]
102494761  VEGFB; vascular endothelial growth factor B [KO:K16858]
102480300  PGF; placental growth factor [KO:K16859]
102498502  VEGFC; vascular endothelial growth factor C [KO:K05449]
102486007  VEGFD; vascular endothelial growth factor D [KO:K05449]
102483689  HGF; hepatocyte growth factor [KO:K05460]
102471695  ANGPT1; angiopoietin 1 [KO:K05465]
102472273  angiopoietin-2 [KO:K05466]
102500020  ANGPT2; angiopoietin 2 [KO:K05466]
102482199  ANGPT4; angiopoietin 4 [KO:K05467]
102502764  EFNA5; ephrin A5 [KO:K05462]
102477308  EFNA1; ephrin A1 [KO:K05462]
102477745  EFNA4; ephrin A4 [KO:K05462]
102468360  EFNA2; ephrin A2 [KO:K05462]
102485304  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102484087  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102484403  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102500041  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102475159  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102498614  NGFR; nerve growth factor receptor [KO:K02583]
102485200  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
102497563  BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
102469167  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102473496  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102488187  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102492413  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102491581  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102489301  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
106733545  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
102480253  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
102482918  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
102489981  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
102485847  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
102498017  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
102487364  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
102493080  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102497468  GAB1; GRB2 associated binding protein 1 [KO:K09593]
102490988  GAB2; GRB2 associated binding protein 2 [KO:K08091]
102481002  SHC1; SHC adaptor protein 1 [KO:K06279]
102481863  SHC2; SHC adaptor protein 2 [KO:K17447]
102472295  SHC3; SHC adaptor protein 3 [KO:K17448]
102479734  SHC4; SHC adaptor protein 4 [KO:K17449]
102485136  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
102498455  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
102494629  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102477222  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102469651  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
102483786  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
102468376  RASGRP1; RAS guanyl releasing protein 1 [KO:K04350]
102468592  RASGRP2; RAS guanyl releasing protein 2 [KO:K12361]
102498774  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
102492372  RASGRP4; RAS guanyl releasing protein 4 [KO:K12363]
102468690  uncharacterized LOC102468690 [KO:K10784]
102498024  T-cell receptor alpha chain V region CTL-F3 [KO:K10784]
102478258  T-cell receptor alpha chain V region PHDS58 [KO:K10784]
102481630  uncharacterized LOC102481630 [KO:K10785]
102483735  uncharacterized LOC102483735 [KO:K10785]
102485402  uncharacterized LOC102485402 [KO:K10785]
102486266  uncharacterized LOC102486266 [KO:K10785]
102469719  ZAP70; zeta-chain (TCR) associated protein kinase 70kDa [KO:K07360] [EC:2.7.10.2]
102501507  LAT; linker for activation of T-cells [KO:K07362]
102486834  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
102482352  GNB1; G protein subunit beta 1 [KO:K04536]
102484212  GNB2; G protein subunit beta 2 [KO:K04537]
102503265  GNB3; G protein subunit beta 3 [KO:K07825]
102487568  GNB5; G protein subunit beta 5 [KO:K04539]
102490695  GNG2; G protein subunit gamma 2 [KO:K07826]
102494820  GNG3; G protein subunit gamma 3 [KO:K04540]
102493758  GNG4; G protein subunit gamma 4 [KO:K04541]
102467951  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102476928  GNG7; G protein subunit gamma 7 [KO:K04543]
102493874  GNG8; G protein subunit gamma 8 [KO:K04544]
102492339  GNG11; G protein subunit gamma 11 [KO:K04546]
102501535  GNG12; G protein subunit gamma 12 [KO:K04347]
102476704  GNG13; G protein subunit gamma 13 [KO:K04547]
102491914  GNGT1; G protein subunit gamma transducin 1 [KO:K04548]
102495706  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
102502506  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102478525  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102482167  RASGRF1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
102479101  RASGRF2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
102469683  GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
102487925  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
102487806  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
102493041  CALM3; calmodulin 3 [KO:K02183]
102484707  neo-calmodulin-like [KO:K02183]
102479773  CALML5; calmodulin like 5 [KO:K02183]
102475973  CALML3; calmodulin-like protein 3 [KO:K02183]
102485493  calmodulin-like [KO:K02183]
102472462  CALM1; calmodulin 1 [KO:K02183]
102493190  CALM2; calmodulin 2 [KO:K02183]
102468681  CALML6; calmodulin like 6 [KO:K02183]
102495258  CALMODULIN; calmodulin-alpha [KO:K02183]
102483795  CALML4; calmodulin like 4 [KO:K02183]
102493230  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102500069  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102496534  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102468234  MRAS; muscle RAS oncogene homolog [KO:K07831]
102491386  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
106734036  ras-related protein R-Ras2-like [KO:K07830]
102496329  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102503100  RASA1; RAS p21 protein activator 1 [KO:K04352]
102493211  RASA2; RAS p21 protein activator 2 [KO:K08053]
102474171  RASA3; RAS p21 protein activator 3 [KO:K12380]
102467921  RASA4; ras GTPase-activating protein 4 [KO:K17630]
102491667  SYNGAP1; synaptic Ras GTPase activating protein 1 [KO:K17631]
102492287  RASAL1; RAS protein activator like 1 [KO:K17632]
102471187  RASAL2; RAS protein activator like 2 [KO:K17633]
102498434  RASAL3; RAS protein activator like 3 [KO:K17634]
102482534  RASSF1; Ras association domain family member 1 [KO:K09850]
102481620  RASSF5; Ras association domain family member 5 [KO:K08015]
102481933  STK4; serine/threonine kinase 4 [KO:K04411]
102500733  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
102479102  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102495436  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102494727  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102495430  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102472173  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
102500036  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
102499692  PAK4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
102474805  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
102493316  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
102487039  RHOA; ras homolog family member A [KO:K04513]
102500530  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102502163  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102483329  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
106736453  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
102469401  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102484444  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102484500  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102472172  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102492771  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102474297  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102476758  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102501308  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102467954  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102487413  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102490451  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102498069  BAD; BCL2 associated agonist of cell death [KO:K02158]
102486626  BCL2L1; BCL2 like 1 [KO:K04570]
102476837  FOXO4; forkhead box O4 [KO:K12358]
102502878  FASLG; Fas ligand [KO:K04389]
102493661  RALGAPA1; Ral GTPase activating protein catalytic alpha subunit 1 [KO:K25768]
102482063  RALGAPA2; Ral GTPase activating protein catalytic alpha subunit 2 [KO:K25768]
102499679  RALGAPB; Ral GTPase activating protein non-catalytic beta subunit [KO:K25769]
102479691  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
102476820  RGL1; ral guanine nucleotide dissociation stimulator like 1 [KO:K17635]
102492496  RGL2; ral guanine nucleotide dissociation stimulator like 2 [KO:K17636]
102481337  RALA; RAS like proto-oncogene A [KO:K07834]
102486756  RALB; RAS like proto-oncogene B [KO:K07835]
102495205  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
102499889  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
102482170  EXOC2; exocyst complex component 2 [KO:K17637]
102484078  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
102489095  REL; REL proto-oncogene, NF-kB subunit [KO:K09254]
102475730  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102472233  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102497095  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102472235  RALBP1; ralA binding protein 1 [KO:K08773]
102488344  CDC42; cell division cycle 42 [KO:K04393]
102477954  AFDN; afadin, adherens junction formation factor [KO:K05702]
102494279  SHOC2; SHOC2, leucine rich repeat scaffold protein [KO:K19613]
102497488  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102476496  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102483700  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102496453  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102483057  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102473695  PLA1A; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
102497076  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
102496651  PLA2G2F; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
102501355  PLA2G2D; phospholipase A2 group IID [KO:K01047] [EC:3.1.1.4]
102501775  PLA2G2A; phospholipase A2 group IIA [KO:K01047] [EC:3.1.1.4]
102502195  PLA2G2E; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
102499549  PLA2G2C; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
102475773  PLA2G3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
102476007  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102501534  PLA2G1B; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
102480654  PLA2G12A; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
102488847  PLA2G12B; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
102473333  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
102470223  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
102471767  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
102472618  JMJD7; jmjC domain-containing protein 7 [KO:K16342] [EC:3.1.1.4]
102470647  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
102477396  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
102488703  PLA2G6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
102485578  PLA2G16; HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102494763  ELK1; ELK1, ETS transcription factor [KO:K04375]
102483908  ETS1; ETS proto-oncogene 1, transcription factor [KO:K02678]
102468142  ETS2; ETS proto-oncogene 2, transcription factor [KO:K21932]
102494468  BRAP; BRCA1 associated protein [KO:K10632] [EC:2.3.2.27]
102473433  KSR1; kinase suppressor of ras 1 [KO:K14958]
102479852  KSR2; kinase suppressor of ras 2 [KO:K18529] [EC:2.7.11.1]
102497002  RAPGEF5; Rap guanine nucleotide exchange factor 5 [KO:K08019]
102475072  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
102472381  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
102499439  PLCE1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
102495954  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102469271  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102497204  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102496301  RIN1; Ras and Rab interactor 1 [KO:K17638]
102470554  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
102477086  ABL2; ABL proto-oncogene 2, non-receptor tyrosine kinase [KO:K08887] [EC:2.7.10.2]
102473232  RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
102500692  RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
102491203  RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
102476416  ARF6; ADP ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
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  Title
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Oncogene 22:8999-9006 (2003)
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Curr Biol 14:R277-8 (2004)
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Signaling threshold regulation by the Ras effector IMP.
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J Biol Chem 284:11007-11 (2009)
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Cell 141:1117-34 (2010)
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
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pathway
tup04010  MAPK signaling pathway
tup04015  Rap1 signaling pathway
tup04020  Calcium signaling pathway
tup04144  Endocytosis
tup04151  PI3K-Akt signaling pathway
tup04660  T cell receptor signaling pathway
tup04720  Long-term potentiation
tup04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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