KEGG   PATHWAY: ccan05132
Entry
ccan05132                   Pathway                                
Name
Salmonella infection - Castor canadensis (American beaver)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
ccan05132  Salmonella infection
ccan05132

Disease
H00111  Typhoid fever
Organism
Castor canadensis (American beaver) [GN:ccan]
Gene
109674162  Rab9b; ras-related protein Rab-9B [KO:K07900]
109674509  Kif5c; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
109674943  [KO:K12757]
109675180  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
109675600  [KO:K05759]
109675874  Hsp90b1; endoplasmin [KO:K09487]
109676493  [KO:K12757]
109678419  [KO:K23934]
109678444  [KO:K02187] [EC:3.4.22.56]
109678454  [KO:K02187] [EC:3.4.22.56]
109678483  Ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
109678987  Wasf3; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
109679330  [KO:K12757]
109679557  Il6; interleukin-6 [KO:K05405]
109679656  [KO:K08738]
109680792  Rps3; 40S ribosomal protein S3 [KO:K02985]
109681245  [KO:K08727]
109681290  Stx10; syntaxin-10 [KO:K23937]
109681514  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109681535  Pfn2; profilin-2 isoform X1 [KO:K05759]
109681576  Myl10; myosin regulatory light chain 10 [KO:K12756]
109681733  Rhob; rho-related GTP-binding protein RhoB [KO:K07856]
109681900  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109681908  Snx9; sorting nexin-9 isoform X1 [KO:K17923]
109682106  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
109682122  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
109682145  Klc4; kinesin light chain 4 [KO:K10407]
109682195  Kif5b; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
109682250  Arl8a; ADP-ribosylation factor-like protein 8A [KO:K07955]
109682659  Vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
109682694  Cyth2; cytohesin-2 [KO:K18441]
109682703  Bax; apoptosis regulator BAX [KO:K02159]
109682712  Cyth1; cytohesin-1 isoform X1 [KO:K18441]
109682713  Pycard; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
109682791  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109682800  Gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
109682952  [KO:K12366]
109682954  [KO:K12366]
109682963  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109683076  Mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
109683259  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109683429  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
109683456  [KO:K04721]
109683487  Exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
109683743  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
109683851  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
109684287  Abi1; LOW QUALITY PROTEIN: abl interactor 1 [KO:K23649]
109684369  [KO:K07374]
109684381  Mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
109684435  [KO:K04733] [EC:2.7.11.1]
109684529  Myd88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729]
109684609  Vps33a; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 33A [KO:K20182]
109684734  Pfn1; profilin-1 [KO:K05759]
109684810  [KO:K07937]
109684863  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
109684923  Exoc2; exocyst complex component 2 [KO:K17637]
109685027  Actr2; actin-related protein 2 isoform X1 [KO:K17260]
109685059  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
109685067  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
109685161  Tlr6; toll-like receptor 6 [KO:K10169]
109685196  Txn2; thioredoxin, mitochondrial [KO:K03671]
109685353  Tlr9; toll-like receptor 9 [KO:K10161]
109685500  Dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
109685543  [KO:K10351]
109685779  Pfn3; profilin-3 [KO:K05759]
109685840  Ripk3; LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
109685899  Dynlrb1; dynein light chain roadblock-type 1 isoform X1 [KO:K10419]
109685902  Myl7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
109686156  Kif5a; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
109686184  Tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
109686235  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109686351  Dctn2; dynactin subunit 2 isoform X1 [KO:K10424]
109686409  [KO:K12757]
109686410  [KO:K12757]
109686460  [KO:K10358]
109686692  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
109686728  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109686738  [KO:K04440] [EC:2.7.11.24]
109686996  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
109687128  Klc2; kinesin light chain 2 [KO:K10407]
109687142  Rela; transcription factor p65 isoform X1 [KO:K04735]
109687228  [KO:K05750]
109687385  Tubb4b; tubulin beta-4B chain [KO:K07375]
109687395  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
109687611  Pkn1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
109687750  Dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
109687808  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
109687824  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109687959  Nlrp3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
109688383  Dynlt1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
109688536  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109688558  Casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
109688561  Tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
109688592  Naip; baculoviral IAP repeat-containing protein 1 [KO:K12807]
109688820  Actr3b; actin-related protein 3B isoform X1 [KO:K18584]
109688935  [KO:K04492]
109688955  Brk1; protein BRICK1 [KO:K05752]
109689037  [KO:K23484]
109689069  [KO:K23484]
109689097  Birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
109689098  Birc3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
109689240  Kpna1; importin subunit alpha-5 [KO:K23940]
109689281  Elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
109689333  [KO:K05749]
109689334  [KO:K05749]
109689438  Wasl; neural Wiskott-Aldrich syndrome protein [KO:K23612]
109689439  [KO:K23612]
109689465  Tcf7; transcription factor 7 isoform X1 [KO:K02620]
109689481  Skp1; S-phase kinase-associated protein 1 [KO:K03094]
109689613  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
109689664  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109689786  [KO:K17092]
109689830  [KO:K17092]
109689849  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109689865  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
109689873  Ctnnb1; catenin beta-1 [KO:K02105]
109690025  Rilp; rab-interacting lysosomal protein isoform X1 [KO:K13883]
109690126  Ripk2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
109690145  [KO:K06111]
109690157  [KO:K06111]
109690215  [KO:K07374]
109690217  Tuba1a; tubulin alpha-1A chain [KO:K07374]
109690218  [KO:K07374]
109690234  [KO:K05750]
109690296  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
109690388  [KO:K04513]
109690391  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
109690402  [KO:K12757]
109690528  Cse1l; exportin-2 isoform X1 [KO:K18423]
109690585  [KO:K00923] [EC:2.7.1.154]
109690717  [KO:K08738]
109690783  Rhoh; LOW QUALITY PROTEIN: rho-related GTP-binding protein RhoH [KO:K07873]
109690826  Gsdmd; LOW QUALITY PROTEIN: gasdermin-D [KO:K20917]
109690874  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
109691074  Tuba4a; tubulin alpha-4A chain [KO:K07374]
109691082  [KO:K07899]
109691111  Kpna3; importin subunit alpha-4 isoform X1 [KO:K23583]
109691297  Actr1a; alpha-centractin [KO:K16575]
109691488  Acbd3; Golgi resident protein GCP60 [KO:K23935]
109691667  Gcc2; GRIP and coiled-coil domain-containing protein 2 isoform X1 [KO:K20282]
109691800  Snx18; sorting nexin-18 [KO:K17923]
109691810  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109691813  Ahnak2; LOW QUALITY PROTEIN: protein AHNAK2 [KO:K23934]
109691919  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
109691927  Cxcl8; interleukin-8 [KO:K10030]
109692052  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
109692110  Ly96; lymphocyte antigen 96 [KO:K05400]
109692393  Klc3; kinesin light chain 3 [KO:K10407]
109692432  Dctn1; dynactin subunit 1 isoform X1 [KO:K04648]
109692528  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
109692564  Plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
109692646  Rab5a; ras-related protein Rab-5A [KO:K07887]
109692761  Tubb3; tubulin beta-3 chain [KO:K07375]
109692781  Tubb1; tubulin beta-1 chain [KO:K07375]
109692857  Tlr5; toll-like receptor 5 [KO:K10168]
109692897  Vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
109692921  Cyth3; cytohesin-3 [KO:K18441]
109692922  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109692935  Txn; thioredoxin [KO:K03671]
109692995  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
109693003  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
109693191  Arf6; ADP-ribosylation factor 6 [KO:K07941]
109693315  Dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
109693344  Vps11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
109693530  Tubb; tubulin beta chain [KO:K07375]
109693564  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
109693757  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
109693856  Myl5; myosin light chain 5 [KO:K12753]
109693991  Fhod1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
109694000  Fos; proto-oncogene c-Fos [KO:K04379]
109694060  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
109694127  Snx33; sorting nexin-33 [KO:K17923]
109694299  Tubb4a; tubulin beta-4A chain [KO:K07375]
109694301  Vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
109694363  Rhog; rho-related GTP-binding protein RhoG [KO:K07863]
109694420  Plekhm1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
109694665  [KO:K18584]
109694671  Dctn3; dynactin subunit 3 [KO:K10425]
109694770  Dctn6; dynactin subunit 6 isoform X1 [KO:K10428]
109694921  Cdc42; cell division control protein 42 homolog [KO:K04393]
109694935  Casp1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
109694936  [KO:K04394] [EC:3.4.22.57 3.4.22.64]
109694940  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109695104  Dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
109695449  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
109695474  Fbxo22; F-box only protein 22 isoform X1 [KO:K10302]
109695505  Fyco1; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954]
109695658  Pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923] [EC:2.7.1.154]
109695774  Rab5c; ras-related protein Rab-5C [KO:K07889]
109696011  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
109696018  Dync1h1; LOW QUALITY PROTEIN: cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
109696098  Tubb6; tubulin beta-6 chain [KO:K07375]
109696167  Dynll1; dynein light chain 1, cytoplasmic [KO:K10418]
109696400  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109696482  Rab7a; ras-related protein Rab-7a [KO:K07897]
109696571  Mlkl; mixed lineage kinase domain-like protein isoform X1 [KO:K08849] [EC:2.7.11.1]
109696650  Dynlrb2; dynein light chain roadblock-type 2 [KO:K10419]
109696859  Flna; filamin-A isoform X1 [KO:K04437]
109696920  Dctn4; dynactin subunit 4 [KO:K10426]
109697143  Dynll2; dynein light chain 2, cytoplasmic [KO:K10418]
109697223  Rab7b; ras-related protein Rab-7b [KO:K07898]
109697245  Kpna4; importin subunit alpha-3 [KO:K23583]
109697260  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
109697305  Arhgef26; rho guanine nucleotide exchange factor 26 [KO:K13744]
109697389  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
109697493  [KO:K08738]
109697510  Klc1; LOW QUALITY PROTEIN: kinesin light chain 1 [KO:K10407]
109697648  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
109697722  M6pr; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
109697844  Rhoa; transforming protein RhoA [KO:K04513]
109697895  [KO:K07375]
109697978  Rab9a; LOW QUALITY PROTEIN: ras-related protein Rab-9A [KO:K07899]
109698042  Hras; GTPase HRas isoform X1 [KO:K02833]
109698249  Cyth4; cytohesin-4 isoform X1 [KO:K18441]
109698434  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
109698469  Tirap; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
109698497  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109698573  Rab5b; ras-related protein Rab-5B [KO:K07888]
109698790  Exoc5; exocyst complex component 5 [KO:K19984]
109698912  Tubb2b; tubulin beta-2B chain [KO:K07375]
109698939  [KO:K07375]
109698990  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
109699038  Nlrc4; NLR family CARD domain-containing protein 4 [KO:K12805]
109699208  Podxl; podocalyxin [KO:K06817]
109699210  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
109699301  [KO:K18584]
109699331  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
109699399  Arl8b; ADP-ribosylation factor-like protein 8B [KO:K07955]
109699439  Il18; interleukin-18 isoform X1 [KO:K05482]
109699638  Dctn5; dynactin subunit 5 [KO:K10427]
109699819  [KO:K07873]
109699943  Myc; myc proto-oncogene protein [KO:K04377]
109700131  Actr10; actin-related protein 10 [KO:K16576]
109700175  [KO:K12755]
109700187  Tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
109700244  Arf1; ADP-ribosylation factor 1 [KO:K07937]
109700274  Fadd; FAS-associated death domain protein [KO:K02373]
109700547  Nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
109700648  [KO:K07374]
109700697  Actr1b; beta-centractin [KO:K16575]
109700700  [KO:K05692]
109700701  Tlr4; toll-like receptor 4 isoform X1 [KO:K10160]
109700777  Jun; transcription factor AP-1 [KO:K04448]
109701040  Pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
109701168  Il1b; interleukin-1 beta isoform X1 [KO:K04519]
109701180  Tlr2; toll-like receptor 2 [KO:K10159]
109701303  Vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
109701401  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
109701411  [KO:K17274]
109701457  Rala; ras-related protein Ral-A [KO:K07834]
109702413  Dync1i1; cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
109702505  [KO:K13744]
109702887  [KO:K07375]
109703004  [KO:K04440] [EC:2.7.11.24]
109703025  Pfn4; profilin-4 [KO:K05759]
109703233  Rhoj; rho-related GTP-binding protein RhoJ [KO:K07864]
109703335  [KO:K07887]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
ccan04010  MAPK signaling pathway
ccan04064  NF-kappa B signaling pathway
ccan04210  Apoptosis
ccan04217  Necroptosis
ccan04621  NOD-like receptor signaling pathway
KO pathway
ko05132   

DBGET integrated database retrieval system