KEGG   PATHWAY: btax04151
Entry
btax04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Budorcas taxicolor (takin)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
btax04151  PI3K-Akt signaling pathway
btax04151

Other DBs
GO: 0043491
Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128050008  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
128055664  TGFA; protransforming growth factor alpha [KO:K08774]
128049547  EREG; proepiregulin [KO:K09784]
128050080  AREG; amphiregulin [KO:K09782]
128050845  FGF1; fibroblast growth factor 1 [KO:K18496]
128062082  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
128049947  FGF5; fibroblast growth factor 5 [KO:K04358]
128069166  FGF4; fibroblast growth factor 4 [KO:K04358]
128069196  FGF3; fibroblast growth factor 3 [KO:K04358]
128070322  FGF16; fibroblast growth factor 16 [KO:K04358]
128057718  FGF9; fibroblast growth factor 9 [KO:K04358]
128051703  FGF22; fibroblast growth factor 22 [KO:K04358]
128052704  FGF17; fibroblast growth factor 17 [KO:K04358]
128065968  FGF10; fibroblast growth factor 10 [KO:K04358]
128066262  FGF18; fibroblast growth factor 18 [KO:K04358]
128053785  FGF7; fibroblast growth factor 7 [KO:K04358]
128048008  FGF6; fibroblast growth factor 6 [KO:K04358]
128067938  FGF8; fibroblast growth factor 8 [KO:K04358]
128068355  FGF20; fibroblast growth factor 20 [KO:K04358]
128069264  FGF19; fibroblast growth factor 19 [KO:K22603]
128064178  FGF21; fibroblast growth factor 21 [KO:K22429]
128048959  FGF23; fibroblast growth factor 23 [KO:K22428]
128045179  NGF; beta-nerve growth factor [KO:K02582]
128060339  BDNF; brain-derived neurotrophic factor [KO:K04355]
128048554  NTF3; neurotrophin-3 [KO:K04356]
128063771  NTF4; neurotrophin-4 isoform X1 [KO:K12457]
128069208  INS; insulin [KO:K04526]
128048032  IGF1; insulin-like growth factor I [KO:K05459]
128068647  IGF2; insulin-like growth factor II [KO:K13769]
128065733  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
128047817  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
128060743  PDGFD; platelet-derived growth factor D [KO:K05450]
128062428  PDGFC; platelet-derived growth factor C [KO:K05450]
128044745  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
128048430  KITLG; kit ligand [KO:K05461]
128063479  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
128055613  VEGFA; vascular endothelial growth factor A [KO:K05448]
128068711  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
128054318  PGF; placenta growth factor [KO:K16859]
128070311  VEGFD; vascular endothelial growth factor D [KO:K05449]
128068325  VEGFC; vascular endothelial growth factor C [KO:K05449]
128046678  HGF; hepatocyte growth factor [KO:K05460]
128059324  ANGPT1; angiopoietin-1 [KO:K05465]
128068156  ANGPT2; angiopoietin-2 [KO:K05466]
128058453  ANGPT4; angiopoietin-4 [KO:K05467]
128044606  EFNA1; ephrin-A1 [KO:K05462]
128045080  EFNA3; ephrin-A3 [KO:K05462]
128045081  EFNA4; ephrin-A4 [KO:K05462]
128051506  EFNA5; ephrin-A5 [KO:K05462]
128051746  EFNA2; ephrin-A2 [KO:K05462]
128066098  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
128051433  NRTN; neurturin [KO:K25414]
128045697  ARTN; artemin [KO:K25415]
128051720  PSPN; LOW QUALITY PROTEIN: persephin [KO:K25416]
128051614  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
128064538  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
128047384  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
128061017  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
128068375  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
128067669  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
128049397  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
128050311  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
128065569  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
128044483  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
128052378  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
128050313  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
128066571  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
128049579  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
128050429  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
128050693  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
128049641  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
128057569  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
128057485  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
128050341  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
128049477  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
128046469  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
128052138  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
128043849  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
128048891  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
128064562  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
128053892  SOS2; son of sevenless homolog 2 [KO:K03099]
128055374  SOS1; son of sevenless homolog 1 [KO:K03099]
128068689  HRAS; GTPase HRas isoform X1 [KO:K02833]
128047937  KRAS; GTPase KRas [KO:K07827]
128044537  NRAS; GTPase NRas [KO:K07828]
128043403  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128054045  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
128050664  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
128043958  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
128062160  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128069000  IRS1; insulin receptor substrate 1 [KO:K16172]
128062410  TLR2; toll-like receptor 2 [KO:K10159]
128052396  TLR4; toll-like receptor 4 [KO:K10160]
128043471  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
128052376  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
128043503  CD19; B-lymphocyte antigen CD19 [KO:K06465]
128068079  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
128065055  GH1; somatotropin [KO:K05438]
128056068  LOW QUALITY PROTEIN: chorionic somatomammotropin hormone 2-like [KO:K05439]
128056134  LOW QUALITY PROTEIN: placental prolactin-related protein 1-like [KO:K05439]
128056189  chorionic somatomammotropin hormone 2-like [KO:K05439]
128056261  placental prolactin-related protein 1-like [KO:K05439]
128056286  placental prolactin-related protein 4-like [KO:K05439]
128056321  placental prolactin-related protein 3-like [KO:K05439]
128056535  prolactin [KO:K05439]
128055157  chorionic somatomammotropin hormone [KO:K05439]
128055513  chorionic somatomammotropin hormone 2-like [KO:K05439]
128062617  OSM; oncostatin-M [KO:K05418]
128062529  IL2; interleukin-2 [KO:K05429]
128051755  interleukin-3 [KO:K04736]
128046952  IL6; interleukin-6 [KO:K05405]
128051558  IL4; interleukin-4 [KO:K05430]
128059511  IL7; interleukin-7 [KO:K05431]
128052429  interferon alpha-H-like [KO:K05414]
128052430  interferon alpha-H-like [KO:K05414]
128052431  interferon alpha-H [KO:K05414]
128052432  interferon alpha-1-like [KO:K05414]
128052433  interferon alpha-H-like [KO:K05414]
128052459  interferon alpha-H-like [KO:K05414]
128052476  interferon alpha-H-like [KO:K05414]
128052682  LOW QUALITY PROTEIN: interferon alpha-3-like [KO:K05414]
128052694  interferon alpha-H-like [KO:K05414]
128052696  interferon alpha-H-like [KO:K05414]
128052697  interferon alpha-1-like [KO:K05414]
128052706  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
128052625  interferon beta-2-like [KO:K05415]
128052626  interferon beta-2-like [KO:K05415]
128052627  interferon beta-2-like [KO:K05415]
128052628  interferon beta-2 [KO:K05415]
128052635  interferon beta-2-like [KO:K05415]
128052636  interferon beta-2-like [KO:K05415]
128052637  interferon beta-2-like [KO:K05415]
128052638  interferon beta-2-like [KO:K05415]
128052639  interferon beta-2-like [KO:K05415]
128052640  interferon beta-2-like [KO:K05415]
128052652  interferon beta-2-like [KO:K05415]
128043795  EPO; erythropoietin [KO:K05437]
128065541  CSF3; granulocyte colony-stimulating factor [KO:K05423]
128065987  GHR; growth hormone receptor isoform X1 [KO:K05080]
128066145  PRLR; prolactin receptor [KO:K05081]
128066061  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
128058762  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
128048204  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
128070243  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
128070407  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
128045517  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
128063317  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
128066211  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
128044048  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
128055500  interferon alpha/beta receptor 2 [KO:K05131]
128051628  EPOR; erythropoietin receptor [KO:K05079]
128045256  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
128044816  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
128052316  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
128051234  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
128065257  COL1A1; collagen alpha-1(I) chain [KO:K06236]
128046458  COL1A2; collagen alpha-2(I) chain [KO:K06236]
128048030  COL2A1; collagen alpha-1(II) chain [KO:K19719]
128069713  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
128070154  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
128070152  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
128057793  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
128057845  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
128071532  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
128050602  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
128057689  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
128045507  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
128060926  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
128048315  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
128044990  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
128058571  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
128059283  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
128053075  LAMA2; laminin subunit alpha-2 [KO:K05637]
128067370  LAMA1; laminin subunit alpha-1 [KO:K05637]
128058740  LAMA5; laminin subunit alpha-5 [KO:K06240]
128067291  LAMA3; laminin subunit alpha-3 [KO:K06240]
128053220  LAMA4; laminin subunit alpha-4 [KO:K06241]
128046398  LAMB1; laminin subunit beta-1 [KO:K05636]
128045013  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
128053060  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
128061642  LAMB3; laminin subunit beta-3 [KO:K06244]
128046270  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
128061859  LAMC1; laminin subunit gamma-1 [KO:K05635]
128061574  LAMC2; laminin subunit gamma-2 [KO:K06246]
128056135  LAMC3; laminin subunit gamma-3 [KO:K06247]
128064700  CHAD; chondroadherin [KO:K06248]
128046249  RELN; reelin [KO:K06249] [EC:3.4.21.-]
128054540  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
128050621  COMP; cartilage oligomeric matrix protein [KO:K04659]
128045667  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
128053041  THBS2; thrombospondin-2 [KO:K04659]
128054588  THBS4; thrombospondin-4 [KO:K04659]
128071425  fibronectin-like [KO:K05717]
128068063  FN1; fibronectin isoform X1 [KO:K05717]
128049806  SPP1; osteopontin [KO:K06250]
128065568  VTN; vitronectin [KO:K06251]
128056428  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
128052187  TNC; tenascin isoform X1 [KO:K06252]
128061587  TNR; tenascin-R [KO:K06252]
128061818  TNN; tenascin-N [KO:K06252]
128048587  VWF; von Willebrand factor [KO:K03900]
128049743  IBSP; bone sialoprotein 2 [KO:K06253]
128065939  ITGA1; integrin alpha-1 [KO:K06480]
128066170  ITGA2; integrin alpha-2 [KO:K06481]
128065265  ITGA2B; integrin alpha-IIb [KO:K06476]
128065072  ITGA3; integrin alpha-3 [KO:K06482]
128043513  ITGA4; integrin alpha-4 [KO:K06483]
128048841  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
128063440  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
128048509  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
128058543  ITGA8; integrin alpha-8 [KO:K06584]
128046826  ITGA9; integrin alpha-9 [KO:K06585]
128044498  ITGA10; integrin alpha-10 [KO:K06586]
128054246  ITGA11; integrin alpha-11 [KO:K06587]
128061467  ITGAV; integrin alpha-V [KO:K06487]
128058839  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
128064875  ITGB3; integrin beta-3 [KO:K06493]
128064497  ITGB4; integrin beta-4 [KO:K06525]
128061565  ITGB5; integrin beta-5 [KO:K06588]
128068538  ITGB6; integrin beta-6 [KO:K06589]
128048309  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
128046829  ITGB8; integrin beta-8 [KO:K06591]
128059235  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
128045803  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
128061813  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128068699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
128050540  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
128044474  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
128066235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
128054190  F2R; proteinase-activated receptor 1 [KO:K03914]
128068993  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
128046777  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
128052575  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
128051634  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
128044777  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
128070397  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
128048822  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
128057542  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
128061341  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
128068195  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
128047979  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
128050433  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
128054091  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
128068668  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
128048580  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
128046927  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
128046735  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
128065234  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
128065366  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
128060129  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
128050902  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
128044580  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
128065926  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
128047579  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
128056632  TSC1; hamartin isoform X1 [KO:K07206]
128043920  TSC2; tuberin isoform X1 [KO:K07207]
128046520  RHEB; GTP-binding protein Rheb [KO:K07208]
128065538  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
128061687  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
128064589  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
128059988  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
128068203  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 isoform X1 [KO:K07205]
128056769  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-like [KO:K03259]
128050970  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
128061904  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
128049601  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
128064578  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
128068526  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
128047355  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
128067666  eukaryotic translation initiation factor 4B-like [KO:K03258]
128052165  RPS6; 40S ribosomal protein S6 [KO:K02991]
128055152  40S ribosomal protein S6 [KO:K02991]
128065393  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128050559  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
128044609  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
128055106  PKN3; serine/threonine-protein kinase N3 [KO:K23692] [EC:2.7.11.13]
128053038  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
128058500  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
128059261  SGK3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
128063870  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128067048  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128061491  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128043844  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
128046206  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
128068055  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
128045409  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
128051757  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
128068193  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
128063523  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
128070222  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
128070224  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
128060694  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
128051169  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
128052002  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
128067781  PPP2R2D; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
128049472  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
128069911  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
128066441  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
128066723  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
128047773  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
128056208  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
128066367  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
128053851  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
128061157  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
128068474  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
128066717  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
128055818  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
128047442  HSP90B1; endoplasmin [KO:K09487]
128051100  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
128044579  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
128063700  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
128067384  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
128067034  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
128066506  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
128070098  MTCP1; protein p13 MTCP-1 [KO:K16837]
128046225  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
128065278  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
128043889  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
128063840  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
128048356  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
128058021  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
128054171  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
128043850  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
128065296  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
128065297  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
128059120  MYC; myc proto-oncogene protein [KO:K04377]
128069030  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
128056953  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
128047650  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
128047622  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
128047322  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
128046639  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
128048410  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
128055411  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
128063478  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
128059332  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
128053483  FOXO3; forkhead box protein O3 [KO:K09408]
128062924  RBL2; retinoblastoma-like protein 2 [KO:K16332]
128061812  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
128055401  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
128058124  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
128058395  14-3-3 protein theta-like [KO:K16197]
128059098  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
128054333  14-3-3 protein zeta/delta-like [KO:K16197]
128055931  YWHAQ; 14-3-3 protein theta [KO:K16197]
128064436  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
128049733  14-3-3 protein epsilon-like [KO:K06630]
128062632  YWHAH; 14-3-3 protein eta [KO:K16198]
128062952  YWHAG; 14-3-3 protein gamma [KO:K16198]
128068977  BAD; bcl2-associated agonist of cell death [KO:K02158]
128058470  BCL2L1; bcl-2-like protein 1 [KO:K04570]
128059210  LOW QUALITY PROTEIN: bcl-2-like protein 1 [KO:K04570]
128067358  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
128061241  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
128071103  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
128061475  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
128065610  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
128047885  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
128048350  LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
128044759  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
128051508  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
128052214  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
128046532  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
128060385  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
128046584  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
128056429  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
128045164  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
128056978  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
128047279  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
128069947  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
128067677  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
128068238  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
128068546  RELA; transcription factor p65 [KO:K04735]
128049417  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
128053294  MYB; transcriptional activator Myb [KO:K09420]
128047314  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
128049822  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
128064672  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
btax00010  Glycolysis / Gluconeogenesis
btax04010  MAPK signaling pathway
btax04012  ErbB signaling pathway
btax04062  Chemokine signaling pathway
btax04064  NF-kappa B signaling pathway
btax04068  FoxO signaling pathway
btax04110  Cell cycle
btax04115  p53 signaling pathway
btax04150  mTOR signaling pathway
btax04210  Apoptosis
btax04370  VEGF signaling pathway
btax04510  Focal adhesion
btax04620  Toll-like receptor signaling pathway
btax04630  JAK-STAT signaling pathway
btax04662  B cell receptor signaling pathway
btax04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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