KEGG   ORTHOLOGY: K06277
Entry
K06277                      KO                                     

Name
RAPGEF1, GRF2
Definition
Rap guanine nucleotide exchange factor 1
Pathway
ko04015  Rap1 signaling pathway
ko04510  Focal adhesion
ko04722  Neurotrophin signaling pathway
ko04910  Insulin signaling pathway
ko05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
 09160 Human Diseases
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
Genes
HSA: 2889(RAPGEF1)
PTR: 464812(RAPGEF1)
PPS: 100972192(RAPGEF1)
GGO: 101140063(RAPGEF1)
PON: 100444262(RAPGEF1)
NLE: 100603139(RAPGEF1)
MCC: 715272(RAPGEF1)
MCF: 102137533(RAPGEF1)
CSAB: 103239727(RAPGEF1)
RRO: 104669757(RAPGEF1)
RBB: 108513945(RAPGEF1)
CJC: 100402777(RAPGEF1)
SBQ: 101052399(RAPGEF1)
MMU: 107746(Rapgef1)
MCAL: 110309132(Rapgef1)
MPAH: 110317565(Rapgef1)
RNO: 63881(Rapgef1)
MUN: 110552091(Rapgef1)
CGE: 100764804(Rapgef1)
NGI: 103742879(Rapgef1)
HGL: 101714387(Rapgef1)
CCAN: 109691895(Rapgef1)
OCU: 100358044(RAPGEF1)
TUP: 102490444(RAPGEF1)
CFA: 491286(RAPGEF1)
VVP: 112927996(RAPGEF1)
AML: 100478465(RAPGEF1)
UMR: 103670406(RAPGEF1)
UAH: 113266537(RAPGEF1)
ORO: 101367883(RAPGEF1)
ELK: 111145866
FCA: 101099507(RAPGEF1)
PTG: 102962616(RAPGEF1)
PPAD: 109249998(RAPGEF1)
AJU: 106985330(RAPGEF1)
BTA: 520454(RAPGEF1)
BOM: 102286409(RAPGEF1)
BIU: 109566561(RAPGEF1)
BBUB: 102392822(RAPGEF1)
CHX: 102176334(RAPGEF1)
OAS: 101121164(RAPGEF1)
SSC: 100511735(RAPGEF1)
CFR: 102521802(RAPGEF1)
CDK: 105085169(RAPGEF1)
BACU: 103016774(RAPGEF1)
LVE: 103068519(RAPGEF1)
OOR: 101281077(RAPGEF1)
DLE: 111177101(RAPGEF1)
PCAD: 102992323(RAPGEF1)
ECB: 100069527(RAPGEF1)
EPZ: 103553650(RAPGEF1)
EAI: 106845379(RAPGEF1)
MYB: 102249993(RAPGEF1)
MYD: 102755223(RAPGEF1)
MNA: 107524638(RAPGEF1)
HAI: 109380820(RAPGEF1)
DRO: 112306444(RAPGEF1)
PALE: 102882490(RAPGEF1)
RAY: 107504562(RAPGEF1)
MJV: 108406801(RAPGEF1)
LAV: 100668712(RAPGEF1)
TMU: 101344782
MDO: 100016537(RAPGEF1)
SHR: 100914252(RAPGEF1)
PCW: 110198895(RAPGEF1)
OAA: 100075047(RAPGEF1)
GGA: 417173(RAPGEF1)
MGP: 100538909(RAPGEF1)
CJO: 107321760(RAPGEF1)
NMEL: 110406774(RAPGEF1)
APLA: 101796594(RAPGEF1)
ACYG: 106044103(RAPGEF1)
TGU: 100223502(RAPGEF1)
LSR: 110477603(RAPGEF1)
SCAN: 103818988(RAPGEF1)
GFR: 102041561(RAPGEF1)
FAB: 101819251(RAPGEF1)
PHI: 102101609(RAPGEF1)
PMAJ: 107211975(RAPGEF1)
CCAE: 111937012(RAPGEF1)
CCW: 104688313(RAPGEF1)
ETL: 114073801(RAPGEF1)
FPG: 101920279(RAPGEF1)
FCH: 102051437(RAPGEF1)
CLV: 102093050(RAPGEF1)
EGZ: 104129824(RAPGEF1)
NNI: 104023176(RAPGEF1)
ACUN: 113486529(RAPGEF1)
PADL: 103915278(RAPGEF1)
AAM: 106490324(RAPGEF1)
ASN: 102376116(RAPGEF1)
AMJ: 102567356(RAPGEF1)
PSS: 102462283(RAPGEF1)
CMY: 102941951(RAPGEF1)
CPIC: 101952144(RAPGEF1)
ACS: 100558908
PVT: 110079600(RAPGEF1)
PBI: 103062364(RAPGEF1)
PMUR: 107291046(RAPGEF1)
PMUA: 114588828(RAPGEF1)
GJA: 107113979(RAPGEF1)
XLA: 108698866(rapgef1.L) 444199(rapgef1.S)
XTR: 733953(rapgef1)
NPR: 108795307(RAPGEF1)
DRE: 394101(rapgef1b) 558635(rapgef1a)
IPU: 108265900 108279164(rapgef1)
AMEX: 103035014 103043049(rapgef1)
EEE: 113577358(rapgef1) 113588027
TRU: 101073444(rapgef1)
LCO: 104924499(rapgef1) 104934753
NCC: 104967939(rapgef1)
ONL: 100693176(rapgef1) 100712315
OLA: 101157374(rapgef1) 101158464
XMA: 102230952(rapgef1) 102235637
XCO: 114150223(rapgef1) 114154767
PRET: 103473427
CVG: 107089763(rapgef1) 107104265
NFU: 107374772 107386212(rapgef1)
KMR: 108230997(rapgef1) 108248096
ALIM: 106516284(rapgef1) 106532135
AOCE: 111564078(rapgef1) 111586833
CSEM: 103390102 103397946(rapgef1)
POV: 109626210(rapgef1)
LCF: 108873981(rapgef1) 108894420
SDU: 111237355(rapgef1) 111237440
SLAL: 111668040(rapgef1)
HCQ: 109517154(rapgef1)
BPEC: 110157298(rapgef1)
MALB: 109957411(rapgef1) 109972316
ELS: 105014664(rapgef1) 105028395
SFM: 108920197 108934417(rapgef1)
PKI: 111841868(rapgef1)
LCM: 102362033(RAPGEF1)
CMK: 103184630(rapgef1)
RTP: 109935633
BFO: 118421354
CIN: 100182646
SPU: 100892239
APLC: 110976276
SKO: 102804221
DME: Dmel_CG42328(C3G)
DER: 6551687
DSE: 6612208
DSI: Dsimw501_GD16179(Dsim_GD16179)
DYA: Dyak_GE16444(Dyak_C3G)
DSR: 110180409
DPE: 6600013
DMN: 108159372
DWI: 6648950
DAZ: 108618515
DNV: 115565081
DHE: 111598874
LCQ: 111678838
AME: 409856
BIM: 100744546
BTER: 100647525
CCAL: 108622115
OBB: 114871731
SOC: 105202120
MPHA: 105836735
AEC: 105146240
ACEP: 105622998
PBAR: 105422754
VEM: 105562580
HST: 105191043
DQU: 106746299
CFO: 105251814
LHU: 105675839
PGC: 109859258
OBO: 105280729
PCF: 106791194
NVI: 100118982
CSOL: 105364247
MDL: 103570110
TCA: 662211
DPA: 109546149
ATD: 109608666
NVL: 108562411
BMOR: 101746299
BMAN: 114239490
PMAC: 106720420
PRAP: 110993770
HAW: 110370762
TNL: 113492608
API: 100167955
DNX: 107164926
AGS: 114126646
CLEC: 106667546
ZNE: 110838972
FCD: 110853223
PVM: 113829055
TUT: 107371081
DPTE: 113795714
CSCU: 111612386
PTEP: 107448403
CEL: CELE_Y34B4A.4(Y34B4A.4)
CBR: CBG14649
BMY: Bm1_35190
TSP: Tsp_03304
PCAN: 112575123
CRG: 105337544
MYI: 110449856
OBI: 106880457
SHX: MS3_02666
NVE: 5511159
EPA: 110243320
ADF: 107340941
AMIL: 114969048
PDAM: 113683168
SPIS: 111339415
DGT: 114521758
HMG: 100200352
AQU: 100634860
DDI: DDB_G0277913(gefJ)
 » show all
Reference
PMID:7806500
  Authors
Knudsen BS, Feller SM, Hanafusa H
  Title
Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk.
  Journal
J Biol Chem 269:32781-7 (1994)
  Sequence
[hsa:2889]
Reference
PMID:9266971
  Authors
van den Berghe N, Cool RH, Horn G, Wittinghofer A
  Title
Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).
  Journal
Oncogene 15:845-50 (1997)
DOI:10.1038/sj.onc.1201407
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