Entry
Name
Salmonella infection - Castor canadensis (American beaver)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Castor canadensis (American beaver) [GN:
ccan ]
Gene
109694420 Plekhm1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282 ]
109693344 Vps11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179 ]
109692897 Vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180 ]
109694301 Vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
109684609 Vps33a; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 33A [KO:K20182 ]
109701303 Vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184 ]
109696018 Dync1h1; LOW QUALITY PROTEIN: cytoplasmic dynein 1 heavy chain 1 [KO:K10413 ]
109687750 Dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415 ]
109693315 Dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416 ]
109685500 Dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416 ]
109685899 Dynlrb1; dynein light chain roadblock-type 1 isoform X1 [KO:K10419 ]
109695505 Fyco1; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954 ]
109692564 Plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348 ]
109697722 M6pr; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089 ]
109697978 Rab9a; LOW QUALITY PROTEIN: ras-related protein Rab-9A [KO:K07899 ]
109691667 Gcc2; GRIP and coiled-coil domain-containing protein 2 isoform X1 [KO:K20282 ]
109678419 LOW QUALITY PROTEIN: neuroblast differentiation-associated protein AHNAK-like [KO:K23934 ]
109689281 Elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
109685543 myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351 ]
109685902 Myl7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754 ]
109683076 Mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758 ]
109693991 Fhod1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938 ]
109678987 Wasf3; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 3 [KO:K06083 ]
109683429 Arpc5l; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754 ]
109681900 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
109689664 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
109687395 Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
109690585 LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta-like [KO:K00923 ] [EC:2.7.1.154 ]
109701040 Pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
109695658 Pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
109698469 Tirap; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403 ]
109684529 Myd88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729 ]
109692995 Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
109692528 Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
109700187 Tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793 ]
109681245 nucleotide-binding oligomerization domain-containing protein 1-like [KO:K08727 ]
109700547 Nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727 ]
109682791 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
109694060 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171 ]
109689097 Birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060 ]
109683456 tumor necrosis factor ligand superfamily member 10-like [KO:K04721 ]
109685840 Ripk3; LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3 [KO:K08847 ] [EC:2.7.11.1 ]
109690783 Rhoh; LOW QUALITY PROTEIN: rho-related GTP-binding protein RhoH [KO:K07873 ]
109687959 Nlrp3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800 ]
109682713 Pycard; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
ccan04621 NOD-like receptor signaling pathway
KO pathway
LinkDB
All DBs