KEGG   PATHWAY: mcoc05014
Entry
mcoc05014                   Pathway                                
Name
Amyotrophic lateral sclerosis - Mastomys coucha (southern multimammate mouse)
Description
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive degeneration of motor neurons in the brain and spinal cord. In 90% of patients, ALS is sporadic, with no clear genetic linkage. On the other hand, the remaining 10% of cases show familial inheritance, with mutations in SOD1, TDP43(TARDBP), FUS, or C9orf72 genes being the most frequent causes. In spite of such difference, familial ALS and sporadic ALS have similarities in their pathological features. Proposed disease mechanisms contributing to motor neuron degeneration in ALS are: impaired proteostasis, aberrant RNA processing, mitochondrial disfunction and oxidative stress, microglia activation, and axonal dysfunction.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mcoc05014  Amyotrophic lateral sclerosis
mcoc05014

Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116077116  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
116072579  caspase-1 [KO:K01370] [EC:3.4.22.36]
116099518  Bid; BH3-interacting domain death agonist isoform X1 [KO:K04726]
116097315  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
116091179  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
116102201  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
116103467  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
116075741  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
116098897  cytochrome c, somatic [KO:K08738]
116090342  cytochrome c, testis-specific [KO:K08738]
116096967  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
116069240  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
116086109  Sod1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
34682989  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
34682993  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
34683008  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
34683011  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
34683010  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
34683015  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
34683016  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
116103309  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
116088857  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
116075130  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
116077484  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
116087026  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
116101528  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
116098581  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
116076179  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
116098636  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
116080991  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
116076712  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
116076307  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
116090075  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
116099623  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
116088778  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
116102910  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
116074922  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
116076188  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
116069436  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
116079733  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
116098773  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
116088464  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
116085890  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
116095068  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
116095820  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
116069684  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
116103899  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
116082796  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
116077266  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
116073091  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
116089452  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
116103359  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
116090451  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
116083700  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
116096591  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
116083218  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
116075723  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
116103302  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
116102591  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
116083193  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
116096943  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
116103322  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
116073180  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
116082198  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
34683018  CYTB; cytochrome b [KO:K00412]
116074595  cytochrome c1, heme protein, mitochondrial [KO:K00413]
116073065  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
116102887  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
116096453  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
116082347  cytochrome b-c1 complex subunit 7 [KO:K00417]
116077290  cytochrome b-c1 complex subunit 8 [KO:K00418]
116069534  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
116075740  cytochrome b-c1 complex subunit 10 [KO:K00420]
34683006  COX3; cytochrome c oxidase subunit III [KO:K02262]
34682999  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
34683002  COX2; cytochrome c oxidase subunit II [KO:K02261]
116092456  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
116070294  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
116071976  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
116088312  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
116100918  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
116068251  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
116101988  cytochrome c oxidase subunit 6B1 [KO:K02267]
116101559  cytochrome c oxidase subunit 6B2 isoform X1 [KO:K02267]
116082439  cytochrome c oxidase subunit 6C [KO:K02268]
116100436  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
116080462  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
116073347  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
116087988  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
116071167  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
116083615  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
116103484  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
116100960  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
116080263  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
116087380  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
116076143  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
116098989  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
116082579  ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
116076583  Atp5f1d; ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134]
116091503  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
34683005  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
116093578  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
116077055  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
116090323  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
116080645  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
116077859  Atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138]
116086146  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
34683004  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
116099029  voltage-dependent anion-selective channel protein 1 [KO:K05862]
116078655  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
116103341  Tomm40l; mitochondrial import receptor subunit TOM40B [KO:K11518]
116101771  Tomm40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
116075282  Mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
116096899  Pink1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
116076805  Prkn; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
116081709  Optn; optineurin isoform X1 [KO:K19946]
116077040  Sqstm1; sequestosome-1 isoform X1 [KO:K14381]
116070311  Map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
116091231  Map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
116076589  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
116090219  Tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
116083801  Wdr41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
116079133  Smcr8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
116087963  C9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
116069541  Rab8a; ras-related protein Rab-8A [KO:K07901]
116074230  Rab39b; ras-related protein Rab-39B [KO:K07925]
116070934  Rab1a; ras-related protein Rab-1A [KO:K07874]
116097015  Mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
116068139  Ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
116078838  Ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
116080067  Atg101; autophagy-related protein 101 [KO:K19730]
116090480  Atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
116088140  Rb1cc1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
116090484  Ambra1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
116077067  Becn1; beclin-1 isoform X1 [KO:K08334]
116071322  Becn2; beclin-2 [KO:K08334]
116073902  Pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
116084614  Atg14; beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889]
116075000  Nrbf2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
116086936  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
116103443  Atg2a; autophagy-related protein 2 homolog A [KO:K17906]
116081190  Atg2b; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
116068694  Wipi2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
116079011  Wipi1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
116088476  Als2; alsin [KO:K04575]
116074344  Rab5a; ras-related protein Rab-5A [KO:K07887]
116068714  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116086049  Chmp2b; charged multivesicular body protein 2b [KO:K12192]
116075343  Fig4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
116090813  Spg11; spatacsin isoform X1 [KO:K19026]
116093830  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116084124  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116084832  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116096012  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
116071362  Ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
116102711  Ubqln3; ubiquilin-3 isoform X1 [KO:K04523]
116093134  Ubqln4; ubiquilin-4 [KO:K04523]
116090013  Ubqln2; ubiquilin-2 [KO:K04523]
116081611  Ubqln1; ubiquilin-1 isoform X1 [KO:K04523]
116095875  Vcp; transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
116081723  Derl1; derlin-1 [KO:K11519]
116080102  Psma6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
116081974  Psma2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
116073836  Psma4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
116086864  Psma8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
116091522  Psma7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
116093624  Psma5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
116102829  Psma1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
116080165  Psma3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
116077049  Psmb6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
116090105  Psmb7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
116078462  Psmb3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
116096647  Psmb2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
116084899  Psmb5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
116079278  Psmb1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
116093378  Psmb4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
116097517  Psmc2; 26S proteasome regulatory subunit 7 [KO:K03061]
116079645  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
116101900  Psmc4; 26S proteasome regulatory subunit 6B [KO:K03063]
116084504  Psmc6; 26S proteasome regulatory subunit 10B [KO:K03064]
116090454  Psmc3; 26S proteasome regulatory subunit 6A [KO:K03065]
116076748  Psmc5; 26S proteasome regulatory subunit 8 [KO:K03066]
116085728  Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
116088686  Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
116077881  Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
116068387  Psmd9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
116077868  Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
116077281  Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
116084513  Psmd6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
116070128  Psmd7; 26S proteasome non-ATPase regulatory subunit 7 isoform X1 [KO:K03038]
116101375  Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
116093388  Psmd4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
116090221  Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
116100325  Psmd8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
116091526  Adrm1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
116098557  Sem1; 26S proteasome complex subunit SEM1 [KO:K10881]
116067979  Hdac6; histone deacetylase 6 [KO:K11407] [EC:3.5.1.98]
116097020  Tardbp; TAR DNA-binding protein 43 isoform X1 [KO:K23600]
116103046  Fus; RNA-binding protein FUS isoform X1 [KO:K13098]
116101350  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
116078665  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
116090337  Hnrnpa3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
116080781  Hnrnpa1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
116091747  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
116098903  Hnrnpa2b1; heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1 [KO:K13158]
116102953  Atxn2l; ataxin-2-like protein isoform X1 [KO:K23625]
116068348  Atxn2; ataxin-2 isoform X1 [KO:K23625]
116086994  Matr3; matrin-3 [KO:K13213]
116085030  Ang; angiogenin [KO:K16631] [EC:3.1.27.-]
116095955  Ncbp1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
116103503  THO complex subunit 4-like [KO:K12881]
116078149  Alyref; THO complex subunit 4 [KO:K12881]
116074693  Srsf3; serine/arginine-rich splicing factor 3 [KO:K12892]
116080775  Srsf7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
116094959  Nxf3; nuclear RNA export factor 3 [KO:K14284]
116103509  Nxf1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
116094489  Nxf5; nuclear RNA export factor 5 [KO:K14284]
116088734  nuclear RNA export factor 2-like [KO:K14284]
116094926  Nxt2; NTF2-related export protein 2 isoform X1 [KO:K14285]
116091100  Nxt1; NTF2-related export protein 1 [KO:K14285]
116094096  nucleoporin GLE1-like [KO:K18723]
116089927  Gle1; nucleoporin GLE1 isoform X1 [KO:K18723]
116100741  Tpr; nucleoprotein TPR [KO:K09291]
116099307  nuclear pore complex protein Nup50-like [KO:K14295]
116077215  Nup50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
116082710  Nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
116102688  nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
116101303  nuclear pore complex protein Nup98-Nup96-like [KO:K14297]
116091481  Rae1; mRNA export factor [KO:K14298]
116099412  Sec13; protein SEC13 homolog [KO:K14004]
116087309  Seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
116070381  Nup133; nuclear pore complex protein Nup133 [KO:K14300]
116075989  Nup107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
116076073  Nup37; nucleoporin Nup37 [KO:K14302]
116091730  Nup160; nuclear pore complex protein Nup160 [KO:K14303]
116079124  Nup85; nuclear pore complex protein Nup85 [KO:K14304]
116097737  Nup43; nucleoporin Nup43 [KO:K14305]
116102148  Nup62; nuclear pore glycoprotein p62 [KO:K14306]
116085352  Nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
116104498  Nup54; nucleoporin p54 isoform X1 [KO:K14308]
116069897  Nup93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
116098720  Nup205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
116089942  Nup188; nucleoporin NUP188 homolog [KO:K14311]
116083156  Nup155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
116090381  Nup35; nucleoporin NUP35 isoform X1 [KO:K14313]
116099266  Nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]
116093204  Nup210l; nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
116096356  Ndc1; nucleoporin NDC1 isoform X1 [KO:K14315]
116104670  nuclear envelope pore membrane protein POM 121-like [KO:K14316]
116082529  Pom121l2; POM121-like protein 2 isoform X1 [KO:K14316]
116089983  Nup214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
116078136  Nup88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
116075526  E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
116089915  Setx; probable helicase senataxin isoform X1 [KO:K10706] [EC:5.6.2.5 5.6.2.3]
116074774  Chchd10; coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial [KO:K22759]
116090044  Hspa5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
116091489  Vapb; vesicle-associated membrane protein-associated protein B/C [KO:K10707]
116103242  Atf6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
116076417  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
116076830  Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
116069833  Xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
116089826  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
116097922  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
116073421  caspase-12 [KO:K04741] [EC:3.4.22.-]
116099053  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
116080060  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
116076129  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
116075536  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
116095860  Sigmar1; sigma non-opioid intracellular receptor 1 [KO:K20719]
116074547  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
116099614  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
116096996  Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
116075120  Daxx; death domain-associated protein 6 [KO:K02308]
116077938  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
116079135  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
116075101  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
116075516  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
116077765  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
116077791  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
116068288  Nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
116101391  Ccs; copper chaperone for superoxide dismutase [KO:K04569]
116096375  Gpx7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
116073980  Gpx1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
116082164  Gpx5; epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
116082166  Gpx6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
116083259  Gpx8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
116076935  Gpx3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
116080963  Gpx2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
116090569  Cat; catalase [KO:K03781] [EC:1.11.1.6]
116082072  Prph; peripherin isoform X1 [KO:K07607]
116084954  Nefl; neurofilament light polypeptide [KO:K04572]
116084754  Nefm; neurofilament medium polypeptide [KO:K04573]
116069362  Nefh; neurofilament heavy polypeptide [KO:K04574]
116092905  Pfn2; profilin-2 [KO:K05759]
116078343  Pfn1; profilin-1 [KO:K05759]
116088575  profilin-2-like [KO:K05759]
116080295  Pfn4; profilin-4 isoform X1 [KO:K05759]
116081648  Pfn3; profilin-3 [KO:K05759]
116099290  actin-85C-like [KO:K05692]
116068700  Actb; actin, cytoplasmic 1 [KO:K05692]
116078777  Actg1; actin, cytoplasmic 2 [KO:K05692]
116084597  Anxa7; annexin A7 isoform X1 [KO:K17095]
116084609  Anxa11; annexin A11 [KO:K17095]
116076048  Kif5a; kinesin heavy chain [KO:K10396]
116086810  Kif5b; kinesin-1 heavy chain isoform X1 [KO:K10396]
116090151  Kif5c; kinesin heavy chain [KO:K10396]
116103373  Klc2; kinesin light chain 2 [KO:K10407]
116101752  Klc3; kinesin light chain 3 [KO:K10407]
116074836  Klc4; kinesin light chain 4 isoform X1 [KO:K10407]
116080751  Klc1; kinesin light chain 1 isoform X1 [KO:K10407]
116098456  tubulin alpha chain-like [KO:K07374]
116099526  Tuba8; tubulin alpha-8 chain [KO:K07374]
116099610  tubulin alpha-3 chain [KO:K07374]
116099794  tubulin alpha-3 chain [KO:K07374]
116082583  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
116088942  tubulin alpha chain-like [KO:K07374]
116074272  Tubb4a; tubulin beta-4A chain [KO:K07375]
116074609  Tubb; tubulin beta chain [KO:K07375]
116075389  tubulin beta chain-like [KO:K07375]
116087298  Tubb6; tubulin beta-6 chain [KO:K07375]
116070367  Tubb3; tubulin beta-3 chain [KO:K07375]
116089797  Tubb4b; tubulin beta-4B chain [KO:K07375]
116091502  Tubb1; tubulin beta-1 chain [KO:K07375]
116099941  Dctn1; dynactin subunit 1 [KO:K04648]
116076416  Dctn2; dynactin subunit 2 isoform X1 [KO:K10424]
116095852  Dctn3; dynactin subunit 3 isoform X1 [KO:K10425]
116087210  Dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
116102915  Dctn5; dynactin subunit 5 [KO:K10427]
116069135  Dctn6; dynactin subunit 6 [KO:K10428]
116103951  Actr1a; alpha-centractin isoform X1 [KO:K16575]
116088310  Actr1b; beta-centractin [KO:K16575]
116080164  Actr10; actin-related protein 10 isoform X1 [KO:K16576]
116078409  Hap1; huntingtin-associated protein 1 isoform X1 [KO:K04647]
116102878  Dnah3; dynein heavy chain 3, axonemal [KO:K10408]
116099097  Dnah6; dynein heavy chain 6, axonemal isoform X1 [KO:K10408]
116074324  Dnah8; dynein heavy chain 8, axonemal [KO:K10408]
116083500  Dnah5; dynein heavy chain 5, axonemal [KO:K10408]
116084130  Dnah1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
116084648  Dnah12; dynein heavy chain 12, axonemal [KO:K10408]
116067876  Dnah14; dynein heavy chain 14, axonemal isoform X1 [KO:K10408]
116068440  Dnah10; dynein heavy chain 10, axonemal isoform X1 [KO:K10408]
116077732  Dnah2; dynein heavy chain 2, axonemal isoform X1 [KO:K10408]
116088417  Dnah7; dynein heavy chain 7, axonemal isoform X1 [KO:K10408]
116078598  Dnah9; dynein heavy chain 9, axonemal isoform X1 [KO:K10408]
116079147  Dnah17; dynein heavy chain 17, axonemal isoform X1 [KO:K10408]
116081181  Dnah11; dynein heavy chain 11, axonemal isoform X1 [KO:K10408]
116096614  Dnali1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
116095842  Dnai1; dynein intermediate chain 1, axonemal [KO:K10409]
116077789  Dnai2; dynein intermediate chain 2, axonemal [KO:K11143]
116079996  Dnal1; dynein light chain 1, axonemal isoform X1 [KO:K10411]
116076010  Dnal4; dynein light chain 4, axonemal [KO:K10412]
116090562  Slc1a2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
116076938  Nos2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
116078447  Gria1; glutamate receptor 1 isoform X1 [KO:K05197]
116093023  Gria2; glutamate receptor 2 isoform X1 [KO:K05198]
116089804  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
116084963  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
116099710  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
116078169  Grin2c; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
116102223  Grin2d; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
116069118  Nrg1; pro-neuregulin-1, membrane-bound isoform isoform X1 [KO:K05455]
116087005  Nrg2; pro-neuregulin-2, membrane-bound isoform isoform X1 [KO:K05456]
116085332  Nrg3; pro-neuregulin-3, membrane-bound isoform isoform X1 [KO:K05457]
116072426  Nrg4; pro-neuregulin-4, membrane-bound isoform [KO:K05458]
116088530  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
Compound
C00001  H2O
C00008  ADP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00039  DNA
C00046  RNA
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C16844  Hydroxyl radical
C16845  Peroxynitrite
Reference
PMID:28700839
  Authors
Brown RH, Al-Chalabi A
  Title
Amyotrophic Lateral Sclerosis.
  Journal
N Engl J Med 377:162-172 (2017)
DOI:10.1056/NEJMra1603471
Reference
PMID:28512398
  Authors
Webster CP, Smith EF, Shaw PJ, De Vos KJ
  Title
Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?
  Journal
Front Mol Neurosci 10:123 (2017)
DOI:10.3389/fnmol.2017.00123
Reference
PMID:30879475
  Authors
Valko K, Ciesla L
  Title
Amyotrophic lateral sclerosis.
  Journal
Prog Med Chem 58:63-117 (2019)
DOI:10.1016/bs.pmch.2018.12.001
Reference
PMID:30870681
  Authors
Mathis S, Goizet C, Soulages A, Vallat JM, Masson GL
  Title
Genetics of amyotrophic lateral sclerosis: A review.
  Journal
J Neurol Sci 399:217-226 (2019)
DOI:10.1016/j.jns.2019.02.030
Reference
PMID:23415570
  Authors
Turner MR, Hardiman O, Benatar M, Brooks BR, Chio A, de Carvalho M, Ince PG, Lin C, Miller RG, Mitsumoto H, Nicholson G, Ravits J, Shaw PJ, Swash M, Talbot K, Traynor BJ, Van den Berg LH, Veldink JH, Vucic S, Kiernan MC
  Title
Controversies and priorities in amyotrophic lateral sclerosis.
  Journal
Lancet Neurol 12:310-22 (2013)
DOI:10.1016/S1474-4422(13)70036-X
Reference
PMID:16924260
  Authors
Pasinelli P, Brown RH
  Title
Molecular biology of amyotrophic lateral sclerosis: insights from genetics.
  Journal
Nat Rev Neurosci 7:710-23 (2006)
DOI:10.1038/nrn1971
Reference
PMID:16723044
  Authors
Goodall EF, Morrison KE
  Title
Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment.
  Journal
Expert Rev Mol Med 8:1-22 (2006)
DOI:10.1017/S1462399406010854
Reference
PMID:28669745
  Authors
Smith EF, Shaw PJ, De Vos KJ
  Title
The role of mitochondria in amyotrophic lateral sclerosis.
  Journal
Neurosci Lett 710:132933 (2019)
DOI:10.1016/j.neulet.2017.06.052
Reference
PMID:32344665
  Authors
Kodavati M, Wang H, Hegde ML
  Title
Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective.
  Journal
Cells 9:E1065 (2020)
DOI:10.3390/cells9041065
Reference
PMID:16372325
  Authors
Hervias I, Beal MF, Manfredi G
  Title
Mitochondrial dysfunction and amyotrophic lateral sclerosis.
  Journal
Muscle Nerve 33:598-608 (2006)
DOI:10.1002/mus.20489
Reference
PMID:16603792
  Authors
Bacman SR, Bradley WG, Moraes CT
  Title
Mitochondrial involvement in amyotrophic lateral sclerosis: trigger or target?
  Journal
Mol Neurobiol 33:113-31 (2006)
DOI:10.1385/MN:33:2:113
Reference
PMID:17051205
  Authors
Lin MT, Beal MF
  Title
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.
  Journal
Nature 443:787-95 (2006)
DOI:10.1038/nature05292
Reference
PMID:16909017
  Authors
Bendotti C, Bao Cutrona M, Cheroni C, Grignaschi G, Lo Coco D, Peviani M, Tortarolo M, Veglianese P, Zennaro E
  Title
Inter- and intracellular signaling in amyotrophic lateral sclerosis: role of p38 mitogen-activated protein kinase.
  Journal
Neurodegener Dis 2:128-34 (2005)
DOI:10.1159/000089617
Reference
PMID:14569202
  Authors
Simpson EP, Yen AA, Appel SH
  Title
Oxidative Stress: a common denominator in the pathogenesis of amyotrophic lateral sclerosis.
  Journal
Curr Opin Rheumatol 15:730-6 (2003)
DOI:10.1097/00002281-200311000-00008
Reference
PMID:15310460
  Authors
Bendotti C, Carri MT
  Title
Lessons from models of SOD1-linked familial ALS.
  Journal
Trends Mol Med 10:393-400 (2004)
DOI:10.1016/j.molmed.2004.06.009
Reference
PMID:12595144
  Authors
Robertson J, Kriz J, Nguyen MD, Julien JP
  Title
Pathways to motor neuron degeneration in transgenic mouse models.
  Journal
Biochimie 84:1151-60 (2002)
DOI:10.1016/S0300-9084(02)00025-1
Reference
PMID:17434459
  Authors
Eve DJ, Dennis JS, Citron BA
  Title
Transcription factor p53 in degenerating spinal cords.
  Journal
Brain Res 1150:174-81 (2007)
DOI:10.1016/j.brainres.2007.02.088
Reference
PMID:27649160
  Authors
Bahar E, Kim H, Yoon H
  Title
ER Stress-Mediated Signaling: Action Potential and Ca(2+) as Key Players.
  Journal
Int J Mol Sci 17:E1558 (2016)
DOI:10.3390/ijms17091558
Reference
PMID:19230774
  Authors
Bezprozvanny I
  Title
Calcium signaling and neurodegenerative diseases.
  Journal
Trends Mol Med 15:89-100 (2009)
DOI:10.1016/j.molmed.2009.01.001
Reference
PMID:16026864
  Authors
von Lewinski F, Keller BU
  Title
Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS.
  Journal
Trends Neurosci 28:494-500 (2005)
DOI:10.1016/j.tins.2005.07.001
Reference
PMID:11239414
  Authors
Julien JP.
  Title
Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded.
  Journal
Cell 104:581-91 (2001)
DOI:10.1016/S0092-8674(01)00244-6
Reference
PMID:11870681
  Authors
Hand CK, Rouleau GA
  Title
Familial amyotrophic lateral sclerosis.
  Journal
Muscle Nerve 25:135-59 (2002)
DOI:10.1002/mus.10000
Reference
PMID:16713195
  Authors
Barber SC, Mead RJ, Shaw PJ
  Title
Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target.
  Journal
Biochim Biophys Acta 1762:1051-67 (2006)
DOI:10.1016/j.bbadis.2006.03.008
Reference
PMID:30837838
  Authors
Prasad A, Bharathi V, Sivalingam V, Girdhar A, Patel BK
  Title
Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis.
  Journal
Front Mol Neurosci 12:25 (2019)
DOI:10.3389/fnmol.2019.00025
Reference
PMID:29626651
  Authors
Nguyen DKH, Thombre R, Wang J
  Title
Autophagy as a common pathway in amyotrophic lateral sclerosis.
  Journal
Neurosci Lett 697:34-48 (2019)
DOI:10.1016/j.neulet.2018.04.006
Reference
PMID:26264610
  Authors
Lee JK, Shin JH, Lee JE, Choi EJ
  Title
Role of autophagy in the pathogenesis of amyotrophic lateral sclerosis.
  Journal
Biochim Biophys Acta 1852:2517-24 (2015)
DOI:10.1016/j.bbadis.2015.08.005
Reference
PMID:28148298
  Authors
Oakes JA, Davies MC, Collins MO
  Title
TBK1: a new player in ALS linking autophagy and neuroinflammation.
  Journal
Mol Brain 10:5 (2017)
DOI:10.1186/s13041-017-0287-x
Reference
PMID:28878620
  Authors
Ramesh N, Pandey UB
  Title
Autophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand.
  Journal
Front Mol Neurosci 10:263 (2017)
DOI:10.3389/fnmol.2017.00263
Reference
PMID:17409386
  Authors
Kunita R, Otomo A, Mizumura H, Suzuki-Utsunomiya K, Hadano S, Ikeda JE
  Title
The Rab5 activator ALS2/alsin acts as a novel Rac1 effector through Rac1-activated endocytosis.
  Journal
J Biol Chem 282:16599-611 (2007)
DOI:10.1074/jbc.M610682200
Reference
PMID:17566607
  Authors
Hadano S, Kunita R, Otomo A, Suzuki-Utsunomiya K, Ikeda JE
  Title
Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration.
  Journal
Neurochem Int 51:74-84 (2007)
DOI:10.1016/j.neuint.2007.04.010
Reference
PMID:26388731
  Authors
Ruffoli R, Bartalucci A, Frati A, Fornai F
  Title
Ultrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesis.
  Journal
Front Cell Neurosci 9:341 (2015)
DOI:10.3389/fncel.2015.00341
Reference
PMID:25991442
  Authors
Menzies FM, Fleming A, Rubinsztein DC
  Title
Compromised autophagy and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 16:345-57 (2015)
DOI:10.1038/nrn3961
Reference
PMID:32119873
  Authors
Casterton RL, Hunt RJ, Fanto M
  Title
Pathomechanism Heterogeneity in the Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Disease Spectrum: Providing Focus Through the Lens of Autophagy.
  Journal
J Mol Biol 432:2692-2713 (2020)
DOI:10.1016/j.jmb.2020.02.018
Reference
PMID:28057298
  Authors
Lin G, Mao D, Bellen HJ
  Title
Amyotrophic Lateral Sclerosis Pathogenesis Converges on Defects in Protein Homeostasis Associated with TDP-43 Mislocalization and Proteasome-Mediated Degradation Overload.
  Journal
Curr Top Dev Biol 121:111-171 (2017)
DOI:10.1016/bs.ctdb.2016.07.004
Reference
PMID:24619348
  Authors
Hetz C, Mollereau B
  Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
  Journal
Nat Rev Neurosci 15:233-49 (2014)
DOI:10.1038/nrn3689
Reference
PMID:27815720
  Authors
Xiang C, Wang Y, Zhang H, Han F
  Title
The role of endoplasmic reticulum stress in neurodegenerative disease.
  Journal
Apoptosis 22:1-26 (2017)
DOI:10.1007/s10495-016-1296-4
Reference
PMID:29476642
  Authors
Hughes D, Mallucci GR
  Title
The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway.
  Journal
FEBS J 286:342-355 (2019)
DOI:10.1111/febs.14422
Reference
PMID:21722302
  Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
  Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
  Journal
J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:16472115
  Authors
Turner BJ, Atkin JD
  Title
ER stress and UPR in familial amyotrophic lateral sclerosis.
  Journal
Curr Mol Med 6:79-86 (2006)
DOI:10.2174/156652406775574550
Reference
PMID:18519638
  Authors
Nishitoh H, Kadowaki H, Nagai A, Maruyama T, Yokota T, Fukutomi H, Noguchi T, Matsuzawa A, Takeda K, Ichijo H
  Title
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.
  Journal
Genes Dev 22:1451-64 (2008)
DOI:10.1101/gad.1640108
Reference
PMID:21834058
  Authors
Walker AK, Atkin JD
  Title
Stress signaling from the endoplasmic reticulum: A central player in the pathogenesis of amyotrophic lateral sclerosis.
  Journal
IUBMB Life 63:754-63 (2011)
DOI:10.1002/iub.520
Reference
PMID:31319884
  Authors
Renaud L, Picher-Martel V, Codron P, Julien JP
  Title
Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia.
  Journal
Acta Neuropathol Commun 7:103 (2019)
DOI:10.1186/s40478-019-0758-7
Reference
PMID:29605155
  Authors
Nguyen HP, Van Broeckhoven C, van der Zee J
  Title
ALS Genes in the Genomic Era and their Implications for FTD.
  Journal
Trends Genet 34:404-423 (2018)
DOI:10.1016/j.tig.2018.03.001
Reference
PMID:25071440
  Authors
Atkin G, Paulson H
  Title
Ubiquitin pathways in neurodegenerative disease.
  Journal
Front Mol Neurosci 7:63 (2014)
DOI:10.3389/fnmol.2014.00063
Reference
PMID:29299811
  Authors
Kim JM, Billington E, Reyes A, Notarianni T, Sage J, Agbas E, Taylor M, Monast I, Stanford JA, Agbas A
  Title
Impaired Cu-Zn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1(G93A) Rodent Spinal Cord Tissue.
  Journal
Neurochem Res 44:228-233 (2019)
DOI:10.1007/s11064-017-2461-z
Reference
PMID:30242016
  Authors
Benarroch EE
  Title
Sigma-1 receptor and amyotrophic lateral sclerosis.
  Journal
Neurology 91:743-747 (2018)
DOI:10.1212/WNL.0000000000006347
Reference
PMID:23361386
  Authors
Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Related
pathway
mcoc00190  Oxidative phosphorylation
mcoc03013  Nucleocytoplasmic transport
mcoc03050  Proteasome
mcoc04010  MAPK signaling pathway
mcoc04012  ErbB signaling pathway
mcoc04020  Calcium signaling pathway
mcoc04115  p53 signaling pathway
mcoc04137  Mitophagy - animal
mcoc04140  Autophagy - animal
mcoc04141  Protein processing in endoplasmic reticulum
mcoc04210  Apoptosis
mcoc04724  Glutamatergic synapse
mcoc04810  Regulation of actin cytoskeleton
KO pathway
ko05014   
LinkDB

DBGET integrated database retrieval system