KEGG   PATHWAY: lcat05022
Entry
lcat05022                   Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Lemur catta (Ring-tailed lemur)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
lcat05022  Pathways of neurodegeneration - multiple diseases
lcat05022

Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123620171  [KO:K08738]
123620296  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
123620321  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
123620323  CDK5R1; LOW QUALITY PROTEIN: cyclin-dependent kinase 5 activator 1 [KO:K11716]
123620478  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
123620525  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
123620561  WNT3; proto-oncogene Wnt-3 [KO:K00312]
123620566  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
123620597  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
123620626  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
123620633  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
123620754  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
123620810  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
123620852  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
123620934  HAP1; huntingtin-associated protein 1 isoform X1 [KO:K04647]
123620977  BECN1; beclin-1 [KO:K08334]
123621033  FZD2; frizzled-2 [KO:K02235]
123621075  UBB; polyubiquitin-B [KO:K08770]
123621103  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
123621118  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123621124  AXIN2; axin-2 isoform X1 [KO:K04385]
123621197  WNT9B; protein Wnt-9b [KO:K01064]
123621235  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
123621470  [KO:K02138]
123621509  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
123621514  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
123621547  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
123621590  [KO:K03948]
123621759  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
123621799  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123621805  SQSTM1; sequestosome-1 [KO:K14381]
123621824  TUBB6; tubulin beta-6 chain [KO:K07375]
123621881  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
123621883  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
123621919  [KO:K02271]
123621957  SPG11; spatacsin isoform X1 [KO:K19026]
123622057  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
123622065  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
123622114  HTT; huntingtin isoform X1 [KO:K04533]
123622324  TUBB1; tubulin beta-1 chain [KO:K07375]
123622325  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
123622419  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
123622513  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
123622515  PDYN; proenkephalin-B [KO:K15840]
123622563  [KO:K05634]
123622686  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
123622735  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
123622846  BCL2L1; bcl-2-like protein 1 [KO:K04570]
123622847  [KO:K02263]
123622878  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
123622897  VAPB; vesicle-associated membrane protein-associated protein B/C [KO:K10707]
123623035  CALML3; calmodulin-like protein 3 [KO:K02183]
123623036  CALML5; calmodulin-like protein 5 [KO:K02183]
123623040  TUBAL3; LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
123623167  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
123623196  DNAH1; dynein axonemal heavy chain 1 [KO:K10408]
123623259  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
123623277  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
123623309  [KO:K00414]
123623346  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
123623368  DNAH12; dynein axonemal heavy chain 12 [KO:K10408]
123623513  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
123623521  CTNNB1; catenin beta-1 [KO:K02105]
123623574  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
123623846  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
123623873  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
123623919  CALM3; calmodulin-3 [KO:K02183]
123623959  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
123623979  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
123624121  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 isoform X1 [KO:K05611] [EC:3.4.19.12]
123624236  [KO:K02128]
123624263  [KO:K02271]
123624276  [KO:K00411] [EC:7.1.1.8]
123624324  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
123624327  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
123624366  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
123624371  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
123624378  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
123624433  [KO:K02270]
123624463  [KO:K02264]
123624466  [KO:K02267]
123624573  [KO:K02738] [EC:3.4.25.1]
123624654  PRKCG; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123624681  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
123624699  [KO:K02267]
123624992  ATXN1L; ataxin-1-like [KO:K23616]
123625148  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
123625208  OPTN; optineurin isoform X1 [KO:K19946]
123625262  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
123625340  [KO:K02263]
123625343  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
123625765  FZD10; frizzled-10 [KO:K02842]
123625801  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
123625814  NEFH; neurofilament heavy polypeptide isoform X1 [KO:K04574]
123625824  [KO:K00419]
123625931  [KO:K02266]
123625959  ULK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
123626048  ATXN2; ataxin-2 isoform X1 [KO:K23625]
123626067  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
123626088  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
123626129  DNAH10; dynein axonemal heavy chain 10 [KO:K10408]
123626142  UBC; polyubiquitin-C [KO:K08770]
123626156  [KO:K07374]
123626228  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123626236  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
123626246  [KO:K07374]
123626251  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
123626259  SEPTIN5; septin-5 isoform X1 [KO:K04557]
123626307  [KO:K03940] [EC:7.1.1.2]
123626416  DCTN6; dynactin subunit 6 [KO:K10428]
123626431  FZD8; frizzled-8 [KO:K02375]
123626515  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123626527  FZD3; frizzled-3 isoform X1 [KO:K02329]
123626606  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
123626607  DKK4; dickkopf-related protein 4 [KO:K02165]
123626631  NEFM; neurofilament medium polypeptide isoform X1 [KO:K04573]
123626632  NEFL; neurofilament light polypeptide [KO:K04572]
123626819  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
123626853  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
123626873  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
123626964  [KO:K07374]
123627044  [KO:K00415]
123627206  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123627290  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123627295  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123627330  SNCA; alpha-synuclein [KO:K04528]
123627462  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
123627504  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
123627539  PSEN2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
123627597  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
123627599  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
123627700  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
123627728  DKK2; dickkopf-related protein 2 [KO:K02165]
123627954  RAB39B; ras-related protein Rab-39B [KO:K07925]
123627957  [KO:K02268]
123628005  [KO:K02977]
123628032  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
123628071  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
123628096  [KO:K02977]
123628103  GRIA3; glutamate receptor 3 [KO:K05199]
123628394  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
123628637  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
123628647  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
123628649  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
123628654  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
123628780  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
123628789  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
123628833  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
123629090  [KO:K03178] [EC:6.2.1.45]
123629091  [KO:K03178] [EC:6.2.1.45]
123629092  [KO:K03178] [EC:6.2.1.45]
123629093  [KO:K03178] [EC:6.2.1.45]
123630171  [KO:K02127]
123630283  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
123630288  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
123630321  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
123630330  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
123630502  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
123630505  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
123630571  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
123630631  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
123630658  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
123630660  [KO:K04520]
123630679  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
123630707  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
123630777  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
123630815  UBE2G2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
123631377  AXIN1; axin-1 isoform X1 [KO:K02157]
123631474  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
123631520  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
123631545  [KO:K03938]
123631548  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123631625  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123631697  TUBB; tubulin beta chain [KO:K07375]
123631724  TNF; tumor necrosis factor [KO:K03156]
123631736  CSNK2B; casein kinase II subunit beta [KO:K03115]
123631742  [KO:K03947]
123631755  CALML4; calmodulin-like protein 4 [KO:K02183]
123631780  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
123631832  DAXX; death domain-associated protein 6 [KO:K02308]
123631901  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
123631926  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
123631967  DNAH8; LOW QUALITY PROTEIN: dynein axonemal heavy chain 8 [KO:K10408]
123632315  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
123632363  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
123632367  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
123632460  DNAH3; dynein axonemal heavy chain 3 [KO:K10408]
123632466  [KO:K00415]
123632485  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
123632487  DCTN5; dynactin subunit 5 isoform X1 [KO:K10427]
123632490  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123632523  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
123632527  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
123632602  HIP1; huntingtin-interacting protein 1 isoform X1 [KO:K04559]
123632607  FZD9; frizzled-9 [KO:K02842]
123632614  STX1A; syntaxin-1A isoform X1 [KO:K04560]
123632685  [KO:K02266]
123632692  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
123632778  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
123632797  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
123632819  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
123632820  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
123632845  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
123632869  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123632871  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123632873  [KO:K00420]
123632875  RYR3; ryanodine receptor 3 [KO:K04963]
123633005  [KO:K02270]
123633065  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
123633156  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
123633303  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
123633346  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
123633420  [KO:K03960]
123633441  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
123633473  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
123633879  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123633935  [KO:K02977]
123633966  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
123633975  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
123634125  [KO:K03963]
123634180  [KO:K00416]
123634459  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
123634464  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
123634479  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
123634485  [KO:K23600]
123634530  PARK7; Parkinson disease protein 7 [KO:K05687] [EC:3.5.1.124]
123634668  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
123634820  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
123634905  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
123634994  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
123635010  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
123635033  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
123635043  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
123635081  NRAS; GTPase NRas [KO:K07828]
123635220  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
123635223  TOMM40L; mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518]
123635226  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
123635431  [KO:K02927]
123635438  [KO:K08683] [EC:1.1.1.35 1.1.1.178]
123635482  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
123635558  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
123635647  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
123635659  [KO:K03948]
123635724  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
123635747  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
123635781  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
123635867  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
123635888  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
123635928  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
123635958  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
123635959  TUBB4A; tubulin beta-4A chain [KO:K07375]
123636020  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
123636026  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
123636458  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
123636470  IL1A; interleukin-1 alpha [KO:K04383]
123636681  [KO:K02183]
123636840  [KO:K02270]
123636893  CALM2; calmodulin-2 [KO:K02183]
123636925  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
123636982  RAB1A; ras-related protein Rab-1A [KO:K07874]
123636996  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
123636997  [KO:K03963]
123637072  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
123637092  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
123637112  DNAH6; dynein axonemal heavy chain 6 [KO:K10408]
123637156  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
123637166  IL1B; interleukin-1 beta [KO:K04519]
123637221  ACTR1B; beta-centractin isoform X1 [KO:K16575]
123637222  [KO:K02265]
123637707  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
123637759  [KO:K00418]
123637772  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
123637811  WNT8A; protein Wnt-8a [KO:K00714]
123637866  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
123637869  [KO:K03963]
123638028  [KO:K08738]
123638043  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
123638059  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
123638063  DCTN4; dynactin subunit 4 [KO:K10426]
123638072  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
123638078  [KO:K00416]
123638083  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
123638125  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123638178  TUBB2A; tubulin beta-2A chain [KO:K07375]
123638179  [KO:K07375]
123638197  [KO:K08738]
123638210  [KO:K03948]
123638302  ATXN1; ataxin-1 [KO:K23616]
123638412  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
123638436  GPX5; epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
123638437  GPX6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
123638517  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
123638521  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
123638560  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
123638566  [KO:K10428]
123638598  TRPC3; short transient receptor potential channel 3 [KO:K04966]
123638639  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
123638644  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
123638661  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
123638759  WNT7A; protein Wnt-7a [KO:K00572]
123638764  [KO:K07375]
123639216  WNT7B; protein Wnt-7b [KO:K00572]
123639242  DNAL4; dynein axonemal light chain 4 [KO:K10412]
123639258  [KO:K08960] [EC:2.7.11.1]
123639404  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
123639435  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
123639558  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
123639600  KIF5A; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
123639604  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
123639606  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
123639613  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
123639636  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
123639645  [KO:K03957]
123639755  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
123639816  ATG101; autophagy-related protein 101 [KO:K19730]
123639854  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
123639881  RAB8A; ras-related protein Rab-8A [KO:K07901]
123639891  KIF5B; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
123639915  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
123639916  [KO:K08738]
123639921  KRAS; GTPase KRas [KO:K07827]
123639979  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
123639999  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
123640135  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
123640141  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
123640169  TUBA8; tubulin alpha-8 chain [KO:K07374]
123640175  BID; BH3-interacting domain death agonist [KO:K04726]
123640189  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
123640194  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
123640204  [KO:K02268]
123640284  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
123640339  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123640418  PRPH; peripherin isoform X1 [KO:K07607]
123640420  TUBA1C; tubulin alpha-1C chain [KO:K07374]
123640422  [KO:K07374]
123640424  [KO:K07374]
123640434  WNT1; proto-oncogene Wnt-1 [KO:K03209]
123640435  WNT10B; protein Wnt-10b [KO:K01357]
123640642  [KO:K02268]
123640722  [KO:K05687] [EC:3.5.1.124]
123640770  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
123640771  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
123641300  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
123641353  RELA; transcription factor p65 isoform X1 [KO:K04735]
123641381  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
123641403  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
123641429  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
123641430  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
123641447  [KO:K02273]
123641584  [KO:K02268]
123641691  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
123641763  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
123641788  [KO:K04741] [EC:3.4.22.-]
123642236  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
123642238  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
123642245  FZD4; frizzled-4 isoform X1 [KO:K02354]
123642293  [KO:K03968]
123642322  WNT11; protein Wnt-11 [KO:K01384]
123642474  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
123642542  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
123642582  CAT; catalase [KO:K03781] [EC:1.11.1.6]
123642652  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
123642654  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
123642678  PSMC3; LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 6A [KO:K03065]
123642684  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
123642703  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
123642737  [KO:K03945]
123642797  FADD; FAS-associated death domain protein [KO:K02373]
123642816  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
123642823  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
123642832  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
123642877  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
123642882  CCS; copper chaperone for superoxide dismutase [KO:K04569]
123642897  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
123642937  HRAS; GTPase HRas isoform X1 [KO:K02833]
123642988  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
123643313  KIF5C; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
123643439  DNAH7; dynein axonemal heavy chain 7 [KO:K10408]
123643524  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
123643576  [KO:K00417]
123643690  [KO:K08738]
123643857  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
123643881  FZD7; frizzled-7 [KO:K02432]
123643885  ALS2; alsin isoform X1 [KO:K04575]
123643895  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
123643900  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
123643931  TANK; LOW QUALITY PROTEIN: TRAF family member-associated NF-kappa-B activator [KO:K12650]
123643954  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
123643962  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
123643981  TUBA4A; tubulin alpha-4A chain [KO:K07374]
123643996  WNT10A; protein Wnt-10a [KO:K01357]
123643997  WNT6; protein Wnt-6 [KO:K00445]
123644027  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
123644069  FZD5; frizzled-5 [KO:K02375]
123644088  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
123644332  [KO:K02268]
123644357  [KO:K03959]
123644439  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
123644457  DERL1; derlin-1 [KO:K11519]
123644528  [KO:K00417]
123644587  [KO:K00417]
123644675  [KO:K02268]
123644873  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
123644875  [KO:K00413]
123645117  [KO:K02273]
123645165  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
123645215  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
123645228  FZD6; frizzled-6 isoform X1 [KO:K02376]
123645245  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
123645258  ATXN3; LOW QUALITY PROTEIN: ataxin-3 [KO:K11863] [EC:3.4.22.-]
123645426  [KO:K08738]
123645581  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
123645603  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
123645611  CALM1; calmodulin-1 [KO:K02183]
123645645  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
123645738  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
123645740  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
123645993  TUBB4B; tubulin beta-4B chain [KO:K07375]
123646042  C9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
123646178  [KO:K13525]
123646191  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
123646193  DCTN3; dynactin subunit 3 [KO:K10425]
123646197  DNAI1; dynein axonemal intermediate chain 1 isoform X1 [KO:K10409]
123646230  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
123646300  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
123646308  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
123646315  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:5.6.1.10]
123646347  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
123646445  [KO:K03945]
123646853  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
123646908  IL6; interleukin-6 [KO:K05405]
123646985  DNAH11; dynein axonemal heavy chain 11 [KO:K10408]
123646992  DNAL1; dynein axonemal light chain 1 [KO:K10411]
123647075  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
123647095  WNT16; protein Wnt-16 [KO:K01558]
123647112  [KO:K04555] [EC:2.3.2.23]
123647138  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
123647171  ZFYVE1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
123647253  [KO:K02272]
123647303  FZD1; frizzled-1 [KO:K02432]
123647359  [KO:K08738]
123647452  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
123647466  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
123647514  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
123647608  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
123647642  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123647646  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
123647696  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
123647735  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
123647773  WNT2; protein Wnt-2 [KO:K00182]
123647781  GPR37; prosaposin receptor GPR37 [KO:K04243]
123647968  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
123647977  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
123648018  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
123648042  [KO:K04558]
123648126  [KO:K21246]
123648206  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
123648232  DNAH5; dynein axonemal heavy chain 5 [KO:K10408]
123648345  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
123648419  APC; adenomatous polyposis coli protein [KO:K02085]
123648577  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
123648620  ACTR10; actin-related protein 10 [KO:K16576]
123648626  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
123648630  [KO:K02272]
123648644  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
123648813  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
123648838  WNT9A; protein Wnt-9a [KO:K01064]
123648839  WNT3A; protein Wnt-3a [KO:K00312]
123648868  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
123649129  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
123649674  [KO:K02927]
123649678  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
123649849  DKK1; dickkopf-related protein 1 [KO:K02165]
123649928  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
123649941  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
123649962  [KO:K02135]
123650082  ACTR1A; alpha-centractin [KO:K16575]
123650126  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
123650129  WNT8B; protein Wnt-8b [KO:K00714]
123650135  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
123650180  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
123650181  FRAT1; proto-oncogene FRAT1 [KO:K03069]
123650270  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
123650285  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
123650296  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123650352  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
123650367  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
123650465  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123650554  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
123650574  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
123650585  [KO:K08738]
123650594  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
123650613  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
123650624  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
123650747  DNAI2; dynein axonemal intermediate chain 2 [KO:K11143]
123650764  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
123650775  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
123650851  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
123650852  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
123650902  DNAH2; dynein axonemal heavy chain 2 isoform X1 [KO:K10408]
68929161  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
68929162  COX3; cytochrome c oxidase subunit III [KO:K02262]
68929165  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
68929167  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
68929174  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
68929177  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
68929182  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
68929184  COX2; cytochrome c oxidase subunit II [KO:K02261]
68929185  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
68929186  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
68929187  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
68929190  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
68929191  CYTB; cytochrome b [KO:K00412]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
  Journal
J Neural Transm (Vienna) 116:1111-62 (2009)
DOI:10.1007/s00702-009-0240-y
Reference
PMID:30743990
  Authors
Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
  Journal
Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
  Journal
Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
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Nat Neurosci 21:1332-1340 (2018)
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Related
pathway
lcat00190  Oxidative phosphorylation
lcat03050  Proteasome
lcat04020  Calcium signaling pathway
lcat04120  Ubiquitin mediated proteolysis
lcat04137  Mitophagy - animal
lcat04140  Autophagy - animal
lcat04141  Protein processing in endoplasmic reticulum
lcat04142  Lysosome biogenesis
lcat04210  Apoptosis
lcat04310  Wnt signaling pathway
lcat04724  Glutamatergic synapse
lcat04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   

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