KEGG   PATHWAY: hsa05152
Entry
hsa05152                    Pathway                                
Name
Tuberculosis - Homo sapiens (human)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
hsa05152  Tuberculosis
hsa05152

Disease
H00342  Tuberculosis
Organism
Homo sapiens (human) [GN:hsa]
Gene
10000  AKT3; RAC-gamma serine/threonine-protein kinase isoform 1 [KO:K04456] [EC:2.7.11.1]
102723407  [KO:K06856]
10312  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 isoform a [KO:K02154]
10332  CLEC4M; C-type lectin domain family 4 member M isoform 1 [KO:K06563]
10333  TLR6; toll-like receptor 6 precursor [KO:K10169]
1051  CEBPB; CCAAT/enhancer-binding protein beta isoform a [KO:K10048]
1054  CEBPG; CCAAT/enhancer-binding protein gamma [KO:K10049]
10892  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform a [KO:K07369] [EC:3.4.22.-]
11151  CORO1A; coronin-1A [KO:K13882]
114609  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform a [KO:K05403]
1263  PLK3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
1378  CR1; complement receptor type 1 isoform S precursor [KO:K04011]
1379  CR1L; complement component receptor 1-like protein precursor [KO:K04011]
1385  CREB1; cyclic AMP-responsive element-binding protein 1 isoform A [KO:K05870]
1387  CREBBP; CREB-binding protein isoform a [KO:K04498] [EC:2.3.1.48]
1432  MAPK14; mitogen-activated protein kinase 14 isoform 2 [KO:K04441] [EC:2.7.11.24]
1509  CTSD; cathepsin D preproprotein [KO:K01379] [EC:3.4.23.5]
1520  CTSS; cathepsin S isoform 1 preproprotein [KO:K01368] [EC:3.4.22.27]
1594  CYP27B1; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [KO:K07438] [EC:1.14.15.18]
163688  CALML6; calmodulin-like protein 6 isoform 1 [KO:K02183]
2033  EP300; histone acetyltransferase p300 isoform 1 [KO:K04498] [EC:2.3.1.48]
207  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
208  AKT2; RAC-beta serine/threonine-protein kinase isoform 1 [KO:K04456] [EC:2.7.11.1]
2207  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma precursor [KO:K07983]
2209  FCGR1A; high affinity immunoglobulin gamma Fc receptor I isoform 2 precursor [KO:K06498]
2212  FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a isoform 1 precursor [KO:K06472]
2213  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor [KO:K12560]
2214  FCGR3A; low affinity immunoglobulin gamma Fc region receptor III-A isoform c precursor [KO:K06463]
2215  FCGR3B; low affinity immunoglobulin gamma Fc region receptor III-B isoform 2 precursor [KO:K06463]
22925  PLA2R1; secretory phospholipase A2 receptor isoform 1 precursor [KO:K06560]
23365  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform 1 [KO:K07532]
23545  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 [KO:K02154]
245972  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
26253  CLEC4E; C-type lectin domain family 4 member E isoform 1 [KO:K10059]
30835  CD209; CD209 antigen isoform 1 [KO:K06563]
3108  HLA-DMA; HLA class II histocompatibility antigen, DM alpha chain precursor [KO:K06752]
3109  HLA-DMB; HLA class II histocompatibility antigen, DM beta chain precursor [KO:K06752]
3111  HLA-DOA; HLA class II histocompatibility antigen, DO alpha chain precursor [KO:K06752]
3112  HLA-DOB; HLA class II histocompatibility antigen, DO beta chain precursor [KO:K06752]
3113  HLA-DPA1; HLA class II histocompatibility antigen, DP alpha 1 chain precursor [KO:K06752]
3115  HLA-DPB1; HLA class II histocompatibility antigen, DP beta 1 chain precursor [KO:K06752]
3117  HLA-DQA1; HLA class II histocompatibility antigen, DQ alpha 1 chain precursor [KO:K06752]
3118  HLA-DQA2; HLA class II histocompatibility antigen, DQ alpha 2 chain precursor [KO:K06752]
3119  HLA-DQB1; HLA class II histocompatibility antigen, DQ beta 1 chain isoform 2 precursor [KO:K06752]
3120  HLA-DQB2; HLA class II histocompatibility antigen, DQ beta 2 chain isoform 2 precursor [KO:K06752]
3122  HLA-DRA; HLA class II histocompatibility antigen, DR alpha chain precursor [KO:K06752]
3123  HLA-DRB1; major histocompatibility complex, class II, DR beta 1 precursor [KO:K06752]
3125  HLA-DRB3; major histocompatibility complex, class II, DR beta 3 precursor [KO:K06752]
3126  HLA-DRB4; major histocompatibility complex, class II, DR beta 4 precursor [KO:K06752]
3127  HLA-DRB5; major histocompatibility complex, class II, DR beta 5 precursor [KO:K06752]
317  APAF1; apoptotic protease-activating factor 1 isoform c [KO:K02084]
3313  HSPA9; stress-70 protein, mitochondrial precursor [KO:K04043]
3329  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
3439  IFNA1; interferon alpha-1 precursor [KO:K05414]
3440  IFNA2; interferon alpha-2 precursor [KO:K05414]
3441  IFNA4; interferon alpha-4 precursor [KO:K05414]
3442  IFNA5; interferon alpha-5 precursor [KO:K05414]
3443  IFNA6; interferon alpha-6 precursor [KO:K05414]
3444  IFNA7; interferon alpha-7 precursor [KO:K05414]
3445  IFNA8; interferon alpha-8 precursor [KO:K05414]
3446  IFNA10; interferon alpha-10 precursor [KO:K05414]
3447  IFNA13; interferon alpha-13 precursor [KO:K05414]
3448  IFNA14; interferon alpha-14 precursor [KO:K05414]
3449  IFNA16; interferon alpha-16 precursor [KO:K05414]
3451  IFNA17; interferon alpha-17 precursor [KO:K05414]
3452  IFNA21; interferon alpha-21 precursor [KO:K05414]
3456  IFNB1; interferon beta precursor [KO:K05415]
3458  IFNG; interferon gamma precursor [KO:K04687]
3459  IFNGR1; interferon gamma receptor 1 isoform 1 precursor [KO:K05132]
3460  IFNGR2; interferon gamma receptor 2 isoform 2 precursor [KO:K05133]
3552  IL1A; interleukin-1 alpha precursor [KO:K04383]
3553  IL1B; interleukin-1 beta proprotein [KO:K04519]
3569  IL6; interleukin-6 isoform 1 precursor [KO:K05405]
3586  IL10; interleukin-10 isoform 1 precursor [KO:K05443]
3587  IL10RA; interleukin-10 receptor subunit alpha isoform 1 precursor [KO:K05134]
3588  IL10RB; interleukin-10 receptor subunit beta isoform 1 precursor [KO:K05135]
3592  IL12A; interleukin-12 subunit alpha isoform 4 precursor [KO:K05406]
3593  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
3606  IL18; interleukin-18 isoform 1 precursor [KO:K05482]
3654  IRAK1; interleukin-1 receptor-associated kinase 1 isoform 1 [KO:K04730] [EC:2.7.11.1]
3656  IRAK2; interleukin-1 receptor-associated kinase-like 2 [KO:K04731] [EC:2.7.11.1]
3684  ITGAM; integrin alpha-M isoform 2 precursor [KO:K06461]
3687  ITGAX; integrin alpha-X isoform 2 precursor [KO:K06462]
3689  ITGB2; integrin beta-2 isoform 1 precursor [KO:K06464]
3716  JAK1; tyrosine-protein kinase JAK1 isoform 1 [KO:K11217] [EC:2.7.10.2]
3717  JAK2; tyrosine-protein kinase JAK2 isoform a [KO:K04447] [EC:2.7.10.2]
387  RHOA; transforming protein RhoA isoform 1 precursor [KO:K04513]
3916  LAMP1; lysosome-associated membrane glycoprotein 1 precursor [KO:K06528]
3920  LAMP2; lysosome-associated membrane glycoprotein 2 isoform A precursor [KO:K06528]
3929  LBP; lipopolysaccharide-binding protein precursor [KO:K05399]
4046  LSP1; lymphocyte-specific protein 1 isoform 1 [KO:K14957]
4261  CIITA; MHC class II transactivator isoform 2 [KO:K08060] [EC:2.7.11.1]
4360  MRC1; macrophage mannose receptor 1 precursor [KO:K06560]
4615  MYD88; myeloid differentiation primary response protein MyD88 isoform 2 [KO:K04729]
4790  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein [KO:K02580]
4800  NFYA; nuclear transcription factor Y subunit alpha isoform 1 [KO:K08064]
4801  NFYB; nuclear transcription factor Y subunit beta isoform b [KO:K08065]
4802  NFYC; nuclear transcription factor Y subunit gamma isoform 6 [KO:K08066]
4843  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
50617  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
51135  IRAK4; interleukin-1 receptor-associated kinase 4 isoform a [KO:K04733] [EC:2.7.11.1]
51561  IL23A; interleukin-23 subunit alpha precursor [KO:K05426]
51606  ATP6V1H; V-type proton ATPase subunit H isoform 1 [KO:K02144]
51806  CALML5; calmodulin-like protein 5 [KO:K02183]
527  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
5289  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform 1 [KO:K00914] [EC:2.7.1.137]
533  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 1 [KO:K03661]
535  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform 1 [KO:K02154]
537  ATP6AP1; V-type proton ATPase subunit S1 precursor [KO:K03662]
54106  TLR9; toll-like receptor 9 precursor [KO:K10161]
54205  CYCS; cytochrome c [KO:K08738]
5530  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform 1 [KO:K04348] [EC:3.1.3.16]
5532  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform b [KO:K04348] [EC:3.1.3.16]
5533  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2 [KO:K04348] [EC:3.1.3.16]
5534  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
5535  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
5594  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  MAPK3; mitogen-activated protein kinase 3 isoform 1 [KO:K04371] [EC:2.7.11.24]
5599  MAPK8; mitogen-activated protein kinase 8 isoform alpha2 [KO:K04440] [EC:2.7.11.24]
5600  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
5601  MAPK9; mitogen-activated protein kinase 9 isoform alpha2 [KO:K04440] [EC:2.7.11.24]
5602  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
5603  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
56848  SPHK2; sphingosine kinase 2 isoform a [KO:K04718] [EC:2.7.1.91]
572  BAD; bcl2-associated agonist of cell death [KO:K02158]
581  BAX; apoptosis regulator BAX isoform alpha [KO:K02159]
5868  RAB5A; ras-related protein Rab-5A isoform 1 [KO:K07887]
5869  RAB5B; ras-related protein Rab-5B isoform 1 [KO:K07888]
5878  RAB5C; ras-related protein Rab-5C isoform a [KO:K07889]
5894  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform b [KO:K04366] [EC:2.7.11.1]
596  BCL2; apoptosis regulator Bcl-2 isoform alpha [KO:K02161]
5970  RELA; transcription factor p65 isoform 1 [KO:K04735]
5993  RFX5; DNA-binding protein RFX5 isoform 1 [KO:K08061]
5994  RFXAP; regulatory factor X-associated protein [KO:K08063]
6300  MAPK12; mitogen-activated protein kinase 12 isoform 1 [KO:K04441] [EC:2.7.11.24]
637  BID; BH3-interacting domain death agonist isoform 2 [KO:K04726]
64127  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform 1 [KO:K10165]
64170  CARD9; caspase recruitment domain-containing protein 9 isoform 1 [KO:K12794]
64581  CLEC7A; C-type lectin domain family 7 member A isoform a [KO:K10074]
6714  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
6772  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform alpha [KO:K11220]
6850  SYK; tyrosine-protein kinase SYK isoform Syk(L) [KO:K05855] [EC:2.7.10.2]
7040  TGFB1; transforming growth factor beta-1 proprotein preproprotein [KO:K13375]
7042  TGFB2; transforming growth factor beta-2 proprotein isoform 2 preproprotein [KO:K13376]
7043  TGFB3; transforming growth factor beta-3 proprotein isoform 1 preproprotein [KO:K13377]
7096  TLR1; toll-like receptor 1 precursor [KO:K05398]
7097  TLR2; toll-like receptor 2 precursor [KO:K10159]
7099  TLR4; toll-like receptor 4 isoform A precursor [KO:K10160]
7124  TNF; tumor necrosis factor [KO:K03156]
7132  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform 1 precursor [KO:K03158]
718  C3; complement C3 preproprotein [KO:K03990]
7189  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
7421  VDR; vitamin D3 receptor isoform VDRA [KO:K08539]
7879  RAB7A; ras-related protein Rab-7a [KO:K07897]
801  CALM1; calmodulin-1 isoform 2 [KO:K02183]
805  CALM2; calmodulin-2 isoform 2 [KO:K02183]
808  CALM3; calmodulin-3 isoform 1 [KO:K02183]
810  CALML3; calmodulin-like protein 3 [KO:K02183]
815  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2 [KO:K04515] [EC:2.7.11.17]
816  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1 [KO:K04515] [EC:2.7.11.17]
817  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3 [KO:K04515] [EC:2.7.11.17]
818  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 7 [KO:K04515] [EC:2.7.11.17]
820  CAMP; cathelicidin antimicrobial peptide preproprotein [KO:K13916]
836  CASP3; caspase-3 isoform a preproprotein [KO:K02187] [EC:3.4.22.56]
841  CASP8; caspase-8 isoform 2 precursor [KO:K04398] [EC:3.4.22.61]
8411  EEA1; early endosome antigen 1 [KO:K12478]
842  CASP9; caspase-9 isoform alpha precursor [KO:K04399] [EC:3.4.22.62]
843  CASP10; caspase-10 isoform 2 preproprotein [KO:K04400] [EC:3.4.22.63]
8625  RFXANK; DNA-binding protein RFXANK isoform a [KO:K08062]
8717  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
8767  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform 1 [KO:K08846] [EC:2.7.11.1]
8772  FADD; FAS-associated death domain protein [KO:K02373]
8844  KSR1; kinase suppressor of Ras 1 isoform 2 [KO:K14958]
8877  SPHK1; sphingosine kinase 1 isoform 3 [KO:K04718] [EC:2.7.1.91]
8915  BCL10; B-cell lymphoma/leukemia 10 isoform 1 [KO:K07368]
9103  FCGR2C; Fc gamma receptor IIc (gene/pseudogene) [KO:K16824]
9114  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
91860  CALML4; calmodulin-like protein 4 isoform 1 [KO:K02183]
929  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
972  CD74; HLA class II histocompatibility antigen gamma chain isoform a [KO:K06505]
9902  MRC2; C-type mannose receptor 2 precursor [KO:K06560]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
hsa04010  MAPK signaling pathway
hsa04210  Apoptosis
hsa04612  Antigen processing and presentation
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
KO pathway
ko05152   

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