KEGG   PATHWAY: rno04014
Entry
rno04014                    Pathway                                
Name
Ras signaling pathway - Rattus norvegicus (rat)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
rno04014  Ras signaling pathway
rno04014

Other DBs
GO: 0032318
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100361891  Rab5al1; ras-related protein Rab-5A [KO:K07887]
103691134  Flt3lg; fms-related tyrosine kinase 3 ligand precursor [KO:K05454]
108348076  Ksr1; kinase suppressor of Ras 1 [KO:K14958]
114110  Flt4; vascular endothelial growth factor receptor 3 precursor [KO:K05097] [EC:2.7.10.1]
114111  Vegfc; vascular endothelial growth factor C precursor [KO:K05449]
114117  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
114118  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
114119  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
114120  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114513  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
114633  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
114858  Shc3; SHC-transforming protein 3 [KO:K17448]
116499  Fgf4; fibroblast growth factor 4 precursor [KO:K04358]
116546  Ralb; ras-related protein Ral-B [KO:K07835]
116554  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116683  Efna5; ephrin-A5 precursor [KO:K05462]
117273  Rhoa; transforming protein RhoA [KO:K04513]
134484121  [KO:K00922] [EC:2.7.1.153]
140635  Flt3; receptor-type tyrosine-protein kinase FLT3 precursor [KO:K05092] [EC:2.7.10.1]
170579  Fgf22; fibroblast growth factor 22 precursor [KO:K04358]
170580  Fgf21; fibroblast growth factor 21 precursor [KO:K22429]
170582  Fgf19; fibroblast growth factor 19 precursor [KO:K22603]
170583  Fgf23; fibroblast growth factor 23 precursor [KO:K22428]
170633  Fgf3; fibroblast growth factor 3 precursor [KO:K04358]
170668  Rasgrp4; RAS guanyl-releasing protein 4 [KO:K12363]
170700  Fgf6; fibroblast growth factor 6 [KO:K04358]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
170901  Efna3; ephrin-A3 isoform X1 [KO:K05462]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
171337  Rap1b; ras-related protein Rap-1b precursor [KO:K07836]
171455  Exoc2; exocyst complex component 2 [KO:K17637]
192117  Syngap1; ras/Rap GTPase-activating protein SynGAP isoform 2 [KO:K17631]
192213  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform 1 [KO:K04349]
207119  Rin1; ras and Rab interactor 1 [KO:K17638]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
24225  Bdnf; brain-derived neurotrophic factor isoform 3 preproprotein [KO:K04355]
24242  Calm1; calmodulin-1 [KO:K02183]
24244  Calm3; calmodulin-3 [KO:K02183]
24329  Egfr; epidermal growth factor receptor isoform 2 precursor [KO:K04361] [EC:2.7.10.1]
24356  Ets1; protein C-ets-1 [KO:K02678]
24400  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
24408  Grin1; glutamate receptor ionotropic, NMDA 1 isoform 1a precursor [KO:K05208]
24409  Grin2a; glutamate receptor ionotropic, NMDA 2A precursor [KO:K05209]
24410  Grin2b; glutamate receptor ionotropic, NMDA 2B precursor [KO:K05210]
24446  Hgf; hepatocyte growth factor preproprotein [KO:K05460]
24482  Igf1; insulin-like growth factor I isoform d preproprotein [KO:K05459]
24483  Igf2; insulin-like growth factor II isoform 2 preproprotein [KO:K13769]
24505  Ins1; insulin-1 preproprotein [KO:K04526]
24506  Ins2; insulin-2 preproprotein [KO:K04526]
24525  Kras; GTPase KRas [KO:K07827]
24553  Met; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
24592  Nf1; neurofibromin [KO:K08052]
24596  Ngfr; tumor necrosis factor receptor superfamily member 16 precursor [KO:K02583]
245986  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
24605  Nras; GTPase NRas [KO:K07828]
24628  Pdgfb; platelet-derived growth factor subunit B precursor [KO:K17386]
24629  Pdgfrb; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
24653  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
24680  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
24681  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
24827  Tgfa; protransforming growth factor alpha preproprotein [KO:K08774]
24888  Bcl2l1; bcl-2-like protein 1 isoform 2 [KO:K04570]
24913  Plaat3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
24954  Insr; insulin receptor preproprotein [KO:K04527] [EC:2.7.10.1]
25022  Fgfr2; fibroblast growth factor receptor 2 isoform b [KO:K05093] [EC:2.7.10.1]
25023  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
25054  Ntrk2; BDNF/NT-3 growth factors receptor isoform 1 precursor [KO:K04360] [EC:2.7.10.1]
25096  Pld1; phospholipase D1 isoform 2 [KO:K01115] [EC:3.1.4.4]
25097  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
25114  Fgfr4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25266  Pdgfa; platelet-derived growth factor subunit A precursor [KO:K04359]
25267  Pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
25272  Mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
25313  Egf; pro-epidermal growth factor precursor [KO:K04357]
25317  Fgf1; fibroblast growth factor 1 [KO:K18496]
25385  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
25443  Fgf10; fibroblast growth factor 10 precursor [KO:K04358]
25444  Fgf9; fibroblast growth factor 9 [KO:K04358]
25482  Mras; ras-related protein M-Ras [KO:K07831]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
25589  Kdr; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
25597  Rasa2; ras GTPase-activating protein 2 [KO:K08053]
25622  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform 2 [KO:K07293] [EC:3.1.3.48]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
25676  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
25718  Igf1r; insulin-like growth factor 1 receptor isoform 2 precursor [KO:K05087] [EC:2.7.10.1]
25730  Ntf4; neurotrophin-4 precursor [KO:K12457]
25738  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
26955  Afdn; afadin [KO:K05702]
287709  Rab5c; ras-related protein Rab-5C [KO:K07889]
288589  Rasa4; ras GTPase-activating protein 4B isoform X1 [KO:K17630]
288691  Ksr2; kinase suppressor of Ras 2 isoform X2 [KO:K18529] [EC:2.7.11.1]
288779  Rab5b; ras-related protein Rab-5B [KO:K07888]
289080  Ralgdsl1; ral guanine nucleotide dissociation stimulator-like 1 [KO:K17635]
289733  Pla2g3; group 3 secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
292756  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
29337  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
29348  Fgf7; fibroblast growth factor 7 precursor [KO:K04358]
29349  Fgf8; fibroblast growth factor 8 isoform 1 precursor [KO:K04358]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
29354  Pla2g5; phospholipase A2 group V precursor [KO:K01047] [EC:3.1.1.4]
29359  Pla2g10; group 10 secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
293621  Hras; GTPase HRas [KO:K02833]
29368  Fgf17; fibroblast growth factor 17 isoform 1 precursor [KO:K04358]
29369  Fgf18; fibroblast growth factor 18 precursor [KO:K04358]
29372  Rasa3; ras GTPase-activating protein 3 [KO:K12380]
29387  Pla2g2c; group IIC secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
294283  Ralgdsl2; ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
29431  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
29432  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
29433  Pak3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
29434  Rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
294962  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
29526  Pla2g1b; phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
295347  Rap1a; ras-related protein Rap-1A [KO:K04353]
296078  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
296091  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
296211  Ralgapa2; ral GTPase-activating protein subunit alpha-2 [KO:K25768]
29622  Ralgds; ral guanine nucleotide dissociation stimulator isoform 1 [KO:K08732]
296269  Angpt4; angiopoietin-4 precursor [KO:K05467]
29692  Pla2g2a; phospholipase A2, membrane associated precursor [KO:K01047] [EC:3.1.1.4]
297173  RSA-14-44; ras homolog gene family, member A [KO:K04513]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
298579  Pla2g2d; group IID secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
298581  Pla2g2e; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
299827  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
301348  Zap70; tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
302415  Foxo4; forkhead box protein O4 [KO:K12358]
304063  Ets2; protein C-ets-2 [KO:K21932]
304109  Tiam1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
304883  Abl2; tyrosine-protein kinase ABL2 [KO:K08887] [EC:2.7.10.2]
304893  Rasal2; ras GTPase-activating protein nGAP isoform 1 [KO:K17633]
305584  Rel; proto-oncogene c-Rel [KO:K09254]
307100  Calml3; calmodulin-like protein 3 [KO:K02183]
307403  Csf1r; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
309165  Rela; transcription factor p65 [KO:K04735]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
309548  Shoc2; leucine-rich repeat protein SHOC-2 [KO:K19613]
310643  Efna4; ephrin-A4 precursor [KO:K05462]
310738  Ngf; beta-nerve growth factor precursor [KO:K02582]
311341  Pla2g4b; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
311450  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
311622  Stk4; serine/threonine-protein kinase 4 [KO:K04411]
311860  Abl1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
313845  Sos1; son of sevenless homolog 1 [KO:K03099]
313874  Rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
314436  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
314596  Rasal3; RAS protein activator like-3 isoform 2 [KO:K17634]
314612  Shc2; SHC-transforming protein 2 [KO:K17447]
360426  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform 1 [KO:K16343] [EC:3.1.1.4]
360457  Vegfd; vascular endothelial growth factor D precursor [KO:K05449]
360814  Rasal1; rasGAP-activating-like protein 1 [KO:K17632]
361388  Gab1; GRB2-associated-binding protein 1 [KO:K09593]
361568  Rras; ras-related protein R-Ras [KO:K07829]
361714  Rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
362039  Pla2g12a; group XIIA secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
362257  Ralgapb; ral GTPase-activating protein subunit beta [KO:K25769]
362799  Rapgef5; rap guanine nucleotide exchange factor 5 isoform 1 [KO:K08019]
363140  Rassf1; ras association domain-containing protein 1 isoform 2 [KO:K09850]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
364774  Calml5; calmodulin-like protein 5 [KO:K02183]
365355  Rras2; ras-related protein R-Ras2 [KO:K07830]
366492  Epha2; ephrin type-A receptor 2 precursor [KO:K05103] [EC:2.7.10.1]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
366957  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
367415  Pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X2 [KO:K01047] [EC:3.1.1.4]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
50658  Mapk9; mitogen-activated protein kinase 9 isoform 2 [KO:K04440] [EC:2.7.11.24]
50663  Calm2; calmodulin-2 [KO:K02183]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
54250  Fgf2; fibroblast growth factor 2 [KO:K18497]
54251  Flt1; vascular endothelial growth factor receptor 1 isoform 2 precursor [KO:K05096] [EC:2.7.10.1]
54355  Rassf5; ras association domain-containing protein 5 [KO:K08015]
56785  Ralgapa1; ral GTPase-activating protein subunit alpha-1 [KO:K25768]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
58979  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
59109  Ntrk1; high affinity nerve growth factor receptor precursor [KO:K03176] [EC:2.7.10.1]
60427  Kitlg; kit ligand isoform 1 precursor [KO:K05461]
60449  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
60464  Fgf16; fibroblast growth factor 16 [KO:K04358]
60662  Fgf5; fibroblast growth factor 5 isoform 1 precursor [KO:K04358]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
64030  Kit; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
64199  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
64465  Cdc42; cell division control protein 42 homolog [KO:K04393]
64633  Rab5a; ras-related protein Rab-5A [KO:K07887]
64639  Bad; bcl2-associated agonist of cell death [KO:K02158]
65032  Htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
66017  Fgf20; fibroblast growth factor 20 [KO:K04358]
66018  Pdgfd; platelet-derived growth factor D precursor [KO:K05450]
679845  Shc4; SHC-transforming protein 4 [KO:K17449]
680149  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
685451  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
685513  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
687346  Brap; BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
688319  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
690388  Pla2g2f; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
690825  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
691455  Calml4; calmodulin-like protein 4 [KO:K02183]
691810  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
691905  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
691907  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
78965  Csf1; macrophage colony-stimulating factor 1 precursor [KO:K05453]
79114  Fgfr1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
79121  Arf6; ADP-ribosylation factor 6 [KO:K07941]
79218  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
79429  Pdgfc; platelet-derived growth factor C precursor [KO:K05450]
80850  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
81504  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
81511  Lat; linker for activation of T-cells family member 1 [KO:K07362]
81667  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
81737  Ntf3; neurotrophin-3 isoform 3 precursor [KO:K04356]
81757  Rala; ras-related protein Ral-A [KO:K07834]
83579  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
83785  Vegfa; vascular endothelial growth factor A isoform 6 precursor [KO:K05448]
84014  Ralbp1; ralA-binding protein 1 [KO:K08773]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
84358  Efna2; ephrin-A2 precursor [KO:K05462]
84477  Gab2; GRB2-associated-binding protein 2 [KO:K08091]
84489  Fgfr3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
85311  Pla1a; phospholipase A1 member A precursor [KO:K13618] [EC:3.1.1.111]
85384  Sos2; son of sevenless homolog 2 [KO:K03099]
85385  Shc1; SHC-transforming protein 1 isoform b [KO:K06279]
89804  Tek; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
89805  Angpt2; angiopoietin-2 precursor [KO:K05466]
89807  Angpt1; angiopoietin-1 precursor [KO:K05465]
89811  Vegfb; vascular endothelial growth factor B precursor [KO:K16858]
94203  Pgf; placenta growth factor precursor [KO:K16859]
94268  Efna1; ephrin-A1 precursor [KO:K05462]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
rno04010  MAPK signaling pathway
rno04015  Rap1 signaling pathway
rno04020  Calcium signaling pathway
rno04144  Endocytosis
rno04151  PI3K-Akt signaling pathway
rno04660  T cell receptor signaling pathway
rno04720  Long-term potentiation
rno04810  Regulation of actin cytoskeleton
KO pathway
ko04014   

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