KEGG   PATHWAY: ocu05164
Entry
ocu05164                    Pathway                                
Name
Influenza A - Oryctolagus cuniculus (rabbit)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
ocu05164  Influenza A
ocu05164

Disease
H00398  Influenza
H00399  Avian influenza
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008602  IFNG; interferon gamma precursor [KO:K04687]
100008606  [KO:K14754]
100008609  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100008733  IL6; interleukin-6 precursor [KO:K05405]
100008751  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100008822  [KO:K05692]
100008840  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100008990  IL1B; interleukin-1 beta precursor [KO:K04519]
100009013  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
100009024  TLR3; toll-like receptor 3 precursor [KO:K05401]
100009038  [KO:K10152]
100009039  [KO:K02089] [EC:2.7.11.22]
100009040  [KO:K02091] [EC:2.7.11.22]
100009072  RAB11A; ras-related protein Rab-11A [KO:K07904]
100009088  TNF; tumor necrosis factor precursor [KO:K03156]
100009129  CXCL8; interleukin-8 precursor [KO:K10030]
100009130  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
100009250  IL1A; interleukin-1 alpha [KO:K04383]
100009272  ACTB; actin, cytoplasmic 1 [KO:K05692]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100009414  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100009451  [KO:K14754]
100009497  TLR4; toll-like receptor 4 [KO:K10160]
100037719  PRKCB; protein kinase C beta type isoform I [KO:K19662] [EC:2.7.11.13]
100037720  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100101588  [KO:K01370] [EC:3.4.22.36]
100101592  [KO:K04399] [EC:3.4.22.62]
100144338  IL18; interleukin-18 [KO:K05482]
100328905  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100328929  RLA-DR-ALPHA; major histocompatibility complex, class II, DR alpha precursor [KO:K06752]
100337764  [KO:K05863]
100337822  [KO:K00922] [EC:2.7.1.153]
100337870  TMPRSS2; transmembrane serine protease 2 [KO:K09633] [EC:3.4.21.122]
100337888  [KO:K03171]
100338097  [KO:K05131]
100338604  [KO:K05130]
100338777  [KO:K14284]
100338854  [KO:K05133]
100338894  [KO:K08060] [EC:2.7.11.1]
100339093  [KO:K03237]
100339353  [KO:K01312] [EC:3.4.21.4]
100339606  [KO:K01312] [EC:3.4.21.4]
100339773  [KO:K14284]
100339859  [KO:K01312] [EC:3.4.21.4]
100339936  [KO:K14285]
100340530  [KO:K14216] [EC:2.7.7.84]
100340535  [KO:K14284]
100340619  [KO:K04498] [EC:2.3.1.48]
100340811  [KO:K04729]
100341037  [KO:K05692]
100341050  [KO:K08738]
100341175  [KO:K08738]
100341358  [KO:K06752]
100341515  [KO:K08738]
100341605  [KO:K04733] [EC:2.7.11.1]
100341787  [KO:K05132]
100341830  [KO:K12653]
100342046  [KO:K14021]
100342324  [KO:K14404]
100342837  [KO:K14284]
100342852  [KO:K04456] [EC:2.7.11.1]
100342931  [KO:K05415]
100342972  [KO:K05863]
100343144  [KO:K06752]
100343451  [KO:K14290]
100343500  [KO:K10652] [EC:2.3.2.27]
100343560  [KO:K12647] [EC:5.6.2.6]
100343572  [KO:K15042]
100343626  [KO:K14297]
100343787  [KO:K01165]
100343893  [KO:K11220]
100344073  [KO:K04389]
100344432  [KO:K04693]
100344467  [KO:K11221]
100344622  [KO:K11219] [EC:2.7.10.2]
100345181  [KO:K00922] [EC:2.7.1.153]
100345250  [KO:K02649]
100345355  [KO:K14396]
100345640  [KO:K06490]
100346062  [KO:K14404]
100346106  [KO:K03158]
100346477  [KO:K05863]
100346984  [KO:K12968] [EC:3.5.4.37]
100347276  [KO:K15045]
100347345  [KO:K04371] [EC:2.7.11.24]
100347351  [KO:K14284]
100347407  [KO:K04366] [EC:2.7.11.1]
100347704  [KO:K10652] [EC:2.3.2.27]
100347707  RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
100348057  [KO:K05863]
100348266  [KO:K12499]
100348477  [KO:K04398] [EC:3.4.22.61]
100348561  [KO:K04371] [EC:2.7.11.24]
100348663  [KO:K00922] [EC:2.7.1.153]
100349007  [KO:K05406]
100349408  [KO:K06752]
100349426  [KO:K02580]
100349506  [KO:K05862]
100349667  [KO:K06752]
100349768  [KO:K05863]
100350168  [KO:K06752]
100350359  [KO:K15042]
100350656  RLA-DRB1; HLA class II histocompatibility antigen, DRB1 beta chain [KO:K06752]
100351037  [KO:K08738]
100351096  [KO:K21348]
100351163  [KO:K06752]
100351382  [KO:K10054] [EC:2.3.2.-]
100351416  [KO:K06752]
100351853  [KO:K15043]
100351903  [KO:K14285]
100352110  [KO:K12799]
100352415  RLA-DMA; histocompatibility antigen DM heterodimer heavy chain-like precursor [KO:K06752]
100352594  [KO:K11217] [EC:2.7.10.2]
100352672  [KO:K06752]
100352927  [KO:K06752]
100353066  [KO:K15043]
100353112  [KO:K12671]
100353390  [KO:K05414]
100353673  [KO:K08738]
100353706  [KO:K04456] [EC:2.7.11.1]
100354135  [KO:K04498] [EC:2.3.1.48]
100354455  [KO:K07211] [EC:2.7.11.10]
100354468  [KO:K08738]
100354654  [KO:K05414]
100354724  [KO:K08738]
100354802  [KO:K05863]
100354852  [KO:K05425]
100355084  [KO:K08738]
100355162  [KO:K09635] [EC:3.4.21.-]
100355543  [KO:K09523]
100355669  [KO:K05414]
100355675  [KO:K02159]
100355808  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
100355883  [KO:K09641] [EC:3.4.21.-]
100355888  [KO:K04467] [EC:2.7.11.10]
100355912  [KO:K05414]
100355948  RLA-DMB; histocompatibility antigen DM heterodimer light chain-like precursor [KO:K06752]
100355976  [KO:K15043]
100355991  [KO:K04726]
100356081  [KO:K12967]
100356326  [KO:K05863]
100356401  [KO:K07209] [EC:2.7.11.10]
100356419  [KO:K05414]
100356540  [KO:K12648]
100356678  [KO:K05414]
100357194  [KO:K05414]
100357329  [KO:K08738]
100357334  [KO:K23940]
100357341  [KO:K04734]
100357708  [KO:K05414]
100357840  [KO:K08738]
100357841  [KO:K02649]
100357844  [KO:K01315] [EC:3.4.21.7]
100358134  [KO:K04447] [EC:2.7.10.2]
100358563  [KO:K07905]
100358566  [KO:K15047]
100358771  [KO:K05410] [EC:2.7.11.10]
100359014  [KO:K14754]
100359017  [KO:K14298]
100359083  [KO:K03174]
100359283  [KO:K02581]
100359310  [KO:K15043]
103346571  [KO:K05411]
103346588  [KO:K04696]
103347723  [KO:K08738]
103348383  [KO:K02084]
103350044  [KO:K00787] [EC:2.5.1.1 2.5.1.10]
103350080  [KO:K14298]
103351963  [KO:K14284]
108175836  [KO:K08738]
108175967  [KO:K09507]
108177422  [KO:K08738]
108178670  [KO:K14216] [EC:2.7.7.84]
108178730  [KO:K08738]
127482571  [KO:K06752]
127483320  [KO:K08738]
127485184  [KO:K04735]
127486116  [KO:K04456] [EC:2.7.11.1]
127488515  [KO:K14396]
127488928  [KO:K11220]
127489434  [KO:K15043]
127489461  [KO:K04368] [EC:2.7.12.2]
127491150  [KO:K11221]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
ocu00900  Terpenoid backbone biosynthesis
ocu03013  Nucleocytoplasmic transport
ocu03015  mRNA surveillance pathway
ocu04010  MAPK signaling pathway
ocu04110  Cell cycle
ocu04144  Endocytosis
ocu04210  Apoptosis
ocu04620  Toll-like receptor signaling pathway
ocu04621  NOD-like receptor signaling pathway
ocu04622  RIG-I-like receptor signaling pathway
ocu04630  JAK-STAT signaling pathway
ocu05416  Viral myocarditis
KO pathway
ko05164   

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