KEGG ORTHOLOGY: K00070

ORTHOLOGY: K00070

Entry

K00070                      KO

Symbol

HSD3B

Name

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map04913

Ovarian steroidogenesis

map04925

Aldosterone synthesis and secretion

map04927

Cortisol synthesis and secretion

map04934

Cushing syndrome

Module

M00107

Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone

M00110

C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone

M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

M00977

C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone

Reaction

R01837

3beta-hydroxyandrost-5-en-17-one:NAD+ 3-oxidoreductase/delta5-delta-4 isomerase

R02216

pregnenolone:NAD+ 3-oxidoreductase

R02499

testosterone delta5-delat4-isomerase

R02840

cortisol delta5-delat4-isomerase

R03327

17alpha-hydroxypregnenolone:NAD+ 3-oxidoreductase

R04163

21-hydroxypregnenolone:NAD+ 3-oxidoreductase

R04678

16alpha-hydroxyandrost-4-ene-3,17-dione delta5-delat4-isomerase

R04849

11-deoxycortisol delta5-delat4-isomerase

Disease

H00216

Congenital adrenal hyperplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
   04925 Aldosterone synthesis and secretion
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
   04927 Cortisol synthesis and secretion
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase

Other DBs

GO:	0003854 0004769

Genes

HSA:	3283(HSD3B1) 3284(HSD3B2)

PTR:	457165(HSD3B2) 469446

PPS:	100982464(HSD3B2) 100983009 100990187

GGO:	101141070 101141801 101146563(HSD3B2)

PON:	100451655 100452394 100455460

PPYG:

129015890 129015909 129015918

NLE:	100596087 100605995(HSD3B2) 100606563 100607955

HMH:	116469522 116469530(HSD3B2)

SSYN:

134733865 134733875 134734675(HSD3B1)

MCC:	712686(HSD3B2) 713091 713272 715337

MCF:	102133592 102134747 102135110

MTHB:

126931035 126931104 126931154 126951788

MNI:	105479071 105479074 105479078 105479082 105479084(HSD3B2)

CSAB:

103224104 103224109(HSD3B2)

CATY:

105599590 105599597(HSD3B2)

PANU:

100999145 101018740 101019096(HSD3B2)

TGE:	112624233 112634262(HSD3B2)

MLEU:

105541296(HSD3B2) 105541330

RRO:	104654599 104654602 104654605

RBB:	108528160 108528161 108528164

TFN:	117074250 117074256

PTEH:

111549589 111549591

CANG:

105505264 105505267

CJC:	100387484 100389654 100400416 100405879

SBQ:	101042680 101051416

CIMI:

108297130 108301104

ANAN:

105721680(HSD3B2) 105721706 110567017

CSYR:

103258418(HSD3B2)

MMUR:

105869786(HSD3B2)

LCAT:

123635118(HSD3B2)

PCOQ:

105809629(HSD3B2)

OGA:

100966795

MMU:	100043456(Hsd3b8) 100043461(Hsd3b9) 15492(Hsd3b1) 15493(Hsd3b2) 15494(Hsd3b3) 15495(Hsd3b4) 15496(Hsd3b5) 15497(Hsd3b6)

MCAL:

110288898 110290813 110290978 110291292 110291371 110291888

MPAH:

110315378 110319834 110319836 110320478 110320490

RNO:	24470(Hsd3b5) 29632(Hsd3b2) 360348(Hsd3b1) 682974(Hsd3b3)

MCOC:

116093252 116094199 116094200 116094201

ANU:	117707219 117707246 117707247 117707273 117707523

MUN:	110542496 110543775 110544885 110544899 110563733 110563735 132656956 132656957 132656958 132656961 132656962 132656967 132657118

CGE:	100770922 113830678 113833179 113833198

MAUA:

101837099 101842851(Hao2) 121138738 121142382

PROB:

127232674 127232675

PLEU:

114688199 114688619 114688620 114688621 114688750 114688751 114688752 114698547

MORG:

121437803 121437911 121438015 121438017

MFOT:

126490105 126510847

AAMP:

119801286 119801287 119801288 119801289

NGI:	103728305 103732007 103738837

HGL:	101707488(Hsd3b1) 101707858

CPOC:

100379573(Hsd3b1) 100725531 100725801

CCAN:

109702728 109702729

DORD:

105991916 105991917

DSP:	122118370 122118374

PLOP:

125344738 125345248 125345249 125345254 125345257 125345259 125345261 125355478 125355479 125355483

NCAR:

124964015 124990189 124992819

MMMA:

107156205(Hao2) 107156207 107156209

OCU:	100346986 100347914

OPI:	101522373 101522782

TUP:

102470981

GVR:	103584548 103607308

CFA:	483146(HSD3B2)

CLUD:

VVP:

VLG:

NPO:

AML:	100464280(HSD3B1)

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:	114208061(HSD3B2)

ZCA:	113909475(HSD3B2)

MLX:	118000525(HSD3B2)

NSU:	110580487(HSD3B2)

LWW:

102742748

FCA:	100616070(HSD3B2)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	281824(HSD3B1)

BOM:

BIU:

BBUB:

BBIS:

CHX:	100860869(3BHSD)

OAS:	100190978(HSD3B1)

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	445539(HSD3B1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100034078(HSD3B2)

EPZ:

103548379

EAI:	106832920(HSD3B2)

MYB:	106723550(HSD3B2)

MMYO:

118672875(HSD3B2)

MLF:	106694328(HSD3B2)

PKL:

118727130

EFUS:

103291359(HSD3B2)

MNA:	107545288(HSD3B2)

DRO:	112314004(HSD3B2)

SHON:

118981952(HSD3B2)

AJM:	119041699(HSD3B2)

PDIC:

114489256

PHAS:

123804497(HSD3B2)

MMF:

118637661

PPAM:

129063973

HAI:	109389868(HSD3B2)

RFQ:	117014453(HAO2)

PALE:

102891879

PGIG:

120585109

PVP:

105296358

RAY:	107518830(HSD3B2)

MJV:

TOD:

SARA:

SETR:

LAV:	100659049(HSD3B2)

TMU:

101358325

ETF:	101663671(HSD3B1)

DNM:

101447815

MDO:

100012668

GAS:

123247232

SHR:	100913530(HSD3B2)

AFZ:

127559197

PCW:	110219672(HSD3B2)

TVP:	118856490(HSD3B2)

OAA:

100080135

GGA:	396015(HSD3B1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

125684639(HSD3B1)

NMEL:

110398845

APLA:

101803865(HSD3B1)

ACYG:

106045741(HSD3B1)

CATA:

118259816(HSD3B1)

AFUL:

116502173

TGU:	751770(HSD3B1)

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

FPG:

FCH:

CLV:

EGZ:

NNI:

PCRI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

AVIT:

CVF:

RTD:

CUCA:

TEO:

BRHI:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:	102367786(HSD3B1)

AMJ:	109280168(HSD3B1)

CPOO:

109319128(HSD3B1)

GGN:	109304596(HSD3B1)

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:	100561899(hsd3b1)

ASAO:

132766487(HSD3B1)

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

131193284(HSD3B1)

PTEX:

113444507

NSS:

113417241

VKO:

123033249

PMUA:

114587929(HSD3B2)

PRAF:

128404595(HSD3B2)

ZVI:	118075222(HSD3B2)

HCG:

128345684

GJA:

107114856

STOW:

125425234(HSD3B2)

EMC:

129345698

XLA:	734818(hsd3b1.L)

XTR:

NPR:

RTEM:

BBUF:

MUO:	115471398(HSD3B1)

GSH:	117358938(HSD3B1)

DRE:	373131(hsd3b2) 553532(hsd3b1)

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122351771(hsd3b1)

LROH:

127170525(hsd3b1)

OMC:	131546787(hsd3b1)

PPRM:

120466714(hsd3b1)

RKG:	130076948(hsd3b1)

MAMB:

125270537(hsd3b1)

CIDE:

127518655

MASI:

127448584

TROS:

130555852(hsd3b1)

TDW:	130427658(hsd3b1)

MANU:

129451507(hsd3b1)

IPU:	100304475(hsd3b1)

IFU:	128609137(hsd3b1)

PHYP:

113524942(hsd3b1)

SMEO:

124379336(hsd3b1)

TFD:	113654422(hsd3b1)

TVC:	132850628(hsd3b1)

TRN:	134323829(hsd3b1)

AMEX:

103027852(hsd3b1)

CMAO:

118800102(hsd3b1)

EEE:

113587753

CHAR:

105913236 105913280 105913281

TRU:	101069884(hsd3b1)

TFS:	130530194(hsd3b1)

TNG:	GSTEN00029150G001

LCO:	104921488(hsd3b1)

TBEN:

117495881(hsd3b1)

CGOB:

115026845(hsd3b1)

PGEO:

117466261(hsd3b1)

GACU:

117536557(hsd3b1)

EMAC:

134867270(hsd3b1)

ELY:	117251590(hsd3b1)

EFO:	125900207(hsd3b1)

PLEP:

121949401(hsd3b1) 121963657

SLUC:

116059361(hsd3b1)

ECRA:

117953315(hsd3b1)

ESP:

116697664

PFLV:

114564020

GAT:	120833929(hsd3b1)

PPUG:

119228951(hsd3b1)

AFB:	129104536(hsd3b1)

CLUM:

117750405(hsd3b1)

PSWI:

130204482(hsd3b1)

MSAM:

119884914 119904488(hsd3b1)

SCHU:

122885279(hsd3b1)

CUD:	121523133(hsd3b1)

ALAT:

119025245(hsd3b1)

MZE:

101485719

ONL:	100534568(hsd3b1)

OAU:	116332553(hsd3b1)

OLA:	100144358(3bhsd)

OML:	112138010(hsd3b1)

CSAI:

133446387(hsd3b1)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122839771(hsd3b1)

PPRL:

129360909(hsd3b1)

CVG:

107087352

CTUL:

119774713(hsd3b1)

GMU:	124871021(hsd3b1)

NFU:	107389612(hsd3b1)

KMR:	108244192(hsd3b1)

ALIM:

106531920

NWH:	119419363(hsd3b1)

AOCE:

111570570(hsd3b1)

MCEP:

125017257(hsd3b1)

CSEM:

103391994(hsd3b1)

POV:

109637945

SSEN:

122785783(hsd3b1)

HHIP:

117755029 117755030

HSP:	118119640 118120310

PPLT:

128455946(hsd3b1)

SMAU:

118283187(hsd3b1)

LCF:

108902437

SDU:

111218347

SLAL:

111652102

XGL:	120801969(hsd3b1)

HCQ:

109522071

SSCV:

125973254

SBIA:

133511988(hsd3b1)

PEE:	133410274(hsd3b1)

PTAO:

133486409(hsd3b1)

BPEC:

110156192(hsd3b1)

MALB:

109951646

BSPL:

114847637(hsd3b1)

SJO:	128367682(hsd3b1)

SASA:

106586600

STRU:

115161098

OTW:	112240651(hsd3b1)

OMY:	100136743(hsd3b1)

OGO:	124044100(hsd3b1)

ONE:

115112196

OKI:

109869285

OKE:	118371546(hsd3b1)

SALP:

111978723

SNH:	120058421(hsd3b1)

CCLU:

121536290(hsd3b1)

ELS:

SFM:

PKI:

AANG:

LOC:	102685561(hsd3b1)

PSPA:

121320746(hsd3b1)

ARUT:

117406697 117406856

PSEX:

120522925(hsd3b1)

LCM:

102345588

CMK:	103180179(hsd3b1) 121852133

RTP:	109918392(hsd3b1)

HOC:	132820585(hsd3b1)

LERI:

129702520(hsd3b1)

PMRN:

116954501

LRJ:

133347820

BFO:	118415735 118426116

BBEL:

109470289 109481615

LPIC:

129254859

DME:	Dmel_CG7724(CG7724)

DER:

6543694

DSI:	Dsimw501_GD14693(Dsim_GD14693)

DYA:	Dyak_GE19901

DSR:	110187899 110190103

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12485

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ003056

CPII:

CNS:

BCOO:

NVI:

CSOL:

TPRE:

FAS:

DAM:

VCAN:

CCIN:

NPT:

NFB:

NLO:

NVG:

AROA:

DCI:

CLEC:

NLU:

HVI:

MQU:

FOC:

TPAL:

ZNE:

CSEC:

IEL:

FCD:

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

ISC:

DSV:

RSAN:

RMP:

VDE:	111247588 111254724

VJA:	111264476 111268118

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

HRO:	HELRODRAFT_89375

PVUL:

126824716

GAE:

121389292

HRF:	124140226 124141700

HRJ:	124260823 124278058

CRG:	105321517 105332656

CANU:

128186867 128188117 128188594

CVN:	111136775 111137023 111137166

OED:	125654276 125659193 125659727

MYI:

110457155

PMAX:

117333059 117333060 117333062 117333069

MMER:

123525098 123534278 123534660 123535125 123535257 123535266 123552007

RPHI:

132742228 132742229 132743368 132753356 132759419 132759420

DPOL:

127839711 127856352 127861538

MAEA:

128229618 128232487 128232575

OSN:

115219210

LJP:	135468058 135477165

LAK:

106151343

LLON:

135485103 135502377

» show all

Reference

PMID:2243100

Authors

Lachance Y, Luu-The V, Labrie C, Simard J, Dumont M, de Launoit Y, Guerin S, Leblanc G, Labrie F

Title

Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells.

Journal

J Biol Chem 265:20469-75 (1990)

Sequence

[hsa:3283] [rno:360348 682974]

LinkDB

ENZYME: 1.1.1.145

Entry

EC 1.1.1.145                Enzyme

Name

3beta-hydroxy-Delta5-steroid dehydrogenase;
progesterone reductase;
Delta5-3beta-hydroxysteroid dehydrogenase;
3beta-hydroxy-5-ene steroid dehydrogenase;
3beta-hydroxy steroid dehydrogenase/isomerase;
3beta-hydroxy-Delta5-C27-steroid dehydrogenase/isomerase;
3beta-hydroxy-Delta5-C27-steroid oxidoreductase;
3beta-hydroxy-5-ene-steroid oxidoreductase;
steroid-Delta5-3beta-ol dehydrogenase;
3beta-HSDH;
5-ene-3-beta-hydroxysteroid dehydrogenase;
3beta-hydroxy-5-ene-steroid dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

3beta-hydroxy-Delta5-steroid:NAD+ 3-oxidoreductase

Reaction(IUBMB)

a 3beta-hydroxy-Delta5-steroid + NAD+ = a 3-oxo-Delta5-steroid + NADH + H+ [RN:R03176]

Reaction(KEGG)

R03176;
(other) R01837 R02216 R02499 R02840 R03327 R04163 R04678 R04849 R09920

Substrate

3beta-hydroxy-Delta5-steroid [CPD:C03836];
NAD+ [CPD:C00003]

Product

3-oxo-Delta5-steroid [CPD:C01034];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

This activity is found in several bifunctional enzymes that catalyse the oxidative conversion of Delta5-3-hydroxy steroids to a Delta4-3-oxo configuration. This conversion is carried out in two separate, sequential reactions; in the first reaction, which requires NAD+, the enzyme catalyses the dehydrogenation of the 3beta-hydroxy steroid to a 3-oxo intermediate. In the second reaction the reduced cosubstrate, which remains attached to the enzyme, activates the isomerization of the Delta5 form to a Delta4 form (cf. EC 5.3.3.1, steroid Delta-isomerase). Substrates include dehydroepiandrosterone (which is converted into androst-5-ene-3,17-dione), pregnenolone (converted to progesterone) and cholest-5-en-3-one, an intermediate of cholesterol degradation.

History

EC 1.1.1.145 created 1972

Pathway

ec00140

Steroid hormone biosynthesis

ec00984

Steroid degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K00070

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase

K16045

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase

K26407

Poxviridae/Iridoviridae 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase

Genes

HSA:	3283(HSD3B1) 3284(HSD3B2)

PTR:	457165(HSD3B2) 469446

PPS:	100982464(HSD3B2) 100983009 100990187

GGO:	101141070 101141801 101146563(HSD3B2)

PON:	100451655 100452394 100455460

PPYG:

129015890 129015909 129015918

NLE:	100596087 100605995(HSD3B2) 100606563 100607955

HMH:	116469522 116469530(HSD3B2)

SSYN:

134733865 134733875 134734675(HSD3B1)

MCC:	712686(HSD3B2) 713091 713272 715337

MCF:	102133592 102134747 102135110

MTHB:

126931035 126931104 126931154 126951788

MNI:	105479071 105479074 105479078 105479082 105479084(HSD3B2)

CSAB:

103224104 103224109(HSD3B2)

CATY:

105599590 105599597(HSD3B2)

PANU:

100999145 101018740 101019096(HSD3B2)

TGE:	112624233 112634262(HSD3B2)

MLEU:

105541296(HSD3B2) 105541330

RRO:	104654599 104654602 104654605

RBB:	108528160 108528161 108528164

TFN:	117074250 117074256

PTEH:

111549589 111549591

CANG:

105505264 105505267

CJC:	100387484 100389654 100400416 100405879

SBQ:	101042680 101051416

CIMI:

108297130 108301104

ANAN:

105721680(HSD3B2) 105721706 110567017

CSYR:

103258418(HSD3B2)

MMUR:

105869786(HSD3B2)

LCAT:

123635118(HSD3B2)

PCOQ:

105809629(HSD3B2)

OGA:

100966795

MMU:	100043456(Hsd3b8) 100043461(Hsd3b9) 15492(Hsd3b1) 15493(Hsd3b2) 15494(Hsd3b3) 15495(Hsd3b4) 15496(Hsd3b5) 15497(Hsd3b6)

MCAL:

110288898 110290813 110290978 110291292 110291371 110291888

MPAH:

110315378 110319834 110319836 110320478 110320490

RNO:	24470(Hsd3b5) 29632(Hsd3b2) 360348(Hsd3b1) 682974(Hsd3b3)

MCOC:

116093252 116094199 116094200 116094201

ANU:	117707219 117707246 117707247 117707273 117707523

MUN:	110542496 110543775 110544885 110544899 110563733 110563735 132656956 132656957 132656958 132656961 132656962 132656967 132657118

CGE:	100770922 113830678 113833179 113833198

MAUA:

101837099 101842851(Hao2) 121138738 121142382

PROB:

127232674 127232675

PLEU:

114688199 114688619 114688620 114688621 114688750 114688751 114688752 114698547

MORG:

121437803 121437911 121438015 121438017

MFOT:

126490105 126510847

AAMP:

119801286 119801287 119801288 119801289

NGI:	103728305 103732007 103738837

HGL:	101707488(Hsd3b1) 101707858

CPOC:

100379573(Hsd3b1) 100725531 100725801

CCAN:

109702728 109702729

DORD:

105991916 105991917

DSP:	122118370 122118374

PLOP:

125344738 125345248 125345249 125345254 125345257 125345259 125345261 125355478 125355479 125355483

NCAR:

124964015 124990189 124992819

MMMA:

107156205(Hao2) 107156207 107156209

OCU:	100346986 100347914

OPI:	101522373 101522782

TUP:

102470981

GVR:	103584548 103607308

CFA:	483146(HSD3B2)

CLUD:

112664108

VVP:

112916789

VLG:

121490669

NPO:

129501295

AML:	100464280(HSD3B1)

UMR:

103677123

UAH:

113244362

UAR:

123795008

ELK:

111143436

LLV:

125099255

MPUF:

101680243

MNP:

132000700

MLK:

131809998

NVS:

122898812

ORO:

101378904

EJU:	114208061(HSD3B2)

ZCA:	113909475(HSD3B2)

MLX:	118000525(HSD3B2)

NSU:	110580487(HSD3B2)

LWW:

102742748

FCA:	100616070(HSD3B2)

PYU:

121027796

PCOO:

112872261

PBG:

122481024

PVIV:

125171536

LRUF:

124514119

PTG:

102957262

PPAD:

109272160

PUC:

125912196

AJU:

106978496

HHV:

120247640

BTA:	281824(HSD3B1)

BOM:

102274088

BIU:

109555859

BBUB:

102413429

BBIS:

104993819

CHX:	100860869(3BHSD)

OAS:	100190978(HSD3B1)

BTAX:

128045498

ODA:

120855999

CCAD:

122435367

MBEZ:

129541051

SSC:	445539(HSD3B1)

CFR:

102512447

CBAI:

105079257

CDK:

105089475

VPC:

102528409

BACU:

103015346

BMUS:

118884274

LVE:

103083046

OOR:

101284283

DLE:

111179902

PCAD:

102987751

PSIU:

116758472

NASI:

112413050

ECB:	100034078(HSD3B2)

EPZ:

103548379

EAI:	106832920(HSD3B2)

MYB:	106723550(HSD3B2)

MMYO:

118672875(HSD3B2)

MLF:	106694328(HSD3B2)

PKL:

118727130

EFUS:

103291359(HSD3B2)

MNA:	107545288(HSD3B2)

DRO:	112314004(HSD3B2)

SHON:

118981952(HSD3B2)

AJM:	119041699(HSD3B2)

PDIC:

114489256

PHAS:

123804497(HSD3B2)

MMF:

118637661

PPAM:

129063973

HAI:	109389868(HSD3B2)

RFQ:	117014453(HAO2)

PALE:

102891879

PGIG:

120585109

PVP:

105296358

RAY:	107518830(HSD3B2)

MJV:

108390800

TOD:

119236234

SARA:

101555226 101555490

SETR:

125997493

LAV:	100659049(HSD3B2)

TMU:

101358325

ETF:	101663671(HSD3B1)

DNM:

101447815

MDO:

100012668

GAS:

123247232

SHR:	100913530(HSD3B2)

AFZ:

127559197

PCW:	110219672(HSD3B2)

TVP:	118856490(HSD3B2)

OAA:

100080135

GGA:	396015(HSD3B1)

PCOC:

116244326

MGP:

104915630

CJO:

107319373

TPAI:

128076148 128090414

LMUT:

125684639(HSD3B1)

NMEL:

110398845

APLA:

101803865(HSD3B1)

ACYG:

106045741(HSD3B1)

CATA:

118259816(HSD3B1)

AFUL:

116502173

TGU:	751770(HSD3B1)

LSR:

110480744

SCAN:

103827136

PMOA:

120506495

OTC:

121339296

PRUF:

121351666

GFR:

102039409

FAB:

101817697

OMA:

130265090

PHI:

102101526

PMAJ:

107211459

CCAE:

111938581

CCW:

104687106

CBRC:

103613933

ETL:

114058198

ZAB:

102062520

ZLE:

135452668

ACHL:

103801073

SVG:

106857875

MMEA:

130582277

HRT:

120749079

FPG:

101921564

FCH:

102052697

CLV:

102087460

EGZ:

104126518

NNI:

104008615

PCRI:

104035039

PLET:

104617853

EHS:

104512760

PCAO:

104053168

ACUN:

113485872

TALA:

104357901

PADL:

103921223

AFOR:

103905431

ACHC:

115344139

HALD:

104319887

HLE:

104831735

AGEN:

126049087

GCL:

127029573

CCRI:

104162430

CSTI:

104558363

CMAC:

104476511

MUI:

104539044

BREG:

104641481

FGA:

104079993

GSTE:

104255879

LDI:

104351289

MNB:

103779544

OHA:

104327359

NNT:

104410259

SHAB:

115601668

DPUB:

104298412

PGUU:

104468993

ACAR:

104520429

CPEA:

104384975

AVIT:

104277939

CVF:

104293163

RTD:

128904122

CUCA:

104055667

TEO:

104373662

BRHI:

104496619

AAM:

106497227

AROW:

112963963

NPD:

112960083

TGT:

104576502

DNE:

112985919

SCAM:

104150689

ASN:	102367786(HSD3B1)

AMJ:	109280168(HSD3B1)

CPOO:

109319128(HSD3B1)

GGN:	109304596(HSD3B1)

PSS:

102453952

CMY:

102934871

CCAY:

125622274

DCC:

119843575

CPIC:

101946936

TST:

117886232

CABI:

116817817

MRV:

120396043

ACS:	100561899(hsd3b1)

ASAO:

132766487(HSD3B1)

PVT:

110076926

SUND:

121922906

PBI:

103067418

PMUR:

107285816

CTIG:

120306125

TSR:

106542700

PGUT:

117661842

APRI:

131193284(HSD3B1)

PTEX:

113444507

NSS:

113417241

VKO:

123033249

PMUA:

114587929(HSD3B2)

PRAF:

128404595(HSD3B2)

ZVI:	118075222(HSD3B2)

HCG:

128345684

GJA:

107114856

STOW:

125425234(HSD3B2)

EMC:

129345698

XLA:	734818(hsd3b1.L)

XTR:

100490622

NPR:

108802532

RTEM:

120928726

BBUF:

120994332

MUO:	115471398(HSD3B1)

GSH:	117358938(HSD3B1)

DRE:	373131(hsd3b2) 553532(hsd3b1)

SRX:

107712267

SANH:

107658243

SGH:

107569293

CCAR:

109052439

CAUA:

113108554 113108799

CGIB:

127965123 128019700

PTET:

122351771(hsd3b1)

LROH:

127170525(hsd3b1)

OMC:	131546787(hsd3b1)

PPRM:

120466714(hsd3b1)

RKG:	130076948(hsd3b1)

MAMB:

125270537(hsd3b1)

CIDE:

127518655

MASI:

127448584

TROS:

130555852(hsd3b1)

TDW:	130427658(hsd3b1)

MANU:

129451507(hsd3b1)

IPU:	100304475(hsd3b1)

IFU:	128609137(hsd3b1)

PHYP:

113524942(hsd3b1)

SMEO:

124379336(hsd3b1)

TFD:	113654422(hsd3b1)

TVC:	132850628(hsd3b1)

TRN:	134323829(hsd3b1)

AMEX:

103027852(hsd3b1)

CMAO:

118800102(hsd3b1)

EEE:

113587753

CHAR:

105913236 105913280 105913281

TRU:	101069884(hsd3b1)

TFS:	130530194(hsd3b1)

TNG:	GSTEN00029150G001

LCO:	104921488(hsd3b1)

TBEN:

117495881(hsd3b1)

CGOB:

115026845(hsd3b1)

PGEO:

117466261(hsd3b1)

GACU:

117536557(hsd3b1)

EMAC:

134867270(hsd3b1)

ELY:	117251590(hsd3b1)

EFO:	125900207(hsd3b1)

PLEP:

121949401(hsd3b1) 121963657

SLUC:

116059361(hsd3b1)

ECRA:

117953315(hsd3b1)

ESP:

116697664

PFLV:

114564020

GAT:	120833929(hsd3b1)

PPUG:

119228951(hsd3b1)

AFB:	129104536(hsd3b1)

CLUM:

117750405(hsd3b1)

PSWI:

130204482(hsd3b1)

MSAM:

119884914 119904488(hsd3b1)

SCHU:

122885279(hsd3b1)

CUD:	121523133(hsd3b1)

ALAT:

119025245(hsd3b1)

MZE:

101485719

ONL:	100534568(hsd3b1)

OAU:	116332553(hsd3b1)

OLA:	100144358(3bhsd)

OML:	112138010(hsd3b1)

CSAI:

133446387(hsd3b1)

XMA:

102228303

XCO:

114147930

XHE:

116723048

PRET:

103477979

PFOR:

103152152

PLAI:

106939754

PMEI:

106917521

GAF:	122839771(hsd3b1)

PPRL:

129360909(hsd3b1)

CVG:

107087352

CTUL:

119774713(hsd3b1)

GMU:	124871021(hsd3b1)

NFU:	107389612(hsd3b1)

KMR:	108244192(hsd3b1)

ALIM:

106531920

NWH:	119419363(hsd3b1)

AOCE:

111570570(hsd3b1)

MCEP:

125017257(hsd3b1)

CSEM:

103391994(hsd3b1)

POV:

109637945

SSEN:

122785783(hsd3b1)

HHIP:

117755029 117755030

HSP:	118119640 118120310

PPLT:

128455946(hsd3b1)

SMAU:

118283187(hsd3b1)

LCF:

108902437

SDU:

111218347

SLAL:

111652102

XGL:	120801969(hsd3b1)

HCQ:

109522071

SSCV:

125973254

SBIA:

133511988(hsd3b1)

PEE:	133410274(hsd3b1)

PTAO:

133486409(hsd3b1)

BPEC:

110156192(hsd3b1)

MALB:

109951646

BSPL:

114847637(hsd3b1)

SJO:	128367682(hsd3b1)

SASA:

106586600

STRU:

115161098

OTW:	112240651(hsd3b1)

OMY:	100136743(hsd3b1)

OGO:	124044100(hsd3b1)

ONE:

115112196

OKI:

109869285

OKE:	118371546(hsd3b1)

SALP:

111978723

SNH:	120058421(hsd3b1)

CCLU:

121536290(hsd3b1)

ELS:

105016430

SFM:

108937872

PKI:

111860692

AANG:

118214002 118214003

LOC:	102685561(hsd3b1)

PSPA:

121320746(hsd3b1)

ARUT:

117406697 117406856

PSEX:

120522925(hsd3b1)

LCM:

102345588

CMK:	103180179(hsd3b1) 121852133

RTP:	109918392(hsd3b1)

HOC:	132820585(hsd3b1)

LERI:

129702520(hsd3b1)

PMRN:

116954501

LRJ:

133347820

BFO:	118415735 118426116

BBEL:

109470289 109481615

LPIC:

129254859

DME:	Dmel_CG7724(CG7724)

DER:

6543694

DSI:	Dsimw501_GD14693(Dsim_GD14693)

DYA:	Dyak_GE19901

DSR:	110187899 110190103

DPO:

4813984

DPE:

6603899

DMN:

108165559

DWI:

6645028

DGR:

6558385

DMO:	Dmoj_GI12485

DAZ:

108612818

DNV:

108651018

DHE:

111602930

CCAT:

101455915

BOD:

106619208

BDR:

105225278

RZE:

108370312

AOQ:

129240938

TDA:

119666775

MDE:

101899660

SCAC:

106092781

LCQ:

111691019

LSQ:

119600382

GFS:

119645278

ECOE:

129948506

CLON:

129611542

HIS:

119650207

AGA:

1277239

ACOZ:

120951979

AARA:

120897593

AMER:

121593679

ASTE:

118514455

AFUN:

125767669

AMOU:

128302512

AALI:

118465094

AAG:

5566270

AALB:

109407756 109418935

ASUA:

134214407

CQU:	CpipJ_CPIJ003056

CPII:

120432614

CNS:

116347823

BCOO:

119081235

NVI:

100120136

CSOL:

105366624

TPRE:

106650065

FAS:

105264423

DAM:

107039335

VCAN:

122411680

CCIN:

107268819

NPT:

124218962

NFB:

124182898

NLO:

107222152

NVG:

124305414

AROA:

105683351

DCI:

103516518

CLEC:

106661338

NLU:

111044911

HVI:

124367113

MQU:

128995074

FOC:

113210108

TPAL:

117644725

ZNE:

110831195

CSEC:

111870363

IEL:

124167557

FCD:

110862702

DMK:

116926030

DPZ:

124315410

PVM:

113815316

PJA:

122252315

PCHN:

125025755

PMOO:

119576789

HAME:

121875688

PCLA:

123764960

CQD:

128692025

PTRU:

123519041

ESN:

126998836

MNZ:

135202439

ISC:

8053025

DSV:

119445622

RSAN:

119377584 119390488

RMP:

119169799

VDE:	111247588 111254724

VJA:	111264476 111268118

TUT:

107363285

DPTE:

113794090

DFR:

124490209

CSCU:

111622487

PTEP:

107437550

ABRU:

129960448

UDV:

129219275

SDM:

118201694

LPOL:

106475760

PMEO:

129587684

HRO:	HELRODRAFT_89375

PVUL:

126824716

GAE:

121389292

HRF:	124140226 124141700

HRJ:	124260823 124278058

CRG:	105321517 105332656

CANU:

128186867 128188117 128188594

CVN:	111136775 111137023 111137166

OED:	125654276 125659193 125659727

MYI:

110457155

PMAX:

117333059 117333060 117333062 117333069

MMER:

123525098 123534278 123534660 123535125 123535257 123535266 123552007

RPHI:

132742228 132742229 132743368 132753356 132759419 132759420

DPOL:

127839711 127856352 127861538

MAEA:

128229618 128232487 128232575

OSN:

115219210

LJP:	135468058 135477165

LAK:

106151343

LLON:

135485103 135502377

ENW:	MJO57_19210

EMP:	EZMO1_1200(nsdHL)

PWU:	A8O14_06055

MTU:

Rv1106c

MTV:	RVBD_1106c

MTC:

MT1137

MRA:

MRA_1117

MTF:	TBFG_11128

MTB:	TBMG_02877

MTK:	TBSG_02893

MTZ:	TBXG_002857

MTG:	MRGA327_06925

MTI:	MRGA423_06915

MTE:	CCDC5079_1022

MTUR:

CFBS_1174

MTL:	CCDC5180_1014

MTO:	MTCTRI2_1136

MTD:

UDA_1106c

MTN:	ERDMAN_1239

MTJ:	J112_05975

MTUB:

MT7199_1133

MTUC:

J113_07785

MTUE:

J114_05980

MTX:	M943_05820

MTUH:

I917_07855

MTUL:

TBHG_01091

MTUT:

HKBT1_1172

MTUU:

HKBT2_1178

MTQ:	HKBS1_1174

MBO:	BQ2027_MB1136C

MBB:

BCG_1166c

MBT:

JTY_1139

MBM:	BCGMEX_1138c

MBK:	K60_011910

MBX:

BCGT_0934

MAF:

MAF_11210

MMIC:

RN08_1242

MCE:	MCAN_11161

MCQ:	BN44_11231

MCV:	BN43_30163

MCX:	BN42_20954

MCZ:	BN45_30150

MORY:

MO_001188

MLE:

ML1942

MLB:

MLBr01942

MPA:

MAP_2688

MAO:

MAP4_1128

MAVI:

RC58_05605

MAVU:

RE97_05600

MAV:

MAV_1225

MIT:

OCO_11340

MIA:

OCU_11320

MID:

MIP_01824

MYO:

OEM_11450

MCHI:

AN480_06750

MIR:

OCQ_11350

MMAL:

CKJ54_05520

MLP:

MLM_1173

MMAN:

MMAN_54580

MSER:

MTY59_30480

MSA:	Mycsm_05045

MUL:

MUL_0172

MMI:

MMAR_4359

MMAE:

MMARE11_41790

MLI:	MULP_04570

MPSE:

MPSD_44990

MSHO:

MSHO_16920

MMC:

Mmcs_4109

MKM:

Mkms_4185

MJL:

Mjls_4340

MMM:

W7S_05545

MKN:	MKAN_07985

MYV:	G155_22700

MYE:	AB431_06460

MHAD:

B586_07090

MDX:	BTO20_08365

MSHG:

MSG_03923

MFJ:	MFLOJ_47450

MSTO:

MSTO_51430

MSIM:

MSIM_37390

MSAK:

MSAS_22240

MKU:	I2456_20620

MLW:	MJO58_21440

MXE:	MYXE_14010

MNV:	MNVI_06140

MPAG:

C0J29_23965

MNM:	MNVM_07790

MGOR:

H0P51_22240

MCOO:

MCOO_20360

MBAI:

MB901379_03818

MSEO:

MSEO_27010

MHEK:

JMUB5695_01344

MGAU:

MGALJ_31210

MLJ:	MLAC_06830

MBRD:

MBRA_27460

MSHJ:

MSHI_03080

MMAM:

K3U93_19010

MSPG:

F6B93_17425

MOT:	LTS72_03400

MLM:	MLPF_2463(hsd)

MPAA:

MKK62_05735

MKY:	IWGMT90018_50180

MADI:

A7U43_09340

MWU:	PT015_11765

MSM:	MSMEG_5228

MSG:	MSMEI_5091

MSB:	LJ00_25860

MSN:	LI99_25865

MSH:	LI98_25870

MVA:

Mvan_4635

MGI:

Mflv_2075

MSP:	Mspyr1_14990

MCB:	Mycch_4050

MNE:	D174_21420

MYN:	MyAD_21005

MFT:	XA26_46570

MPHL:

MPHLCCUG_04229

MVQ:

MYVA_4444

MLL:	B1R94_06430

MRH:	MycrhN_3550

MTHN:

4412656_03537

MHAS:

MHAS_03213

MDU:	MDUV_00690

MCHT:

MCHIJ_25440

MAUU:

NCTC10437_04362

MMAG:

MMAD_42700

MMOR:

MMOR_18320

MFX:	MFAL_37920

MAIC:

MAIC_43720

MIJ:	MINS_38420

MALV:

MALV_48580

MTY:	MTOK_04970

MPSC:

MPSYJ_22130

MARZ:

MARA_54320

MGAD:

MGAD_52480

MHEV:

MHEL_09990

MSAR:

MSAR_27010

MANY:

MANY_26880

MAUB:

MAUB_43590

MPOF:

MPOR_47010

MPHU:

MPHO_25810

MMUC:

C1S78_005420

MMAT:

MMAGJ_05590

MBOK:

MBOE_27320

MFG:	K6L26_09070

MSEI:

MSEDJ_54960

MFLV:

NCTC10271_01108

MCEE:

MCEL_44150

MMON:

EWR22_22255

MGO:	AFA91_14490

MHOL:

K3U96_06035

MSEN:

K3U95_21790

MPAE:

K0O64_06045

MRF:	MJO55_20980

MDF:	K0O62_22395

MCRO:

MI149_06755

MGRO:

FZ046_26400

MKR:	MKOR_40410

MPAK:

MIU77_04215

MJD:	JDM601_1056

MTER:

4434518_01040

MMIN:

MMIN_27080

MHIB:

MHIB_06150

MHER:

K3U94_05970

MVM:	MJO54_06060

SNF:	JYK04_07456(auaH_3)

LOB:	NEF87_000807

» show all

Reference

1 [PMID:4226148]

Authors

Cheatum SG, Watten JC.

Title

Purification and properties of 3-beta-hydroxysteroid dehydrogenase and delta-5-3-ketosteroid isomerase from bovine corpora lutea.

Journal

Biochim Biophys Acta 122:1-13 (1966)
DOI:10.1016/0926-6593(66)90086-5

Reference

2 [PMID:14220672]

Authors

KORITZ SB.

Title

THE CONVERSION OF PREGNENOLONE TO PROGESTERONE BY SMALL PARTICLES FROM RAT ADRENAL.

Journal

Biochemistry 3:1098-102 (1964)
DOI:10.1021/bi00896a015

Reference

Authors

Neville, A.M., Orr, J.C. and Engel, L.L.

Title

Delta5-3beta-Hydroxy steroid dehydrogenase activities of bovine adrenal cortex.

Journal

Biochem J 107:20 (1968)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.145

IUBMB Enzyme Nomenclature:

1.1.1.145

ExPASy - ENZYME nomenclature database:

1.1.1.145

BRENDA, the Enzyme Database:

1.1.1.145

CAS:

9044-85-3

LinkDB

REACTION: R02216

Entry

R02216                      Reaction

Name

pregnenolone:NAD+ 3-oxidoreductase

Definition

Pregnenolone + NAD+ <=> Progesterone + NADH + H+

Equation

C01953 + C00003 <=> C00410 + C00004 + C00080

Comment

3beta-hydroxysteroid dehydrogenase/ Delta5-Delta4-isomerase
two-step reaction

Reaction class

RC00001

C00003_C00004

RC00146

C00410_C01953

Enzyme

1.1.1.145 5.3.3.1

Pathway

rn00140

Steroid hormone biosynthesis

rn01100

Metabolic pathways

Module

M00107

Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R02216  Pregnenolone + NAD+ <=> Progesterone + NADH + H+
5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R02216  Pregnenolone + NAD+ <=> Progesterone + NADH + H+

Orthology

K00070

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]

LinkDB

DBGET integrated database retrieval system