KEGG   PATHWAY: mlf05170
Entry
mlf05170                    Pathway                                
Name
Human immunodeficiency virus 1 infection - Myotis lucifugus (little brown bat)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
mlf05170  Human immunodeficiency virus 1 infection
mlf05170

Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102427698  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
102427664  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
102432689  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
102432509  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
102421559  CUL1; cullin-1 isoform X1 [KO:K03347]
102431403  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
102427675  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102427230  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
102429580  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
102431273  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
102438598  guanine nucleotide-binding protein G(o) subunit alpha-like [KO:K04534]
102422649  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102441064  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102433534  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102427890  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102441522  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
102429230  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102426106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102419324  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
102442955  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102442091  PTK2B; protein-tyrosine kinase 2-beta isoform X4 [KO:K05871] [EC:2.7.10.2]
102427666  PXN; paxillin isoform X1 [KO:K05760]
102440736  CRK; adapter molecule crk isoform X1 [KO:K04438]
102420269  CRKL; crk-like protein isoform X1 [KO:K04438]
102443221  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102439923  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102434974  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102429245  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
102433676  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102435748  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102424236  RELA; transcription factor p65 [KO:K04735]
102417433  FOS; proto-oncogene c-Fos [KO:K04379]
102437415  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
102437980  BAD; bcl2-associated agonist of cell death [KO:K02158]
102431999  KRAS; GTPase KRas isoform X1 [KO:K07827]
102430744  NRAS; GTPase NRas [KO:K07828]
102434453  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102417411  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
102423748  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102417755  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102422236  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102424688  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
102424028  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
102421330  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102420000  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
102422734  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
102442861  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102430787  CALM2; calmodulin-2 isoform X1 [KO:K02183]
102417912  calmodulin-A-like isoform X1 [KO:K02183]
102419493  calmodulin-like protein 3 [KO:K02183]
102419808  calmodulin-like protein 5 [KO:K02183]
102426645  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
102434863  CALM1; calmodulin-1 [KO:K02183]
102440407  calmodulin-like [KO:K02183]
102443136  calmodulin-like [KO:K02183]
102434410  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102441003  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102421207  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102430192  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102428803  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102428507  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
102441857  NFATC2; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
102426111  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102417139  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
102438932  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102428240  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102419083  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
102420431  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102420482  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102428334  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102431535  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
102420203  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
102441805  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
102442437  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102428001  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
102422498  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
106697041  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102432910  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102432599  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102428066  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102431853  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
102432692  guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548]
102420164  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102435667  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102418852  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102423786  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
102436424  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102438044  PAK3; serine/threonine-protein kinase PAK 3 isoform X4 [KO:K05733] [EC:2.7.11.1]
102420569  PAK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
102443084  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
102431483  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
102431984  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
102437257  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
102436650  CFL2; cofilin-2 isoform X2 [KO:K05765]
102427794  CFL1; cofilin-1 [KO:K05765]
102437558  TNF; tumor necrosis factor isoform X1 [KO:K03156]
102429153  TNFRSF1B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1B [KO:K05141]
102443091  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102424442  TLR2; toll-like receptor 2 [KO:K10159]
102437402  TLR4; toll-like receptor 4 [KO:K10160]
102425374  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
102433848  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X3 [KO:K04733] [EC:2.7.11.1]
102418742  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
102436804  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102427825  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102439412  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
102429407  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102425603  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102417312  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4 [KO:K07209] [EC:2.7.11.10]
102436137  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
102422347  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102417209  IFNB1; interferon beta [KO:K05415]
102438914  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102437934  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102430582  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102437455  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102418507  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102428890  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
102434781  TMEM173; stimulator of interferon genes protein [KO:K12654]
102424113  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
102422872  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
111824110  DNA dC->dU-editing enzyme APOBEC-3G-like [KO:K18750] [EC:3.5.4.-]
111824111  DNA dC->dU-editing enzyme APOBEC-3G-like [KO:K18750] [EC:3.5.4.-]
102435310  DNA dC->dU-editing enzyme APOBEC-3G-like [KO:K18750] [EC:3.5.4.-]
102439233  DNA dC->dU-editing enzyme APOBEC-3G-like [KO:K18750] [EC:3.5.4.-]
106695187  DNA dC->dU-editing enzyme APOBEC-3G-like [KO:K18750] [EC:3.5.4.-]
106695188  DNA dC->dU-editing enzyme APOBEC-3A-like isoform X1 [KO:K18750] [EC:3.5.4.-]
102435613  DNA dC->dU-editing enzyme APOBEC-3C [KO:K18750] [EC:3.5.4.-]
102434062  DNA dC->dU-editing enzyme APOBEC-3G-like isoform X3 [KO:K18750] [EC:3.5.4.-]
106695661  DNA dC->dU-editing enzyme APOBEC-3A-like isoform X1 [KO:K18750] [EC:3.5.4.-]
102424504  SAMHD1; LOW QUALITY PROTEIN: deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [KO:K22544] [EC:3.1.5.-]
111822979  tripartite motif-containing protein 5-like [KO:K10648] [EC:2.3.2.27]
102431987  tripartite motif-containing protein 5-like isoform X1 [KO:K10648] [EC:2.3.2.27]
106694372  LOW QUALITY PROTEIN: tripartite motif-containing protein 5-like [KO:K10648] [EC:2.3.2.27]
102437606  tripartite motif-containing protein 5 [KO:K10648] [EC:2.3.2.27]
111827152  tripartite motif-containing protein 5-like [KO:K10648] [EC:2.3.2.27]
106695088  BST2; bone marrow stromal antigen 2 isoform X5 [KO:K06731]
102419664  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102425101  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
102433190  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
102436664  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
102426303  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
102429748  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102439228  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102433075  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
111824600  FADD; FAS-associated death domain protein [KO:K02373]
102439369  CASP8; LOW QUALITY PROTEIN: caspase-8 [KO:K04398] [EC:3.4.22.61]
102423950  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
102417074  BAX; apoptosis regulator BAX [KO:K02159]
102437326  BAK1; LOW QUALITY PROTEIN: bcl-2 homologous antagonist/killer [KO:K14021]
102432611  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
102420929  cytochrome c-like [KO:K08738]
102436841  cytochrome c-like [KO:K08738]
102419640  cytochrome c [KO:K08738]
102424392  cytochrome c [KO:K08738]
102422013  cytochrome c-like [KO:K08738]
102421025  cytochrome c-like [KO:K08738]
102428235  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
102438419  CASP3; caspase-3 isoform X3 [KO:K02187] [EC:3.4.22.56]
102438976  CD3E; T-cell surface glycoprotein CD3 epsilon chain isoform X2 [KO:K06451]
102436522  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
102436834  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
102427887  CD247; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
102421555  TAP1; LOW QUALITY PROTEIN: antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
102422762  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
102437357  TAPBP; tapasin [KO:K08058]
102433278  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
102438377  CALR; calreticulin [KO:K08057]
102440675  HLA class I histocompatibility antigen, B-46 alpha chain-like isoform X10 [KO:K06751]
102442541  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
102433344  HLA class I histocompatibility antigen, B-67 alpha chain-like isoform X2 [KO:K06751]
102438185  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X2 [KO:K06751]
102435002  HLA class I histocompatibility antigen, B-67 alpha chain-like isoform X3 [KO:K06751]
102429481  HLA class I histocompatibility antigen, B-67 alpha chain-like isoform X12 [KO:K06751]
111822980  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X3 [KO:K06751]
111822961  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
102432715  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X6 [KO:K06751]
102429581  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
102417058  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
102435927  HLA class I histocompatibility antigen, B-67 alpha chain-like isoform X1 [KO:K06751]
102431662  HLA class I histocompatibility antigen, B-18 alpha chain-like isoform X1 [KO:K06751]
102428684  HLA class I histocompatibility antigen, B-57 alpha chain-like [KO:K06751]
102418243  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]
102424088  H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751]
102440606  HLA class I histocompatibility antigen, B-54 alpha chain-like isoform X1 [KO:K06751]
102416963  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
111823006  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
102431053  HLA class I histocompatibility antigen, B-82 alpha chain-like [KO:K06751]
102442224  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
102438496  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
102441816  patr class I histocompatibility antigen, A-108 alpha chain-like isoform X1 [KO:K06751]
102418018  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
102422972  HLA class I histocompatibility antigen, B-57 alpha chain-like [KO:K06751]
102424815  HLA class I histocompatibility antigen, B-45 alpha chain-like isoform X3 [KO:K06751]
102422085  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
102424768  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
102417991  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102421494  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
102440537  AP1G2; AP-1 complex subunit gamma-like 2 isoform X2 [KO:K12391]
102443203  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
102438139  AP1M1; AP-1 complex subunit mu-1 isoform X3 [KO:K12393]
102432064  AP1M2; LOW QUALITY PROTEIN: AP-1 complex subunit mu-2 [KO:K12393]
102419274  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
102418013  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
102440123  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
102439654  B2M; beta-2-microglobulin [KO:K08055]
102425640  ELOB; LOW QUALITY PROTEIN: elongin-B [KO:K03873]
102434055  ELOC; elongin-C isoform X1 [KO:K03872]
102437959  CUL5; cullin-5 isoform X1 [KO:K10612]
102430072  DCAF1; DDB1- and CUL4-associated factor 1 isoform X2 [KO:K11789] [EC:2.7.11.1]
102432295  DDB1; LOW QUALITY PROTEIN: DNA damage-binding protein 1 [KO:K10610]
102440228  CUL4B; cullin-4B isoform X1 [KO:K10609]
102428833  CUL4A; LOW QUALITY PROTEIN: cullin-4A [KO:K10609]
102440135  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
102440870  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
102437641  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
102419273  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
102422695  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
102442457  WEE1; LOW QUALITY PROTEIN: wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
102426745  CCNB1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
102441382  CCNB2; LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B2 [KO:K21770]
102418588  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
102440693  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:22749173
  Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
  Journal
Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
PMID:23806647
  Authors
Abbas W, Herbein G
  Title
Plasma membrane signaling in HIV-1 infection.
  Journal
Biochim Biophys Acta 1838:1132-42 (2014)
DOI:10.1016/j.bbamem.2013.06.020
Reference
PMID:20041213
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
PMID:22085380
  Authors
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Related
pathway
mlf03050  Proteasome
mlf04010  MAPK signaling pathway
mlf04020  Calcium signaling pathway
mlf04064  NF-kappa B signaling pathway
mlf04110  Cell cycle
mlf04141  Protein processing in endoplasmic reticulum
mlf04142  Lysosome
mlf04150  mTOR signaling pathway
mlf04151  PI3K-Akt signaling pathway
mlf04210  Apoptosis
mlf04612  Antigen processing and presentation
mlf04620  Toll-like receptor signaling pathway
mlf04623  Cytosolic DNA-sensing pathway
mlf04668  TNF signaling pathway
mlf04810  Regulation of actin cytoskeleton
KO pathway
ko05170   
LinkDB

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