KEGG   PATHWAY: rno04621
Entry
rno04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Rattus norvegicus (rat)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
rno04621  NOD-like receptor signaling pathway
rno04621

Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100361294  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100362733  Irgm2; interferon inducible GTPase 2 [KO:K14139] [EC:3.6.5.-]
100911527  Ifna4l1; interferon alpha-11-like [KO:K05414]
100912314  [KO:K05414]
100912356  [KO:K05414]
103692848  Brcc3dc; BRCA1/BRCA2-containing complex, subunit 3, domain containing [KO:K11864] [EC:3.4.19.-]
114105  Cxcl2; C-X-C motif chemokine 2 precursor [KO:K05505]
114114  Dnm1l; dynamin-1-like protein [KO:K17065] [EC:3.6.5.5]
114555  Casp4; caspase 4 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
116484  Txn1; thioredoxin [KO:K03671]
116554  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117273  Rhoa; transforming protein RhoA [KO:K04513]
117514  Txnip; thioredoxin-interacting protein [KO:K20910]
120098596  Gabarapl4; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
134484162  [KO:K08341]
134485808  [KO:K20899]
134487075  [KO:K05414]
134487077  [KO:K05414]
156117  Casp12; caspase-12 [KO:K04741] [EC:3.4.22.-]
170538  Prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
171164  Gbp2; guanylate-binding protein 2 [KO:K20897]
171390  Nlrp6; NACHT, LRR and PYD domains-containing protein 6 [KO:K20863]
171551  Cxcl3; C-X-C motif chemokine 3 precursor [KO:K05505]
191568  Naip6; NLR family, apoptosis inhibitory protein 6 [KO:K12807]
192281  Oas1a; 2'-5'-oligoadenylate synthase 1A [KO:K14216] [EC:2.7.7.84]
192647  Mfn1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
207122  Pkn2; serine/threonine-protein kinase N2 [KO:K23691]
24224  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
24247  Casr; extracellular calcium-sensing receptor precursor [KO:K04612]
24481  Ifnb1; interferon beta precursor [KO:K05415]
24494  Il1b; interleukin-1 beta [KO:K04519]
24498  Il6; interleukin-6 precursor [KO:K05405]
24516  Jun; transcription factor Jun [KO:K04448]
246240  Ripk3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
246268  Oas1b; inactive 2'-5'-oligoadenylate synthase 1B [KO:K14216] [EC:2.7.7.84]
24654  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
24770  Ccl2; C-C motif chemokine 2 precursor [KO:K14624]
24835  Tnf; tumor necrosis factor [KO:K03156]
24888  Bcl2l1; bcl-2-like protein 1 isoform 2 [KO:K04570]
25031  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
25124  Stat1; signal transducer and activator of transcription 1-alpha/beta isoform beta [KO:K11220]
25166  Casp1; caspase-1 [KO:K01370] [EC:3.4.22.36]
25262  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform 3 [KO:K04958]
25272  Mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
252961  Tank; TRAF family member-associated NF-kappa-B activator isoform 2 [KO:K12650]
25493  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
25679  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
266610  Fadd; FAS-associated death domain protein [KO:K02373]
282817  Pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
286958  Np4; defensin alpha 4 precursor [KO:K05230]
286995  Defa5; neutrophil antibiotic peptide NP-2 precursor [KO:K05230]
287362  Nlrp3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
287464  Dhx33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
287562  Ccl12; C-C motif chemokine ligand 12 precursor [KO:K14624]
288264  Ifnar1; interferon alpha/beta receptor 1 isoform 1 precursor [KO:K05130]
288774  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
290408  Sugt1; protein SGT1 homolog [KO:K12795]
290856  Defa24; defensin 5 precursor [KO:K05230]
291912  Nod2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
29197  Il18; interleukin-18 [KO:K05482]
292541  Nlrp12; NACHT, LRR and PYD domains-containing protein 12 [KO:K20865]
29260  Tlr4; toll-like receptor 4 precursor [KO:K10160]
292892  Irf3; interferon regulatory factor 3 [KO:K05411]
29322  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
29355  Pkn1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
293624  Irf7; interferon regulatory factor 7 [KO:K09447]
294329  Trpm2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
294394  Gprc6a; G-protein coupled receptor family C group 6 member A precursor [KO:K04622]
294560  Mcu; calcium uniporter protein, mitochondrial precursor [KO:K20858]
29465  Trpv2; transient receptor potential cation channel subfamily V member 2 [KO:K04971]
294691  Naip5; baculoviral IAP repeat-containing protein 1f isoform X2 [KO:K12807]
294770  Card6; caspase recruitment domain-containing protein 6 [KO:K12797]
29513  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
296099  Tp53bp1; TP53-binding protein 1 [KO:K20915]
29665  P2rx7; P2X purinoceptor 7 [KO:K05220]
297173  RSA-14-44; ras homolog gene family, member A [KO:K04513]
297508  Nampt; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
29753  Ywhae; 14-3-3 protein epsilon [KO:K06630]
298205  Ifna4; interferon, alpha 4 precursor [KO:K05414]
298210  Ifna5; interferon alpha-1 precursor [KO:K05414]
298213  Ifna2; interferon alpha family, gene 2 precursor [KO:K05414]
298784  Nlrc4; NLR family CARD domain-containing protein 4 [KO:K12805]
299331  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
299827  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
300177  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
300732  Pstpip1; proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
301059  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
301252  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
303090  Irgm; immunity-related GTPase family M protein [KO:K14139] [EC:3.6.5.-]
304266  Gbp1; guanylate-binding protein 1 [KO:K20899]
304507  Oas1i; 2 ' -5 ' oligoadenylate synthetase 1I [KO:K14216] [EC:2.7.7.84]
304987  Aim2; interferon-inducible protein AIM2 isoform X1 [KO:K12966]
305633  Antxr2; anthrax toxin receptor 2 precursor [KO:K20909]
305896  Irf9; interferon regulatory factor 9 [KO:K04693]
306886  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
308267  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
309165  Rela; transcription factor p65 [KO:K04735]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
310917  Gbp4; guanylate-binding protein 4 [KO:K20899]
311245  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
311430  Mavs; mitochondrial antiviral-signaling protein [KO:K12648]
311786  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
313121  Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
315084  Gsdmd; gasdermin-D [KO:K20917]
315139  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
315435  Panx1; pannexin-1 isoform a [KO:K03443]
315599  Nlrx1; NLR family member X1 precursor [KO:K12653]
316010  Camp; cathelicidin antimicrobial peptide precursor [KO:K13916]
316794  Brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
317546  Tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
359726  Rnasel; 2-5A-dependent ribonuclease [KO:K01165]
360557  Nlrp1a; NACHT, LRR and PYD domains-containing protein 1a allele 1 [KO:K12798]
360850  Nek7; serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
361321  Atg12; ubiquitin-like protein ATG12 [KO:K08336]
362050  Gbp5; guanylate-binding protein 5 [KO:K20898]
362245  Map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
362393  Antxr1; anthrax toxin receptor 1 [KO:K20909]
362491  Ripk2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
362788  Traf3; TNF receptor-associated factor 3 [KO:K03174]
363278  Atg16l1; autophagy-related protein 16-1 [KO:K17890]
363328  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
363938  Oas2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
363984  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
364386  Rnf31; E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
365601  Atg5; autophagy protein 5 isoform 1 [KO:K08339]
365661  Erbin; erbin isoform X1 [KO:K12796]
406163  Gpsm3; G-protein-signaling modulator 3 [KO:K15838]
494202  Oas3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
498658  Defa9; uncharacterized protein LOC498658 precursor [KO:K05230]
498659  RatNP-3b; neutrophil antibiotic peptide NP-3B precursor [KO:K05230]
498840  Sting1; stimulator of interferon genes protein [KO:K12654]
500133  Nod1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
500491  Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414]
502959  Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414]
502961  Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414]
50658  Mapk9; mitogen-activated protein kinase 9 isoform 2 [KO:K04440] [EC:2.7.11.24]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
58923  Mefv; pyrin [KO:K12803]
58974  Gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
60352  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
60371  Birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
60383  Rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
613220  Defal1; defensin alpha-like protein 1 precursor [KO:K05230]
613223  Defa6; alpha-defensin 6 precursor [KO:K05230]
613224  Defa8; alpha-defensin 8 precursor [KO:K05230]
613225  Defa11; neutrophil defensin 4 precursor [KO:K05230]
63879  Xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
64044  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
641624  Defb5; beta-defensin 5 precursor [KO:K21100]
641627  Defb14; beta-defensin 14 precursor [KO:K23126]
64171  Card9; caspase recruitment domain-containing protein 9 [KO:K12794]
64389  Defb4; beta-defensin 4 precursor [KO:K21100]
64476  Mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
64529  Ctsb; cathepsin B preproprotein [KO:K01363] [EC:3.4.22.1]
64670  Gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
64862  Map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
66021  Cybb; cytochrome b-245 beta chain [KO:K21421] [EC:1.-.-.-]
679906  Trpm7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
683206  Tnfaip3; TNF alpha induced protein 3 [KO:K11859] [EC:3.4.19.12]
684173  Traf5; TNF receptor-associated factor 5 [KO:K09849]
685067  Gbp7; uncharacterized protein LOC685067 [KO:K20899]
685116  Gbp3; LOW QUALITY PROTEIN: guanylate-binding protein 1-like [KO:K20899]
686323  Trip6; thyroid receptor-interacting protein 6 [KO:K12792]
686326  Ifnar2; interferon alpha and beta receptor subunit 2 isoform 1 precursor [KO:K05131]
689161  Gabarapl1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
689314  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
690894  Ifna1; interferon alpha family, gene 5 precursor [KO:K05414]
691998  Nlrp1b; NACHT, LRR and PYD domains-containing protein 1b allele 3-like [KO:K12798]
78971  Birc3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
79129  Cyba; cytochrome b-245 light chain [KO:K08009]
79462  Txn2; thioredoxin, mitochondrial precursor [KO:K03671]
81503  Cxcl1; growth-regulated alpha protein precursor [KO:K05505]
81525  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
81649  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
81678  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
81780  Ccl5; C-C motif chemokine 5 precursor [KO:K12499]
81859  [KO:K20894]
83529  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
83531  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
83532  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
84598  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
85240  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
rno04010  MAPK signaling pathway
rno04064  NF-kappa B signaling pathway
rno04140  Autophagy - animal
rno04620  Toll-like receptor signaling pathway
KO pathway
ko04621   

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