KEGG   PATHWAY: cpoc05417
Entry
cpoc05417                   Pathway                                
Name
Lipid and atherosclerosis - Cavia porcellus (domestic guinea pig)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
cpoc05417  Lipid and atherosclerosis
cpoc05417

Organism
Cavia porcellus (domestic guinea pig) [GN:cpoc]
Gene
100725937  Apob; apolipoprotein B-100 [KO:K14462]
100732215  Apoa4; apolipoprotein A-IV [KO:K08760]
100729378  Apoa1; apolipoprotein A-I [KO:K08757]
100724238  Ldlr; low-density lipoprotein receptor [KO:K12473]
100725301  Olr1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
100713259  Arhgef1; rho guanine nucleotide exchange factor 1 [KO:K12330]
100727966  interstitial collagenase [KO:K01388] [EC:3.4.24.7]
100733542  Rhoa; transforming protein RhoA [KO:K04513]
100713798  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100135577  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100720622  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100727986  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100735084  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100734206  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100730242  Pik3r1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100734044  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100719925  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100714724  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100724315  Akt3; LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100730890  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
100734151  Bad; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100730495  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
100733337  Bcl2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
100722333  Mapk8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
100718766  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100714249  Mapk9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100135623  Sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
100713627  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100716380  Pou2f3; POU domain, class 2, transcription factor 3 [KO:K09364]
100723701  Pou2f2; LOW QUALITY PROTEIN: POU domain, class 2, transcription factor 2 [KO:K09364]
100735919  Pou2f1; POU domain, class 2, transcription factor 1 isoform X2 [KO:K09364]
100728791  Cd40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
100733664  Cd40lg; CD40 ligand [KO:K03161]
100135512  Cyp1a1; cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
100726130  Ager; advanced glycosylation end product-specific receptor isoform X3 [KO:K19722]
100735465  Nox1; NADPH oxidase 1 isoform X2 [KO:K08008]
100735552  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100726055  Ncf1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
100732048  cytochrome b-245 light chain isoform X1 [KO:K08009]
100733153  Ncf2; neutrophil cytosol factor 2 [KO:K08010]
100729267  Ncf4; neutrophil cytosol factor 4 [KO:K08012]
100727219  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
100728509  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
100722908  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
100717084  Stat3; signal transducer and activator of transcription 3 isoform X3 [KO:K04692]
100717195  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
100733674  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100731057  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X2 [KO:K04431] [EC:2.7.12.2]
100713572  Fos; proto-oncogene c-Fos [KO:K04379]
100728775  Jun; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
106027640  C-C motif chemokine 2-like [KO:K14624]
100135494  Ccl2; C-C motif chemokine 2 precursor [KO:K14624]
100717967  Icam1; LOW QUALITY PROTEIN: intercellular adhesion molecule 1 [KO:K06490]
100379599  Cxcl8; interleukin-8 precursor [KO:K10030]
100726100  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100731419  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100724974  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100723285  Mapk14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100729280  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100735038  Hras; GTPase HRas isoform X1 [KO:K02833]
100716262  Kras; GTPase KRas isoform X3 [KO:K07827]
100135584  Nras; GTPase NRas [KO:K07828]
100715180  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100725692  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100724366  Rela; transcription factor p65 isoform X1 [KO:K04735]
100730075  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100716992  Sele; LOW QUALITY PROTEIN: E-selectin [KO:K06494]
100716162  Selp; P-selectin [KO:K06496]
100722681  Vcam1; LOW QUALITY PROTEIN: vascular cell adhesion protein 1 [KO:K06527]
100729101  Mmp3; stromelysin-1 [KO:K01394] [EC:3.4.24.17]
100728510  Mmp9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
100726403  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100135556  Il1b; interleukin-1 beta [KO:K04519]
106027696  Il6; interleukin-6 [KO:K05405]
100135630  Tnf; tumor necrosis factor [KO:K03156]
100715481  Hspd1; LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
100713849  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
100717205  heat shock 70 kDa protein 1B [KO:K03283]
100717481  heat shock 70 kDa protein 1-like [KO:K03283]
100715119  Hspa6; heat shock 70 kDa protein 6 [KO:K03283]
100729464  heat shock 70 kDa protein 1B-like [KO:K03283]
100713571  Hspa2; LOW QUALITY PROTEIN: heat shock-related 70 kDa protein 2 [KO:K26598]
100735343  Hspa4; heat shock 70 kDa protein 4 [KO:K09489]
100733372  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
100729935  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
100725824  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
100723767  Hsp90b1; endoplasmin isoform X2 [KO:K09487]
100717682  Tlr2; toll-like receptor 2 [KO:K10159]
100731373  Lbp; lipopolysaccharide-binding protein [KO:K05399]
100735312  Cd14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391]
100729146  Ly96; lymphocyte antigen 96 isoform X1 [KO:K05400]
100724803  Tlr4; toll-like receptor 4 [KO:K10160]
100732763  Tirap; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
100733381  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100729751  Irak4; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
100735146  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
100724447  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100735373  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100717911  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
100718100  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100726357  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100724538  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100722308  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100723189  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
101788890  Ticam2; TIR domain-containing adapter molecule 2 [KO:K05409]
100717594  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
100734492  Traf3; TNF receptor-associated factor 3 isoform X2 [KO:K03174]
100721079  Mib1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
100727066  Mib2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase MIB2 [KO:K10645] [EC:2.3.2.27]
100721939  Tank; TRAF family member-associated NF-kappa-B activator [KO:K12650]
100716187  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100731956  Tbk1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
101788200  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
100724910  Irf3; LOW QUALITY PROTEIN: interferon regulatory factor 3 [KO:K05411]
100726990  interferon alpha-17-like [KO:K05414]
100728098  interferon alpha-4 [KO:K05414]
100729220  interferon alpha-21-like [KO:K05414]
100735600  interferon alpha-21-like [KO:K05414]
100722772  interferon alpha-1-like [KO:K05414]
100734117  interferon alpha-4-like [KO:K05414]
100718817  interferon alpha-17-like [KO:K05414]
100716684  interferon alpha-4-like [KO:K05414]
100728479  interferon alpha-17-like [KO:K05414]
100722040  interferon alpha-5-like [KO:K05414]
100717234  interferon alpha-17-like [KO:K05414]
100720391  interferon alpha-4-like [KO:K05414]
100725261  interferon alpha-4 [KO:K05414]
100730474  interferon alpha-4-like [KO:K05414]
100734169  interferon alpha-10-like [KO:K05414]
100721849  interferon alpha-17-like [KO:K05414]
100717707  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
100724988  interferon alpha-17-like [KO:K05414]
100714884  interferon alpha-13-like [KO:K05414]
100734449  interferon beta [KO:K05415]
100733284  interferon beta-like [KO:K05415]
111757491  Ifnb1; interferon beta [KO:K05415]
100730182  Cd36; platelet glycoprotein 4 [KO:K06259]
100729138  Pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
100728437  Rxra; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
100732959  Rxrb; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
100731736  Rxrg; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
100714653  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100713221  Vav1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
100714719  Vav3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
100728155  Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100733137  Tlr6; toll-like receptor 6 [KO:K10169]
100713608  Rap1a; ras-related protein Rap-1A [KO:K04353]
100713271  ras-related protein Rap-1b-like [KO:K07836]
100734094  Rap1b; ras-related protein Rap-1b [KO:K07836]
100135495  Ccl5; C-C motif chemokine 5 precursor [KO:K12499]
100734903  C-C motif chemokine 3-like [KO:K05408]
100735187  C-C motif chemokine 3-like [KO:K05408]
100135510  Cxcl1; growth-regulated alpha protein precursor [KO:K05505]
100379543  Il12a; interleukin-12 subunit alpha precursor [KO:K05406]
100135554  Il12b; interleukin-12 subunit beta precursor [KO:K05425]
100726352  Nlrp3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
100734451  Il18; interleukin-18 [KO:K05482]
100731108  Hspa5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
100730337  Atf6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
101787388  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
100730741  Ero1a; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
100713023  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100727059  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2 [KO:K04515] [EC:2.7.11.17]
100725858  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
100719406  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X12 [KO:K04515] [EC:2.7.11.17]
100717077  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
100725836  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
100716377  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100732296  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100733391  Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
100733145  Traf2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
100722979  Map3k5; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100719734  Xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
100720792  Abca1; ATP-binding cassette sub-family A member 1 [KO:K05641]
100721963  Abcg1; ATP-binding cassette sub-family G member 1 isoform X2 [KO:K05679]
100734862  Nfe2l2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
100734858  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
100730749  LOW QUALITY PROTEIN: caspase-1-like [KO:K01370] [EC:3.4.22.36]
100725217  caspase-1 [KO:K01370] [EC:3.4.22.36]
100725662  Vldlr; very low-density lipoprotein receptor [KO:K20053]
100735138  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100714392  Gsk3b; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100730044  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X4 [KO:K04446]
100722868  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
100728433  Nfatc3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
100729394  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100714143  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [KO:K05858] [EC:3.1.4.11]
100727662  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100730572  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100716986  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100728342  Calml3; calmodulin-like protein 3 [KO:K02183]
100730149  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100734544  Calm1; calmodulin-1 [KO:K02183]
100728625  calmodulin-4 [KO:K02183]
100729712  calmodulin-like [KO:K02183]
106027819  Calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
100169692  Calm3; calmodulin [KO:K02183]
100724214  Calm2; calmodulin [KO:K02183]
100727741  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100725315  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100728974  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
106027879  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
100721882  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
100734497  Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
101787877  tumor necrosis factor receptor superfamily member 10A isoform X3 [KO:K04722]
100713890  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X3 [KO:K03158]
100714139  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100713334  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100728186  Bid; BH3-interacting domain death agonist [KO:K04726]
100731649  LOW QUALITY PROTEIN: cytochrome c, somatic [KO:K08738]
100733235  LOW QUALITY PROTEIN: cytochrome c, somatic-like [KO:K08738]
100724240  cytochrome c-like [KO:K08738]
100719903  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
100714954  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100713360  Casp6; caspase-6 [KO:K04396] [EC:3.4.22.59]
100718309  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100715159  Casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
100379269  Tp53; cellular tumor antigen p53 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
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Related
pathway
cpoc04020  Calcium signaling pathway
cpoc04115  p53 signaling pathway
cpoc04141  Protein processing in endoplasmic reticulum
cpoc04151  PI3K-Akt signaling pathway
cpoc04210  Apoptosis
cpoc04620  Toll-like receptor signaling pathway
cpoc04621  NOD-like receptor signaling pathway
cpoc04668  TNF signaling pathway
cpoc04670  Leukocyte transendothelial migration
cpoc04975  Fat digestion and absorption
cpoc04979  Cholesterol metabolism
cpoc05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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