KEGG   PATHWAY: ocu05010
Entry
ocu05010                    Pathway                                
Name
Alzheimer disease - Oryctolagus cuniculus (rabbit)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ocu05010  Alzheimer disease
ocu05010

Disease
H00056  Alzheimer disease
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008594  [KO:K03965]
100008609  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100008733  IL6; interleukin-6 precursor [KO:K05405]
100008751  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100008752  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100008801  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100008833  [KO:K13241] [EC:1.14.13.39]
100008840  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100008852  [KO:K08008]
100008886  [KO:K04505] [EC:3.4.23.-]
100008911  [KO:K04527] [EC:2.7.10.1]
100008939  [KO:K04960]
100008990  IL1B; interleukin-1 beta precursor [KO:K04519]
100009013  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
100009030  WNT11; protein Wnt-11 [KO:K01384]
100009033  [KO:K00312]
100009074  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
100009088  TNF; tumor necrosis factor precursor [KO:K03156]
100009089  [KO:K01367] [EC:3.4.22.52]
100009092  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100009227  CSNK1A1; casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
100009243  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
100009248  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
100009250  IL1A; interleukin-1 alpha [KO:K04383]
100009251  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100009327  TUBA1B; tubulin alpha-1B chain [KO:K07374]
100009337  APOE; apolipoprotein E [KO:K04524]
100009381  WNT5A; protein Wnt-5a precursor [KO:K00444]
100009414  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100009423  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100009473  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100009487  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
100009504  DKK1; dickkopf-related protein 1 precursor [KO:K02165]
100009505  [KO:K04958]
100009545  RYR3; ryanodine receptor 3 [KO:K04963]
100009546  APP; amyloid-beta precursor protein precursor [KO:K04520]
100009547  [KO:K04550]
100009566  [KO:K03068]
100009585  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100037716  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
100038308  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100101555  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100101591  [KO:K04397] [EC:3.4.22.60]
100101592  [KO:K04399] [EC:3.4.22.62]
100101613  [KO:K06059] [EC:3.4.24.86]
100101614  [KO:K06704] [EC:3.4.24.81]
100125985  [KO:K02105]
100126569  WNT2; protein Wnt-2 precursor [KO:K00182]
100301531  CSNK2B; casein kinase II subunit beta [KO:K03115]
100301533  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
100303773  [KO:K00408]
100327259  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100327269  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor [KO:K02263]
100327270  COX6A1; cytochrome c oxidase subunit 6A1, mitochondrial precursor [KO:K02266]
100328584  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
100328585  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
100328669  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
100328673  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
100328815  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
100328905  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100337764  [KO:K05863]
100337822  [KO:K00922] [EC:2.7.1.153]
100337889  [KO:K05209]
100337904  [KO:K08957] [EC:2.7.11.1]
100337966  [KO:K00417]
100337973  [KO:K03097] [EC:2.7.11.1]
100337999  [KO:K04440] [EC:2.7.11.24]
100338005  [KO:K02737] [EC:3.4.25.1]
100338219  UQCRQ; cytochrome b-c1 complex subunit 8 [KO:K00418]
100338247  [KO:K02729] [EC:3.4.25.1]
100338269  [KO:K03035]
100338362  [KO:K09565] [EC:5.2.1.8]
100338439  [KO:K04452]
100338467  [KO:K20720]
100338517  [KO:K02727] [EC:3.4.25.1]
100338566  [KO:K02731] [EC:3.4.25.1]
100338577  [KO:K05453]
100338910  [KO:K14713]
100339009  [KO:K02131]
100339067  [KO:K03037]
100339082  [KO:K03961]
100339093  [KO:K03237]
100339305  [KO:K17445]
100339336  [KO:K02353]
100339383  [KO:K04374]
100339424  [KO:K11351]
100339544  [KO:K02329]
100339597  [KO:K10396] [EC:5.6.1.3]
100339628  [KO:K02271]
100339697  [KO:K21423] [EC:1.6.3.-]
100339765  [KO:K04385]
100339862  [KO:K17906]
100339897  [KO:K03030]
100339940  [KO:K09027]
100339981  [KO:K16172]
100340171  LPL; lipoprotein lipase precursor [KO:K01059] [EC:3.1.1.34]
100340336  [KO:K02165]
100340437  [KO:K08845] [EC:2.7.11.1]
100340483  [KO:K07374]
100340498  [KO:K04426] [EC:2.7.11.25]
100340527  [KO:K17908]
100340606  [KO:K05864] [EC:5.2.1.8]
100340633  [KO:K04604]
100340645  [KO:K02268]
100340705  [KO:K14715]
100340719  [KO:K04634]
100340939  [KO:K07374]
100341050  [KO:K08738]
100341175  [KO:K08738]
100341219  [KO:K02266]
100341256  [KO:K00237]
100341372  [KO:K20858]
100341474  [KO:K02266]
100341512  [KO:K05858] [EC:3.1.4.11]
100341515  [KO:K08738]
100341581  [KO:K07375]
100341658  [KO:K03063]
100341681  [KO:K08960] [EC:2.7.11.1]
100341772  [KO:K02132]
100341888  [KO:K01408] [EC:3.4.24.56]
100341941  [KO:K03934] [EC:7.1.1.2]
100341993  [KO:K03955]
100342092  [KO:K07747] [EC:3.4.23.45]
100342099  [KO:K02354]
100342149  [KO:K02738] [EC:3.4.25.1]
100342159  [KO:K02728] [EC:3.4.25.1]
100342209  [KO:K06172]
100342235  [KO:K08683] [EC:1.1.1.35 1.1.1.178]
100342532  [KO:K21398]
100342664  [KO:K04440] [EC:2.7.11.24]
100342678  [KO:K03954]
100342714  [KO:K03938]
100342852  [KO:K04456] [EC:2.7.11.1]
100342870  [KO:K00714]
100342972  [KO:K05863]
100342984  [KO:K04133]
100342986  [KO:K04809]
100342996  [KO:K02271]
100343142  [KO:K19722]
100343255  [KO:K02273]
100343442  [KO:K04521] [EC:3.4.23.46]
100343622  [KO:K02732] [EC:3.4.25.1]
100343671  [KO:K04522] [EC:3.4.23.-]
100343693  [KO:K02128]
100343793  [KO:K02265]
100343824  [KO:K08333] [EC:2.7.11.1]
100343963  [KO:K14711]
100343982  [KO:K00416]
100344003  [KO:K04380]
100344154  [KO:K02131]
100344233  [KO:K03937]
100344241  [KO:K07828]
100344371  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
100344394  [KO:K02376]
100344446  [KO:K08334]
100344533  [KO:K06268]
100344741  [KO:K06171]
100344965  [KO:K02131]
100345181  [KO:K00922] [EC:2.7.1.153]
100345232  [KO:K03038]
100345250  [KO:K02649]
100345290  [KO:K06693]
100345307  [KO:K03939]
100345365  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
100345503  [KO:K08957] [EC:2.7.11.1]
100345526  [KO:K02183]
100345745  [KO:K02263]
100345777  [KO:K03960]
100345803  [KO:K02842]
100345955  [KO:K02270]
100346106  [KO:K03158]
100346169  [KO:K00237]
100346411  [KO:K02264]
100346477  [KO:K05863]
100346557  [KO:K14718]
100346573  [KO:K04129]
100346652  [KO:K07374]
100346670  [KO:K02267]
100346706  [KO:K14716]
100346750  [KO:K02128]
100346817  [KO:K03964]
100346929  [KO:K04440] [EC:2.7.11.24]
100347143  [KO:K00415]
100347288  [KO:K03962]
100347345  [KO:K04371] [EC:2.7.11.24]
100347407  [KO:K04366] [EC:2.7.11.1]
100347447  [KO:K06170]
100347487  [KO:K07827]
100347545  [KO:K03968]
100347571  [KO:K00414]
100347823  [KO:K03948]
100347856  [KO:K02183]
100347858  [KO:K07375]
100347864  [KO:K00419]
100347938  [KO:K03952]
100348057  [KO:K05863]
100348075  [KO:K07374]
100348082  [KO:K03028]
100348127  [KO:K02157]
100348135  [KO:K00411] [EC:7.1.1.8]
100348141  [KO:K10396] [EC:5.6.1.3]
100348290  [KO:K07375]
100348477  [KO:K04398] [EC:3.4.22.61]
100348523  [KO:K02734] [EC:3.4.25.1]
100348561  [KO:K04371] [EC:2.7.11.24]
100348563  [KO:K03949]
100348581  [KO:K08957] [EC:2.7.11.1]
100348663  [KO:K00922] [EC:2.7.1.153]
100348672  [KO:K05858] [EC:3.1.4.11]
100348842  [KO:K03083] [EC:2.7.11.26]
100348984  [KO:K02271]
100348986  [KO:K00445]
100349209  [KO:K07374]
100349288  [KO:K03950]
100349320  [KO:K03955]
100349426  [KO:K02580]
100349446  [KO:K02739] [EC:3.4.25.1]
100349506  [KO:K05862]
100349558  [KO:K17985]
100349579  [KO:K00444]
100349642  [KO:K03956]
100349768  [KO:K05863]
100349785  [KO:K03066]
100349792  [KO:K07375]
100349847  [KO:K00182]
100350027  [KO:K07374]
100350045  [KO:K07375]
100350046  [KO:K07374]
100350107  [KO:K02183]
100350226  [KO:K08331]
100350240  [KO:K19730]
100350243  [KO:K04532]
100350252  [KO:K07375]
100350395  [KO:K05858] [EC:3.1.4.11]
100350521  [KO:K02235]
100350526  [KO:K02131]
100350580  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
100350591  [KO:K03062]
100350704  [KO:K03958]
100350787  [KO:K00411] [EC:7.1.1.8]
100350803  [KO:K21357] [EC:2.7.11.1]
100350840  [KO:K21246]
100350916  [KO:K03066]
100350967  [KO:K07374]
100351037  [KO:K08738]
100351141  [KO:K03946]
100351178  [KO:K14714]
100351316  [KO:K01357]
100351343  [KO:K14709]
100351492  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
100351783  [KO:K02735] [EC:3.4.25.1]
100351820  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
100351840  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
100351850  [KO:K11716]
100351898  [KO:K17589]
100351964  [KO:K04365] [EC:2.7.11.1]
100352000  [KO:K03068]
100352168  [KO:K03935] [EC:7.1.1.2]
100352227  [KO:K01064]
100352330  [KO:K03953]
100352353  [KO:K08334]
100352363  [KO:K02268]
100352392  CALM2; calmodulin [KO:K02183]
100352412  [KO:K14712]
100352479  [KO:K08957] [EC:2.7.11.1]
100352563  [KO:K02725] [EC:3.4.25.1]
100352693  [KO:K10396] [EC:5.6.1.3]
100352718  [KO:K03951]
100352775  [KO:K02090] [EC:2.7.11.22]
100352836  [KO:K03061]
100352839  [KO:K01357]
100352881  [KO:K17908]
100352919  [KO:K02375]
100353090  [KO:K01558]
100353118  [KO:K08269] [EC:2.7.11.1]
100353266  [KO:K05210]
100353292  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X3 [KO:K02136]
100353320  [KO:K02271]
100353478  [KO:K07374]
100353514  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
100353559  [KO:K01064]
100353576  [KO:K14720]
100353585  [KO:K14719]
100353595  [KO:K03031]
100353673  [KO:K08738]
100353706  [KO:K04456] [EC:2.7.11.1]
100353867  [KO:K06172]
100353930  [KO:K10407]
100353955  [KO:K03064]
100353976  [KO:K02085]
100354000  [KO:K03065]
100354018  [KO:K03209]
100354074  [KO:K02127]
100354159  [KO:K04529]
100354254  [KO:K02273]
100354352  [KO:K07374]
100354468  [KO:K08738]
100354583  [KO:K00312]
100354603  [KO:K03959]
100354630  [KO:K03036]
100354712  [KO:K08334]
100354724  [KO:K08738]
100354735  [KO:K10407]
100354802  [KO:K05863]
100354847  [KO:K08860] [EC:2.7.11.1]
100354905  [KO:K02183]
100354976  [KO:K05853] [EC:7.2.2.10]
100355084  [KO:K08738]
100355217  [KO:K02726] [EC:3.4.25.1]
100355248  [KO:K07374]
100355264  [KO:K03039]
100355295  [KO:K02726] [EC:3.4.25.1]
100355313  [KO:K04131]
100355349  [KO:K03936] [EC:7.1.1.2]
100355422  [KO:K02267]
100355529  [KO:K11352]
100355680  [KO:K03062]
100355697  [KO:K00572]
100355888  [KO:K04467] [EC:2.7.11.10]
100355972  [KO:K14717]
100355991  [KO:K04726]
100356145  [KO:K02165]
100356164  [KO:K07203] [EC:2.7.11.1]
100356196  [KO:K08957] [EC:2.7.11.1]
100356245  [KO:K04348] [EC:3.1.3.16]
100356308  [KO:K00415]
100356326  [KO:K05863]
100356338  [KO:K05211]
100356368  [KO:K02432]
100356401  [KO:K07209] [EC:2.7.11.10]
100356448  [KO:K00914] [EC:2.7.1.137]
100356563  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
100356593  [KO:K03948]
100356756  [KO:K02270]
100356786  [KO:K02271]
100356806  [KO:K04959]
100356829  [KO:K02730] [EC:3.4.25.1]
100357166  [KO:K03033]
100357261  [KO:K04853]
100357329  [KO:K08738]
100357346  [KO:K08852] [EC:2.7.11.1 3.1.26.-]
100357567  [KO:K07374]
100357660  [KO:K02271]
100357840  [KO:K08738]
100357841  [KO:K02649]
100357931  [KO:K17889]
100357933  [KO:K00714]
100357982  [KO:K09027]
100358206  [KO:K20723]
100358208  [KO:K00419]
100358239  [KO:K02270]
100358367  [KO:K02353]
100358536  [KO:K09054]
100358587  [KO:K02158]
100358684  [KO:K03943] [EC:7.1.1.2]
100358689  [KO:K07375]
100358698  [KO:K14709]
100359144  [KO:K02127]
100359228  [KO:K04528]
103345165  [KO:K02183]
103345313  [KO:K04431] [EC:2.7.12.2]
103346018  [KO:K02085]
103346157  [KO:K17906]
103346363  [KO:K05212]
103346555  [KO:K11353]
103346740  [KO:K03944]
103347262  [KO:K02731] [EC:3.4.25.1]
103347536  [KO:K05858] [EC:3.1.4.11]
103347723  [KO:K08738]
103348383  [KO:K02084]
103348902  [KO:K03032]
103348917  [KO:K02432]
103348994  [KO:K03957]
103349113  [KO:K07187]
103349485  [KO:K00420]
103349801  [KO:K02270]
103350026  [KO:K00236]
103350677  [KO:K04741] [EC:3.4.22.-]
103350693  [KO:K03967]
103351400  [KO:K03069]
103351932  [KO:K17446]
103352372  [KO:K02375]
108175360  [KO:K00237]
108175419  [KO:K03948]
108175479  [KO:K02272]
108175623  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
108175836  [KO:K08738]
108176887  [KO:K02268]
108176933  [KO:K10881]
108177067  [KO:K03945]
108177262  [KO:K02272]
108177422  [KO:K08738]
108177708  [KO:K02272]
108178067  [KO:K02272]
108178368  [KO:K10881]
108178409  [KO:K03096]
108178730  [KO:K08738]
127483320  [KO:K08738]
127484381  [KO:K02270]
127484606  [KO:K02270]
127484881  [KO:K03957]
127485184  [KO:K04735]
127485529  [KO:K00420]
127485674  [KO:K02085]
127486116  [KO:K04456] [EC:2.7.11.1]
127486372  [KO:K03942] [EC:7.1.1.2]
127486401  [KO:K03966]
127486440  [KO:K03965]
127486605  [KO:K02833]
127486849  [KO:K07747] [EC:3.4.23.45]
127486867  [KO:K03941] [EC:7.1.1.2]
127486893  [KO:K05208]
127486945  [KO:K00413]
127487016  [KO:K02730] [EC:3.4.25.1]
127487394  [KO:K14711]
127487406  [KO:K02133] [EC:7.1.2.2]
127488114  [KO:K03963]
127488313  [KO:K02090] [EC:2.7.11.22]
127488679  [KO:K07375]
127489209  [KO:K02134]
127489236  [KO:K07827]
127489271  [KO:K02353]
127489461  [KO:K04368] [EC:2.7.12.2]
127489739  [KO:K10407]
127490235  [KO:K03939]
127490241  [KO:K06691]
127492394  [KO:K02270]
127493058  [KO:K19722]
808221  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
808222  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
808223  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
808224  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
808225  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
808226  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
808227  CYTB; cytochrome b [KO:K00412]
808228  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
808229  COX3; cytochrome c oxidase subunit III [KO:K02262]
808230  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
808231  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
808232  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
808233  COX2; cytochrome c oxidase subunit II [KO:K02261]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:15232608
  Authors
Dickson DW
  Title
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
  Journal
J Clin Invest 114:23-7 (2004)
DOI:10.1172/JCI22317
Reference
PMID:15750290
  Authors
Takuma K, Yan SS, Stern DM, Yamada K
  Title
Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.
  Journal
J Pharmacol Sci 97:312-6 (2005)
DOI:10.1254/jphs.CPJ04006X
Reference
PMID:18675468
  Authors
Bezprozvanny I, Mattson MP
  Title
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
  Journal
Trends Neurosci 31:454-63 (2008)
DOI:10.1016/j.tins.2008.06.005
Reference
PMID:9848086
  Authors
Holscher C
  Title
Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.
  Journal
Neurobiol Dis 5:129-41 (1998)
DOI:10.1006/nbdi.1998.0193
Reference
PMID:18035450
  Authors
Bojarski L, Herms J, Kuznicki J
  Title
Calcium dysregulation in Alzheimer's disease.
  Journal
Neurochem Int 52:621-33 (2008)
DOI:10.1016/j.neuint.2007.10.002
Reference
PMID:25450339
  Authors
Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N
  Title
Ion channels in the regulation of apoptosis.
  Journal
Biochim Biophys Acta 1848:2532-46 (2015)
DOI:10.1016/j.bbamem.2014.10.030
Reference
PMID:29890840
  Authors
Popugaeva E, Pchitskaya E, Bezprozvanny I
  Title
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
  Journal
Antioxid Redox Signal 29:1176-1188 (2018)
DOI:10.1089/ars.2018.7506
Reference
PMID:25767489
  Authors
Tan Y, Deng Y, Qing H
  Title
Calcium channel blockers and Alzheimer's disease.
  Journal
Neural Regen Res 7:137-40 (2012)
DOI:10.3969/j.issn.1673-5374.2012.02.010
Reference
PMID:11484003
  Authors
Small DH, Mok SS, Bornstein JC
  Title
Alzheimer's disease and Abeta toxicity: from top to bottom.
  Journal
Nat Rev Neurosci 2:595-8 (2001)
DOI:10.1038/35086072
Reference
PMID:15177383
  Authors
Parihar MS, Hemnani T
  Title
Alzheimer's disease pathogenesis and therapeutic interventions.
  Journal
J Clin Neurosci 11:456-67 (2004)
DOI:10.1016/j.jocn.2003.12.007
Reference
PMID:17568632
  Authors
Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A
  Title
Presenilin-mediated signal transduction.
  Journal
Physiol Behav 92:93-7 (2007)
DOI:10.1016/j.physbeh.2007.05.053
Reference
PMID:22842534
  Authors
Honarnejad K, Herms J
  Title
Presenilins: role in calcium homeostasis.
  Journal
Int J Biochem Cell Biol 44:1983-6 (2012)
DOI:10.1016/j.biocel.2012.07.019
Reference
PMID:21663966
  Authors
Supnet C, Bezprozvanny I
  Title
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
  Journal
Cell Calcium 50:303-9 (2011)
DOI:10.1016/j.ceca.2011.05.013
Reference
PMID:16677790
  Authors
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE
  Title
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
  Journal
Exp Gerontol 41:668-73 (2006)
DOI:10.1016/j.exger.2006.03.012
Reference
PMID:14557245
  Authors
Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL
  Title
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
  Journal
J Cell Biol 163:27-33 (2003)
DOI:10.1083/jcb.200304003
Reference
PMID:24051203
  Authors
Eckert A, Nisbet R, Grimm A, Gotz J
  Title
March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease.
  Journal
Biochim Biophys Acta 1842:1258-66 (2014)
DOI:10.1016/j.bbadis.2013.08.013
Reference
PMID:30741722
  Authors
Strickland MR, Holtzman DM
  Title
Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
  Journal
J Clin Invest 129:969-971 (2019)
DOI:10.1172/JCI127578
Reference
PMID:10527810
  Authors
Ivins KJ, Thornton PL, Rohn TT, Cotman CW
  Title
Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.
  Journal
Neurobiol Dis 6:440-9 (1999)
DOI:10.1006/nbdi.1999.0268
Reference
PMID:31655116
  Authors
Sushma, Mondal AC
  Title
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
  Journal
Mol Cell Neurosci 101:103414 (2019)
DOI:10.1016/j.mcn.2019.103414
Reference
PMID:18648507
  Authors
Sanz-Blasco S, Valero RA, Rodriguez-Crespo I, Villalobos C, Nunez L
  Title
Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.
  Journal
PLoS One 3:e2718 (2008)
DOI:10.1371/journal.pone.0002718
Reference
PMID:20332425
  Authors
Mattson MP
  Title
ER calcium and Alzheimer's disease: in a state of flux.
  Journal
Sci Signal 3:pe10 (2010)
DOI:10.1126/scisignal.3114pe10
Reference
PMID:16394273
  Authors
Lee SY, Hwang DY, Kim YK, Lee JW, Shin IC, Oh KW, Lee MK, Lim JS, Yoon DY, Hwang SJ, Hong JT
  Title
PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release.
  Journal
FASEB J 20:151-3 (2006)
DOI:10.1096/fj.05-4017fje;1
Reference
PMID:11551913
  Authors
Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, Mori K, Rozmahel R, Fraser P, George-Hyslop PS, Tohyama M
  Title
Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.
  Journal
J Biol Chem 276:43446-54 (2001)
DOI:10.1074/jbc.M104096200
Reference
PMID:28057414
  Authors
Lane-Donovan C, Herz J
  Title
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
  Journal
Trends Endocrinol Metab 28:273-284 (2017)
DOI:10.1016/j.tem.2016.12.001
Reference
PMID:27994051
  Authors
Wasser CR, Herz J
  Title
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
  Journal
J Biol Chem 292:1330-1338 (2017)
DOI:10.1074/jbc.R116.766782
Reference
PMID:21116052
  Authors
Lilja AM, Porras O, Storelli E, Nordberg A, Marutle A
  Title
Functional interactions of fibrillar and oligomeric amyloid-beta with alpha7 nicotinic receptors in Alzheimer's disease.
  Journal
J Alzheimers Dis 23:335-47 (2011)
DOI:10.3233/JAD-2010-101242
Reference
PMID:24847263
  Authors
Anastasio TJ
  Title
Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-beta on synaptic plasticity.
  Journal
Front Pharmacol 5:85 (2014)
DOI:10.3389/fphar.2014.00085
Reference
PMID:29378302
  Authors
Vargas LM, Cerpa W, Munoz FJ, Zanlungo S, Alvarez AR
  Title
Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1148-1159 (2018)
DOI:10.1016/j.bbadis.2018.01.023
Reference
PMID:25394486
  Authors
Tu S, Okamoto S, Lipton SA, Xu H
  Title
Oligomeric Abeta-induced synaptic dysfunction in Alzheimer's disease.
  Journal
Mol Neurodegener 9:48 (2014)
DOI:10.1186/1750-1326-9-48
Reference
PMID:31191253
  Authors
Palomer E, Buechler J, Salinas PC
  Title
Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.
  Journal
Front Cell Neurosci 13:227 (2019)
DOI:10.3389/fncel.2019.00227
Reference
PMID:27807401
  Authors
Vallee A, Lecarpentier Y
  Title
Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma.
  Journal
Front Neurosci 10:459 (2016)
DOI:10.3389/fnins.2016.00459
Reference
PMID:19903023
  Authors
Origlia N, Arancio O, Domenici L, Yan SS
  Title
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.
  Journal
Expert Rev Neurother 9:1635-45 (2009)
DOI:10.1586/ern.09.107
Reference
PMID:19464758
  Authors
Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Munch G
  Title
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.
  Journal
Neurobiol Aging 32:763-77 (2011)
DOI:10.1016/j.neurobiolaging.2009.04.016
Reference
PMID:12805290
  Authors
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J
  Title
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
  Journal
J Neurosci 23:4499-508 (2003)
DOI:10.1523/JNEUROSCI.23-11-04499.2003
Reference
PMID:15645263
  Authors
Roy S, Zhang B, Lee VM, Trojanowski JQ
  Title
Axonal transport defects: a common theme in neurodegenerative diseases.
  Journal
Acta Neuropathol 109:5-13 (2005)
DOI:10.1007/s00401-004-0952-x
Reference
PMID:26074767
  Authors
Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG
  Title
Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.
  Journal
Front Cell Neurosci 9:191 (2015)
DOI:10.3389/fncel.2015.00191
Reference
PMID:24529521
  Authors
De Felice FG, Lourenco MV, Ferreira ST
  Title
How does brain insulin resistance develop in Alzheimer's disease?
  Journal
Alzheimers Dement 10:S26-32 (2014)
DOI:10.1016/j.jalz.2013.12.004
Reference
PMID:26136647
  Authors
Bedse G, Di Domenico F, Serviddio G, Cassano T
  Title
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
  Journal
Front Neurosci 9:204 (2015)
DOI:10.3389/fnins.2015.00204
Reference
PMID:20101724
  Authors
Funderburk SF, Marcellino BK, Yue Z
  Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
  Journal
Mt Sinai J Med 77:59-68 (2010)
DOI:10.1002/msj.20161
Related
pathway
ocu00190  Oxidative phosphorylation
ocu03050  Proteasome
ocu04020  Calcium signaling pathway
ocu04140  Autophagy - animal
ocu04141  Protein processing in endoplasmic reticulum
ocu04210  Apoptosis
ocu04310  Wnt signaling pathway
ocu04910  Insulin signaling pathway
ocu04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

DBGET integrated database retrieval system