KEGG   PATHWAY: cge04151
Entry
cge04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Cricetulus griseus (Chinese hamster)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
cge04151  PI3K-Akt signaling pathway
cge04151

Other DBs
GO: 0043491
Organism
Cricetulus griseus (Chinese hamster) [GN:cge]
Gene
100763146  Egf; pro-epidermal growth factor isoform X2 [KO:K04357]
100754730  Tgfa; LOW QUALITY PROTEIN: protransforming growth factor alpha isoform X2 [KO:K08774]
100771728  Ereg; proepiregulin [KO:K09784]
100772017  Areg; amphiregulin isoform X2 [KO:K09782]
100764257  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
100757429  Fgf2; fibroblast growth factor 2 isoform X2 [KO:K18497]
100764611  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100772115  Fgf6; fibroblast growth factor 6 [KO:K04358]
103160353  Fgf22; fibroblast growth factor 22 isoform X2 [KO:K04358]
100758023  Fgf4; fibroblast growth factor 4 isoform X2 [KO:K04358]
100773578  Fgf20; fibroblast growth factor 20 [KO:K04358]
100759509  Fgf9; fibroblast growth factor 9 [KO:K04358]
100761599  Fgf7; fibroblast growth factor 7 [KO:K04358]
100750999  Fgf8; fibroblast growth factor 8 isoform X2 [KO:K04358]
100757734  Fgf3; fibroblast growth factor 3 isoform X2 [KO:K04358]
100751051  Fgf10; fibroblast growth factor 10 [KO:K04358]
100767099  Fgf16; fibroblast growth factor 16 isoform X2 [KO:K04358]
100763237  Fgf5; fibroblast growth factor 5 [KO:K04358]
100761504  fibroblast growth factor 18 isoform X2 [KO:K04358]
100758307  Fgf19; fibroblast growth factor 19 isoform X2 [KO:K22603]
100757339  Fgf21; fibroblast growth factor 21 [KO:K22429]
100763837  Fgf23; fibroblast growth factor 23 [KO:K22428]
100750778  Ngf; beta-nerve growth factor [KO:K02582]
113836414  LOW QUALITY PROTEIN: brain-derived neurotrophic factor-like [KO:K04355]
100774728  Ntf3; neurotrophin-3 [KO:K04356]
113836309  neurotrophin-4 [KO:K12457]
100760716  Ins; insulin [KO:K04526]
100751642  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
100762359  Igf2; LOW QUALITY PROTEIN: insulin-like growth factor II isoform X2 [KO:K13769]
100771503  Pdgfa; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
100774990  Pdgfb; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
100756952  Pdgfd; platelet-derived growth factor D isoform X2 [KO:K05450]
100765334  Pdgfc; platelet-derived growth factor C [KO:K05450]
100767142  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100752139  Kitlg; kit ligand isoform X1 [KO:K05461]
100773162  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
100755957  Vegfa; LOW QUALITY PROTEIN: vascular endothelial growth factor A isoform X2 [KO:K05448]
100759545  Vegfb; vascular endothelial growth factor B isoform X2 [KO:K16858]
100754799  Pgf; placenta growth factor [KO:K16859]
100773421  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
100753419  Vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
100764472  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
100774625  angiopoietin-1 isoform X2 [KO:K05465]
100756240  Angpt2; angiopoietin-2 [KO:K05466]
100761260  Angpt4; angiopoietin-4 [KO:K05467]
100773125  Efna3; ephrin-A3 isoform X2 [KO:K05462]
100756587  Efna5; ephrin-A5 isoform X2 [KO:K05462]
100758074  Efna1; ephrin-A1 [KO:K05462]
100755670  Efna2; ephrin-A2 isoform X2 [KO:K05462]
113833115  Efna4; ephrin-A4 isoform X2 [KO:K05462]
100773138  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
113835842  neurturin [KO:K25414]
100755266  Artn; artemin [KO:K25415]
100761935  Pspn; persephin [KO:K25416]
100774580  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100759983  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100767681  Erbb3; receptor tyrosine-protein kinase erbB-3 isoform X2 [KO:K05084] [EC:2.7.10.1]
100760475  receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
100773586  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100763455  Fgfr2; fibroblast growth factor receptor 2 isoform X4 [KO:K05093] [EC:2.7.10.1]
100764560  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100765320  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100755566  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100751271  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
100754339  Ntrk2; BDNF/NT-3 growth factors receptor isoform X2 [KO:K04360] [EC:2.7.10.1]
100766818  Insr; insulin receptor isoform X2 [KO:K04527] [EC:2.7.10.1]
100768531  Igf1r; insulin-like growth factor 1 receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
100760258  Pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
100764374  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100763221  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100751027  Kit; mast/stem cell growth factor receptor Kit isoform X3 [KO:K05091] [EC:2.7.10.1]
100761902  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X2 [KO:K05092] [EC:2.7.10.1]
100761329  Flt1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
100766609  Flt4; vascular endothelial growth factor receptor 3 isoform X2 [KO:K05097] [EC:2.7.10.1]
100756294  Kdr; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
100751933  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100764854  Tek; LOW QUALITY PROTEIN: angiopoietin-1 receptor isoform X2 [KO:K05121] [EC:2.7.10.1]
100752851  Epha2; ephrin type-A receptor 2 isoform X2 [KO:K05103] [EC:2.7.10.1]
100772741  Ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [KO:K05126] [EC:2.7.10.1]
100769627  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
100757521  Sos1; son of sevenless homolog 1 isoform X2 [KO:K03099]
100769325  Sos2; son of sevenless homolog 2 isoform X3 [KO:K03099]
100773737  Hras; GTPase HRas isoform X2 [KO:K02833]
100763178  Kras; GTPase KRas isoform X4 [KO:K07827]
113839127  GTPase KRas-like [KO:K07827]
113837935  GTPase KRas-like isoform X2 [KO:K07827]
113837956  GTPase KRas-like [KO:K07827]
113838653  GTPase KRas-like isoform X2 [KO:K07827]
113838692  GTPase KRas-like [KO:K07827]
113838722  GTPase KRas-like isoform X1 [KO:K07827]
113838818  GTPase KRas-like [KO:K07827]
113837633  GTPase KRas-like isoform X1 [KO:K07827]
113838146  GTPase KRas-like isoform X1 [KO:K07827]
113838876  GTPase KRas-like [KO:K07827]
113838228  GTPase KRas-like isoform X1 [KO:K07827]
113839011  GTPase KRas-like [KO:K07827]
100771078  GTPase KRas-like isoform X2 [KO:K07827]
113837960  GTPase KRas-like [KO:K07827]
113838098  GTPase KRas-like [KO:K07827]
113838326  GTPase KRas-like [KO:K07827]
113838417  GTPase KRas-like isoform X1 [KO:K07827]
113838488  GTPase KRas-like [KO:K07827]
113838583  GTPase KRas-like isoform X1 [KO:K07827]
113838676  GTPase KRas-like [KO:K07827]
113838679  GTPase KRas-like isoform X1 [KO:K07827]
113838746  GTPase KRas-like [KO:K07827]
113838796  GTPase KRas-like isoform X1 [KO:K07827]
113838871  GTPase KRas-like [KO:K07827]
113838872  GTPase KRas-like [KO:K07827]
113838892  GTPase KRas-like [KO:K07827]
113838898  GTPase KRas-like [KO:K07827]
113838914  GTPase KRas-like [KO:K07827]
113838921  GTPase KRas-like [KO:K07827]
113838942  GTPase KRas-like isoform X1 [KO:K07827]
113838943  GTPase KRas-like isoform X1 [KO:K07827]
113839007  GTPase HRas-like isoform X1 [KO:K07827]
118239746  GTPase KRas-like isoform X1 [KO:K07827]
118239767  GTPase KRas-like isoform X1 [KO:K07827]
118239768  GTPase KRas-like [KO:K07827]
118239770  GTPase KRas-like [KO:K07827]
118239801  GTPase KRas-like [KO:K07827]
118239825  GTPase KRas-like isoform X1 [KO:K07827]
100757614  Nras; GTPase NRas [KO:K07828]
100769018  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100689403  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113835540  dual specificity mitogen-activated protein kinase kinase 1-like isoform X1 [KO:K04368] [EC:2.7.12.2]
103158537  dual specificity mitogen-activated protein kinase kinase 1-like isoform X2 [KO:K04368] [EC:2.7.12.2]
100774204  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100759514  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100753149  Mapk3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
100755710  Irs1; insulin receptor substrate 1 [KO:K16172]
100771475  Tlr2; LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
100689329  Tlr4; toll-like receptor 4 precursor [KO:K10160]
100756792  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
113837706  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
113831736  immunoglobulin heavy variable 3-48 [KO:K06856]
113831730  uncharacterized protein LOC113831730 [KO:K06856]
113838236  uncharacterized protein LOC113838236 [KO:K06856]
100758656  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
100765953  Cd19; B-lymphocyte antigen CD19 [KO:K06465]
100764327  Pik3ap1; phosphoinositide 3-kinase adapter protein 1 isoform X2 [KO:K12230]
100770534  Gh1; somatotropin [KO:K05438]
100751961  prolactin-6A1-like [KO:K05439]
100763880  prolactin-5A1-like [KO:K05439]
100760990  prolactin-2A1-like [KO:K05439]
100761279  prolactin-2C5-like [KO:K05439]
100763308  prolactin-7C1-like isoform X1 [KO:K05439]
100750601  prolactin [KO:K05439]
100752249  prolactin-3D4-like [KO:K05439]
100752545  prolactin-3D1-like [KO:K05439]
100753747  prolactin-3D1 isoform X2 [KO:K05439]
100751675  prolactin [KO:K05439]
113834987  prolactin-3D1-like [KO:K05439]
100758591  Osm; oncostatin-M isoform X1 [KO:K05418]
100755773  Il2; interleukin-2 [KO:K05429]
100689186  Il6; interleukin-6 [KO:K05405]
100755642  Il4; interleukin-4 [KO:K05430]
100756443  Il7; interleukin-7 isoform X1 [KO:K05431]
100760028  interferon alpha-12 [KO:K05414]
100760616  interferon alpha-9 isoform X2 [KO:K05414]
100760323  interferon alpha-12 [KO:K05414]
100762064  interferon alpha-12 [KO:K05414]
100762655  interferon alpha-9 [KO:K05414]
100763520  interferon alpha-3 [KO:K05414]
100765269  interferon alpha-9 [KO:K05414]
100765849  interferon alpha-12 [KO:K05414]
100766144  interferon alpha-12 [KO:K05414]
100766726  interferon alpha-12 [KO:K05414]
100759741  interferon alpha-12 [KO:K05414]
100750635  interferon alpha-12 [KO:K05414]
100750928  interferon alpha-2-like [KO:K05414]
100751221  interferon alpha-12 [KO:K05414]
100769352  interferon alpha-12 [KO:K05414]
100769640  interferon alpha-9 [KO:K05414]
103160615  Ifnb1; interferon beta [KO:K05415]
100753960  Epo; erythropoietin isoform X1 [KO:K05437]
100755744  Csf3; granulocyte colony-stimulating factor isoform X2 [KO:K05423]
100763540  Ghr; growth hormone receptor isoform X2 [KO:K05080]
100757415  Prlr; prolactin receptor isoform X1 [KO:K05081]
100772447  Osmr; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
100764797  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
113832088  interleukin-2 receptor subunit beta-like isoform X2 [KO:K05069]
100756284  Il2rg; cytokine receptor common subunit gamma [KO:K05070]
113838537  interleukin-3 receptor subunit alpha-like [KO:K04737]
100750971  Il6r; interleukin-6 receptor subunit alpha isoform X3 [KO:K05055]
100762840  Il4r; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
100757700  Il7r; interleukin-7 receptor subunit alpha [KO:K05072]
100768581  Ifnar1; interferon alpha/beta receptor 1 isoform X2 [KO:K05130]
100768006  interferon alpha/beta receptor 2 isoform X4 [KO:K05131]
100769376  Epor; erythropoietin receptor isoform X2 [KO:K05079]
100760185  Csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
100754824  Jak1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100769337  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
100773497  Jak3; tyrosine-protein kinase JAK3 isoform X2 [KO:K11218] [EC:2.7.10.2]
100759814  Col1a1; collagen alpha-1(I) chain [KO:K06236]
100766269  Col1a2; collagen alpha-2(I) chain isoform X2 [KO:K06236]
100755037  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
107976999  Col4a2; collagen alpha-2(IV) chain isoform X2 [KO:K06237]
100757740  Col4a1; collagen alpha-1(IV) chain isoform X4 [KO:K06237]
103158667  Col4a3; collagen alpha-3(IV) chain isoform X2 [KO:K06237]
100772869  collagen alpha-6(IV) chain isoform X3 [KO:K06237]
100772575  collagen alpha-5(IV) chain isoform X2 [KO:K06237]
100756006  collagen alpha-4(IV) chain isoform X2 [KO:K06237]
100770126  Col6a5; collagen alpha-5(VI) chain isoform X2 [KO:K06238]
100754390  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100755078  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
100769833  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
100770413  collagen alpha-4(VI) chain isoform X2 [KO:K06238]
103164567  collagen alpha-3(VI) chain isoform X2 [KO:K06238]
100755811  Col9a1; collagen alpha-1(IX) chain isoform X2 [KO:K08131]
100753027  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
100757317  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
100771923  laminin subunit alpha-2 isoform X3 [KO:K05637]
100765555  Lama1; laminin subunit alpha-1 isoform X2 [KO:K05637]
100755004  Lama3; laminin subunit alpha-3 isoform X3 [KO:K06240]
100755091  Lama5; laminin subunit alpha-5 [KO:K06240]
100757321  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
100757343  Lamb1; laminin subunit beta-1 isoform X1 [KO:K05636]
100762566  Lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
100763082  Lamb3; laminin subunit beta-3 [KO:K06244]
100761564  Lamc1; laminin subunit gamma-1 isoform X2 [KO:K05635]
100765048  Lamc2; laminin subunit gamma-2 isoform X2 [KO:K06246]
100751974  Lamc3; laminin subunit gamma-3 isoform X2 [KO:K06247]
100758456  Chad; chondroadherin [KO:K06248]
100758172  Reln; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
100760878  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
100756924  Thbs3; thrombospondin-3 isoform X1 [KO:K04659]
100766091  Comp; cartilage oligomeric matrix protein isoform X2 [KO:K04659]
100752022  Thbs2; thrombospondin-2 [KO:K04659]
100762358  Thbs4; thrombospondin-4 isoform X2 [KO:K04659]
100751189  Fn1; fibronectin isoform X1 [KO:K05717]
100769547  Spp1; osteopontin isoform X2 [KO:K06250]
100767624  Vtn; vitronectin [KO:K06251]
100767397  tenascin-X isoform X2 [KO:K06252]
100754133  Tnc; tenascin isoform X1 [KO:K06252]
100753104  Tnn; tenascin-N [KO:K06252]
100753701  Tnr; tenascin-R isoform X1 [KO:K06252]
100750531  Vwf; von Willebrand factor [KO:K03900]
100752803  Ibsp; bone sialoprotein 2 isoform X2 [KO:K06253]
100750393  Itga1; integrin alpha-1 [KO:K06480]
100774579  Itga2; integrin alpha-2 isoform X2 [KO:K06481]
100762814  Itga2b; integrin alpha-IIb isoform X2 [KO:K06476]
100758471  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
100762323  Itga4; integrin alpha-4 [KO:K06483]
100768174  Itga5; integrin alpha-5 isoform X2 [KO:K06484]
100769534  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
100773038  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
100769007  Itga8; integrin alpha-8 isoform X1 [KO:K06584]
100754465  Itga9; integrin alpha-9 isoform X2 [KO:K06585]
100754198  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
100761554  Itga11; integrin alpha-11 [KO:K06587]
100752313  Itgav; integrin alpha-V isoform X2 [KO:K06487]
100763033  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
100775048  Itgb3; integrin beta-3 isoform X2 [KO:K06493]
100756849  Itgb4; integrin beta-4 isoform X2 [KO:K06525]
100765378  Itgb5; integrin beta-5 isoform X3 [KO:K06588]
100768511  Itgb6; integrin beta-6 [KO:K06589]
100770075  Itgb7; integrin beta-7 [KO:K06590]
100769713  Itgb8; integrin beta-8 [KO:K06591]
100759464  Ptk2; focal adhesion kinase 1 isoform X5 [KO:K05725] [EC:2.7.10.2]
100689251  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100769225  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100689252  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100771181  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
100750761  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100774067  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100758351  F2r; proteinase-activated receptor 1 isoform X2 [KO:K03914]
100755522  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
100770997  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
100757522  Lpar1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
100753903  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
100759265  Lpar3; lysophosphatidic acid receptor 3 [KO:K04294]
100752179  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
100765885  Lpar5; lysophosphatidic acid receptor 5 isoform X2 [KO:K08390]
100750873  Lpar6; lysophosphatidic acid receptor 6 [KO:K04273]
100689442  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100756281  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X2 [KO:K04537]
100756790  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
100757050  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100764899  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100768753  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100755128  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100769650  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
118238929  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2-like [KO:K07826]
100755432  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100767992  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100757206  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
103162614  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100752390  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
103163959  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
113832276  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
100765832  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
113837383  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100755995  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 isoform X2 [KO:K04545]
100761038  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100757536  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
107978884  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100774382  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100760746  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100754408  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100765862  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
100751224  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X4 [KO:K21290]
100751518  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X2 [KO:K21290]
100772477  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
100765813  Stk11; serine/threonine-protein kinase STK11 isoform X4 [KO:K07298] [EC:2.7.11.1]
100767909  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2 [KO:K07198] [EC:2.7.11.31]
100769574  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2 [KO:K07198] [EC:2.7.11.31]
100759745  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
100767621  Tsc1; hamartin isoform X1 [KO:K07206]
100755849  Tsc2; tuberin isoform X1 [KO:K07207]
100768233  Rheb; GTP-binding protein Rheb isoform X2 [KO:K07208]
100757018  Mlst8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
100755421  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100761529  Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
100769654  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100773768  Eif4e; eukaryotic translation initiation factor 4E isoform X3 [KO:K03259]
100764716  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X2 [KO:K03259]
100766778  Eif4e1b; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
100757513  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100760227  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100758911  Eif4b; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
100753707  Rps6; 40S ribosomal protein S6 isoform X2 [KO:K02991]
100767070  40S ribosomal protein S6 isoform X2 [KO:K02991]
113837892  40S ribosomal protein S6-like [KO:K02991]
113837022  40S ribosomal protein S6-like [KO:K02991]
103159011  40S ribosomal protein S6-like isoform X2 [KO:K02991]
113838911  40S ribosomal protein S6-like [KO:K02991]
100766006  Prkca; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
100752729  Pkn1; serine/threonine-protein kinase N1 isoform X3 [KO:K06071] [EC:2.7.11.13]
100754441  Pkn2; serine/threonine-protein kinase N2 isoform X3 [KO:K23691] [EC:2.7.11.13]
100769931  Pkn3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
100771433  Sgk1; serine/threonine-protein kinase Sgk1 isoform X2 [KO:K13302] [EC:2.7.11.1]
100772733  Sgk2; serine/threonine-protein kinase Sgk2 isoform X3 [KO:K13303] [EC:2.7.11.1]
100767615  Sgk3; serine/threonine-protein kinase Sgk3 isoform X2 [KO:K13304] [EC:2.7.11.1]
100768351  Akt2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100752454  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100769460  Akt1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100768378  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
100759337  Magi2; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X3 [KO:K05629]
100764294  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X3 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100769809  Them4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
100757400  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X2 [KO:K04382] [EC:3.1.3.16]
103164195  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X2 [KO:K04382] [EC:3.1.3.16]
118237628  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X2 [KO:K04382] [EC:3.1.3.16]
100771272  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
100773447  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2 [KO:K03456]
100750924  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
100758873  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
100774343  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X5 [KO:K04354]
100763205  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3 [KO:K04354]
100752573  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
100760513  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
113837435  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta-like isoform X1 [KO:K11583]
100759774  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma-like [KO:K11583]
100764403  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X4 [KO:K11584]
100769874  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100758888  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
100762509  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
100754775  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X7 [KO:K11584]
100753076  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like [KO:K11584]
100689397  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
100773331  Hsp90b1; endoplasmin [KO:K09487]
100760178  Cdc37; hsp90 co-chaperone Cdc37 isoform X2 [KO:K09554]
100751848  Crtc2; CREB-regulated transcription coactivator 2 isoform X7 [KO:K16333]
100750559  Phlpp1; LOW QUALITY PROTEIN: PH domain leucine-rich repeat-containing protein phosphatase 1 isoform X2 [KO:K16340] [EC:3.1.3.16]
100754973  Phlpp2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X2 [KO:K16340] [EC:3.1.3.16]
100761565  Tcl1a; T-cell leukemia/lymphoma protein 1A [KO:K10167]
100753735  Mtcp1; protein p13 MTCP-1 [KO:K16837]
100769961  Nos3; nitric oxide synthase, endothelial isoform X3 [KO:K13242] [EC:1.14.13.39]
100770724  Brca1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
100760865  Gsk3b; glycogen synthase kinase-3 beta isoform X7 [KO:K03083] [EC:2.7.11.26]
100770628  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
100769788  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
100758749  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
100762618  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
100762184  G6pc2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
100753219  G6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
100763214  G6pc; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
100773301  Myc; myc proto-oncogene protein isoform X2 [KO:K04377]
100689063  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
103160601  Cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
100689401  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100689039  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100760122  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100764515  Cdk6; cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
100771544  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
100766025  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100760464  Ccne2; G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
100753358  Ccne1; G1/S-specific cyclin-E1 isoform X2 [KO:K06626]
100770315  Foxo3; forkhead box protein O3 [KO:K09408]
100770221  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
100773293  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100771754  Bcl2l11; bcl-2-like protein 11 isoform X2 [KO:K16341]
100757122  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
100758637  14-3-3 protein theta [KO:K16197]
100766119  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
100751694  Ywhaq; 14-3-3 protein theta [KO:K16197]
100753603  14-3-3 protein epsilon isoform X2 [KO:K06630]
100771398  Ywhah; 14-3-3 protein eta isoform X2 [KO:K16198]
100770325  14-3-3 protein gamma isoform X2 [KO:K16198]
100760426  Bad; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100689371  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
100774873  Bcl2; apoptosis regulator Bcl-2 isoform X3 [KO:K02161]
103160479  caspase-9-like [KO:K04399] [EC:3.4.22.62]
100689370  caspase-9 [KO:K04399] [EC:3.4.22.62]
113833881  caspase-9-like [KO:K04399] [EC:3.4.22.62]
100761582  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100754663  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100689386  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100762192  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
100771872  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2 [KO:K09048]
100766300  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100774488  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100772940  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100764159  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
100767112  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X2 [KO:K09049]
100764237  Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X2 [KO:K02539]
113836994  LOW QUALITY PROTEIN: induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
100768377  Rxra; retinoic acid receptor RXR-alpha isoform X2 [KO:K08524]
100764218  Nr4a1; nuclear receptor subfamily 4 group A member 1 isoform X2 [KO:K04465]
100759762  Ikbkg; NF-kappa-B essential modulator isoform X6 [KO:K07210]
100754432  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X5 [KO:K04467] [EC:2.7.11.10]
100750488  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100763542  Rela; transcription factor p65 isoform X4 [KO:K04735]
100770607  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
100753578  Myb; transcriptional activator Myb isoform X2 [KO:K09420]
100770120  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X3 [KO:K06643] [EC:2.3.2.27]
100682525  Tp53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
cge00010  Glycolysis / Gluconeogenesis
cge04010  MAPK signaling pathway
cge04012  ErbB signaling pathway
cge04062  Chemokine signaling pathway
cge04064  NF-kappa B signaling pathway
cge04068  FoxO signaling pathway
cge04110  Cell cycle
cge04115  p53 signaling pathway
cge04150  mTOR signaling pathway
cge04210  Apoptosis
cge04370  VEGF signaling pathway
cge04510  Focal adhesion
cge04620  Toll-like receptor signaling pathway
cge04630  JAK-STAT signaling pathway
cge04662  B cell receptor signaling pathway
cge04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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