KEGG   PATHWAY: oga05163
Entry
oga05163                    Pathway                                
Name
Human cytomegalovirus infection - Otolemur garnettii (small-eared galago)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
oga05163  Human cytomegalovirus infection
oga05163

Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100961338  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100947138  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100953367  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100954109  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100956838  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100952580  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100949858  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100959825  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100955276  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100945977  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100954949  TSC1; hamartin isoform X2 [KO:K07206]
100956811  TSC2; tuberin isoform X3 [KO:K07207]
100950216  RHEB; GTP-binding protein Rheb [KO:K07208]
100957753  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100963859  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100945805  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100940650  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X5 [KO:K04688] [EC:2.7.11.1]
100949554  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100946157  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100958883  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100951061  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100957990  RELA; transcription factor p65 isoform X3 [KO:K04735]
100950302  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100948701  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100958517  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100943020  SOS2; son of sevenless homolog 2 [KO:K03099]
100951644  HRAS; GTPase HRas isoform X1 [KO:K02833]
100953050  KRAS; GTPase KRas isoform X3 [KO:K07827]
100949583  NRAS; GTPase NRas isoform X1 [KO:K07828]
100941062  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100959926  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100956072  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100951533  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100957343  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100949181  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
100953042  SP1; transcription factor Sp1 [KO:K04684]
100945899  ITGAV; integrin alpha-V [KO:K06487]
100949430  ITGB3; integrin beta-3 [KO:K06493]
100941865  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
100951369  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100957182  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100948274  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
100954771  RHOA; transforming protein RhoA [KO:K04513]
100960993  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
100960636  TMEM173; stimulator of interferon genes protein [KO:K12654]
100940759  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100943304  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
100962353  interferon alpha-10-like [KO:K05414]
100955951  interferon alpha-10-like isoform X2 [KO:K05414]
100945944  interferon alpha-4-like [KO:K05414]
100945309  interferon alpha-5-like [KO:K05414]
100956963  interferon alpha-5-like [KO:K05414]
100957574  interferon alpha-5-like [KO:K05414]
100958440  interferon alpha-5-like [KO:K05414]
100958763  interferon alpha-10-like [KO:K05414]
100959074  interferon alpha-5-like [KO:K05414]
100946255  interferon alpha-10-like [KO:K05414]
100959385  IFNB1; interferon beta [KO:K05415]
100963613  TNF; tumor necrosis factor [KO:K03156]
100955892  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100949124  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
100952230  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100957799  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
100966378  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100944877  IL1B; interleukin-1 beta [KO:K04519]
100959140  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
100947991  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100951799  C-C motif chemokine 2-like [KO:K14624]
100952119  C-C motif chemokine 7 [KO:K14624]
100957034  CCL5; C-C motif chemokine 5 [KO:K12499]
111725388  CXCL8; interleukin-8 [KO:K10030]
100949231  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
100964694  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100940763  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100950950  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100961335  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100954252  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
111726116  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100947073  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100967014  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
111723289  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
111724938  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
111728356  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111723667  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
100954553  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100950477  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111727847  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
111725594  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100954240  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
111724020  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100946783  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100949562  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100966029  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100966182  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858] [EC:3.1.4.11]
100953462  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858] [EC:3.1.4.11]
100951857  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
100964437  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100954512  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100942290  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100952803  calmodulin-like [KO:K02183]
100956147  calmodulin-like [KO:K02183]
105887316  CALML6; calmodulin-like protein 6 [KO:K02183]
100942721  calmodulin-like [KO:K02183]
100941613  CALM3; calmodulin-3 [KO:K02183]
100964319  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100946498  CALM2; calmodulin-2 [KO:K02183]
100966114  CALML5; calmodulin-like protein 5 [KO:K02183]
100948288  CALM1; calmodulin-1 [KO:K02183]
100961754  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100961025  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
100945846  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
105886540  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105887331  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100940498  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100955220  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
100966615  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
100950273  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100944482  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100962114  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100945007  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100962000  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X2 [KO:K04630]
100966468  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
100955472  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100941250  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100942592  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100949638  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100942320  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100963748  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100956925  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100952034  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100943767  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100964083  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100966533  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100955463  C-C motif chemokine 3 [KO:K05408]
100955778  C-C motif chemokine 3-like [KO:K05408]
100955150  C-C motif chemokine 4 [KO:K12964]
100945057  CX3CL1; fractalkine isoform X2 [KO:K05508]
100956403  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100963709  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
100951083  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
100942946  ARHGEF11; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 11 [KO:K12331]
100957349  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
100957209  AKAP13; A-kinase anchor protein 13 isoform X1 [KO:K16529]
100964845  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
100953342  ROCK2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.39]
100966689  CTNNB1; catenin beta-1 [KO:K02105]
100963130  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
100965094  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
100948374  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
100947256  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100966244  neuroendocrine secretory protein 55 [KO:K04632]
100966563  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
100952751  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
100958947  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100952981  MYC; myc proto-oncogene protein [KO:K04377]
100947685  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
100955095  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100958469  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100960272  VEGFA; vascular endothelial growth factor A [KO:K05448]
100962457  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100956269  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100957118  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100963993  MAPK11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
100964304  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100964324  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
100966891  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
100940993  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100966324  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
100951671  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100941510  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100955062  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100952085  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100952718  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100951769  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X2 [KO:K09049]
100946548  CXCL12; stromal cell-derived factor 1 [KO:K10031]
100945275  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100965377  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100943579  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100956877  PRKCG; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100959766  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100962373  PTK2; focal adhesion kinase 1 isoform X2 [KO:K05725] [EC:2.7.10.2]
100955552  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
100958636  CRK; adapter molecule crk isoform X1 [KO:K04438]
100951208  CRKL; crk-like protein [KO:K04438]
100941877  PXN; paxillin isoform X1 [KO:K05760]
100962082  IL10RA; LOW QUALITY PROTEIN: interleukin-10 receptor subunit alpha [KO:K05134]
105886322  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
100954261  C-X-C chemokine receptor type 2-like [KO:K05050]
100954571  C-X-C chemokine receptor type 2-like [KO:K05050]
100945016  C-X-C chemokine receptor type 2-like [KO:K05050]
100951890  CCR1; C-C chemokine receptor type 1 [KO:K04176]
100952202  CCR3; C-C chemokine receptor type 3 [KO:K04178]
100953162  CCR5; C-C chemokine receptor type 5 [KO:K04180]
100966979  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
105886923  antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100940392  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
100965502  TAPBP; tapasin isoform X2 [KO:K08058]
100944942  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
100942739  CALR; calreticulin [KO:K08057]
100954043  calreticulin-like [KO:K08057]
100961793  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
100952503  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
100957517  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
100956897  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
100959427  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X2 [KO:K06751]
100946825  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-36 alpha chain [KO:K06751]
100947452  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
100958806  HLA class I histocompatibility antigen, B-42 alpha chain-like isoform X1 [KO:K06751]
100952177  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
100952822  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X1 [KO:K06751]
100954387  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
100953138  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
100943555  B2M; beta-2-microglobulin [KO:K08055]
100943080  cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
100961605  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
100947328  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
100953808  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
111727809  E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
100963622  TP53; cellular tumor antigen p53 [KO:K04451]
100946725  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100960589  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100952236  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100951476  RB1; retinoblastoma-associated protein [KO:K06618]
100957114  E2F1; transcription factor E2F1 [KO:K17454]
100956861  E2F2; transcription factor E2F2 [KO:K09389]
100942819  E2F3; transcription factor E2F3 [KO:K06620]
100951008  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100957582  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100960309  FADD; FAS-associated death domain protein [KO:K02373]
100965468  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100960302  BID; BH3-interacting domain death agonist [KO:K04726]
100957285  BAX; apoptosis regulator BAX [KO:K02159]
100941755  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
100952744  cytochrome c, somatic [KO:K08738]
100946237  cytochrome c [KO:K08738]
100961637  cytochrome c, testis-specific [KO:K08738]
100951508  cytochrome c-like [KO:K08738]
100957904  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100961435  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
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Related
pathway
oga00590  Arachidonic acid metabolism
oga03050  Proteasome
oga04010  MAPK signaling pathway
oga04064  NF-kappa B signaling pathway
oga04110  Cell cycle
oga04150  mTOR signaling pathway
oga04151  PI3K-Akt signaling pathway
oga04210  Apoptosis
oga04612  Antigen processing and presentation
oga04623  Cytosolic DNA-sensing pathway
oga04630  JAK-STAT signaling pathway
oga04668  TNF signaling pathway
oga04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
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