KEGG   PATHWAY: oor05417
Entry
oor05417                    Pathway                                
Name
Lipid and atherosclerosis - Orcinus orca (killer whale)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
oor05417  Lipid and atherosclerosis
oor05417

Organism
Orcinus orca (killer whale) [GN:oor]
Gene
101281005  APOB; apolipoprotein B-100 [KO:K14462]
101285096  APOA4; apolipoprotein A-IV [KO:K08760]
101284590  APOA1; apolipoprotein A-I [KO:K08757]
101283356  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
101269745  oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
101279717  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
101270980  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
101273830  RHOA; transforming protein RhoA [KO:K04513]
101289250  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101280520  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101278075  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101278974  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101283011  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101277568  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101285437  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101281352  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101272095  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101288103  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101273316  AKT1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101285349  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
101274967  BAD; bcl2-associated agonist of cell death [KO:K02158]
101288063  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101276750  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101287701  MAPK9; mitogen-activated protein kinase 9 isoform X5 [KO:K04440] [EC:2.7.11.24]
101277656  MAPK10; mitogen-activated protein kinase 10 isoform X4 [KO:K04440] [EC:2.7.11.24]
101281228  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
101280512  SOD2; superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
101276350  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101281331  POU2F2; POU domain, class 2, transcription factor 2 isoform X9 [KO:K09364]
101280171  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
101280569  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
101278975  CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160]
101274859  CD40LG; CD40 ligand [KO:K03161]
101287158  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
101287985  cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101275831  AGER; advanced glycosylation end product-specific receptor isoform X2 [KO:K19722]
101284466  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
101279174  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101276678  NCF1; neutrophil cytosol factor 1 isoform X2 [KO:K08011]
101274948  cytochrome b-245 light chain [KO:K08009]
101284420  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
101289018  NCF4; neutrophil cytosol factor 4 [KO:K08012]
101274018  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101275089  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101281369  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101270289  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101270607  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101288079  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X3 [KO:K04431] [EC:2.7.12.2]
101286650  FOS; protein c-Fos [KO:K04379]
101288913  JUN; transcription factor Jun [KO:K04448]
101289706  C-C motif chemokine 2 [KO:K14624]
101276958  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
101278129  CXCL8; interleukin-8 [KO:K10030]
101275666  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
101280413  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101269212  MAPK13; mitogen-activated protein kinase 13 isoform X7 [KO:K04441] [EC:2.7.11.24]
101269458  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101287579  mitogen-activated protein kinase 12 isoform X6 [KO:K04441] [EC:2.7.11.24]
101287833  mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
101271947  GTPase HRas-like isoform X4 [KO:K02833]
101286301  HRAS; GTPase HRas isoform X2 [KO:K02833]
101281897  KRAS; GTPase KRas isoform X2 [KO:K07827]
101276138  NRAS; GTPase NRas [KO:K07828]
101273287  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101289394  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101270342  RELA; transcription factor p65 isoform X1 [KO:K04735]
101279857  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101269377  SELE; E-selectin [KO:K06494]
101290454  SELP; P-selectin isoform X1 [KO:K06496]
101284784  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
101270746  stromelysin-1 isoform X1 [KO:K01394] [EC:3.4.24.17]
101277919  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101284022  FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390]
101284892  IL1B; interleukin-1 beta isoform X2 [KO:K04519]
101281783  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
101269870  TNF; tumor necrosis factor [KO:K03156]
101289849  HSPD1; 60 kDa heat shock protein, mitochondrial isoform X2 [KO:K04077] [EC:5.6.1.7]
101274177  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
101278046  heat shock cognate 71 kDa protein [KO:K03283]
101283817  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
101284066  heat shock 70 kDa protein 1B [KO:K03283]
101284311  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
101282770  LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
101284349  heat shock cognate 71 kDa protein-like [KO:K03283]
125963979  LOW QUALITY PROTEIN: heat shock 70 kDa protein 6-like [KO:K03283]
125965152  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101276206  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
101272709  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
101285036  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101278395  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101271249  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
101289801  HSP90B1; endoplasmin [KO:K09487]
101276053  TLR2; toll-like receptor 2 [KO:K10159]
101277992  LBP; lipopolysaccharide-binding protein isoform X2 [KO:K05399]
101283534  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101289671  LY96; lymphocyte antigen 96 isoform X2 [KO:K05400]
101282217  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
101284698  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
101278425  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
101283238  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101280639  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X2 [KO:K04730] [EC:2.7.11.1]
101277553  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
101282675  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
101284365  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101283961  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101281072  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101285763  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101272428  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101289477  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105747698  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
101271374  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101288184  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101277515  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
101280656  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X3 [KO:K10645] [EC:2.3.2.27]
101275571  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
101273673  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X4 [KO:K07211] [EC:2.7.11.10]
101290315  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101277458  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
101272168  IRF3; interferon regulatory factor 3 [KO:K05411]
101274041  interferon alpha-1-like [KO:K05414]
101275016  interferon alpha-1-like [KO:K05414]
101275275  interferon alpha-1-like [KO:K05414]
101287367  interferon alpha-3-like [KO:K05414]
125964698  interferon alpha-1-like [KO:K05414]
125964699  interferon alpha-1-like [KO:K05414]
125964701  interferon alpha-3-like [KO:K05414]
125964702  interferon alpha-3-like [KO:K05414]
125964703  interferon alpha-3-like [KO:K05414]
101289058  IFNB1; interferon beta [KO:K05415]
101272221  CD36; platelet glycoprotein 4 isoform X3 [KO:K06259]
101272154  peroxisome proliferator-activated receptor gamma isoform X2 [KO:K08530]
101270600  RXRA; retinoic acid receptor RXR-alpha isoform X4 [KO:K08524]
101287304  RXRB; retinoic acid receptor RXR-beta isoform X4 [KO:K08525]
101289285  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
101280666  LYN; tyrosine-protein kinase Lyn isoform X2 [KO:K05854] [EC:2.7.10.2]
101275490  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101290166  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101269690  VAV2; guanine nucleotide exchange factor VAV2 isoform X11 [KO:K05730]
101282339  VAV1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
125960249  TLR6; toll-like receptor 6 [KO:K10169]
101287340  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
101284281  RAP1B; ras-related protein Rap-1b [KO:K07836]
101273776  C-C motif chemokine 5 isoform X2 [KO:K12499]
101274027  C-C motif chemokine 3-like [KO:K05408]
101283498  C-C motif chemokine 3-like [KO:K05408]
101283229  C-C motif chemokine 3-like [KO:K05408]
101285495  growth-regulated alpha protein-like isoform X1 [KO:K05505]
101277391  growth-regulated alpha protein-like [KO:K05505]
101285237  growth-regulated protein homolog beta-like [KO:K05505]
101279088  IL12A; interleukin-12 subunit alpha [KO:K05406]
101272835  IL12B; interleukin-12 subunit beta [KO:K05425]
101282000  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
101271274  IL18; interleukin-18 isoform X1 [KO:K05482]
101289151  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
101284204  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
101278090  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101281527  ERO1A; ERO1-like protein alpha isoform X1 [KO:K10950] [EC:1.8.4.-]
101282737  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
101269181  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X16 [KO:K04515] [EC:2.7.11.17]
101287513  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5 [KO:K04515] [EC:2.7.11.17]
101281498  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X8 [KO:K04515] [EC:2.7.11.17]
101271879  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101282451  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101281288  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101283438  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101288419  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101281303  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101277232  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101288279  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101273707  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
101278286  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
101281809  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X4 [KO:K05638]
101287122  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
101289850  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
101289549  VLDLR; very low-density lipoprotein receptor isoform X3 [KO:K20053]
101270868  PDPK1; LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101283259  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101283533  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
101289855  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101285271  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101274558  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101270548  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101270961  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101281417  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X9 [KO:K05858] [EC:3.1.4.11]
101281412  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101278649  CALML6; calmodulin-like protein 6 [KO:K02183]
101273078  CALM2; calmodulin-2 [KO:K02183]
101285814  CALM1; calmodulin-1 [KO:K02183]
101279979  CALM3; calmodulin-3 [KO:K02183]
101282017  calmodulin-alpha-like isoform X1 [KO:K02183]
105748632  LOW QUALITY PROTEIN: myosin light chain 1, skeletal muscle isoform-like [KO:K02183]
101284096  calmodulin-1-like [KO:K02183]
125961823  calmodulin-1-like [KO:K02183]
125961824  calmodulin-1-like [KO:K02183]
125961825  calmodulin-1-like [KO:K02183]
125961826  calmodulin-1-like [KO:K02183]
125961827  calmodulin-1-like [KO:K02183]
125961828  calmodulin-1-like [KO:K02183]
101271019  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X7 [KO:K04348] [EC:3.1.3.16]
101278517  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X3 [KO:K04348] [EC:3.1.3.16]
101286888  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7 [KO:K04348] [EC:3.1.3.16]
105748080  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
101272877  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101282902  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X2 [KO:K04721]
101271509  tumor necrosis factor receptor superfamily member 10A isoform X9 [KO:K04722]
101282502  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101272436  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101281780  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101277745  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
105747906  cytochrome c-like [KO:K08738]
101283052  cytochrome c [KO:K08738]
101275631  cytochrome c-like [KO:K08738]
105747703  cytochrome c 2 [KO:K08738]
101272869  cytochrome c-like [KO:K08738]
117203203  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
101280303  APAF1; apoptotic protease-activating factor 1 isoform X4 [KO:K02084]
101271677  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101285172  CASP6; caspase-6 isoform X2 [KO:K04396] [EC:3.4.22.59]
101289847  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
101287199  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
101285670  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
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Related
pathway
oor04020  Calcium signaling pathway
oor04115  p53 signaling pathway
oor04141  Protein processing in endoplasmic reticulum
oor04151  PI3K-Akt signaling pathway
oor04210  Apoptosis
oor04620  Toll-like receptor signaling pathway
oor04621  NOD-like receptor signaling pathway
oor04668  TNF signaling pathway
oor04670  Leukocyte transendothelial migration
oor04975  Fat digestion and absorption
oor04979  Cholesterol metabolism
oor05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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