KEGG   PATHWAY: ola04010
Entry
ola04010                    Pathway                                
Name
MAPK signaling pathway - Oryzias latipes (Japanese medaka)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ola04010  MAPK signaling pathway
ola04010

Other DBs
GO: 0000165
Organism
Oryzias latipes (Japanese medaka) [GN:ola]
Gene
105357443  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X3 [KO:K04344]
101170273  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
101167885  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
101157063  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
101173517  voltage-dependent L-type calcium channel subunit alpha-1C isoform X3 [KO:K04850]
101171831  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101157531  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101163316  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
101173258  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
101171913  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
101171727  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04853]
101161560  voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
101169039  voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
110013491  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
101170269  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1 isoform X2 [KO:K04857]
101160313  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
101156213  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
101164397  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
101156079  voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
101155679  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
101158014  voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
101159822  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
101171407  voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
101173028  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
101157217  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X5 [KO:K04862]
101161015  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
101164307  voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
101157698  voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
100192310  cacnb4.1; calcium channel, voltage-dependent, beta 4 subunit [KO:K04865]
101158981  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
101163462  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
101160714  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
101167711  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
101174247  cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
101166629  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
101161218  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
101161488  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
101167457  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
101171469  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
101167428  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
101159506  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
101163670  voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
101165420  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
101173155  voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
101164920  voltage-dependent calcium channel gamma-7 subunit isoform X2 [KO:K04872]
101163260  voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
101165174  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
101160964  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101163742  cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101170876  cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
101160305  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
101159746  protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
101160465  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105353642  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101161464  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101164921  protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
101166935  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
110015484  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
101161831  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X2 [KO:K04347]
101156706  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101162612  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101168142  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101172250  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101169815  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101168674  calcineurin subunit B type 1-like [KO:K06268]
101161991  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
101158694  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101154767  ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
101157792  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
101156500  rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
101169327  rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
101159840  RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
101160849  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
101172059  ras guanyl-releasing protein 3-like [KO:K12362]
105353619  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
101158677  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
101162776  nf1; neurofibromin isoform X1 [KO:K08052]
101165895  rasa1; ras GTPase-activating protein 1 [KO:K04352]
101167470  rasa2; ras GTPase-activating protein 2 [KO:K08053]
101167529  ras-related protein Rap-1A [KO:K04353]
101171247  ras-related protein O-Krev [KO:K04353]
101172864  ras-related protein Rap-1b [KO:K07836]
101167023  egf; pro-epidermal growth factor [KO:K04357]
101166855  uncharacterized protein LOC101166855 [KO:K08774]
101166137  proepiregulin [KO:K09784]
101168387  fgf1; fibroblast growth factor 1 isoform X5 [KO:K18496]
101161650  putative fibroblast growth factor 1 [KO:K18496]
100049318  fgf20a; fibroblast growth factor 20a [KO:K04358]
100049319  fgf20b; fibroblast growth factor 20b [KO:K04358]
101169181  fgf4; fibroblast growth factor 4 [KO:K04358]
101174814  fgf3; fibroblast growth factor 3 isoform X1 [KO:K04358]
101173793  fgf18; fibroblast growth factor 18 isoform X3 [KO:K04358]
101174421  fgf6; fibroblast growth factor 6 [KO:K04358]
101174269  fgf10; fibroblast growth factor 10 [KO:K04358]
101167802  fgf16; fibroblast growth factor 16 isoform X1 [KO:K04358]
101174326  fibroblast growth factor 8b-like [KO:K04358]
100125457  fgf8; fibroblast growth factor 8 isoform X2 [KO:K04358]
101159024  fgf5; fibroblast growth factor 5 [KO:K04358]
101162992  fibroblast growth factor 22 [KO:K04358]
101161850  fibroblast growth factor 6 [KO:K04358]
101171313  fgf7; fibroblast growth factor 7 [KO:K04358]
101168929  fgf19; fibroblast growth factor 19 [KO:K22603]
111946374  fibroblast growth factor 21-like [KO:K22429]
101158272  uncharacterized protein LOC101158272 [KO:K22428]
101175208  fgf23; fibroblast growth factor 23 isoform X1 [KO:K22428]
101164147  nerve growth factor-like [KO:K02582]
101157368  nerve growth factor [KO:K02582]
101167940  bdnf; brain-derived neurotrophic factor isoform X2 [KO:K04355]
101173352  ntf3; neurotrophin-3 isoform X1 [KO:K04356]
100125446  insulin [KO:K04526]
101172253  insulin-like [KO:K04526]
105354483  insulin-like growth factor I [KO:K05459]
101168167  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
101172047  igf2; insulin-like growth factor II [KO:K13769]
101156252  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
101171139  platelet-derived growth factor subunit A-like [KO:K04359]
101162100  pdgfb; platelet-derived growth factor subunit B [KO:K17386]
101159654  pdgfc; platelet-derived growth factor C [KO:K05450]
101163754  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
101175300  kitlg; kit ligand [KO:K05461]
105357082  uncharacterized protein LOC105357082 [KO:K05461]
105354863  vegfb; vascular endothelial growth factor B isoform X1 [KO:K05448]
100125510  vegfa; vascular endothelial growth factor A isoform X2 [KO:K05448]
101161449  placenta growth factor [KO:K16859]
101168772  vascular endothelial growth factor C [KO:K05449]
100125534  vegfc; vascular endothelial growth factor C precursor [KO:K05449]
101167035  hgf; hepatocyte growth factor [KO:K05460]
101156453  hepatocyte growth factor [KO:K05460]
101171463  angiopoietin-1 isoform X1 [KO:K05465]
101170856  angpt1; angiopoietin-1 [KO:K05465]
101154790  angiopoietin-2 [KO:K05466]
101168484  angpt2; angiopoietin-2 [KO:K05466]
101155840  ephrin-A2 [KO:K05462]
101164066  efna5; ephrin-A5 isoform X1 [KO:K05462]
101160423  ephrin-A3 [KO:K05462]
111948169  ephrin-A1-like isoform X1 [KO:K05462]
101159120  ephrin-A5b [KO:K05462]
101174773  ephrin-A4 [KO:K05462]
101169993  efna1; ephrin-A1 [KO:K05462]
101175360  ephrin-A2 isoform X1 [KO:K05462]
101175022  efna3; ephrin-A3 [KO:K05462]
101173472  glial cell line-derived neurotrophic factor [KO:K05452]
101164238  gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105356296  neurturin [KO:K25414]
101162318  artemin [KO:K25415]
101170641  pspn; persephin [KO:K25416]
101159776  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101169984  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
101174230  receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
101172402  erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101172978  receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
101165379  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101165111  erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
100125448  fgfr1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
101155126  fibroblast growth factor receptor 1-A [KO:K04362] [EC:2.7.10.1]
100049483  fgfr2; fibroblast growth factor receptor 2 isoform X2 [KO:K05093] [EC:2.7.10.1]
101174210  fibroblast growth factor receptor homolog 1 isoform X1 [KO:K05093] [EC:2.7.10.1]
100049424  fgfr3; fibroblast growth factor receptor 3 isoform X3 [KO:K05094] [EC:2.7.10.1]
100049521  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101170271  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101163518  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101166088  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101164184  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101159930  BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101172248  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101166254  insulin receptor [KO:K04527] [EC:2.7.10.1]
101168764  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
101173298  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101163560  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100049280  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101156428  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101155039  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111948643  macrophage colony-stimulating factor 1 receptor 2-like [KO:K05090] [EC:2.7.10.1]
101157786  macrophage colony-stimulating factor 1 receptor 1 isoform X1 [KO:K05090] [EC:2.7.10.1]
101161964  kit; mast/stem cell growth factor receptor Kit isoform X4 [KO:K05091] [EC:2.7.10.1]
101164953  mast/stem cell growth factor receptor kita [KO:K05091] [EC:2.7.10.1]
101173420  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
110013400  receptor-type tyrosine-protein kinase FLT3-like isoform X1 [KO:K05092] [EC:2.7.10.1]
100049480  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
101172940  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100335137  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101162439  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101174570  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101154942  ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
101158510  ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101156037  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101160816  grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101168334  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101166461  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101165278  hras; GTPase HRas [KO:K02833]
100049322  kras; GTPase KRas [KO:K07827]
101154954  GTPase HRas [KO:K07827]
101162668  rras2; ras-related protein R-Ras2 [KO:K07830]
101174431  ras-related protein R-Ras [KO:K07830]
101159234  mras; ras-related protein M-Ras [KO:K07831]
101159594  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101155814  braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101173784  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101162677  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101173453  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101169004  lamtor3; ragulator complex protein LAMTOR3 isoform X2 [KO:K04370]
101159747  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101162905  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101154939  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
101172484  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
101168378  rps6ka6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
101169648  ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
101163402  ribosomal protein S6 kinase alpha-2-like isoform X1 [KO:K04373] [EC:2.7.11.1]
101165012  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
101172388  atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101168714  atf4-2; cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
101165887  ETS domain-containing protein Elk-1 [KO:K04375]
101171074  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
101164933  myc; myc proto-oncogene protein [KO:K04377]
101171524  c-myc17; uncharacterized protein LOC101171524 [KO:K04377]
101171772  srf; serum response factor isoform X1 [KO:K04378]
105358811  serum response factor-like isoform X1 [KO:K04378]
100820712  c-fos; c-fos protein [KO:K04379]
101167759  proto-oncogene c-Fos [KO:K04379]
101165186  proto-oncogene c-Fos isoform X1 [KO:K04379]
101160113  microtubule-associated protein tau isoform X1 [KO:K04380]
111948201  stathmin-like [KO:K04381]
101174071  stathmin [KO:K04381]
101172400  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101156151  pla2g4c; cytosolic phospholipase A2 gamma isoform X2 [KO:K16342] [EC:3.1.1.4]
101172593  tumor necrosis factor-like [KO:K03156]
101169209  interleukin-1 beta [KO:K04519]
101157631  transforming growth factor beta-1 [KO:K13375]
101155037  transforming growth factor beta-2 [KO:K13376]
101165927  tgfb3; transforming growth factor beta-3 [KO:K13377]
101155815  transforming growth factor beta-3 [KO:K13377]
105355952  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105354417  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101157257  interleukin-1 receptor type 1 [KO:K04386]
101168842  il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
101170689  tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101174785  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101159737  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101167049  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
101172757  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101159016  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101175028  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101158699  ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
101163549  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105354522  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101164658  cell division control protein 42 homolog [KO:K04393]
101164400  cell division control protein 42 homolog isoform X1 [KO:K04393]
101172972  cell division control protein 42 homolog isoform X1 [KO:K04393]
101174454  cell division control protein 42 homolog [KO:K04393]
101165962  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100049215  casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100049265  caspase 3B [KO:K02187] [EC:3.4.22.56]
101159764  traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101155367  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101167626  TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
101167464  death domain-associated protein 6 [KO:K02308]
101168580  myd88; myeloid differentiation primary response protein MyD88 isoform X2 [KO:K04729]
101166698  interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
101158603  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101161132  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
100049506  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101165223  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101162606  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101174118  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
101155619  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
101163042  growth arrest and DNA damage-inducible protein GADD45 beta isoform X1 [KO:K04402]
111946817  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
101163057  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
101168511  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
101156202  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
101165250  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
101174648  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
101157981  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
101156098  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
101164663  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101167280  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101169249  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101175466  serine/threonine-protein kinase 4 [KO:K04411]
101155570  serine/threonine-protein kinase 3 [KO:K04412]
101155229  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
101159779  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
101166009  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
101160297  map3k2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
101169290  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
101156127  mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
101169326  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
101161665  map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
101172131  mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
101160549  mitogen-activated protein kinase kinase kinase 12 isoform X2 [KO:K04423] [EC:2.7.11.25]
101162759  mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
101170310  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
101160858  map3k20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
101168074  mitogen-activated protein kinase kinase kinase 21 [KO:K04424] [EC:2.7.11.25]
101167985  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101175702  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101164271  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
105356874  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
101174856  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
101155230  serine/threonine-protein kinase TAO2 isoform X2 [KO:K04429] [EC:2.7.11.1]
101156330  taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
101163990  serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
101166893  serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
101169206  serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
101160676  serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
101174917  map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101161098  dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
101164950  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101170843  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101163933  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105354262  C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
101159567  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
101169779  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
101157621  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
101173301  filamin-A isoform X3 [KO:K04437]
101157634  crk; adapter molecule crk isoform X1 [KO:K04438]
110016423  adapter molecule crk [KO:K04438]
101164077  crkl; crk-like protein [KO:K04438]
101163309  arrb1; beta-arrestin-1 [KO:K04439]
101159286  arrb2; beta-arrestin-2 [KO:K04439]
101157952  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101168799  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101164997  mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
101158978  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101171243  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101160731  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
101159668  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101162042  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
101172944  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101175696  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101154993  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101160912  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
101157364  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101159256  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04444] [EC:2.7.11.1]
101156158  MAP kinase-activated protein kinase 2 [KO:K04444] [EC:2.7.11.1]
101166594  ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
101167564  ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
101168663  cdc25b; M-phase inducer phosphatase 2 isoform X2 [KO:K05866] [EC:3.1.3.48]
101161493  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101158005  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101173291  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101172896  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
101174822  transcription factor AP-1 [KO:K04448]
101173011  jun; transcription factor AP-1 [KO:K04448]
101160956  transcription factor AP-1 [KO:K04448]
101168195  jund; transcription factor jun-D [KO:K04449]
101161843  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100049321  tp53; cellular tumor antigen p53 [KO:K04451]
101163653  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
101169155  protein max [KO:K04453]
101172048  protein max isoform X7 [KO:K04453]
101160563  mef2c; myocyte-specific enhancer factor 2C isoform X9 [KO:K04454]
101160992  myocyte-specific enhancer factor 2C-like isoform X1 [KO:K04454]
101166150  heat shock protein beta-1 [KO:K04455]
101174244  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101162468  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101174851  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101172294  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101155451  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101159369  protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
101170947  protein phosphatase 1B [KO:K04457] [EC:3.1.3.16]
101155070  ppm1a; protein phosphatase 1A isoform X3 [KO:K04457] [EC:3.1.3.16]
101171625  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
101163224  tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
101170079  ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
101173794  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101174193  dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101161296  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101157459  dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111946967  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101166402  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101158832  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101158099  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101175078  dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101164462  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101167166  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101173264  dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101172819  dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101158545  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
101156612  protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
101157967  ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
100125492  hsp70-5; heat shock protein 70 [KO:K03283]
100125493  hsp70-3; heat shock protein 70 [KO:K03283]
100049425  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
111947723  heat shock 70 kDa protein 1 [KO:K03283]
101169944  heat shock 70 kDa protein 1 [KO:K03283]
111947725  heat shock 70 kDa protein 1 [KO:K03283]
100125490  heat shock cognate 70 kDa protein [KO:K03283]
101169455  heat shock 70 kDa protein 1-like [KO:K03283]
101169474  mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
101169919  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X2 [KO:K04463] [EC:2.7.12.2]
101157651  mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
101175402  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101165550  probable nuclear hormone receptor HR38 [KO:K04465]
101174595  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101166422  uncharacterized protein LOC101166422 isoform X1 [KO:K04466] [EC:2.7.11.25]
101171857  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101159621  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101170684  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101162681  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101162387  nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101168711  serine/threonine-protein kinase NLK2 [KO:K04468] [EC:2.7.11.24]
101167764  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101166900  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X3 [KO:K04469]
101158728  putative transcription factor p65 homolog [KO:K04735]
101157716  relb; transcription factor RelB isoform X2 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
PMID:22296764
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Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
ola04070  Phosphatidylinositol signaling system
ola04110  Cell cycle
ola04115  p53 signaling pathway
ola04210  Apoptosis
ola04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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