KEGG   PATHWAY: pvp04151
Entry
pvp04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Pteropus vampyrus (large flying fox)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
pvp04151  PI3K-Akt signaling pathway
pvp04151

Other DBs
GO: 0043491
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105293045  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105295757  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
105292346  EREG; proepiregulin [KO:K09784]
105292347  AREG; amphiregulin [KO:K09782]
105297044  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105288737  FGF7; fibroblast growth factor 7 [KO:K04358]
105296547  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105304647  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105292122  FGF9; fibroblast growth factor 9 [KO:K04358]
105292386  FGF5; fibroblast growth factor 5 [KO:K04358]
105299317  FGF18; fibroblast growth factor 18 [KO:K04358]
105293259  FGF6; fibroblast growth factor 6 [KO:K04358]
105301286  FGF10; fibroblast growth factor 10 [KO:K04358]
105308889  FGF16; fibroblast growth factor 16 [KO:K04358]
105309888  fibroblast growth factor 4-like [KO:K04358]
105311363  FGF4; fibroblast growth factor 4 [KO:K04358]
105295548  FGF20; fibroblast growth factor 20 [KO:K04358]
105302250  FGF22; fibroblast growth factor 22 [KO:K04358]
105307123  fibroblast growth factor 19-like [KO:K22603]
105307127  fibroblast growth factor 19-like [KO:K22603]
105301799  FGF21; fibroblast growth factor 21 [KO:K22429]
105293279  FGF23; fibroblast growth factor 23 [KO:K22428]
105296475  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
105293721  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105295984  NTF3; neurotrophin-3 [KO:K04356]
105301755  neurotrophin-4 [KO:K12457]
105301756  NTF4; neurotrophin-4 [KO:K12457]
105310714  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
105299512  IGF2; insulin-like growth factor II [KO:K13769]
105294593  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105298078  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105297442  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105292199  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105297143  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105293228  KITLG; kit ligand isoform X1 [KO:K05461]
105301742  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
105310803  fms-related tyrosine kinase 3 ligand-like isoform X1 [KO:K05454]
105288488  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105297988  VEGFB; vascular endothelial growth factor B [KO:K16858]
105299223  PGF; placenta growth factor isoform X1 [KO:K16859]
105299636  VEGFC; vascular endothelial growth factor C [KO:K05449]
105293998  VEGFD; vascular endothelial growth factor D [KO:K05449]
105295521  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105298291  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105305272  ANGPT2; angiopoietin-2 [KO:K05466]
105305482  ANGPT4; angiopoietin-4 [KO:K05467]
105296373  EFNA1; ephrin-A1 [KO:K05462]
105296374  EFNA4; ephrin-A4 [KO:K05462]
105296443  EFNA3; ephrin-A3 [KO:K05462]
105302235  EFNA2; ephrin-A2 [KO:K05462]
105295466  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
105299104  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105311595  LOW QUALITY PROTEIN: neurturin [KO:K25414]
105301078  PSPN; persephin [KO:K25416]
105306141  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
105307498  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105302594  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105291094  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
105300315  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105291441  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105301871  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
105293516  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
105295432  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105296416  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
105300054  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
105307438  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
105290270  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105293808  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105299436  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105299435  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105293773  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105292132  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105292131  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105307777  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
105300011  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105293771  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105300269  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105308731  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
105294337  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105309193  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X4 [KO:K05126] [EC:2.7.10.1]
105293353  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105292949  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105309535  SOS2; son of sevenless homolog 2 [KO:K03099]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105294059  KRAS; GTPase KRas isoform X2 [KO:K07827]
105296550  NRAS; GTPase NRas isoform X1 [KO:K07828]
105299021  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105309827  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105306744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105294748  IRS1; insulin receptor substrate 1 [KO:K16172]
105291526  TLR2; toll-like receptor 2 [KO:K10159]
105292652  TLR4; toll-like receptor 4 [KO:K10160]
105294623  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105300248  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
105304584  CD19; B-lymphocyte antigen CD19 [KO:K06465]
105301401  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
105297761  somatotropin [KO:K05438]
105306493  PRL; prolactin [KO:K05439]
105300916  OSM; oncostatin-M [KO:K05418]
105302208  IL2; interleukin-2 [KO:K05429]
105293643  interleukin-3-like [KO:K04736]
105293152  IL6; interleukin-6 isoform X2 [KO:K05405]
105293550  IL4; interleukin-4 [KO:K05430]
105302950  IL7; interleukin-7 isoform X1 [KO:K05431]
105298437  interferon alpha-1-like [KO:K05414]
105309143  interferon alpha-4-like [KO:K05414]
105309144  interferon alpha-4-like [KO:K05414]
105309148  interferon alpha-10-like [KO:K05414]
105309141  IFNB1; interferon beta [KO:K05415]
105299734  EPO; erythropoietin [KO:K05437]
105307511  CSF3; granulocyte colony-stimulating factor [KO:K05423]
105299105  GHR; growth hormone receptor [KO:K05080]
105305879  PRLR; prolactin receptor [KO:K05081]
105299113  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
105307737  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
105311493  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
105299605  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
105308004  interleukin-3 receptor subunit alpha-like [KO:K04737]
105296452  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
105303367  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
105305877  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
105295861  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105301255  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
105305625  EPOR; erythropoietin receptor [KO:K05079]
105290707  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
105298360  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
105303192  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105296612  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
105294361  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105295430  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105297573  COL2A1; collagen alpha-1(II) chain [KO:K19719]
105294766  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
105296151  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
105301331  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
105294764  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
105301330  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105296119  collagen alpha-5(IV) chain isoform X1 [KO:K06237]
105288504  collagen alpha-6(VI) chain [KO:K06238]
105288515  collagen alpha-4(VI) chain-like [KO:K06238]
105305972  collagen alpha-1(VI) chain-like [KO:K06238]
105308836  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
105308677  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
105304051  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
105292803  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
105301451  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105291179  LAMA2; laminin subunit alpha-2 [KO:K05637]
105296207  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
105292271  LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240]
105301444  LAMA5; laminin subunit alpha-5 [KO:K06240]
105295219  LAMA4; laminin subunit alpha-4 [KO:K06241]
105300344  LAMB1; laminin subunit beta-1 [KO:K05636]
105302419  LAMB2; laminin subunit beta-2 [KO:K06243]
105302420  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
105300311  laminin subunit beta-3 [KO:K06244]
105300342  LAMB4; laminin subunit beta-4 [KO:K06245]
105292827  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
105292869  LAMC2; laminin subunit gamma-2 [KO:K06246]
105298668  LAMC3; laminin subunit gamma-3 [KO:K06247]
105295400  CHAD; chondroadherin [KO:K06248]
105295497  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
105288620  THBS1; thrombospondin-1 [KO:K16857]
105296367  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105296582  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
105303667  THBS4; thrombospondin-4 [KO:K04659]
105303727  THBS2; thrombospondin-2 [KO:K04659]
105291123  FN1; fibronectin [KO:K05717]
105289571  SPP1; osteopontin [KO:K06250]
105292010  VTN; vitronectin [KO:K06251]
105305336  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
105292688  TNC; tenascin [KO:K06252]
105292895  TNN; tenascin-N [KO:K06252]
105292894  TNR; tenascin-R [KO:K06252]
105296024  VWF; von Willebrand factor [KO:K03900]
105289573  IBSP; bone sialoprotein 2 [KO:K06253]
105307929  ITGA1; integrin alpha-1 [KO:K06480]
105307927  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
105303529  ITGA2B; integrin alpha-IIb [KO:K06476]
105295411  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
105291916  ITGA4; integrin alpha-4 [KO:K06483]
105302702  ITGA5; integrin alpha-5 [KO:K06484]
105290414  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105302613  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105305015  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
105288745  ITGA9; integrin alpha-9 [KO:K06585]
105297781  ITGA10; integrin alpha-10 [KO:K06586]
105310261  ITGA11; integrin alpha-11 [KO:K06587]
105289673  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
105303008  ITGB1; integrin beta-1 [KO:K05719]
105303446  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105293425  ITGB4; integrin beta-4 [KO:K06525]
105297528  ITGB5; integrin beta-5 [KO:K06588]
105291118  ITGB6; integrin beta-6 isoform X4 [KO:K06589]
105302663  ITGB7; integrin beta-7 [KO:K06590]
105293829  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105307748  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105297140  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105302193  F2R; proteinase-activated receptor 1 [KO:K03914]
105297824  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105291625  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105295316  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
105296556  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
105289073  LPAR3; lysophosphatidic acid receptor 3 isoform X2 [KO:K04294]
105307100  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105295963  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105300022  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
105303584  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105299738  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105295952  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105307521  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105288758  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105309385  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
105297807  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X2 [KO:K04540]
105302718  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
105289068  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105310269  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
111744611  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
105307968  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
105294373  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105307158  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
105295886  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105303281  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X4 [KO:K04547]
105294383  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105307274  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
105300332  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
105291261  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
105291351  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
105303144  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105302230  STK11; LOW QUALITY PROTEIN: serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
105299096  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
105298997  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
105288832  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105298655  TSC1; hamartin isoform X1 [KO:K07206]
105303335  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
105303777  RHEB; GTP-binding protein Rheb [KO:K07208]
105303344  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
105294429  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105301186  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
105300185  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105289536  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
105305994  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
105293632  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
105306550  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
105302100  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105302672  EIF4B; eukaryotic translation initiation factor 4B isoform X2 [KO:K03258]
105295596  RPS6; 40S ribosomal protein S6 [KO:K02991]
105297702  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105308506  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
105289090  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
105294806  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
105289483  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
105298240  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
105295079  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105300159  RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105290992  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X8 [KO:K05631]
105293112  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105303852  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
105299964  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105293570  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
105306596  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
105295648  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
105304489  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
105292175  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
105297060  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
105300821  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
105309591  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2 [KO:K11583]
105303199  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
105288460  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
105297866  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
105308612  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
105299291  PPP2R5C; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
105295010  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
105288497  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
105299280  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
105310743  HSP90B1; endoplasmin [KO:K09487]
105305598  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
105296392  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
105305861  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
105292752  PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
105298802  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
105302510  MTCP1; protein p13 MTCP-1 [KO:K16837]
105303769  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
105306256  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
105301304  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105306545  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
105301759  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
105298776  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
105310334  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
105290741  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
105306265  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
105303498  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
105292561  MYC; myc proto-oncogene protein [KO:K04377]
105307128  uncharacterized protein LOC105307128 [KO:K04503]
105288383  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105302792  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
105302600  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105307393  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
105294446  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
105293261  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105288434  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
105308799  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
105295250  FOXO3; forkhead box protein O3 [KO:K09408]
105292082  RBL2; retinoblastoma-like protein 2 [KO:K16332]
105299797  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105303970  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
105298225  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
105302907  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
105291867  YWHAE; 14-3-3 protein epsilon [KO:K06630]
105299698  YWHAG; 14-3-3 protein gamma [KO:K16198]
105308338  YWHAH; 14-3-3 protein eta [KO:K16198]
105297848  BAD; bcl2-associated agonist of cell death [KO:K02158]
105305503  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105292717  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
105294412  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105298404  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105290195  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105298070  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105296460  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
105306745  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
105290070  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
105306466  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
105291624  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105293217  cyclic AMP-responsive element-binding protein 5 [KO:K09047]
105305286  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
105303816  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
105302941  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
105307011  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
105302532  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105304619  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105301022  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105297999  RELA; transcription factor p65 [KO:K04735]
105293029  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105289479  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
105301329  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
105291226  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
pvp00010  Glycolysis / Gluconeogenesis
pvp04010  MAPK signaling pathway
pvp04012  ErbB signaling pathway
pvp04062  Chemokine signaling pathway
pvp04064  NF-kappa B signaling pathway
pvp04068  FoxO signaling pathway
pvp04110  Cell cycle
pvp04115  p53 signaling pathway
pvp04150  mTOR signaling pathway
pvp04210  Apoptosis
pvp04370  VEGF signaling pathway
pvp04510  Focal adhesion
pvp04620  Toll-like receptor signaling pathway
pvp04630  JAK-STAT signaling pathway
pvp04662  B cell receptor signaling pathway
pvp04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

DBGET integrated database retrieval system