KEGG   PATHWAY: pon05163
Entry
pon05163                    Pathway                                
Name
Human cytomegalovirus infection - Pongo abelii (Sumatran orangutan)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
pon05163  Human cytomegalovirus infection
pon05163

Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100431735  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100432846  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100453779  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103889133  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100174298  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100173589  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100437617  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100454279  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100448114  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100442100  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100147742  TSC1; hamartin [KO:K07206]
100441126  TSC2; tuberin isoform X1 [KO:K07207]
100447214  RHEB; GTP-binding protein Rheb [KO:K07208]
100456786  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100455169  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100462008  LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100459428  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100456988  RPS6KB1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100174735  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100440586  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3 [KO:K07209] [EC:2.7.11.10]
100449496  IKBKG; NF-kappa-B essential modulator isoform X5 [KO:K07210]
100461595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100456049  RELA; transcription factor p65 [KO:K04735]
100459280  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
100173972  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100434331  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100458733  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100459427  HRAS; GTPase HRas [KO:K02833]
100462513  KRAS; GTPase KRas isoform X1 [KO:K07827]
100174317  NRAS; GTPase NRas precursor [KO:K07828]
100173732  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100446021  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100450988  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100169740  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100431824  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100432611  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100440745  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
100451792  ITGAV; integrin alpha-V [KO:K06487]
100445345  ITGB3; integrin beta-3 [KO:K06493]
100436498  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100443271  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100431483  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
112129584  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100171605  RHOA; transforming protein RhoA precursor [KO:K04513]
100456001  CGAS; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
100459760  TMEM173; stimulator of interferon genes protein [KO:K12654]
100433568  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
100441280  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
100459543  interferon alpha-10 [KO:K05414]
100432532  IFNA8; interferon alpha-8 [KO:K05414]
100432906  IFNA2; interferon alpha-2 [KO:K05414]
100434036  IFNA6; interferon alpha-6 [KO:K05414]
100434796  interferon alpha-5 [KO:K05414]
100435169  interferon alpha-14 [KO:K05414]
100438871  interferon alpha-17-like [KO:K05414]
100439978  IFNA21; interferon alpha-21 [KO:K05414]
100432153  interferon alpha-1/13 [KO:K05414]
100445711  interferon alpha-10-like [KO:K05414]
100438149  interferon alpha-4-like [KO:K05414]
100437034  interferon alpha-4-like [KO:K05414]
100433301  interferon alpha-1/13-like [KO:K05414]
112134962  interferon alpha-10-like [KO:K05414]
100443523  interferon alpha-4-like [KO:K05414]
100441074  IFNB1; interferon beta [KO:K05415]
100447558  TNF; tumor necrosis factor [KO:K03156]
100438667  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100449028  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K02861] [EC:2.7.11.1]
100442719  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
100453867  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
100458089  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100454379  IL1B; interleukin-1 beta [KO:K04519]
100172810  IL1R1; interleukin-1 receptor type 1 precursor [KO:K04386]
100459445  NF-kappa-B inhibitor alpha [KO:K04734]
100172740  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
100435461  CCL5; C-C motif chemokine 5 [KO:K12499]
100437111  interleukin-8 isoform X1 [KO:K10030]
100437488  LOW QUALITY PROTEIN: interleukin-8 [KO:K10030]
112128505  interleukin-8 [KO:K10030]
100453941  IL6; interleukin-6 isoform X2 [KO:K05405]
100173664  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100458183  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
100453483  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2 [KO:K07825]
100455858  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100171833  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100172647  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor [KO:K07826]
100453366  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100190818  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor [KO:K04541]
100171710  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 precursor [KO:K04542]
100453407  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
112130221  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100433177  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100439475  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 isoform X2 [KO:K04546]
100173039  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 precursor [KO:K04347]
112130240  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
112129369  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100439849  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X3 [KO:K04548]
100452739  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100458686  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100460338  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100458716  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100460060  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100434502  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100461961  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100445922  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100434318  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100434127  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100436432  CALML5; calmodulin-like protein 5 [KO:K02183]
100436811  CALML3; calmodulin-like protein 3 [KO:K02183]
100444426  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
100172680  CALM1; calmodulin [KO:K02183]
100173214  CALM2; calmodulin [KO:K02183]
100172890  CALM3; calmodulin [KO:K02183]
100451658  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
100455662  calmodulin-alpha-like [KO:K02183]
103892390  calmodulin-like [KO:K02183]
100174530  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
100455542  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100436675  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X9 [KO:K04348] [EC:3.1.3.16]
100461146  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
103889825  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100436209  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100450332  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
100458008  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X3 [KO:K17333]
100461543  NFATC4; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
100436566  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100456074  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100172679  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100458137  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100454626  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
100449504  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
100445431  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100431221  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100460806  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100454138  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100438178  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100436577  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100461383  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
103889530  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100174748  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform 2 [KO:K04345] [EC:2.7.11.11]
100431906  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
100437102  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100439532  C-C motif chemokine 3 [KO:K05408]
100460653  C-C motif chemokine 3-like 1 [KO:K05408]
100439906  C-C motif chemokine 4 isoform X4 [KO:K12964]
100461018  C-C motif chemokine 4-like isoform X4 [KO:K12964]
100172425  CX3CL1; fractalkine precursor [KO:K05508]
100173387  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100461065  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
100438951  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
100450531  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X2 [KO:K12331]
100457621  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
100454484  AKAP13; A-kinase anchor protein 13 isoform X5 [KO:K16529]
100432582  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100461801  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100173739  CTNNB1; catenin beta-1 [KO:K02105]
100438451  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
100440992  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
100447375  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X5 [KO:K04260]
100445063  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100442753  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X3 [KO:K04632]
103888841  neuroendocrine secretory protein 55 [KO:K04632]
100447772  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100171625  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100456735  MYC; myc proto-oncogene protein [KO:K04377]
100459702  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
100433477  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100171541  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100448769  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100448382  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100449269  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100449853  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100437263  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100438358  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100294619  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
100450554  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100462459  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100431578  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
100432292  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100436186  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100438869  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100127093  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100441756  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100439720  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100172895  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
100173045  CXCL12; stromal cell-derived factor 1 precursor [KO:K10031]
100451032  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100434355  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100439900  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100451563  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100174613  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
100447959  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103889518  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
100452410  CRK; adapter molecule crk isoform X1 [KO:K04438]
100443298  CRKL; crk-like protein [KO:K04438]
100173313  PXN; paxillin [KO:K05760]
100436549  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
100442754  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
100461066  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
112132689  CCR1; C-C chemokine receptor type 1 [KO:K04176]
100442868  CCR3; C-C chemokine receptor type 3 isoform X2 [KO:K04178]
100190809  CCR5; C-C chemokine receptor type 5 [KO:K04180]
100444044  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
100444404  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100431428  TAPBP; tapasin isoform X2 [KO:K08058]
100174305  PDIA3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
100451803  CALR; calreticulin [KO:K08057]
100173719  DKFZP469M1914; major histocompatibility complex, class I, C precursor [KO:K06751]
100189734  DKFZP469I0912 protein isoform X1 [KO:K06751]
100432875  HLA class I histocompatibility antigen, alpha chain F isoform X1 [KO:K06751]
100456603  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
100440558  popy class I histocompatibility antigen, alpha chain E isoform X3 [KO:K06751]
100438533  patr class I histocompatibility antigen, B-2 alpha chain isoform X1 [KO:K06751]
100435866  popy Class I histocompatibility antigen, A-1 alpha chain [KO:K06751]
100450716  HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751]
100452132  class I histocompatibility antigen, Gogo-B*0102 alpha chain isoform X1 [KO:K06751]
100435133  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100449631  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
100174579  B2M; beta-2-microglobulin isoform X1 [KO:K08055]
100461015  cyclin-dependent kinase inhibitor 2A [KO:K06621]
100171532  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
100435218  TP53; cellular tumor antigen p53 [KO:K04451]
100453682  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100443314  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
100454924  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100462155  RB1; retinoblastoma-associated protein [KO:K06618]
100435851  E2F1; transcription factor E2F1 [KO:K17454]
100458002  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
100448297  E2F3; transcription factor E2F3 isoform X3 [KO:K06620]
100461418  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100439256  FADD; FAS-associated death domain protein [KO:K02373]
100172115  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100173269  BID; BH3-interacting domain death agonist [KO:K04726]
100450682  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100460189  bcl-2 homologous antagonist/killer [KO:K14021]
100432001  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
100171479  CYCS; cytochrome c [KO:K08738]
100462404  cytochrome c-like [KO:K08738]
112128551  cytochrome c-like [KO:K08738]
100445149  cytochrome c-like [KO:K08738]
112128607  cytochrome c-like [KO:K08738]
112130824  cytochrome c-like [KO:K08738]
112132396  LOW QUALITY PROTEIN: cytochrome c 2-like [KO:K08738]
112133797  cytochrome c-like [KO:K08738]
112134675  cytochrome c-like [KO:K08738]
112134685  cytochrome c-like [KO:K08738]
112134371  cytochrome c-like [KO:K08738]
112134960  cytochrome c-like [KO:K08738]
112135506  cytochrome c-like [KO:K08738]
100460459  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100435491  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
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Trends Mol Med 10:19-23 (2004)
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Microbes Infect 6:1084-93 (2004)
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Pathogens 7:E30 (2018)
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Annu Rev Virol 3:215-236 (2016)
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Biomol Ther (Seoul) 25:69-79 (2017)
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HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2.
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Reference
PMID:28488292
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Wang X, Sanchez J, Stone MJ, Payne RJ
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Sulfation of the Human Cytomegalovirus Protein UL22A Enhances Binding to the Chemokine RANTES.
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Related
pathway
pon00590  Arachidonic acid metabolism
pon03050  Proteasome
pon04010  MAPK signaling pathway
pon04064  NF-kappa B signaling pathway
pon04110  Cell cycle
pon04150  mTOR signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04210  Apoptosis
pon04612  Antigen processing and presentation
pon04623  Cytosolic DNA-sensing pathway
pon04630  JAK-STAT signaling pathway
pon04668  TNF signaling pathway
pon04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
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