KEGG   PATHWAY: mleu04151
Entry
mleu04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Mandrillus leucophaeus (drill)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mleu04151  PI3K-Akt signaling pathway
mleu04151

Other DBs
GO: 0043491
Organism
Mandrillus leucophaeus (drill) [GN:mleu]
Gene
105532399  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105529939  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
105529095  EREG; proepiregulin [KO:K09784]
105529096  AREG; amphiregulin [KO:K09782]
105549556  FGF1; LOW QUALITY PROTEIN: fibroblast growth factor 1 [KO:K18496]
105538400  FGF2; fibroblast growth factor 2 [KO:K18497]
105551128  FGF6; fibroblast growth factor 6 [KO:K04358]
105539362  FGF20; fibroblast growth factor 20 [KO:K04358]
105534158  FGF10; fibroblast growth factor 10 [KO:K04358]
105529146  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105529994  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
105537058  FGF9; fibroblast growth factor 9 [KO:K04358]
105530786  FGF16; fibroblast growth factor 16 [KO:K04358]
105537775  FGF8; fibroblast growth factor 8 [KO:K04358]
105544529  FGF4; fibroblast growth factor 4 [KO:K04358]
105544530  FGF3; fibroblast growth factor 3 [KO:K04358]
105531001  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105544989  FGF18; fibroblast growth factor 18 [KO:K04358]
105539207  FGF21; fibroblast growth factor 21 [KO:K22429]
105551129  FGF23; fibroblast growth factor 23 [KO:K22428]
105554362  NGF; beta-nerve growth factor [KO:K02582]
105528120  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105551116  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
105539162  NTF4; neurotrophin-4 [KO:K12457]
105545324  INS; insulin isoform X1 [KO:K04526]
105530906  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105545322  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
105537884  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105538858  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105532330  PDGFC; platelet-derived growth factor C [KO:K05450]
105542755  PDGFD; platelet-derived growth factor D [KO:K05450]
105531934  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
105545859  KITLG; kit ligand isoform X1 [KO:K05461]
105539145  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
105544346  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105549166  VEGFB; vascular endothelial growth factor B [KO:K16858]
105540798  PGF; placenta growth factor isoform X1 [KO:K16859]
105543587  VEGFC; vascular endothelial growth factor C [KO:K05449]
105550584  FIGF; vascular endothelial growth factor D [KO:K05449]
105543916  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105549563  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105550706  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105539533  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
105528796  ephrin-A5-like [KO:K05462]
105544832  EFNA4; LOW QUALITY PROTEIN: ephrin-A4 [KO:K05462]
105544836  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
105544838  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
105528968  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105530116  NRTN; neurturin [KO:K25414]
105530067  PSPN; persephin [KO:K25416]
105529594  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105553066  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105531953  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105543943  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
105548990  fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
105554550  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105532657  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105546717  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105553281  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
105548667  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105541629  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105541159  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
105531828  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105529382  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
105543434  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105543435  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105548468  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105553811  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105553816  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105537301  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105548470  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105553697  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
105549728  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
105549416  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105534464  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105538707  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105551898  SOS1; son of sevenless homolog 1 [KO:K03099]
105553627  SOS2; son of sevenless homolog 2 [KO:K03099]
105549333  HRAS; GTPase HRas isoform X1 [KO:K02833]
105550009  KRAS; GTPase KRas [KO:K07827]
105554356  NRAS; GTPase NRas isoform X1 [KO:K07828]
105542175  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105530797  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105530027  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105541405  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105544764  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105543176  IRS1; insulin receptor substrate 1 [KO:K16172]
105531455  TLR2; toll-like receptor 2 [KO:K10159]
105534560  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
105551438  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105546567  ras-related protein Rac1-like [KO:K04392]
105532929  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105532934  uncharacterized protein LOC105532934 [KO:K06856]
105535254  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105535256  LOW QUALITY PROTEIN: uncharacterized protein LOC105535256 [KO:K06856]
105548664  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105536925  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105537275  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105537413  uncharacterized protein LOC105537413 [KO:K06856]
105538227  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105547549  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
105541382  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
105554027  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
105551725  somatotropin isoform X1 [KO:K05438]
105551727  somatotropin-like isoform X1 [KO:K05438]
105551728  somatotropin-like [KO:K05438]
105551730  somatotropin-like isoform X1 [KO:K05438]
105551752  somatotropin-like [KO:K05438]
105552490  PRL; prolactin [KO:K05439]
105538992  OSM; oncostatin-M isoform X1 [KO:K05418]
105538406  IL2; interleukin-2 [KO:K05429]
105531358  IL3; interleukin-3 [KO:K04736]
105534984  IL6; interleukin-6 isoform X1 [KO:K05405]
105531344  IL4; interleukin-4 isoform X1 [KO:K05430]
105545992  IL7; interleukin-7 isoform X1 [KO:K05431]
105533798  interferon alpha-1/13 [KO:K05414]
105533799  IFNA8; interferon alpha-8 [KO:K05414]
105533800  IFNA2; interferon alpha-2 [KO:K05414]
105537891  IFNA6; interferon alpha-6 [KO:K05414]
105537892  interferon alpha-14 [KO:K05414]
105537894  interferon alpha-17 isoform X1 [KO:K05414]
105545746  IFNB1; interferon beta [KO:K05415]
105543667  EPO; erythropoietin isoform X1 [KO:K05437]
105553051  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
105529330  GHR; growth hormone receptor isoform X1 [KO:K05080]
105531227  PRLR; prolactin receptor [KO:K05081]
105529089  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
105535718  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
105538904  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
105548157  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
105554243  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
105544816  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
105541484  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
105555430  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
105546382  interferon alpha/beta receptor 1-like [KO:K05130]
105553144  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105546376  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
105533027  erythropoietin receptor [KO:K05079]
105550189  erythropoietin receptor-like [KO:K05079]
105545944  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
105543512  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105545438  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
105547548  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
105553265  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105535560  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
105544943  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
105546552  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105546564  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
105541413  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
105541512  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
105543172  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
105543173  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
105551554  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
105551555  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
105539834  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
105538157  collagen alpha-4(VI) chain-like [KO:K06238]
105538158  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
105538159  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
105531466  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
105548366  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105537944  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
105551977  LAMA2; laminin subunit alpha-2 [KO:K05637]
105549719  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
105545233  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
105548407  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
105532439  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
105544087  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
105540363  LAMB2; laminin subunit beta-2 [KO:K06243]
105536421  LAMB3; laminin subunit beta-3 [KO:K06244]
105544107  LAMB4; laminin subunit beta-4 [KO:K06245]
105550421  LAMC1; laminin subunit gamma-1 [KO:K05635]
105550424  LAMC2; laminin subunit gamma-2 [KO:K06246]
105532867  LAMC3; laminin subunit gamma-3 [KO:K06247]
105553257  CHAD; chondroadherin [KO:K06248]
105543273  RELN; reelin [KO:K06249] [EC:3.4.21.-]
105546194  THBS1; thrombospondin-1 [KO:K16857]
105553558  THBS2; thrombospondin-2 [KO:K04659]
105547095  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
105548283  THBS4; thrombospondin-4 [KO:K04659]
105544845  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105528087  FN1; fibronectin [KO:K05717]
105547229  SPP1; osteopontin isoform X1 [KO:K06250]
105552039  VTN; vitronectin isoform X1 [KO:K06251]
105531513  TNXB; tenascin-X [KO:K06252]
105552734  TNC; tenascin isoform X1 [KO:K06252]
105540723  TNN; tenascin-N [KO:K06252]
105540726  TNR; tenascin-R [KO:K06252]
105541774  VWF; von Willebrand factor [KO:K03900]
105547231  IBSP; bone sialoprotein 2 [KO:K06253]
105552123  ITGA1; integrin alpha-1 [KO:K06480]
105552128  ITGA2; integrin alpha-2 [KO:K06481]
105543805  ITGA2B; integrin alpha-IIb [KO:K06476]
105553271  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
105553874  ITGA4; integrin alpha-4 [KO:K06483]
105548552  ITGA5; integrin alpha-5 [KO:K06484]
105548065  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105532010  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105530532  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
105553436  ITGA9; integrin alpha-9 [KO:K06585]
105550282  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
105530986  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
105553894  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105549004  ITGB1; integrin beta-1 [KO:K05719]
105534546  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105528575  ITGB4; integrin beta-4 [KO:K06525]
105533226  ITGB5; integrin beta-5 [KO:K06588]
105547780  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
105555020  ITGB7; integrin beta-7 [KO:K06590]
105534972  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105546847  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105539923  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105552763  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105549588  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105547376  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105543389  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105531763  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105551619  F2R; proteinase-activated receptor 1 [KO:K03914]
105549065  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105550540  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105529288  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
105547339  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
105541201  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
105530242  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105541792  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105552838  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
105544663  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
105543670  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105541805  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
105539926  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105544043  GNB5; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105553607  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
105549051  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105550079  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
105550105  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105535557  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105553288  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
105544111  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
105534427  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
105534428  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
105541556  PDPK1; LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105551941  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
105534954  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
105529209  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
105547479  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105542939  TSC1; hamartin isoform X1 [KO:K07206]
105529748  TSC2; tuberin isoform X1 [KO:K07207]
105542689  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
105529753  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
105551388  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105530212  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
105532368  EIF4E; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E [KO:K03259]
105539799  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
105546726  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
105539063  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105544470  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
105528270  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
105541827  eukaryotic translation initiation factor 4B [KO:K03258]
105548579  RPS6; 40S ribosomal protein S6 isoform X1 [KO:K02991]
105548239  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105540986  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
105541172  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
105545609  PKN3; serine/threonine-protein kinase N3 [KO:K23692] [EC:2.7.11.13]
105547766  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
105551303  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
105536987  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
105540494  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105541755  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105542359  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105539895  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
105543522  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
105546962  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105534708  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
105531324  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
105537996  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105528891  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
105537397  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
105540292  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
105554910  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105542334  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
105555283  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
105553868  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
105550174  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
105551588  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
105547866  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
105536391  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
105549120  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
105544321  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
105538435  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
105547864  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
105544357  HSP90AB1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
105536204  HSP90B1; endoplasmin [KO:K09487]
105549814  CDC37; hsp90 co-chaperone Cdc37 isoform X1 [KO:K09554]
105554056  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
105537203  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
105547904  TCL1A; T-cell leukemia/lymphoma protein 1A isoform X1 [KO:K10167]
105547905  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
105533483  MTCP1; protein p13 MTCP-1 [KO:K16837]
105542707  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
105553071  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
105544615  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105531538  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
105539163  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
105532712  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
105538322  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
105545290  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
105552932  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
105543793  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
105537628  MYC; myc proto-oncogene protein [KO:K04377]
105544506  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105544234  CDKN1A; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1 [KO:K06625]
105549206  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
105531943  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105545589  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
105552568  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
105551132  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
105544297  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105538723  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
105550361  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
105536576  FOXO3; forkhead box protein O3 [KO:K09408]
105545612  RBL2; retinoblastoma-like protein 2 [KO:K16332]
105554126  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105540034  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
105552102  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
105553393  LOW QUALITY PROTEIN: 14-3-3 protein beta/alpha [KO:K16197]
105542098  YWHAZ; 14-3-3 protein zeta/delta isoform X1 [KO:K16197]
105528530  YWHAQ; 14-3-3 protein theta isoform X1 [KO:K16197]
105553496  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
105538952  YWHAH; 14-3-3 protein eta isoform X1 [KO:K16198]
105536867  YWHAG; 14-3-3 protein gamma [KO:K16198]
105549098  BAD; bcl2-associated agonist of cell death [KO:K02158]
105539496  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105535165  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
105549432  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
105549382  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105548041  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
105538852  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
105539715  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105554054  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
105554841  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
105530028  CREB3L3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
105550535  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105533710  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105531497  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
105534759  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
105547812  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
105555401  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
105534277  IKBKG; LOW QUALITY PROTEIN: NF-kappa-B essential modulator [KO:K07210]
105537745  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105554929  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105528449  RELA; transcription factor p65 isoform X1 [KO:K04735]
105548314  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105547759  MYB; transcriptional activator Myb [KO:K09420]
105537114  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
105549866  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mleu00010  Glycolysis / Gluconeogenesis
mleu04010  MAPK signaling pathway
mleu04012  ErbB signaling pathway
mleu04062  Chemokine signaling pathway
mleu04064  NF-kappa B signaling pathway
mleu04068  FoxO signaling pathway
mleu04110  Cell cycle
mleu04115  p53 signaling pathway
mleu04150  mTOR signaling pathway
mleu04210  Apoptosis
mleu04370  VEGF signaling pathway
mleu04510  Focal adhesion
mleu04620  Toll-like receptor signaling pathway
mleu04630  JAK-STAT signaling pathway
mleu04662  B cell receptor signaling pathway
mleu04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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