KEGG   PATHWAY: ccar04010
Entry
ccar04010                   Pathway                                
Name
MAPK signaling pathway - Cyprinus carpio (common carp)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ccar04010  MAPK signaling pathway
ccar04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Cyprinus carpio (common carp) [GN:ccar]
Gene
109045151  [KO:K04344]
109045235  efna5a; ephrin-A5b [KO:K05462]
109045321  [KO:K07861]
109045333  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109045414  [KO:K04421] [EC:2.7.11.25]
109045435  [KO:K04729]
109045437  [KO:K04868]
109045614  [KO:K04854]
109045698  [KO:K04358]
109045709  [KO:K04402]
109045710  [KO:K04402]
109045861  [KO:K04349]
109045868  [KO:K04457] [EC:3.1.3.16]
109045914  [KO:K12361]
109046024  [KO:K05090] [EC:2.7.10.1]
109046062  [KO:K04402]
109046075  [KO:K05462]
109046196  [KO:K04463] [EC:2.7.12.2]
109046273  [KO:K05089] [EC:2.7.10.1]
109046274  [KO:K05089] [EC:2.7.10.1]
109046330  csf1rb; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
109046348  [KO:K05084] [EC:2.7.10.1]
109046398  [KO:K04859]
109046405  [KO:K04358]
109046541  [KO:K04527] [EC:2.7.10.1]
109046603  [KO:K04361] [EC:2.7.10.1]
109046639  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
109046734  map2k2a; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109046750  [KO:K25416]
109046752  [KO:K04359]
109046759  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
109046854  [KO:K04434]
109046975  [KO:K04359]
109047026  [KO:K04469]
109047034  [KO:K04457] [EC:3.1.3.16]
109047070  [KO:K04435]
109047134  gng14; GGL domain-containing protein [KO:K04347]
109047284  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
109047393  [KO:K04348] [EC:3.1.3.16]
109047400  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109047402  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109047426  [KO:K04378]
109047536  [KO:K04380]
109047610  [KO:K04348] [EC:3.1.3.16]
109047666  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
109047700  [KO:K04866]
109048105  [KO:K07827]
109048201  [KO:K04448]
109048465  rras; ras-related protein R-Ras [KO:K07830]
109048483  si:ch211-195b15.8; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109048662  [KO:K04393]
109048836  [KO:K04426] [EC:2.7.11.25]
109049051  [KO:K04393]
109049076  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
109049087  [KO:K05462]
109049193  [KO:K04358]
109049194  [KO:K22603]
109049195  [KO:K04358]
109049198  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
109049214  arrb2b; arrestin red cell [KO:K04439]
109049336  efna1b; ephrin-A1b [KO:K05462]
109049401  [KO:K04358]
109049422  [KO:K04364]
109049465  [KO:K04466] [EC:2.7.11.25]
109049617  [KO:K08018]
109049683  fgf21; fibroblast growth factor 21 [KO:K22429]
109049848  [KO:K04421] [EC:2.7.11.25]
109049860  [KO:K04729]
109050003  [KO:K07861]
109050033  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
109050066  [KO:K04439]
109050185  [KO:K16342] [EC:3.1.1.4]
109050263  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109050338  [KO:K04361] [EC:2.7.10.1]
109050576  [KO:K04434]
109050658  [KO:K04358]
109050659  [KO:K04358]
109050773  [KO:K07827]
109051318  [KO:K02583]
109051326  [KO:K02583]
109051603  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
109051708  [KO:K04464] [EC:2.7.11.24]
109051709  [KO:K04464] [EC:2.7.11.24]
109051735  sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
109051849  map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
109051855  [KO:K04423] [EC:2.7.11.25]
109051932  [KO:K04393]
109051935  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
109051973  [KO:K04864]
109052010  [KO:K04439]
109052082  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
109052186  prkacaa; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
109052188  [KO:K25415]
109052191  [KO:K04345] [EC:2.7.11.11]
109052343  [KO:K04424] [EC:2.7.11.25]
109052512  [KO:K19662] [EC:2.7.11.13]
109052551  [KO:K05085] [EC:2.7.10.1]
109052888  [KO:K04428] [EC:2.7.11.25]
109053029  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
109053046  mknk2a; MAP kinase-interacting serine/threonine-protein kinase 2a [KO:K04372] [EC:2.7.11.1]
109053049  [KO:K22429]
109053323  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
109053382  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109053514  [KO:K04358]
109053980  [KO:K04392]
109054108  [KO:K04867]
109054154  [KO:K04457] [EC:3.1.3.16]
109054179  [KO:K03283]
109054396  [KO:K05084] [EC:2.7.10.1]
109054710  prkacbb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109054715  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
109054723  [KO:K04345] [EC:2.7.11.11]
109054776  [KO:K25414]
109054809  [KO:K04443] [EC:2.7.11.1]
109054917  [KO:K04380]
109055038  [KO:K04378]
109055087  [KO:K04436]
109055145  [KO:K13375]
109055244  [KO:K17333]
109055250  [KO:K04461] [EC:3.1.3.16]
109055291  [KO:K04873]
109055293  [KO:K04871]
109055300  [KO:K04872]
109055353  fgfr1b; fibroblast growth factor receptor 1b isoform X1 [KO:K04362] [EC:2.7.10.1]
109055369  [KO:K02833]
109055395  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109055737  [KO:K04358]
109055797  [KO:K04445] [EC:2.7.11.1]
109055822  [KO:K05085] [EC:2.7.10.1]
109055931  [KO:K04853]
109056079  [KO:K04865]
109056230  [KO:K12326]
109056386  [KO:K04417] [EC:2.7.11.25]
109056402  [KO:K04369] [EC:2.7.12.2]
109056593  [KO:K05449]
109056684  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
109056700  cacng6b; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
109056808  [KO:K04372] [EC:2.7.11.1]
109056862  [KO:K04373] [EC:2.7.11.1]
109056907  [KO:K04402]
109057104  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
109057131  [KO:K04865]
109057161  hsp70.3; heat shock 70 kDa protein [KO:K03283]
109057193  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109057196  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
109057220  [KO:K04371] [EC:2.7.11.24]
109057235  [KO:K21946] [EC:3.1.3.16 3.1.3.48]
109057375  [KO:K04344]
109057516  [KO:K04458] [EC:3.1.3.48]
109057594  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109058062  [KO:K04405]
109058092  [KO:K05098] [EC:2.7.10.1]
109058118  [KO:K05091] [EC:2.7.10.1]
109058233  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
109058312  [KO:K05121] [EC:2.7.10.1]
109058708  [KO:K07830]
109058889  [KO:K04456] [EC:2.7.11.1]
109059197  [KO:K04456] [EC:2.7.11.1]
109059246  [KO:K07827]
109059295  [KO:K04457] [EC:3.1.3.16]
109059303  [KO:K04441] [EC:2.7.11.24]
109059319  [KO:K05087] [EC:2.7.10.1]
109059401  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
109059460  [KO:K04862]
109059466  [KO:K04358]
109059470  [KO:K22428]
109059501  fgf16; fibroblast growth factor 16 [KO:K04358]
109059552  [KO:K04862]
109059668  [KO:K04352]
109059697  [KO:K04454]
109059699  mef2ca; myocyte enhancer factor 2ca isoform X1 [KO:K04454]
109059783  [KO:K02583]
109060014  map2k4b; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4b [KO:K04430] [EC:2.7.12.2]
109060035  [KO:K04868]
109060043  [KO:K25415]
109060201  atf4b; activating transcription factor 4b [KO:K04374]
109060203  [KO:K04374]
109060204  pdgfbb; uncharacterized protein pdgfbb [KO:K04359]
109060270  [KO:K13377]
109060317  [KO:K04344]
109060407  [KO:K04424] [EC:2.7.11.25]
109060494  [KO:K04392]
109060735  [KO:K04438]
109060897  [KO:K04362] [EC:2.7.10.1]
109061083  [KO:K07830]
109061518  [KO:K04358]
109061547  [KO:K05449]
109061637  [KO:K04419] [EC:2.7.11.25]
109061761  [KO:K04457] [EC:3.1.3.16]
109061857  efna3b; ephrin-A3b [KO:K05462]
109061876  [KO:K05462]
109062099  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
109062129  [KO:K16510] [EC:2.7.11.1]
109062345  [KO:K04379]
109062359  fgf24; fibroblast growth factor 18 isoform X1 [KO:K04358]
109062396  [KO:K04468] [EC:2.7.11.24]
109062821  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
109062992  il1b; interleukin-1 beta [KO:K04519]
109062994  [KO:K04519]
109063023  [KO:K04373] [EC:2.7.11.1]
109063028  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
109063179  [KO:K03173] [EC:2.3.2.27]
109063188  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
109063190  [KO:K02583]
109063194  [KO:K02583]
109063271  [KO:K04461] [EC:3.1.3.16]
109063360  [KO:K04465]
109063396  [KO:K05091] [EC:2.7.10.1]
109063449  [KO:K04344]
109063458  [KO:K08018]
109063472  [KO:K03156]
109063573  [KO:K05459]
109063617  [KO:K19663] [EC:2.7.11.13]
109063690  [KO:K04421] [EC:2.7.11.25]
109063702  rps6kal; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
109063756  [KO:K05097] [EC:2.7.10.1]
109063835  [KO:K04345] [EC:2.7.11.11]
109064022  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109064184  [KO:K05085] [EC:2.7.10.1]
109064245  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
109064262  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109064382  [KO:K12361]
109064384  [KO:K04456] [EC:2.7.11.1]
109065003  [KO:K03173] [EC:2.3.2.27]
109065147  [KO:K05099] [EC:2.7.10.1]
109065183  [KO:K04858]
109065229  [KO:K25414]
109065283  [KO:K04356]
109065463  [KO:K03175] [EC:2.3.2.27]
109065543  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
109065551  [KO:K04434]
109065580  [KO:K04441] [EC:2.7.11.24]
109065588  [KO:K04441] [EC:2.7.11.24]
109065600  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
109065695  [KO:K18497]
109065938  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
109065947  [KO:K05462]
109066088  [KO:K04434]
109066138  [KO:K03173] [EC:2.3.2.27]
109066208  [KO:K04431] [EC:2.7.12.2]
109066210  [KO:K04431] [EC:2.7.12.2]
109066314  [KO:K05083] [EC:2.7.10.1]
109066494  rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
109066517  [KO:K04867]
109066530  angpt4; angiopoietin-4 [KO:K05467]
109066531  [KO:K04456] [EC:2.7.11.1]
109066532  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
109066700  dusp7; dual specificity protein phosphatase 7 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109066802  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109066881  [KO:K04386]
109066900  [KO:K04441] [EC:2.7.11.24]
109066930  [KO:K05462]
109066952  [KO:K07831]
109066966  [KO:K05098] [EC:2.7.10.1]
109067044  pla2g4f.1; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
109067201  [KO:K04441] [EC:2.7.11.24]
109067319  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109067672  [KO:K07836]
109067782  [KO:K04439]
109067892  [KO:K17386]
109067996  [KO:K04850]
109068037  [KO:K02582]
109068176  [KO:K04857]
109068276  [KO:K04857]
109068396  [KO:K05093] [EC:2.7.10.1]
109068468  [KO:K03283]
109068603  [KO:K04374]
109068702  mapta; microtubule-associated protein tau isoform X1 [KO:K04380]
109068761  [KO:K05459]
109068875  [KO:K04465]
109069080  [KO:K04405]
109069112  [KO:K04414] [EC:2.7.11.1]
109069421  map4k6; mitogen-activated protein kinase kinase kinase kinase 6 [KO:K04414] [EC:2.7.11.1]
109069462  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
109069463  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
109069464  [KO:K04438]
109069553  [KO:K07827]
109069591  [KO:K04430] [EC:2.7.12.2]
109070023  [KO:K04730] [EC:2.7.11.1]
109070180  cacng2b; calcium channel, voltage-dependent, gamma subunit 2b [KO:K04867]
109070198  [KO:K04403]
109070463  [KO:K12362]
109070518  [KO:K04858]
109070595  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109070618  igf2a; insulin-like growth factor 2a [KO:K13769]
109070678  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X3 [KO:K04404]
109070813  [KO:K02833]
109070898  [KO:K04451]
109070909  [KO:K05091] [EC:2.7.10.1]
109071096  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
109071169  [KO:K05460]
109071182  [KO:K05103] [EC:2.7.10.1]
109071201  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
109071291  [KO:K04865]
109071296  [KO:K02187] [EC:3.4.22.56]
109071297  [KO:K02187] [EC:3.4.22.56]
109071504  [KO:K03283]
109071508  [KO:K04458] [EC:3.1.3.48]
109071522  [KO:K05462]
109071631  [KO:K16342] [EC:3.1.1.4]
109071938  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
109071996  [KO:K17534] [EC:2.7.11.25]
109072038  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109072067  [KO:K02582]
109072174  rap1b; ras-related protein Rap-1b [KO:K07836]
109072227  [KO:K04864]
109072229  [KO:K05461]
109072257  [KO:K21946] [EC:3.1.3.16 3.1.3.48]
109072258  [KO:K05461]
109072264  [KO:K08018]
109072335  [KO:K05462]
109072388  si:dkey-246i14.3; ephrin-A4 isoform X1 [KO:K05462]
109072577  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
109072578  [KO:K04452]
109072673  [KO:K03156]
109072788  [KO:K04345] [EC:2.7.11.11]
109073159  [KO:K16342] [EC:3.1.1.4]
109073235  [KO:K04372] [EC:2.7.11.1]
109073386  [KO:K06268]
109074006  zmp:0000000936; interleukin-1 receptor type 1 [KO:K04386]
109074070  [KO:K04856]
109074165  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
109074435  [KO:K16342] [EC:3.1.1.4]
109074483  pla2g4f.2; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
109074589  [KO:K19662] [EC:2.7.11.13]
109074644  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
109074685  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
109074830  myca; transcriptional regulator Myc-2 isoform X1 [KO:K04377]
109074831  [KO:K04377]
109074872  [KO:K04424] [EC:2.7.11.25]
109075242  ntf3; neurotrophin-3 [KO:K04356]
109075374  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109075409  [KO:K04466] [EC:2.7.11.25]
109075440  [KO:K04402]
109075469  hspb15; heat shock protein, alpha-crystallin-related, b15 [KO:K04455]
109076240  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
109076273  [KO:K04349]
109076649  max; protein max isoform X2 [KO:K04453]
109076719  [KO:K04864]
109076921  [KO:K04358]
109077190  [KO:K08018]
109077293  pdgfab; platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359]
109077376  igf1; insulin-like growth factor I, adult form isoform X1 [KO:K05459]
109077378  [KO:K12362]
109077408  [KO:K05459]
109077428  [KO:K04466] [EC:2.7.11.25]
109078065  [KO:K03099]
109078070  [KO:K04353]
109078077  [KO:K02677] [EC:2.7.11.13]
109078082  [KO:K04392]
109078095  [KO:K04870]
109078267  [KO:K04378]
109078395  [KO:K04359]
109078443  [KO:K04723]
109078605  [KO:K04381]
109078623  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
109078681  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
109078846  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
109078847  [KO:K04454]
109078932  [KO:K16342] [EC:3.1.1.4]
109078942  [KO:K16342] [EC:3.1.1.4]
109078955  [KO:K16342] [EC:3.1.1.4]
109078965  [KO:K16342] [EC:3.1.1.4]
109079006  [KO:K04361] [EC:2.7.10.1]
109079029  [KO:K22603]
109079204  [KO:K05448]
109079207  [KO:K04441] [EC:2.7.11.24]
109079208  [KO:K04441] [EC:2.7.11.24]
109079273  [KO:K04371] [EC:2.7.11.24]
109079321  [KO:K04374]
109079342  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
109079451  [KO:K05866] [EC:3.1.3.48]
109079452  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
109079543  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
109079549  angpt2a; angiopoietin-2a [KO:K05466]
109079632  nf1a; neurofibromin isoform X1 [KO:K08052]
109079739  [KO:K04365] [EC:2.7.11.1]
109079742  [KO:K05087] [EC:2.7.10.1]
109079770  [KO:K04358]
109079917  [KO:K04358]
109079942  [KO:K04455]
109080218  [KO:K09253]
109080616  [KO:K04441] [EC:2.7.11.24]
109080931  [KO:K04379]
109080936  [KO:K04379]
109081018  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109081065  [KO:K19663] [EC:2.7.11.13]
109081435  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109081481  [KO:K04429] [EC:2.7.11.1]
109081532  [KO:K04352]
109081536  rasa1a; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
109081563  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
109081564  [KO:K13376]
109081813  [KO:K05460]
109081919  [KO:K04358]
109081920  [KO:K04358]
109081938  [KO:K16342] [EC:3.1.1.4]
109082280  [KO:K16342] [EC:3.1.1.4]
109082299  [KO:K04460] [EC:3.1.3.16]
109082573  [KO:K04371] [EC:2.7.11.24]
109082764  [KO:K04451]
109082808  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
109082869  [KO:K16342] [EC:3.1.1.4]
109082969  [KO:K04735]
109083117  [KO:K04402]
109083140  [KO:K04674] [EC:2.7.11.30]
109083614  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
109083633  [KO:K04403]
109083993  [KO:K04376]
109084454  [KO:K04437]
109084529  [KO:K04371] [EC:2.7.11.24]
109084538  [KO:K03283]
109084657  [KO:K04441] [EC:2.7.11.24]
109084682  [KO:K07828]
109084683  [KO:K07828]
109084739  [KO:K04443] [EC:2.7.11.1]
109084783  rras2; ras-related protein R-Ras2 [KO:K07830]
109084935  [KO:K04440] [EC:2.7.11.24]
109084942  [KO:K04358]
109085243  [KO:K13769]
109085261  [KO:K04526]
109085271  [KO:K04526]
109085548  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109085624  [KO:K04455]
109085837  [KO:K04350]
109085854  [KO:K05090] [EC:2.7.10.1]
109085865  dusp8b; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109086168  [KO:K04358]
109086348  [KO:K04854]
109086707  [KO:K05095] [EC:2.7.10.1]
109086779  [KO:K03099]
109086797  [KO:K05461]
109086854  [KO:K05103] [EC:2.7.10.1]
109086865  [KO:K05452]
109086868  [KO:K16510] [EC:2.7.11.1]
109086881  [KO:K04381]
109086882  [KO:K04381]
109086906  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
109087122  [KO:K05450]
109087149  [KO:K04853]
109087632  jund; transcription factor jun-D [KO:K04449]
109087650  [KO:K07831]
109087789  [KO:K04380]
109087818  rasa2; ras GTPase-activating protein 2 [KO:K08053]
109087888  [KO:K04456] [EC:2.7.11.1]
109087896  [KO:K08053]
109087914  [KO:K04856]
109088127  [KO:K04364]
109088191  [KO:K04346]
109088214  [KO:K07210]
109088262  egf; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
109088382  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
109088445  [KO:K04420] [EC:2.7.11.25]
109088491  [KO:K03173] [EC:2.3.2.27]
109088584  [KO:K07210]
109088721  [KO:K04388] [EC:2.7.11.30]
109088775  fgf20b; fibroblast growth factor 20b [KO:K04358]
109089113  [KO:K02187] [EC:3.4.22.56]
109089728  [KO:K02677] [EC:2.7.11.13]
109090031  [KO:K05449]
109090037  [KO:K05465]
109090263  [KO:K05085] [EC:2.7.10.1]
109090280  [KO:K05103] [EC:2.7.10.1]
109090283  [KO:K05103] [EC:2.7.10.1]
109090421  [KO:K04449]
109090455  [KO:K04373] [EC:2.7.11.1]
109090456  [KO:K04373] [EC:2.7.11.1]
109090577  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
109090578  [KO:K04348] [EC:3.1.3.16]
109090606  [KO:K12326]
109090707  fgf10b; fibroblast growth factor 10b [KO:K04358]
109090887  [KO:K04358]
109090909  [KO:K04358]
109090960  rps6ka3b; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
109091017  [KO:K08774]
109091092  [KO:K04348] [EC:3.1.3.16]
109091193  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
109091194  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
109091679  [KO:K04866]
109091699  stk3; serine/threonine-protein kinase 3 [KO:K04412]
109091771  [KO:K04441] [EC:2.7.11.24]
109091772  [KO:K04377]
109091836  [KO:K04392]
109091860  [KO:K04870]
109091880  [KO:K05452]
109091940  [KO:K05126] [EC:2.7.10.1]
109091950  [KO:K04852]
109092014  [KO:K22428]
109092019  [KO:K04859]
109092068  [KO:K04869]
109092120  [KO:K04426] [EC:2.7.11.25]
109092137  [KO:K04467] [EC:2.7.11.10]
109092233  [KO:K04368] [EC:2.7.12.2]
109092234  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
109092279  [KO:K08845] [EC:2.7.11.1]
109092287  [KO:K05462]
109092295  [KO:K05453]
109092369  [KO:K04347]
109092408  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
109092454  mapk14a; LOW QUALITY PROTEIN: mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
109092498  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870]
109092640  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
109092988  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
109093162  [KO:K04463] [EC:2.7.12.2]
109093172  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
109093186  [KO:K03171]
109093367  ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X2 [KO:K18018] [EC:3.1.3.48]
109093401  [KO:K03175] [EC:2.3.2.27]
109093415  [KO:K04414] [EC:2.7.11.1]
109093419  [KO:K17333]
109093640  [KO:K19662] [EC:2.7.11.13]
109093850  [KO:K04358]
109093910  [KO:K04735]
109094113  [KO:K03283]
109094194  [KO:K04863]
109094263  mapk8a; mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
109094421  [KO:K04353]
109094476  [KO:K04868]
109094548  insb; preproinsulin b [KO:K04526]
109094618  [KO:K08052]
109094655  [KO:K05461]
109094683  [KO:K05465]
109094867  fgf8b; fibroblast growth factor 8b [KO:K04358]
109095046  [KO:K04361] [EC:2.7.10.1]
109095097  [KO:K04353]
109095150  [KO:K07209] [EC:2.7.11.10]
109095178  fgf9; fibroblast growth factor 4A isoform X1 [KO:K04358]
109095226  [KO:K04355]
109095246  [KO:K04402]
109095252  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
109095255  [KO:K05087] [EC:2.7.10.1]
109095354  [KO:K04375]
109095401  [KO:K04868]
109095418  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
109095420  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
109095426  [KO:K04402]
109095566  [KO:K04358]
109096009  [KO:K07831]
109096024  [KO:K04388] [EC:2.7.11.30]
109096081  [KO:K04428] [EC:2.7.11.25]
109096227  [KO:K04358]
109096232  efna3a; ephrin-A3 [KO:K05462]
109096362  [KO:K04348] [EC:3.1.3.16]
109096391  [KO:K05085] [EC:2.7.10.1]
109096399  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
109096543  [KO:K02187] [EC:3.4.22.56]
109096556  [KO:K04440] [EC:2.7.11.24]
109096565  casp3a; caspase-3 [KO:K02187] [EC:3.4.22.56]
109096567  [KO:K05121] [EC:2.7.10.1]
109096570  [KO:K04448]
109096626  [KO:K04415] [EC:2.7.11.25]
109096718  [KO:K07831]
109096902  [KO:K04364]
109096971  [KO:K04429] [EC:2.7.11.1]
109096996  [KO:K04869]
109097009  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
109097010  [KO:K04869]
109097257  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
109097258  [KO:K04416] [EC:2.7.11.25]
109097286  [KO:K04362] [EC:2.7.10.1]
109097335  [KO:K03283]
109097342  [KO:K03283]
109097453  rasa1b; ras GTPase-activating protein 1 [KO:K04352]
109097519  [KO:K05452]
109097889  [KO:K12326]
109098212  [KO:K04674] [EC:2.7.11.30]
109098337  [KO:K04441] [EC:2.7.11.24]
109098343  [KO:K04429] [EC:2.7.11.1]
109098463  [KO:K05462]
109098492  [KO:K05094] [EC:2.7.10.1]
109098494  [KO:K05094] [EC:2.7.10.1]
109098538  [KO:K13769]
109098540  igf2b; insulin-like growth factor 2b [KO:K13769]
109098585  [KO:K04358]
109098722  [KO:K04409] [EC:2.7.11.1]
109098739  [KO:K05462]
109098750  [KO:K04372] [EC:2.7.11.1]
109098772  taok3a; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
109098785  cacna2d3; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
109098788  cacna1da; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
109098873  [KO:K04444] [EC:2.7.11.1]
109099003  [KO:K04358]
109099095  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
109099356  [KO:K05095] [EC:2.7.10.1]
109099370  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
109099460  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
109099463  [KO:K04439]
109099476  [KO:K09253]
109099518  [KO:K04358]
109099537  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
109099543  [KO:K07861]
109099626  [KO:K05092] [EC:2.7.10.1]
109099628  [KO:K05096] [EC:2.7.10.1]
109099689  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
109099690  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
109099970  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109100030  [KO:K04369] [EC:2.7.12.2]
109100174  [KO:K04381]
109100225  [KO:K04412]
109100262  [KO:K04422] [EC:2.7.11.25]
109100263  [KO:K04422] [EC:2.7.11.25]
109100305  [KO:K04386]
109100408  [KO:K17534] [EC:2.7.11.25]
109100443  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
109100514  [KO:K04360] [EC:2.7.10.1]
109100522  [KO:K06268]
109100549  [KO:K17386]
109100658  [KO:K04467] [EC:2.7.11.10]
109100701  [KO:K05093] [EC:2.7.10.1]
109100773  [KO:K04370]
109100905  [KO:K04456] [EC:2.7.11.1]
109100916  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
109101073  [KO:K04527] [EC:2.7.10.1]
109101117  [KO:K25415]
109101277  [KO:K04440] [EC:2.7.11.24]
109101305  [KO:K04852]
109101483  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
109101578  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109101640  [KO:K13376]
109101949  [KO:K02580]
109101953  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109102100  [KO:K05083] [EC:2.7.10.1]
109102309  [KO:K04355]
109102567  [KO:K04730] [EC:2.7.11.1]
109102572  [KO:K04345] [EC:2.7.11.11]
109102658  [KO:K17333]
109102734  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
109102888  [KO:K05097] [EC:2.7.10.1]
109102935  si:zfos-2326c3.2; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
109103005  [KO:K25414]
109103033  [KO:K04460] [EC:3.1.3.16]
109103035  [KO:K13375]
109103249  [KO:K04438]
109103380  [KO:K04462] [EC:2.1.1.367]
109103466  [KO:K03173] [EC:2.3.2.27]
109103470  [KO:K04460] [EC:3.1.3.16]
109103499  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
109103559  [KO:K04438]
109103597  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
109103603  [KO:K04433] [EC:2.7.12.2]
109103639  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X1 [KO:K04462] [EC:2.1.1.367]
109103722  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
109103799  [KO:K04379]
109103802  [KO:K04379]
109103832  [KO:K04353]
109104004  [KO:K04377]
109104191  akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
109104287  [KO:K05084] [EC:2.7.10.1]
109104293  [KO:K05084] [EC:2.7.10.1]
109104295  [KO:K04850]
109104427  [KO:K08052]
109104460  [KO:K05087] [EC:2.7.10.1]
109104576  [KO:K04406] [EC:2.7.11.1]
109104691  [KO:K02308]
109104746  [KO:K05462]
109104836  [KO:K04375]
109104876  cdc42l; cell division cycle 42, like [KO:K04393]
109104877  [KO:K04393]
109104926  [KO:K02582]
109105038  [KO:K03176] [EC:2.7.10.1]
109105108  [KO:K04392]
109105131  [KO:K04410] [EC:2.7.11.1]
109105133  [KO:K04360] [EC:2.7.10.1]
109105154  [KO:K18018] [EC:3.1.3.48]
109105217  [KO:K04406] [EC:2.7.11.1]
109105294  [KO:K04419] [EC:2.7.11.25]
109105413  [KO:K04426] [EC:2.7.11.25]
109105479  [KO:K04424] [EC:2.7.11.25]
109105553  ngfb; nerve growth factor [KO:K02582]
109105815  [KO:K05448]
109105843  [KO:K05465]
109106189  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
109106217  [KO:K04348] [EC:3.1.3.16]
109106243  [KO:K03176] [EC:2.7.10.1]
109106245  [KO:K05462]
109106267  [KO:K25416]
109106385  [KO:K04872]
109106453  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
109106613  [KO:K04388] [EC:2.7.11.30]
109106773  [KO:K04456] [EC:2.7.11.1]
109106881  [KO:K04873]
109106882  [KO:K04871]
109106994  sh3yl1; uncharacterized protein sh3yl1 [KO:K04364]
109107093  [KO:K16859]
109107183  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
109107281  [KO:K07860]
109107413  [KO:K04456] [EC:2.7.11.1]
109107425  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
109108031  [KO:K04390]
109108101  [KO:K04373] [EC:2.7.11.1]
109108119  [KO:K16859]
109108124  [KO:K04429] [EC:2.7.11.1]
109108143  pgfa; snake venom vascular endothelial growth factor toxin ICPP isoform X1 [KO:K16859]
109108151  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
109108174  [KO:K04406] [EC:2.7.11.1]
109108201  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
109108309  [KO:K05460]
109108447  [KO:K04373] [EC:2.7.11.1]
109108459  [KO:K04362] [EC:2.7.10.1]
109108460  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
109108771  [KO:K04855]
109108837  [KO:K05460]
109109058  [KO:K04441] [EC:2.7.11.24]
109109065  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
109109176  [KO:K04358]
109109449  [KO:K04435]
109109500  [KO:K04861]
109109517  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
109109723  [KO:K04858]
109109842  [KO:K04358]
109109927  [KO:K05453]
109110085  [KO:K04350]
109110162  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
109110358  [KO:K04468] [EC:2.7.11.24]
109110512  pak1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
109110699  [KO:K04429] [EC:2.7.11.1]
109110870  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109110929  [KO:K05096] [EC:2.7.10.1]
109111089  [KO:K04358]
109111096  [KO:K04388] [EC:2.7.11.30]
109111098  [KO:K04388] [EC:2.7.11.30]
109111438  fgf1b; fibroblast growth factor 1b [KO:K18496]
109111830  [KO:K04421] [EC:2.7.11.25]
109111849  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
109112244  [KO:K05466]
109112245  angpt2b; angiopoietin-2b [KO:K05466]
109112339  [KO:K04873]
109112341  [KO:K04446]
109112419  [KO:K04861]
109112504  [KO:K04871]
109112554  [KO:K04461] [EC:3.1.3.16]
109112702  [KO:K03156]
109112763  pla2g4ab; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
109112840  [KO:K04418] [EC:2.7.11.25]
109112913  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
109112983  [KO:K04427] [EC:2.7.11.25]
109113014  [KO:K04363] [EC:2.7.10.1]
109113016  [KO:K05091] [EC:2.7.10.1]
109113241  [KO:K04404]
109113326  [KO:K05096] [EC:2.7.10.1]
109113360  jun; transcription factor AP-1 [KO:K04448]
109113363  [KO:K04448]
109113379  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
109113515  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
109113517  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
109113757  [KO:K04346]
109113842  [KO:K04389]
122133965  ikbkb; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
122134682  [KO:K05448]
122136556  [KO:K04867]
122136564  [KO:K03283]
122136822  [KO:K04466] [EC:2.7.11.25]
122137324  [KO:K16342] [EC:3.1.1.4]
122137615  [KO:K22429]
122137938  [KO:K03283]
122138267  [KO:K04853]
122138744  [KO:K04526]
122139891  [KO:K05450]
122140189  [KO:K13377]
122142008  [KO:K05121] [EC:2.7.10.1]
122142323  [KO:K04358]
122142425  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
122144283  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
122144815  [KO:K04849]
122145921  [KO:K03283]
122146968  [KO:K02583]
122147390  [KO:K21278] [EC:3.1.3.16 3.1.3.48]
122147495  fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
122147526  [KO:K05450]
122147805  [KO:K04723]
122148962  [KO:K04457] [EC:3.1.3.16]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
ccar04070  Phosphatidylinositol signaling system
ccar04110  Cell cycle
ccar04115  p53 signaling pathway
ccar04210  Apoptosis
ccar04310  Wnt signaling pathway
KO pathway
ko04010   

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