KEGG ORTHOLOGY: K04505

ORTHOLOGY: K04505

Entry

K04505                      KO

Symbol

PSEN1, PS1

Name

presenilin 1 [EC:3.4.23.-]

Pathway

map04310

Wnt signaling pathway

map04330

Notch signaling pathway

map04361

Axon regeneration

map04722

Neurotrophin signaling pathway

map05010

Alzheimer disease

map05022

Pathways of neurodegeneration - multiple diseases

map05165

Human papillomavirus infection

Disease

H00056

Alzheimer disease

H00078

Frontotemporal lobar degeneration

H00294

Dilated cardiomyopathy

H00681

Acne inversa

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04505  PSEN1, PS1; presenilin 1
   04330 Notch signaling pathway
    K04505  PSEN1, PS1; presenilin 1
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04505  PSEN1, PS1; presenilin 1
  09158 Development and regeneration
   04361 Axon regeneration
    K04505  PSEN1, PS1; presenilin 1
09160 Human Diseases
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K04505  PSEN1, PS1; presenilin 1
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04505  PSEN1, PS1; presenilin 1
   05022 Pathways of neurodegeneration - multiple diseases
    K04505  PSEN1, PS1; presenilin 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04505  PSEN1, PS1; presenilin 1
Peptidases and inhibitors [BR:ko01002]
Aspartic peptidases
  Family A22: presenilin family
   K04505  PSEN1, PS1; presenilin 1

Other DBs

GO:	0005262 0008013 0042500 0045296

TC:	1.A.54.1.1

Genes

HSA:	5663(PSEN1)

PTR:	739740(PSEN1)

PPS:	100969213(PSEN1)

GGO:	101137687(PSEN1)

PON:	100173083(PSEN1)

PPYG:

129012559(PSEN1)

NLE:	100586383(PSEN1)

HMH:	116484654(PSEN1)

SSYN:

129487692(PSEN1)

MCC:	696274(PSEN1)

MCF:	102138674(PSEN1)

MTHB:

126959532

MNI:	105494293(PSEN1)

CSAB:

103229302(PSEN1)

CATY:

105599553(PSEN1)

PANU:

101000508(PSEN1)

TGE:	112628561(PSEN1)

MLEU:

105541857(PSEN1)

RRO:	104656202(PSEN1)

RBB:	108536192(PSEN1)

TFN:	117069370(PSEN1)

PTEH:

111520458(PSEN1)

CANG:

105517190(PSEN1)

CJC:	100401034(PSEN1)

SBQ:	101027408(PSEN1)

CIMI:

108304377(PSEN1)

ANAN:

105707273(PSEN1)

CSYR:

103272106(PSEN1)

MMUR:

105858213(PSEN1)

LCAT:

123647138(PSEN1)

PCOQ:

105819854(PSEN1)

MMU:	19164(Psen1)

MCAL:

110306943(Psen1)

MPAH:

110324269(Psen1)

RNO:	29192(Psen1)

MCOC:

116079629(Psen1)

ANU:	117697133(Psen1)

MUN:	110558609(Psen1)

CGE:	100770550(Psen1)

MAUA:

101839207(Psen1)

PROB:

127230950(Psen1)

PLEU:

114698444(Psen1)

MORG:

121452267(Psen1)

MFOT:

126515147

AAMP:

119818546(Psen1)

NGI:	103747390(Psen1)

HGL:	101716186(Psen1)

CPOC:

100728153(Psen1)

CCAN:

109693684(Psen1)

DORD:

105986114(Psen1)

DSP:	122118706(Psen1)

PLOP:

125363459(Psen1)

NCAR:

124976090

MMMA:

107148860(Psen1)

OCU:

100008886

TUP:	102497708(PSEN1)

GVR:	103599728(PSEN1)

CFA:	403408(PSEN1)

CLUD:

112658022(PSEN1)

VVP:	112927245(PSEN1)

VLG:	121493104(PSEN1)

NPO:	129496031(PSEN1)

AML:	100477956(PSEN1)

UMR:	103671416(PSEN1)

UAH:	113270366(PSEN1)

UAR:	123799015(PSEN1)

ELK:

111148789

LLV:

125103933

MPUF:

101692341(PSEN1)

MNP:	132000196(PSEN1)

MLK:	131836905(PSEN1)

NVS:	122893867(PSEN1)

ORO:	101382233(PSEN1)

EJU:	114198138(PSEN1)

ZCA:	113908939(PSEN1)

MLX:	118002427(PSEN1)

NSU:	110571627(PSEN1)

LWW:	102741649(PSEN1)

FCA:	101087239(PSEN1)

PYU:	121032012(PSEN1)

PCOO:

112856080(PSEN1)

PBG:	122469289(PSEN1)

PVIV:

125167696(PSEN1)

LRUF:

124512055

PTG:	102966511(PSEN1)

PPAD:

109253789(PSEN1)

PUC:

125909363

AJU:

106974447

HHV:	120222219(PSEN1)

BTA:	282705(PSEN1)

BOM:	102282629(PSEN1)

BIU:	109565317(PSEN1)

BBUB:

102395946(PSEN1)

BBIS:

105000100(PSEN1)

CHX:	102182879(PSEN1)

OAS:	101102488(PSEN1)

BTAX:

128053976(PSEN1)

ODA:	120852739(PSEN1)

CCAD:

122443826(PSEN1) 122454484

MBEZ:

129562460(PSEN1)

SSC:	780411(PSEN1)

CFR:	102507075(PSEN1)

CBAI:

105074854(PSEN1)

CDK:	105086131(PSEN1)

VPC:	102531879(PSEN1)

BACU:

103001941(PSEN1)

BMUS:

118890069(PSEN1)

LVE:	103070847(PSEN1)

OOR:	101274140(PSEN1)

DLE:	111176287(PSEN1)

PCAD:

102996079(PSEN1)

PSIU:

116748770(PSEN1)

NASI:

112394837(PSEN1)

ECB:	100050164(PSEN1)

EPZ:	103567122(PSEN1)

EAI:	106827683(PSEN1)

MYB:	102251307(PSEN1)

MYD:	102773904(PSEN1)

MMYO:

118657710(PSEN1)

MLF:	102435757(PSEN1)

PKL:	118715602(PSEN1)

EFUS:

103283603(PSEN1)

MNA:	107533468(PSEN1)

DRO:	112311152(PSEN1)

SHON:

118976976(PSEN1)

AJM:	119035518(PSEN1)

PDIC:

114492257(PSEN1)

PHAS:

123808027(PSEN1)

MMF:	118627610(PSEN1)

PPAM:

129065916(PSEN1)

HAI:	109381602(PSEN1)

RFQ:	117023253(PSEN1)

PALE:

102883360(PSEN1)

PGIG:

120619472(PSEN1)

PVP:	105299254(PSEN1)

RAY:	107505017(PSEN1)

MJV:	108395378(PSEN1)

TOD:	119239264(PSEN1)

SARA:

101541977(PSEN1)

SETR:

126004024(PSEN1) 126017356

LAV:	100669746(PSEN1)

TMU:

101347137

ETF:	101660004(PSEN1)

DNM:	101438038(PSEN1)

MDO:	100019628(PSEN1)

GAS:	123237791(PSEN1)

SHR:	100914418(PSEN1)

AFZ:

127549529

PCW:	110208361(PSEN1)

TVP:	118828181(PSEN1)

OAA:	100091250(PSEN1)

GGA:	373977(PSEN1)

PCOC:

116229246(PSEN1)

MGP:	100548338(PSEN1)

CJO:	107314867(PSEN1)

TPAI:

128086668(PSEN1)

LMUT:

125694437(PSEN1)

NMEL:

110401024(PSEN1)

APLA:

101804384(PSEN1)

ACYG:

106042662(PSEN1)

CATA:

118244863(PSEN1)

AFUL:

116489671(PSEN1)

TGU:	100223971(PSEN1)

LSR:	110472139(PSEN1)

SCAN:

103826631(PSEN1)

PMOA:

120500273(PSEN1)

OTC:	121333449(PSEN1)

PRUF:

121349521(PSEN1)

GFR:	102031986(PSEN1)

FAB:	101810998(PSEN1)

OMA:	130253726(PSEN1)

PHI:	102110260(PSEN1)

PMAJ:

107206154(PSEN1)

CCAE:

111930257(PSEN1)

CCW:	104683275(PSEN1)

CBRC:

103620786(PSEN1)

ETL:	114055470(PSEN1)

ZAB:	102067584(PSEN1)

ZLE:	135448432(PSEN1)

ACHL:

103806554(PSEN1)

SVG:	106849014(PSEN1)

MMEA:

130573800(PSEN1)

HRT:	120754347(PSEN1)

FPG:	101922107(PSEN1)

FCH:	102052047(PSEN1)

CLV:	102098339(PSEN1)

EGZ:	104132283(PSEN1)

NNI:	104020330(PSEN1)

PCRI:

104031783(PSEN1)

PLET:

104621651(PSEN1)

EHS:	104504896(PSEN1)

PCAO:

104048572(PSEN1)

ACUN:

113480611(PSEN1)

TALA:

104364631(PSEN1)

PADL:

103912788(PSEN1)

AFOR:

103898889(PSEN1)

ACHC:

115352859(PSEN1)

HALD:

104320529(PSEN1)

HLE:	104831124(PSEN1)

AGEN:

126049278

GCL:

127016620

CCRI:

104157995(PSEN1)

CSTI:

104556392(PSEN1)

CMAC:

104474980(PSEN1)

MUI:	104535253(PSEN1)

BREG:

104634481(PSEN1)

FGA:	104076841(PSEN1)

GSTE:

104258100(PSEN1)

LDI:	104354524(PSEN1)

MNB:	103770591(PSEN1)

OHA:	104328133(PSEN1)

NNT:	104403004(PSEN1)

SHAB:

115606846(PSEN1)

DPUB:

104300333(PSEN1)

PGUU:

104460374(PSEN1)

ACAR:

104530114(PSEN1)

CPEA:

104390575(PSEN1)

AVIT:

104278160(PSEN1)

CVF:	104284037(PSEN1)

RTD:	128908359(PSEN1)

CUCA:

104061824(PSEN1)

TEO:

104377453

BRHI:

104491509(PSEN1)

AAM:	106498263(PSEN1)

AROW:

112972368(PSEN1)

NPD:	112946699(PSEN1)

TGT:	104565229(PSEN1)

DNE:	112980673(PSEN1)

SCAM:

104141215(PSEN1)

ASN:	102377042(PSEN1)

AMJ:	102558796(PSEN1)

CPOO:

109321216(PSEN1)

GGN:	109298818(PSEN1)

PSS:	102445249(PSEN1)

CMY:	102942887(PSEN1)

CCAY:

125637852(PSEN1)

DCC:	119857156(PSEN1)

CPIC:

101947248(PSEN1)

TST:	117876818(PSEN1)

CABI:

116825385(PSEN1)

MRV:	120404701(PSEN1)

ACS:	100553615(psen1)

ASAO:

132766898(PSEN1)

PVT:	110088088(PSEN1)

SUND:

121934283

PBI:	103054489(PSEN1)

PMUR:

107294171(PSEN1)

CTIG:

120303250(PSEN1)

TSR:	106556916(PSEN1)

PGUT:

117665613(PSEN1)

APRI:

131187557(PSEN1)

PTEX:

113441950(PSEN1)

NSS:	113414278(PSEN1)

VKO:	123026440(PSEN1)

PMUA:

114594609(PSEN1)

PRAF:

128411814(PSEN1)

ZVI:	118083865(PSEN1)

HCG:	128339586(PSEN1)

GJA:	107117905(PSEN1)

STOW:

125426031(PSEN1)

EMC:	129324025(PSEN1)

XLA:	108699733(psen1.S) 399258(psen1.L)

XTR:	394924(psen1)

NPR:	108799871(PSEN1)

RTEM:

120920597(PSEN1)

BBUF:

120981859(PSEN1)

BGAR:

122921561(PSEN1)

MUO:	115477778(PSEN1)

GSH:	117364171(PSEN1)

DRE:	30221(psen1)

SRX:	107723284 107753355

SANH:

107684238 107687832

SGH:	107570253 107589779

CCAR:

109054586 109054589

CAUA:

113060378 113116959

CGIB:

127976284 128031384

PTET:

122362247(psen1)

LROH:

127179713(psen1)

OMC:	131522752(psen1)

PPRM:

120462472(psen1)

RKG:	130088867(psen1)

MAMB:

125268267(psen1)

CIDE:

127498783

MASI:

127410966 127455381

TROS:

130560214(psen1)

TDW:	130436794(psen1)

MANU:

129417027(psen1)

IPU:	108269999(psen1)

IFU:	128612875(psen1)

PHYP:

113538938

SMEO:

124390553(psen1)

TFD:	113659665(psen1)

TVC:	132852201(psen1)

TRN:	134325193(psen1)

AMEX:

103047839(psen1)

CMAO:

118823815(psen1)

EEE:

113580660

CHAR:

105899117(psen1)

TRU:

101077303

TFS:	130540165(psen1)

TNG:	GSTEN00004436G001

LCO:

104935360

TBEN:

117493854(psen1)

CGOB:

115027585

PGEO:

117467798

GACU:

117556760

EMAC:

134881523(psen1)

ELY:	117267573(psen1)

EFO:	125900918(psen1)

PLEP:

121953483(psen1)

SLUC:

116057560(psen1)

ECRA:

117935968(psen1)

ESP:

116686124

PFLV:

114546819

GAT:	120833066(psen1)

PPUG:

119227778(psen1)

AFB:	129103383(psen1)

CLUM:

117751364(psen1)

PSWI:

130201518(psen1)

MSAM:

119910220 119918994

SCHU:

122862196(psen1)

CUD:	121526321(psen1)

ALAT:

119004409(psen1)

MZE:

101485940

ONL:

100697238

OAU:	116318059(psen1)

OLA:

101154844

OML:	112148748(psen1)

CSAI:

133461974(psen1)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122846120(psen1)

PPRL:

129377441(psen1)

CVG:

107099431

CTUL:

119794937(psen1)

GMU:	124855699(psen1)

NFU:

107391854

KMR:	108237314(psen1)

ALIM:

106532604

NWH:	119427050(psen1)

AOCE:

111573543

MCEP:

125023599(psen1)

CSEM:

103381643

POV:

109636468

SSEN:

122783141(psen1)

HHIP:

117755654(psen1)

HSP:	118116313(psen1)

PPLT:

128451020(psen1)

SMAU:

118286307(psen1)

LCF:	108876619(psen1)

SDU:

111226163

SLAL:

111646823

XGL:	120795817(psen1)

HCQ:

109517281

SSCV:

125981025

SBIA:

133513398(psen1)

PEE:	133412999(psen1)

PTAO:

133487389(psen1)

BPEC:

110157438

MALB:

109962428

BSPL:

114848802(psen1)

SJO:	128375689(psen1)

SASA:

106580298 106611426

STRU:

115173027

OTW:	112236365(psen1)

OMY:	110498296(psen1)

OGO:	124002224(psen1) 124002267

ONE:

OKI:

OKE:

SNH:

CCLU:

ELS:

SFM:

PKI:	111852014(psen1)

AANG:

118208211(psen1)

LOC:	102685395(psen1)

PSPA:

121324431 121329794

ARUT:

117422675 117433704(psen1)

PSEX:

120518604(psen1)

LCM:	102350642(PSEN1)

CMK:	103178476 103191072

CPLA:

122553893(psen1)

HOC:	132817795(psen1)

LERI:

129700431(psen1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG18803(Psn)

DER:

6545885

DSE:

6616304

DSI:	Dsimw501_GD14885(Dsim_GD14885)

DYA:	Dyak_GE23235 Dyak_GE27522

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI13394

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108357363 108364854

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ009724

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:	115875138 115885380

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_202258

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110373378(psn)

HZE:

124639932

TNL:	113506695 113506733

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM238320

FOC:

113206431

TPAL:

117650268

ZNE:	110828598 110831731

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_205191(PSN)

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

DSV:	119458060 119462455

RSAN:

119374537

RMP:	119164778 119167506

TUT:

DPTE:

CSCU:

PTEP:

CEL:	CELE_C18E3.8(hop-1) CELE_F35H12.3(sel-12) CELE_ZK524.1(spe-4)

CBR:	CBG_08092(Cbr-sel-12) CBG_11944(Cbr-spe-4) CBG_11946 CBG_12097(Cbr-hop-1)

CRQ:	GCK72_000110 GCK72_022227

NAI:	NECAME_02694 NECAME_12266

BMY:	BM_BM3856(Bma-sel-12) BM_BM7487(Bma-spe-4.1)

LOA:	LOAG_09666 LOAG_17037

HRO:	HELRODRAFT_114139 HELRODRAFT_87358

LGI:	LOTGIDRAFT_138705

PCAN:

BGT:

GAE:

MYI:

PMAX:

OBI:

OSN:

LAK:

SMM:	Smp_153960

SHX:	MS3_00007567(PSEN1)

OVI:	T265_05825

EGL:

LLON:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

TAD:	TRIADDRAFT_57183

AQU:

100640576

ATH:	AT1G08700(PS1) AT2G29900(PS2)

ALY:	9315306 9328532

CRB:	17889410 17900297

CSAT:

104700510 104734101 104739465 104749900 104755057 104766991 104786681 104786909

EUS:	EUTSA_v10007596mg EUTSA_v10016742mg

BRP:	103868001 103871613

BNA:	106346314 106377250 106401110 106434107

BOE:	106294998 106336887

RSZ:	108812772 108812942

THJ:	104818347 104819399 104821361

CPAP:

110807083 110808796

CIT:	102610609 102625910

CIC:	CICLE_v10031453mg

PVY:	116105952 116109672 116109678 116122758

MINC:

123209324 123210022 123221357

TCC:	18599765 18604840

GRA:	105788183 105804379

GHI:	107890049 107941447 107948937 107953480

GAB:	108453389 108470557

HSYR:

120172246 120199125 120208576

DZI:	111276989 111289564 111291218 111294042

EGR:	104420568 104425312

GMX:	100780823 100799010 100799643 100819461

GSJ:	114391840 114400108 114405716 114411801

PVU:	PHAVU_001G107800g PHAVU_003G184600g

VRA:	106753789 106765558

VAR:	108327839 108331703

VUN:	114175129 114175261

VUM:	124824889 124830680

CCAJ:

109802017 109807836

APRC:

113847661 113863170

MTR:	11433216 25493887

TPRA:

123885354 123889223

CAM:	101508430 101513317

PSAT:

127073721 127126559

VVO:	131604566 131623674 131627753

LJA:	130711280 130729957

ADU:	107468621 107494298

AIP:	107604763 107627121 107634561

AHF:	112696858 112709613 112722587 112754719

LANG:

109353816 109358799

PCIN:

129309861 129317570 129319399

QSA:	O6P43_002220 O6P43_006247 O6P43_022913

FVE:	101311895 101312154

RCN:	112180201 112193521

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103436940 103437890 108169216

MSYL:

126599747 126626600 126627042

PXB:	103930624 103937705 103961085

ZJU:	107418931 107433021

MNT:	21385581 21390524

CSAV:

115709684 115723281

CSV:	101213290 101223166

CMO:	103492136 103495868

BHJ:	120074222 120082753

MCHA:

CMAX:

CMOS:

CPEP:

RCU:	8268579 8284429

MEAN:

126674789 126675529

JCU:	105632555 105640631

HBR:	110655759 110666511 110668412

MESC:

110616582 110619927 110621951

POP:	18105749 7482392

PEU:	105112543 105141512

PALZ:

118033412 118042437

JRE:	108994197 109007426

CILL:

122277158 122281862

CAVE:

132176434 132191587

QLO:	115951294 115951375 115965747

TWL:	119986491 120016663 120017014

VVI:	100262038 100263915

VRI:	117903940 117919782

SLY:	101254775 101256336

SPEN:

107012510 107031956

SOT:	102590742 102605567

SSTN:

125857758 125864723

SDUL:

129877489 129896207

CANN:

107843736 107862316

LBB:	132607302 132632858

NTA:	107765978 107790304 107802357 107823683

NSY:	104216181 104217320

NTO:	104089410 104091410

NAU:	109223768 109240948

INI:	109158967 109193483

ITR:	116008702 116030553

SIND:

105155770 105158005

OEU:	111369374 111372407

EGT:	105954845 105959943

SSPL:

121762080 121765036 121787265 121795788 121797651

SMIL:

131003519 131020326

SHIS:

125192737 125211138 125213480

APAN:

127241144 127256779

HAN:	110865433 110879650

ECAD:

122589096 122593216

LSV:	111902273 111917080

CCAV:

112507829 112529880

DCR:	108225010 108228150

CSIN:

114273002 114311556 114311906 114323058

RVL:	131299171 131318453

AEW:	130767628 130790327 130796453

BVG:	104905949 104907893

SOE:	110795153 110795635

CQI:	110699349 110700707 110726337 110733511

ATRI:

130798385 130803107 130804006

MOF:	131143808 131146560

NNU:	104589243 104599242

MING:

122077487 122086958

TSS:	122655563 122660170

PSOM:

113271749 113280936 113287278 113294981

OSA:	4324260 9272037

OBR:	102699483 102710915

OGL:	127763021 127767615

BDI:	100835500 100838582

ATS:	109739695 109755181

TDC:	119267992 119275856 119286661 119295094

TAES:

123061106 123069689 123078175 123086863 123091117 123096119

TUA:	125543667 125550638

LPER:

127293873 127342520

LRD:	124662204 124699522 124699816

SBI:	8054664 8062529

ZMA:	100272410 100282893 100285753

SITA:

101766211 101778272

SVS:	117837062 117858891

PVIR:

120650396 120673501 120687982 120706543

PHAI:

112878030 112895489

PDA:	103699359 103704474 120112827

EGU:	105035124 105046657

MUS:	103982907 103984204

ZOF:	121973068 122031857 122051706 122056237

DCT:	110092341 110107125

PEQ:	110021166 110026434

AOF:	109834129 109840869 109846833

MSIN:

131228956 131251104

NCOL:

116249801 116257052

ATR:	18425168 18435734

SMO:	SELMODRAFT_55385 SELMODRAFT_65341

PPP:

112280619

CRE:	CHLRE_02g078858v5

VCN:	VOLCADRAFT_82983

CSL:	COCSUDRAFT_16765

CVR:	CHLNCDRAFT_144542

APRO:

F751_5912

OLU:	OSTLU_46801

OTA:	OT_ostta10g01290

BPG:	Bathy11g01200

MIS:	MICPUN_89940

GSL:	Gasu_16870

CCP:	CHC_T00004351001

MBR:	MONBRDRAFT_29512

SRE:	PTSG_01723

DDI:	DDB_G0291352(psenA) DDB_G0292310(psenB)

DPP:	DICPUDRAFT_51947 DICPUDRAFT_87693

DFA:	DFA_00454(psenA) DFA_06669(psenB)

EHI:	EHI_188280(75.t00030)

EDI:	EDI_158600

EIV:	EIN_389800

ACAN:

ACA1_333260

PTI:	PHATRDRAFT_9388

FCY:	FRACYDRAFT_225896 FRACYDRAFT_239522

TPS:	THAPSDRAFT_261548 THAPSDRAFT_268976

AAF:	AURANDRAFT_67233

PIF:	PITG_00176 PITG_01777 PITG_17343

PSOJ:

PHYSODRAFT_316247 PHYSODRAFT_350670 PHYSODRAFT_534649

SPAR:

SPRG_02256 SPRG_05362 SPRG_09815

GTT:	GUITHDRAFT_159148

TVA:	TVAG_2v0002270 TVAG_2v0505230

» show all

Reference

PMID:8641442

Authors

Sahara N, Yahagi Y, Takagi H, Kondo T, Okochi M, Usami M, Shirasawa T, Mori H

Title

Identification and characterization of presenilin I-467, I-463 and I-374.

Journal

FEBS Lett 381:7-11 (1996)
DOI:10.1016/0014-5793(96)00054-3

Sequence

[hsa:5663]

Reference

PMID:10545183

Authors

Steiner H, Romig H, Pesold B, Philipp U, Baader M, Citron M, Loetscher H, Jacobsen H, Haass C

Title

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis.

Journal

Biochemistry 38:14600-5 (1999)
DOI:10.1021/bi9914210

Sequence

[hsa:5663]

LinkDB

ORTHOLOGY: K04522

Entry

K04522                      KO

Symbol

PSEN2, PS2

Name

presenilin 2 [EC:3.4.23.-]

Pathway

map04330

Notch signaling pathway

map04722

Neurotrophin signaling pathway

map05010

Alzheimer disease

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00056

Alzheimer disease

H00294

Dilated cardiomyopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    K04522  PSEN2, PS2; presenilin 2
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04522  PSEN2, PS2; presenilin 2
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04522  PSEN2, PS2; presenilin 2
   05022 Pathways of neurodegeneration - multiple diseases
    K04522  PSEN2, PS2; presenilin 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04522  PSEN2, PS2; presenilin 2
Peptidases and inhibitors [BR:ko01002]
Aspartic peptidases
  Family A22: presenilin family
   K04522  PSEN2, PS2; presenilin 2

Other DBs

GO:

0042500

TC:	1.A.54.1.2

Genes

HSA:	5664(PSEN2)

PTR:	457790(PSEN2)

PPS:	100975191(PSEN2)

GGO:	101137786(PSEN2)

PON:	100172138(PSEN2)

PPYG:

129021880(PSEN2)

NLE:	100596029(PSEN2)

HMH:	116457564(PSEN2)

SSYN:

129458425(PSEN2)

MCC:	698770(PSEN2)

MCF:	102117766(PSEN2)

MTHB:

126935884

MNI:	105478639(PSEN2)

CSAB:

103229985(PSEN2)

CATY:

105576920(PSEN2)

PANU:

101005201(PSEN2)

TGE:	112610462(PSEN2)

MLEU:

105536583(PSEN2)

RRO:	104677021(PSEN2)

RBB:	108535935(PSEN2)

TFN:	117074640(PSEN2)

PTEH:

111537068(PSEN2)

CANG:

105516694(PSEN2)

CJC:	100399890(PSEN2)

SBQ:	101051940(PSEN2)

CIMI:

108302749(PSEN2)

ANAN:

105722330(PSEN2)

CSYR:

103271842(PSEN2)

MMUR:

105863820(PSEN2)

LCAT:

123627539(PSEN2)

PCOQ:

105810413(PSEN2)

OGA:	100958952(PSEN2)

MMU:	19165(Psen2)

MCAL:

110298007(Psen2)

MPAH:

110321711(Psen2)

RNO:	81751(Psen2)

MCOC:

116104626(Psen2)

ANU:	117721886(Psen2)

MUN:	110559485(Psen2)

CGE:	100752237(Psen2)

MAUA:

101835004(Psen2)

PROB:

127223694(Psen2)

PLEU:

114690634(Psen2)

MORG:

121435835(Psen2)

MFOT:

126502217

AAMP:

119827510(Psen2)

NGI:	103725095(Psen2)

HGL:	101705181(Psen2)

CPOC:

100717114(Psen2)

CCAN:

109690752(Psen2)

DORD:

105986552(Psen2)

DSP:	122126773(Psen2)

PLOP:

125345234 125359911(Psen2)

NCAR:

124962040

MMMA:

107140486(Psen2)

OCU:

100343671

OPI:	101521444(PSEN2)

TUP:	102490523(PSEN2)

GVR:	103600283(PSEN2)

CFA:	490382(PSEN2)

CLUD:

112648798(PSEN2)

VVP:	112923553(PSEN2)

VLG:	121499842(PSEN2)

NPO:	129509080(PSEN2)

AML:	100466510(PSEN2)

UMR:	103667043(PSEN2)

UAH:	113262931(PSEN2)

UAR:	123791662(PSEN2)

ELK:

111150660

LLV:

125085890

MPUF:

101693386(PSEN2)

MNP:	132025399(PSEN2)

MLK:	131814549(PSEN2)

NVS:	122918545(PSEN2)

ORO:	101371937(PSEN2)

EJU:	114215772(PSEN2)

ZCA:	113933533(PSEN2)

MLX:	118014577(PSEN2)

NSU:	110580209(PSEN2)

LWW:

102747561

FCA:	101081693(PSEN2)

PYU:

121024701

PCOO:

112863137(PSEN2)

PBG:	122476485(PSEN2)

PVIV:

125155626(PSEN2)

LRUF:

124510287

PTG:	102972248(PSEN2)

PPAD:

109250950(PSEN2)

PUC:

125925871

AJU:

106968626

HHV:	120234142(PSEN2)

BTA:	282010(PSEN2)

BOM:	102284134(PSEN2)

BIU:	109570674(PSEN2)

BBUB:

102402822(PSEN2)

BBIS:

104997905(PSEN2)

CHX:	102190980(PSEN2)

OAS:	101113776(PSEN2)

BTAX:

128061239(PSEN2)

ODA:	120880328(PSEN2)

CCAD:

122452101(PSEN2)

MBEZ:

129551626(PSEN2)

SSC:	780410(PSEN2)

CFR:	102516800(PSEN2)

CBAI:

105083776(PSEN2)

CDK:	105099573(PSEN2)

VPC:	102524839(PSEN2)

BACU:

102998556(PSEN2)

BMUS:

118902664(PSEN2)

OOR:	101284327(PSEN2)

DLE:	111177533(PSEN2)

PCAD:

102973884(PSEN2)

PSIU:

116758258(PSEN2)

NASI:

112395675(PSEN2)

ECB:	100054506(PSEN2)

EPZ:

103558515

EAI:	106846370(PSEN2)

MYB:	102242706(PSEN2)

MYD:	102772354(PSEN2)

MMYO:

118678803(PSEN2)

MLF:

102427086

PKL:	118727734(PSEN2)

EFUS:

103301080(PSEN2)

MNA:	107528344(PSEN2)

DRO:	112318833(PSEN2)

SHON:

119003167(PSEN2)

AJM:	119044458(PSEN2)

PDIC:

114512279(PSEN2)

PHAS:

123805170(PSEN2)

MMF:	118640601(PSEN2)

PPAM:

129073012(PSEN2)

HAI:	109391446(PSEN2)

RFQ:	117018604(PSEN2)

PALE:

102888829(PSEN2)

PGIG:

120619111(PSEN2)

PVP:	105292607(PSEN2)

RAY:	107517103(PSEN2)

MJV:	108396215(PSEN2)

TOD:	119244553(PSEN2)

SARA:

101538877(PSEN2)

SETR:

126003809 126013418(PSEN2)

LAV:	100660389(PSEN2)

TMU:

101356799

ETF:	101660961(PSEN2)

DNM:

101411493

MDO:	100026453(PSEN2)

GAS:	123247789(PSEN2)

SHR:	100928719(PSEN2)

AFZ:

127559553

PCW:	110205512(PSEN2)

TVP:	118848403(PSEN2)

OAA:	100076299(PSEN2)

GGA:	374188(PSEN2)

PCOC:

116232172(PSEN2)

MGP:	100547513(PSEN2)

CJO:	107310896(PSEN2)

TPAI:

128082769(PSEN2)

LMUT:

125689526(PSEN2)

NMEL:

110395322(PSEN2)

APLA:

101791857(PSEN2)

ACYG:

106031593(PSEN2)

CATA:

118257169(PSEN2)

AFUL:

116487655(PSEN2)

TGU:	100232599(PSEN2)

LSR:	110473970(PSEN2)

SCAN:

103821306(PSEN2)

PMOA:

120506001(PSEN2)

OTC:	121346932(PSEN2)

PRUF:

121357068(PSEN2)

GFR:	102040969(PSEN2)

FAB:	101821118(PSEN2)

OMA:	130250919(PSEN2)

PHI:	102107717(PSEN2)

PMAJ:

107201877(PSEN2)

CCAE:

111926282(PSEN2)

CCW:	104685571(PSEN2)

CBRC:

103612685(PSEN2)

ETL:	114073549(PSEN2)

ZAB:	102068930(PSEN2)

ZLE:	135446072(PSEN2)

ACHL:

103798461(PSEN2)

SVG:	106853887(PSEN2)

MMEA:

130578655(PSEN2)

HRT:	120750090(PSEN2)

FPG:	101914026(PSEN2)

FCH:	102052189(PSEN2)

CLV:	102086670(PSEN2)

EGZ:	104134612(PSEN2)

NNI:	104019271(PSEN2)

PCRI:

104025634(PSEN2)

PLET:

104624415(PSEN2)

EHS:	104503401(PSEN2)

PCAO:

104053903(PSEN2)

ACUN:

113478947(PSEN2)

TALA:

104366618(PSEN2)

PADL:

103925007(PSEN2)

AFOR:

103904173(PSEN2)

ACHC:

115350048(PSEN2)

HALD:

104321008(PSEN2)

HLE:	104838151(PSEN2)

AGEN:

126052659

GCL:

127015340

CCRI:

104164712(PSEN2)

CSTI:

104550545(PSEN2)

CMAC:

104485250(PSEN2)

MUI:	104537208(PSEN2)

BREG:

104629946(PSEN2)

FGA:	104070958(PSEN2)

GSTE:

104251611(PSEN2)

LDI:	104351612(PSEN2)

MNB:	103772536(PSEN2)

OHA:	104331959(PSEN2)

NNT:	104404102(PSEN2)

SHAB:

115613991(PSEN2)

DPUB:

104303233

PGUU:

104463825(PSEN2)

ACAR:

104530118(PSEN2)

CPEA:

104386211(PSEN2)

AVIT:

104268061(PSEN2)

CVF:	104283586(PSEN2)

RTD:	128906681(PSEN2)

CUCA:

104067041(PSEN2)

TEO:	104370517(PSEN2)

BRHI:

104497902(PSEN2)

AAM:	106482720(PSEN2)

AROW:

112963409(PSEN2)

NPD:	112954816(PSEN2)

TGT:	104570942(PSEN2)

DNE:	112980049(PSEN2)

SCAM:

104151492(PSEN2)

ASN:	102387066(PSEN2)

AMJ:	102572042(PSEN2)

CPOO:

109319789(PSEN2)

GGN:	109296911(PSEN2)

PSS:	102444598(PSEN2)

CMY:	102932404(PSEN2)

CCAY:

125633704(PSEN2)

DCC:	119852555(PSEN2)

CPIC:

101931945(PSEN2)

TST:	117874520(PSEN2)

CABI:

116835398(PSEN2)

MRV:	120401994(PSEN2)

ACS:	100567182(psen2)

ASAO:

132761361(PSEN2)

PVT:	110087560(PSEN2)

SUND:

121914770(PSEN2)

PBI:	103051424(PSEN2)

PMUR:

107291203(PSEN2)

CTIG:

120307236(PSEN2)

TSR:	106538735(PSEN2)

PGUT:

117671777(PSEN2)

APRI:

131190267(PSEN2)

PTEX:

113433217(PSEN2)

NSS:	113421528(PSEN2)

VKO:	123026669(PSEN2)

PMUA:

114594604(PSEN2)

PRAF:

128411053(PSEN2)

ZVI:	118083232(PSEN2)

HCG:	128349884(PSEN2)

GJA:	107118519(PSEN2)

STOW:

125439150(PSEN2)

EMC:	129330706(PSEN2) 129336286

XLA:	108716701(psen2.L) 397713(psen2.S)

XTR:	549935(psen2)

NPR:

108789850

RTEM:

120937579(PSEN2)

BBUF:

BGAR:

MUO:

GSH:

DRE:	58026(psen2)

SRX:	107747431 107757025

SANH:

107675694 107684264

SGH:	107594418(psen2)

CCAR:

109046774 109107333

CAUA:

113044005 113044116 113047188

CGIB:

127949017 128020920

PTET:

122345648(psen2)

LROH:

127167920(psen2)

OMC:	131544514(psen2)

RKG:	130087332(psen2)

MAMB:

125271909(psen2)

CIDE:

127521384

MASI:

127444057 127445261

TROS:

130552956(psen2)

TDW:	130434834(psen2)

MANU:

129444103(psen2)

IPU:	108258586(psen2)

IFU:	128601862(psen2)

PHYP:

113537368

SMEO:

124378381(psen2)

TFD:	113663591(psen2)

TVC:	132839864(psen2)

TRN:	134328753(psen2)

AMEX:

103047139(psen2)

CMAO:

118797883(psen2)

EEE:

113579670

CHAR:

105909396(psen2)

TRU:	101066600(psen2)

TFS:	130527476(psen2)

TNG:	GSTEN00004150G001

LCO:

104939462

TBEN:

117484604(psen2)

CGOB:

115006185

EMAC:

134862752(psen2)

ELY:	117255682(psen2)

EFO:	125885532(psen2)

SLUC:

116048132(psen2)

PFLV:

114568663

GAT:	120824614(psen2)

PPUG:

119218242(psen2)

AFB:	129114751(psen2)

CLUM:

117737420(psen2)

PSWI:

130191381(psen2)

MSAM:

119899857(psen2)

SCHU:

122873460(psen2)

CUD:	121508866(psen2)

ALAT:

119023968(psen2)

MZE:

101475262

ONL:

100710620

OAU:	116317828(psen2)

OLA:	101156628(psen2)

OML:	112143463(psen2)

CSAI:

133445986(psen2)

XMA:	102228767(psen2)

XCO:

114144028

XHE:	116720116(psen2)

PRET:

103471903(psen2)

PFOR:

103130109(psen2)

PLAI:

106942401

PMEI:

106910414(psen2)

GAF:	122828944(psen2)

PPRL:

129356020 129356396

CVG:

107104490

CTUL:

119785523(psen2)

GMU:	124868074(psen2)

NFU:	107393984(psen2)

KMR:	108229062(psen2)

ALIM:

106535157

NWH:	119422305(psen2)

AOCE:

111583303

MCEP:

125004067(psen2)

CSEM:

103383288(psen2)

POV:

109647972

SSEN:

122771274(psen2)

HHIP:

117764153(psen2)

HSP:	118121110(psen2)

PPLT:

128437483(psen2)

SMAU:

118312173(psen2)

LCF:	108882296(psen2)

SDU:	111237573(psen2)

SLAL:

111672890

XGL:	120799864(psen2)

HCQ:	109527634(psen2)

SSCV:

125968505

SBIA:

133505670(psen2)

PEE:	133403959(psen2)

PTAO:

133476935(psen2)

BPEC:

110162540

MALB:

109971823

BSPL:

114857686(psen2)

SJO:	128378246(psen2)

SASA:

100194958(psn2) 106586215

STRU:

115178279 115208527

OTW:	112237712 112265587(psen2)

OMY:	110493758(psen2)

OGO:	124004310(psen2)

ONE:	115142639(psen2)

OKI:	109865262 109890007

OKE:	118389133(psen2)

SALP:

SNH:

CCLU:

ELS:

SFM:	108927122(psen2)

PKI:	111835702(psen2)

AANG:

118218390 118219468(psen2)

LOC:	102692912(psen2)

PSPA:

121316092 121317217

ARUT:

117402569 117411533

PSEX:

120516741(psen2)

LCM:	102353018(PSEN2)

CMK:	103178605(psen2)

RTP:	109912001(psen2)

CPLA:

122542745(psen2)

HOC:	132833793(psen2)

LERI:

129696971(psen2)

PMRN:

LRJ:

ARUN:

DCI:

LSM:

TCF:

PPOI:

DSV:	119462073 119462187

RSAN:

RMP:

VDE:

VJA:

DFR:	124489867 124492835

ABRU:

UDV:

SDM:

LPOL:

PMEO:

PVUL:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

LJP:

XEN:

HSY:

RES:

TBR:	Tb09.160.3510

TBG:	TbgDal_IX2640

TCR:	503543.10 508277.50

LMA:	LMJF_15_1530

LIF:	LINJ_15_1600

LDO:	LDBPK_151600

LMI:	LMXM_15_1530

LBZ:	LBRM_15_1530

LPAN:

LPMP_151490

» show all

Reference

PMID:10497236

Authors

Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haass C

Title

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.

Journal

J Biol Chem 274:28669-73 (1999)
DOI:10.1074/jbc.274.40.28669

Reference

PMID:8618867

Authors

Li J, Ma J, Potter H

Title

Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3.

Journal

Proc Natl Acad Sci U S A 92:12180-4 (1995)
DOI:10.1073/pnas.92.26.12180

Sequence

[hsa:5664]

LinkDB

DBGET integrated database retrieval system