KEGG   PATHWAY: tge04010
Entry
tge04010                    Pathway                                
Name
MAPK signaling pathway - Theropithecus gelada (gelada)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
tge04010  MAPK signaling pathway
tge04010

Other DBs
GO: 0000165
Organism
Theropithecus gelada (gelada) [GN:tge]
Gene
112612428  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
112607972  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
112634000  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
112618467  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
112624796  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
112614995  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
112608876  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
112614052  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
112632965  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
112625837  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
112621007  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
112618240  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
112619238  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
112634396  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
112610281  CACNB1; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
112631593  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
112634725  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
112636036  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
112609815  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
112633248  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
112614191  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
112609490  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
112609916  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
112613267  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
112613221  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
112611925  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
112608183  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
112618864  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112612552  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
112609643  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112614190  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
112613317  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112620279  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
112624588  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112630471  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112631469  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112624557  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112608621  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
112604751  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
112628060  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
112625910  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
112627599  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
112606964  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
112604574  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
112613560  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
112624756  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
112610227  NF1; neurofibromin isoform X1 [KO:K08052]
112625711  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
112619290  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
112626061  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
112635460  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
112624610  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112604653  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
112625209  EREG; proepiregulin [KO:K09784]
112624816  AREG; amphiregulin [KO:K09782]
112626218  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
112624619  FGF2; fibroblast growth factor 2 [KO:K18497]
112628041  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
112635323  FGF6; fibroblast growth factor 6 [KO:K04358]
112606831  FGF4; fibroblast growth factor 4 [KO:K04358]
112607217  FGF3; fibroblast growth factor 3 [KO:K04358]
112630377  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
112630484  FGF20; fibroblast growth factor 20 [KO:K04358]
112616411  FGF16; fibroblast growth factor 16 [KO:K04358]
112631781  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
112624795  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
112610592  FGF9; fibroblast growth factor 9 [KO:K04358]
112626373  FGF18; fibroblast growth factor 18 [KO:K04358]
112626403  FGF10; fibroblast growth factor 10 [KO:K04358]
112612323  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
112606810  FGF19; fibroblast growth factor 19 [KO:K22603]
112613542  FGF21; fibroblast growth factor 21 [KO:K22429]
112635291  FGF23; fibroblast growth factor 23 [KO:K22428]
112608614  NGF; beta-nerve growth factor [KO:K02582]
112607193  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
112634735  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
112613253  NTF4; neurotrophin-4 [KO:K12457]
112635504  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
112605601  IGF2; insulin-like growth factor II [KO:K13769]
112620011  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
112633086  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
112606868  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
112625330  PDGFC; platelet-derived growth factor C [KO:K05450]
112605466  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
112635307  KITLG; kit ligand isoform X1 [KO:K05461]
112611838  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
112622794  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
112607256  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
112629345  PGF; placenta growth factor isoform X1 [KO:K16859]
112615683  VEGFD; vascular endothelial growth factor D [KO:K05449]
112625469  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
112620515  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112630669  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
112629962  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
112633366  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
112624372  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
112610717  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
112611866  EFNA2; ephrin-A2 [KO:K05462]
112626705  EFNA5; ephrin-A5 [KO:K05462]
112612330  EFNA4; LOW QUALITY PROTEIN: ephrin-A4 [KO:K05462]
112627143  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
112613231  NRTN; neurturin [KO:K25414]
112636110  ARTN; artemin isoform X1 [KO:K25415]
112613369  PSPN; persephin [KO:K25416]
112620091  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112608971  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112634585  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
112636548  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
112629744  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112631500  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
112625207  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
112625972  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
112609431  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
112607006  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
112607806  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
112613164  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
112628505  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112625154  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
112626117  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112625968  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
112624589  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
112610848  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
112610885  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
112626121  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
112624522  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
112620574  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
112608598  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
112604695  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
112631475  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
112608918  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
112628758  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
112604731  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112607359  HRAS; GTPase HRas isoform X1 [KO:K02833]
112634105  KRAS; GTPase KRas isoform X1 [KO:K07827]
112619416  NRAS; GTPase NRas isoform X1 [KO:K07828]
112612574  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
112606963  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
112618821  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
112616121  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
112620354  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
112619721  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112627624  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
112612394  MAP2K2; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112624556  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
112614214  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
112632792  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
112612712  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
112606886  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
112622271  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
112630760  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
112615705  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
112616634  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
112632664  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
112607111  ETS domain-containing protein Elk-1-like isoform X1 [KO:K04375]
112616509  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
112628044  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
112630275  MYC; myc proto-oncogene protein [KO:K04377]
112622452  SRF; serum response factor [KO:K04378]
112628560  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
112609254  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
112630238  STMN1; stathmin isoform X1 [KO:K04381]
112627871  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
112627983  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
112614273  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
112611901  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
112627440  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
112627837  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
112622917  TNF; tumor necrosis factor [KO:K03156]
112604839  IL1A; interleukin-1 alpha [KO:K04383]
112604696  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
112612158  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
112636300  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
112629301  TGFB3; transforming growth factor beta-3 [KO:K13377]
112635096  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
112604908  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
112619670  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
112608164  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
112618545  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
112636918  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
112631569  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
112626119  CD14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391]
112620191  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
112633210  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
112609500  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
112627433  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112614422  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
112622580  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
112625066  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112608018  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112623229  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
112618384  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
112615074  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
112617260  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
112617282  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
112607412  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112608708  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112611273  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
112612483  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X1 [KO:K04402]
112633811  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
112622975  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
112612861  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
112605048  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
112636978  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
112613558  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
112606386  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
112618517  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
112633320  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
112629923  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
112607331  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
112632119  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
112626113  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
112606485  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
112635784  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
112608888  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
112628781  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
112613610  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
112631594  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
112635511  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
112618518  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
112636030  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
112620626  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
112623422  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
112622899  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112623312  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
112613887  serine/threonine-protein kinase TAO2-like [KO:K04429] [EC:2.7.11.1]
112609150  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
112634479  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
112609481  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
112613256  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
112608997  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
112609390  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
112606978  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
112632708  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
112614456  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
112615064  FLNA; filamin-A isoform X1 [KO:K04437]
112609430  CRK; adapter molecule crk isoform X1 [KO:K04438]
112632798  CRKL; crk-like protein isoform X1 [KO:K04438]
112606510  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
112609501  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
112624632  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112631631  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112626308  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112622701  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112623522  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
112633066  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
112633654  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
112635040  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
112629024  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
112619102  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
112628450  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
112607126  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
112633719  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
112614067  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
112619625  JUN; transcription factor AP-1 [KO:K04448]
112612432  JUND; transcription factor jun-D isoform X1 [KO:K04449]
112636593  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
112610199  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
112634041  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
112628931  MAX; protein max isoform X1 [KO:K04453]
112625783  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
112620377  HSPB1; heat shock protein beta-1 [KO:K04455]
112629473  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112609286  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112612288  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112628744  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
112635392  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
112606343  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
112624057  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
112625873  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
112630411  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112631985  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112604701  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112619787  DUSP7; dual specificity protein phosphatase 7 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112634574  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112605992  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112634159  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
112615087  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
112612451  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
112609072  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
112611995  PPP5C; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
112604780  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
112636485  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
112608124  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
112623761  HSPA1B; heat shock 70 kDa protein 1B isoform X1 [KO:K03283]
112623762  heat shock 70 kDa protein 1-like [KO:K03283]
112609472  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
112605795  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
112618964  MECOM; MDS1 and EVI1 complex locus protein isoform X1 [KO:K04462] [EC:2.1.1.367]
112627876  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
112609132  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
112634399  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
112609983  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
112632013  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112629970  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112616513  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112616847  NF-kappa-B essential modulator-like [KO:K07210]
112609928  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
112624752  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112632105  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
112605794  RELA; transcription factor p65 isoform X1 [KO:K04735]
112612566  RELB; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
tge04070  Phosphatidylinositol signaling system
tge04110  Cell cycle
tge04115  p53 signaling pathway
tge04210  Apoptosis
tge04310  Wnt signaling pathway
tge04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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