KEGG   PATHWAY: hmh04010
Entry
hmh04010                    Pathway                                
Name
MAPK signaling pathway - Hylobates moloch (silvery gibbon)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
hmh04010  MAPK signaling pathway
hmh04010

Other DBs
GO: 0000165
Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116478572  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X2 [KO:K04344]
116475947  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
116472525  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
116473372  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X9 [KO:K04851]
116457963  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
116811686  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
116474359  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X5 [KO:K04854]
116462356  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
116458615  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
116457338  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116814159  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
116473437  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X3 [KO:K04859]
116473364  CACNA2D3; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
116472522  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
116474744  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
116476036  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
116462038  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
116810802  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
116483438  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
116458425  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
116471148  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
116483811  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
116483824  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X2 [KO:K04870]
116479704  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
116479167  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
116479595  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
116458418  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
116469844  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116478588  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116483969  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116471147  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116479165  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
116810819  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
116469917  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
116483814  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
116459475  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116461844  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116483520  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
116475348  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
116481469  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
116471046  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
116481506  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
116468962  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
116480555  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
116480739  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
116465643  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
116474531  NF1; neurofibromin isoform X3 [KO:K08052]
116471023  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
116461649  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
116469612  RAP1A; ras-related protein Rap-1A [KO:K04353]
116478979  RAP1B; ras-related protein Rap-1b [KO:K07836]
116479721  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
116483502  TGFA; protransforming growth factor alpha [KO:K08774]
116466917  EREG; proepiregulin [KO:K09784]
116475072  AREG; amphiregulin [KO:K09782]
116471654  FGF1; LOW QUALITY PROTEIN: fibroblast growth factor 1 [KO:K18496]
116463600  FGF2; fibroblast growth factor 2 [KO:K18497]
116483940  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
116484687  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116468258  FGF4; fibroblast growth factor 4 [KO:K04358]
116468259  FGF3; fibroblast growth factor 3 [KO:K04358]
116811338  FGF16; fibroblast growth factor 16 [KO:K04358]
116461936  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116471846  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
116472375  FGF20; fibroblast growth factor 20 [KO:K04358]
116472553  FGF6; fibroblast growth factor 6 [KO:K04358]
116482647  FGF7; fibroblast growth factor 7 [KO:K04358]
116466374  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
116456678  FGF10; fibroblast growth factor 10 [KO:K04358]
116467157  FGF9; fibroblast growth factor 9 [KO:K04358]
116468256  FGF19; fibroblast growth factor 19 [KO:K22603]
116479726  FGF21; fibroblast growth factor 21 [KO:K22429]
116472213  FGF23; fibroblast growth factor 23 [KO:K22428]
116468350  NGF; beta-nerve growth factor [KO:K02582]
116476405  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
116472566  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
116478219  NTF4; neurotrophin-4 [KO:K12457]
116478036  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
116469151  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
116462932  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116458711  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
116476871  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
116463464  platelet-derived growth factor C isoform X1 [KO:K05450]
116463488  platelet-derived growth factor C isoform X1 [KO:K05450]
116469641  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
116479070  KITLG; kit ligand isoform X1 [KO:K05461]
116478208  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
116459737  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
116468948  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
116485057  PGF; placenta growth factor isoform X1 [KO:K16859]
116811530  VEGFD; vascular endothelial growth factor D [KO:K05449]
116466046  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
116813515  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
116473842  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
116461063  ANGPT4; angiopoietin-4 [KO:K05467]
116483932  EFNA2; ephrin-A2 [KO:K05462]
116469334  EFNA1; ephrin-A1 [KO:K05462]
116469337  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
116469338  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
116470959  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
116456961  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
116464802  neurturin [KO:K25414]
116464888  neurturin [KO:K25414]
116473063  ARTN; artemin isoform X1 [KO:K25415]
116478328  PSPN; persephin [KO:K25416]
116812436  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116474757  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116480929  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
116810355  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X5 [KO:K05085] [EC:2.7.10.1]
116462129  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116482607  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116456707  FGFR3; fibroblast growth factor receptor 3 isoform X5 [KO:K05094] [EC:2.7.10.1]
116471901  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
116474666  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
116467918  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
116475199  NTRK2; BDNF/NT-3 growth factors receptor isoform X2 [KO:K04360] [EC:2.7.10.1]
116479486  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
116482110  IGF1R; insulin-like growth factor 1 receptor isoform X4 [KO:K05087] [EC:2.7.10.1]
116467343  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116471711  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116471709  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
116467540  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
116467123  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
116467120  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116471959  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116467558  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
116814273  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
116458259  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
116812973  EPHA2; ephrin type-A receptor 2 isoform X2 [KO:K05103] [EC:2.7.10.1]
116461332  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
116484153  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
116484062  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
116484470  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116466571  HRAS; GTPase HRas isoform X3 [KO:K02833]
116472788  KRAS; GTPase KRas isoform X1 [KO:K07827]
116469568  NRAS; GTPase NRas [KO:K07828]
116478211  RRAS; ras-related protein R-Ras [KO:K07829]
116476491  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
116461696  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
116811640  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
116814428  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116466754  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116482295  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116814342  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
116483548  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116484354  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
116459126  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116470222  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116484019  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
116472430  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
116811564  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X2 [KO:K04373] [EC:2.7.11.1]
116811841  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
116813127  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
116473757  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
116458613  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
116810327  LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
116465188  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
116457493  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
116813588  MYC; myc proto-oncogene protein [KO:K04377]
116460349  SRF; serum response factor [KO:K04378]
116456218  FOS; protein c-Fos [KO:K04379]
116475002  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
116813101  STMN1; stathmin [KO:K04381]
116457704  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
116478269  PLA2G4C; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
116481592  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
116482123  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
116482184  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
116482519  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
116460115  TNF; tumor necrosis factor isoform X2 [KO:K03156]
116483240  IL1A; interleukin-1 alpha [KO:K04383]
116483283  IL1B; interleukin-1 beta [KO:K04519]
116480647  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
116457529  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
116456166  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
116483372  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
116479965  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
116475322  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
116473711  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
116472296  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
116457822  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
116471599  CD14; monocyte differentiation antigen CD14 [KO:K04391]
116480287  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
116810870  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116458566  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
116483790  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
116813051  CDC42; cell division control protein 42 homolog isoform X2 [KO:K04393]
116471376  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
116466067  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
116475877  TRAF2; TNF receptor-associated factor 2 isoform X3 [KO:K03173] [EC:2.3.2.27]
116459840  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
116473667  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
116812171  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
116481090  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
116476347  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
116469918  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
116483299  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
116475228  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
116458812  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
116463159  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
116463202  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
116478488  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
116483681  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
116484015  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X3 [KO:K04407] [EC:2.7.11.1]
116480736  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X2 [KO:K04408] [EC:2.7.11.1]
116476722  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
116479999  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116460867  STK4; serine/threonine-protein kinase 4 [KO:K04411]
116813464  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
116468965  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
116462065  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
116462248  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
116469010  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
116462992  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
116458740  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
116484762  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X6 [KO:K04417] [EC:2.7.11.25]
116480038  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
116464513  mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
116464517  mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
116457482  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
116480994  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
116479925  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
116810650  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
116813174  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
116472781  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
116469793  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
116473620  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
116477849  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
116470179  TAOK2; serine/threonine-protein kinase TAO2 isoform X2 [KO:K04429] [EC:2.7.11.1]
116474578  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
116459332  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
116478375  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116483006  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
116483711  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
116476310  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
116458990  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
116462519  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X2 [KO:K04436]
116812166  FLNA; filamin-A isoform X1 [KO:K04437]
116458283  CRK; adapter molecule crk isoform X1 [KO:K04438]
116458915  CRKL; crk-like protein [KO:K04438]
116476694  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
116459229  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
116460769  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116471970  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116463128  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116458518  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
116458519  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
116459642  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
116459649  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
116477906  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
116457332  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X2 [KO:K04443] [EC:2.7.11.1]
116473432  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
116456094  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
116468960  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
116461428  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
116474369  LOW QUALITY PROTEIN: M-phase inducer phosphatase 2-like [KO:K05866] [EC:3.1.3.48]
116468452  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
116471414  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
116457363  JUN; transcription factor Jun [KO:K04448]
116810639  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
116459052  TP53; cellular tumor antigen p53 [KO:K04451]
116480869  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
116484930  MAX; protein max isoform X1 [KO:K04453]
116471014  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
116811162  HSPB1; heat shock protein beta-1 [KO:K04455]
116457903  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116485139  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116480683  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116456333  PPM1A; protein phosphatase 1A isoform X4 [KO:K04457] [EC:3.1.3.16]
116479009  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
116476440  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
116457324  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
116471853  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
116469162  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116461810  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116472697  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116473412  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116483507  DUSP2; dual specificity protein phosphatase 2 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116483774  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116479078  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
116812188  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
116457573  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
116474916  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
116482960  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
116477090  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
116460285  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
116460286  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
116460287  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
116473328  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
116481217  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
116482344  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X3 [KO:K04463] [EC:2.7.12.2]
116483083  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
116461658  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
116474979  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
116485121  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116461632  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
116464818  IKBKG; NF-kappa-B essential modulator isoform X2 [KO:K07210]
116474630  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
116483343  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116484343  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
116469011  RELA; transcription factor p65 isoform X1 [KO:K04735]
116482928  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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PMID:12191611
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Pharmacol Ther 93:193-202 (2002)
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PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Gene 320:3-21 (2003)
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
hmh04070  Phosphatidylinositol signaling system
hmh04110  Cell cycle
hmh04115  p53 signaling pathway
hmh04210  Apoptosis
hmh04310  Wnt signaling pathway
hmh04668  TNF signaling pathway
KO pathway
ko04010   
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